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Humidity-induced synaptic plasticity of ZnO artificial synapses using peptide insulator for neuromorphic computing

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Journal of Materials Science & Technology 2022年第24期119卷 150-155页

作者： Min-Kyu Song Hojung lee Jeong Hyun Yoon Young-Woong Song Seok Daniel Namgung Taehoon Sung Yoon-Sik lee Jong-Seok lee Ki Tae Nam Jang-yeon Kwon School of Integrated Technology Yonsei UniversityIncheon 21983South Korea Department of Materials Science and Engineering Seoul National UniversitySeoul 08826South Korea Soft Foundry Seoul National UniversitySeoul 08826South Korea School of Chemical and Biological Engineering Seoul National UniversitySeoul 08826South Korea

Neuromorphic devices inspired by the human brain have attracted significant attention because of their excellent ability for cognitive and parallel *** study presents ZnO-based artificial synapses with peptide insulators for the electrical emulation of biological *** demonstrated the dynamic responses of the device under various environmental *** proton-conducting property of the tyrosine-rich peptide enables time-dependent responses under ambient conditions such that various aspects of synaptic behaviors are emulated by the *** transition from short-term memory to longterm memory is achieved via electrochemical doping of ZnO by ***,we demonstrate an image classification simulation using a multi-layer perceptron model to evaluate the potential of the device for use in neuromorphic *** neural network based on our device achieved a recognition accuracy of 87.47% for the MNIST handwritten digit *** work proposes a novel device platform inspired by biosystems for brain-mimetic hardware systems.

关键词： Artificial synapse Neuromorphic computing Oxide semiconductor Proton conductor Artificial neural network

Tyrosine-mediated analog resistive switching for artificial neural networks

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Nano Research 2023年第1期16卷 858-864页

作者： Min-Kyu Song Seok Daniel Namgung Hojung lee Jeong Hyun Yoon Young-Woong Song Kang Hee Cho Yoon-Sik lee Jong-Seok lee Ki Tae Nam Jang-yeon Kwon School of Integrated Technology Yonsei UniversityIncheon 21983Republic of Korea Department of Mechanical Engineering Massachusetts Institute of TechnologyMA 02139USA Research Laboratory of Electronics Massachusetts Institute of TechnologyMA 02139USA Department of Materials Science and Engineering Seoul National UniversitySeoul 08826Republic of Korea Soft Foundry Seoul National UniversitySeoul 08826Republic of Korea School of Chemical and Biological Engineering Seoul National UniversitySeoul 08826Republic of Korea

The fourth industrial revolution indispensably brings explosive data processing and storage;thus,a new computing paradigm based on artificial intelligence-enabling device structure is urgently *** have received considerable attention in this regard because of their ability to process and store data at the same ***,fundamental problems with abrupt switching characteristics limit their practical *** address this problem,we utilized the concept of metaplasticity inspired by biosystems and observed gradual switching in the peptide-based memristor at high proton *** unexpectedly high slope value>1.7 in the logI–V curve at low voltage(≤400 mV)was considered the main origin,and it might arise from the modulatory response of proton ions on the threshold of Ag ion migration in the peptide *** the obtained gradual switching property at high proton conductivity,the device showed significantly increased accuracy of image recognition(~82.5%).We believe that such a demonstration not only contributes to the practical application of neuromorphic devices but also expands the bioinspired functional synthetic platform.

关键词： artificial synapse neuromorphic computing proton conductor peptide materials artificial neural network

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试论西周带墓道大墓墓道的区域特征

江汉考古 2024年第2期 72-84页

作者：李准烨北京大学考古文博学院北京100871

西周时期带墓道大墓根据墓道后端是否有较宽大的平台可分为“一段式墓道”“二段式墓道”两种类型,各类型下又有“深墓室式”“通二层台式”“通墓底式”等亚型。西周带墓道大墓可分为三个区,即以陕西、山西、宁夏和北京为代表的I区,以... 详细信息

西周时期带墓道大墓根据墓道后端是否有较宽大的平台可分为“一段式墓道”“二段式墓道”两种类型,各类型下又有“深墓室式”“通二层台式”“通墓底式”等亚型。西周带墓道大墓可分为三个区,即以陕西、山西、宁夏和北京为代表的I区,以河南、山东为代表的II区和以湖北为代表的III区。各区带墓道大墓的特点如下:***区基本沿用了晚商时期的墓道底形制,少见墓道内摆放马车现象。2.I区二段式墓道较为流行,这一形制与墓道内摆放马车有关,并随着摆放马车习俗的消退,二段式墓道逐渐由一段式通二层台式墓道所取代,部分非姬姓周人还使用了一段式深墓室式墓道。***区流行一段式深墓室式墓道,墓道内不见马车随葬。

关键词：西周带墓道大墓墓道区域特征

Variations in microstructure and bending formability of extruded Mg–Al–Zn–Ca–Y–MM alloy with precompression and subsequent annealing treatment conditions

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Journal of Magnesium and Alloys 2022年第9期10卷 2475-2490页

