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Associations of genetic polymorphisms of the transporters organic cation transporter 2(OCT2),multidrug and toxin extrusion 1(MATE1),and ATP-binding cassette subfamily C member 2(ABCC2) with platinum-based chemotherapy response and toxicity in non-small cel

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Chinese Journal of Cancer 2016年第11期35卷 604-616页

作者： Chen-Yue Qian Yi Zheng ying Wang Juan Chen Jun-Yan Liu Hong-Hao Zhou ji-ye yin Zhao-Qian Liu Department of Clinical Pharmacology Xiangya HospitalCentral South Uni-versityChangsha 410008HunanP.R.China. Institute of Clinical Pharmacol-ogy Hunan Key Laboratory of PharmacogeneticsCentral South UniversityChangsha 410078HunanP.R.China. Hunan Province Cooperation Innovation Center for Molecular Target New Drug Study Hengyang 421001HunanP.R.China. Key Laboratory of Hunan Province for Traditional Chinese Medicine in Obstetrics&Gynecology Research The Maternal and Child Health Hospital of Hunan ProvinceChangsha 410008HunanP.R.China. The affiliated Cancer Hospital of Xiangya School of Medicine Central South UniversityChangsha 410008HunanP.R.China. Xiangya School of Medicine Central South UniversityChangsha 410008HunanP.R.China.

Background:Platinum-based chemotherapy is the first-line treatment of non-small cell lung cancer(NSCLC);it is therefore important to discover biomarkers that can be used to predict the efficacy and toxicity of this *** important transporter genes are expressed in the kidney,including organic cation transporter 2(OCT2),multidrug and toxin extrusion 1(MATEl),ATP-binding cassette subfamily B member 1 {ABCB1),and ATP-binding cassette subfamily C member 2(ABCC2),and genetic polymorphisms in these genes may alter the efficacy and adverse effects of platinum *** study aimed to evaluate the association of genetic polymorphisms of these transporters with platinumbased chemotherapy response and toxicity in NSCLC ***:A total of 403 Chinese NSCLC patients were recruited for this *** patients were newly diagnosed with NSCLC and received at least two cycles of platinum-based *** tumor response and toxicity were evaluated after two cycles of treatment,and the patients' genomic DNA was *** single-nucleotide polymorphisms in four transporter genes were selected to investigate their associations with platinum-based chemotherapy toxicity and ***:OCT2 rs316019 was associated with hepatotoxicity(P = 0.026) and hematological toxicity(P = 0.039),and MATEl rs2289669 was associated with hematological toxicity induced by platinum(P = 0.016).In addition,ABCC2rs717620 was significantly associated with the platinum-based chemotherapy response(P = 0.031).ABCB1 polymorphisms were associated with neither response nor ***:OCT2 rs316019,MATEl rs2289669,and ABCC2 rs717620 might be potential clinical markers for predicting chemotherapy toxicity and response induced by platinum-based treatment in NSCLC *** registration Chinese Clinical Trial Registry

关键词： OCT2 MATE1 ABCC2 Non-small cell lung cancer Platinum-based chemotherapy

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Soft coarse-grained particle model for particle-fluid systems

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Particuology 2024年第1期