作者： Jong Un lee Sang-Hoon Kim Dong Hee lee Hyun ji Kim Young Min Kim Sung Hyuk Park School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Agency for Defense Development Daejeon 34186Republic of Korea Implementation Research Division Korea Institute of Materials ScienceChangwon 51508Republic of Korea

In this study, the bending formability of an extruded Mg–9Al–1Zn–0.3Mn–0.9Ca–0.6Y–0.5 MM(AZXWMM91100, wt%) alloy at room temperature is significantly improved through application of a combined precompression and subsequent annealing(PCA) treatment. As the amount of precompression applied along the extrusion direction(ED)(i.e., the total strain) increases from 4% to 6%, the area fraction of ED-oriented grains of the PCA-treated alloy increases, which consequently causes an improvement in its bending formability because these grains accommodate larger tensile strain along the ED during bending. As the temperature of the subsequent annealing treatment increases from 350 ℃ to 450 ℃, both the area fraction of the ED-oriented grains and the average grain size increase, and the residual dislocation density decreases owing to the promotion of boundary migration and occurrence of the recovery process at higher ***, the bending formability of both the 4%-precompressed and the 6%-precompressed samples increases with an increase in the annealing temperature. However, when the precompressed samples are annealed at 300 ℃, their bending formability is lower than that of the extruded alloy because the dislocations formed by precompression remain even after the subsequent annealing at this temperature.

关键词： Magnesium Extrusion Bending Formability Texture

Differential ligand binding/trafficking for distinct CTLA-4 fates: is it an expandable mechanism?

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Cellular & Molecular Immunology 2023年第1期20卷 1-2页

作者： ji Eon Kim Eunmi Kim Jung Weon lee Department of Pharmacy Research Institute of Pharmaceutical SciencesCollege of PharmacySeoul National UniversitySeoul08826Republic of Korea

In a recent issue of Nature Immunology,Kennedy et *** that CTLA-4(CD152)differentially targets two distinct ligands,CD80 and CD86,on antigen-presenting cells(APCs)for destruction or recycling following transendocytosis(TE),resulting in separate fates for CTLA-4 on T_(reg) cells and thereby regulating ***,whereas CTLA-4 tightly binds CD80 for TE and causes ubiquitination and trafficking to late endosomes and lysosomes for degradation,CTLA-4 weakly binds CD86 for TE,resulting in dissociation under acidic conditions(pH<6)and recycling of CTLA-4 to the plasma membrane for further CD86 ***,CD86 targeting by CTLA-4 regulates T-cell function in autoimmunity[1]and presumably immune surveillance of cancer cells(Fig.1).

关键词： thereby traffic weakly

Design to reduce electromagnetic vibration in integral-slot SPM machine considering force modulation effect

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Science China(Technological Sciences) 2022年第8期65卷 1867-1877页

作者： ZHU ShengDao ZHAO WenXiang ji jingHua LIU GuoHai lee Christopher H.T. School of Electrical and Information Engineering Jiangsu UniversityZhenjiang 212013China School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore 639798Singapore

In this paper, two different designs, with dummy slots and bread-loaf magnets techniques, are presented to reduce the electromagnetic vibration in integral-slot surface-mounted permanent-magnet(SPM) machines. Firstly, the stator slotting effect on the magnetic field modulation and radial force modulation is investigated. It reveals the amplitude of the modulated magnetic field and modulated radial force is greatly affected by the slot opening effect, while the spatial order is closely associated with the slot numbers. Subsequently, the dummy slots and bread-loaf magnets design are developed for a 36-slot/12-pole integral-slot SPM machine to reduce the electromagnetic vibration. Finally, two SPM machines, with conventional and bread-loaf magnets,are manufactured. Experimental tests are carried out to validate the theoretical analyses.

关键词： surface-mounted permanent-magnet machine slot opening width dummy slots bread-loaf magnets vibration reduction

Reprogramming of cancer-associated fibroblasts by apoptotic cancer cells inhibits lung metastasis via Notch1-WISP-1 signaling

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Cellular & Molecular Immunology 2022年第12期19卷 1373-1391页

作者： Hee Ja Kim Kyungwon Yang Kiyoon Kim Ye‐ji lee Sieun lee Sung Yong Ahn Young‐Ho Ahn jihee lee Kang Department of Physiology College of MedicineEwha Womans UniversitySeoul07804Korea Inflammation-Cancer Microenvironment Research Center College of MedicineEwha Womans UniversitySeoul07804Korea Department of Molecular Medicine College of MedicineEwha Womans UniversitySeoul07804Korea

The interplay between apoptotic cancer cells and the tumor microenvironment modulates cancer progression and ***-associated fibroblasts(CAFs)play a crucial role in promoting these events through paracrine ***,we demonstrate that conditioned medium(CM)from lung CAFs exposed to apoptotic cancer cells suppresses TGF-β1-induced migration and invasion of cancer cells and *** exposure of CAFs to apoptotic 344SQ cells(ApoSQ)inhibited CAF migration and invasion and the expression of CAF activation *** secretion of Wnt‐induced signaling protein 1(WISP-1)by CAFs exposed to ApoSQ was required for these antimigratory and anti-invasive *** inhibition of Notch1 activation or siRNA-mediated Notch1 silencing prevented WISP-1 production by CAFs and reversed the antimigratory and anti-invasive *** expression of the Notch ligand delta-like protein 1 on the surface of ultraviolet-irradiated apoptotic lung cancer cells triggered Notch1-WISP-1 *** receptor brain-specific angiogenesis inhibitor 1(BAI1)-Rac1 signaling,which facilitated efferocytosis by CAFs,participated in crosstalk with Notch1 signaling for optimal production of *** addition,a single injection of ApoSQ enhanced WISP-1 production,suppressed the expression of CAF activation markers in isolated Thy1^(+)CAFs,and inhibited lung metastasis in syngeneic immunocompetent mice via Notch1 *** with CM from CAFs exposed to ApoSQ suppressed tumor growth and lung metastasis,whereas treatment with WISP-1-immunodepleted CM from CAFs exposed to ApoSQ reversed the antitumorigenic and antimetastatic ***,treatment with CM from CAFs exposed to apoptotic lung cancer cells could be therapeutically applied to suppress CAF activation,thereby preventing cancer progression and metastasis.

关键词： CAFs Apoptotic lung cancer cells Notch1 WiSP-1 Efferocytosis Migration Invasion Metastasis

Bilateral superficial cervical plexus block for parathyroidectomy during pregnancy:A case report

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World Journal of Clinical Cases 2022年第13期10卷 4153-4160页

作者： Jun-Young Chung Yo Seob lee Seung yeon Pyeon Sang-Ah Han Hyub Huh Department of Anesthesiology and Pain Medicine Kyung Hee University Hospital at GangdongCollege of MedicineKyung Hee UniversitySeoul 05278South Korea Department of Obstetrics&Gynecology Kyung Hee University Hospital at GangdongCollege of MedicineKyung Hee UniversitySeoul 05278South Korea Department of Surgery Kyung Hee University Hospital at GangdongCollege of MedicineKyung Hee UniversitySeoul 05278South Korea

BACKGROUND Primary hyperparathyroidism(PHPT)is the most common cause of pregnancyrelated *** can cause maternal and fetal complications in pregnant *** anesthesia for non-obstetric surgery in pregnant women is associated with maternal hazards and concerns regarding long-term neonatal neurocognitive *** removal of the lesion in mid-pregnancy is currently the primary treatment option for pregnant patients with ***,the blood calcium concentration at which surgery should be considered remains under discussion due to the risk of *** SUMMARY A 31-year-old nulliparous woman at 11 wk of gestation was admitted to our hospital for *** patient had a history of intrauterine fetal death with unknown etiology at 16 wk of gestation 1 year *** blood test results showed that the serum calcium level was elevated to 12.9 mg/dL,and the parathyroid hormone level was elevated to 157 pg/*** a neck ultrasound,it revealed a 0.8 cm×1.5 cm sized oval,hypoechoic mass in the upper posterior of the left thyroid gland,which was compatible with parathyroid *** cervical plexus block(SCPB)for parathyroidectomy was *** surgery,the obstetrician checked the status of the fetus,and there were no abnormal *** then her calcium level returned to normal values after one week of surgery and a healthy male neonate of 2910 g was delivered vaginally at 38 wk of *** Our case suggests that SCPB can be an anesthetic option for parathyroidectomy during the first trimester of pregnancy.

关键词： Bilateral superficial cervical plexus block Hypercalcemia Parathyroid adenoma Parathyroidectomy Pregnancy Case report

Risks of non-conservative design according to ASME B31.1 for high-temperature piping subjected to long-term operation in the creep range

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Nuclear Science and Techniques 2019年第5期30卷 59-69页

作者： Hyeong-yeon lee Seok-Kwon Son Min-Gu Won ji-Young Jeong Korea Atomic Energy Research Institute National Fusion Research Institute School of Mechanical Engineering Sungkyunkwan University

This study investigates the risks of non-conservative piping design according to ASME B31.1 for hightemperature piping subjected to long-term operation at high temperature in a creep regime based on a sensitivity analysis of the hold time. Design evaluations of hightemperature piping were conducted over a range of hold times in the creep regime according to ASME B31.1,which implicitly considers the creep effects, and the French high-temperature design code of the RCC-MRx, which explicitly considers the creep effects. Conservatisms were quantified among the codes in terms of the hold times. In the case of B31.1, the design evaluation results do not change depending on the hold time at high temperature,whereas in the case of RCC-MRx, they do. It was shown that the design limits of RCC-MRx were exceeded when the hold time exceeded certain values, whereas those of B31.1 were satisfied regardless of the hold times. Thus, the design evaluations according to B31.1 did not consistently yield conservative results and might lead to non-conservative results in the case of long-term operations in the creep range.

关键词： ASME B31.1 Creep Hold time Hightemperature piping RCC-MRx Sensitivity analysis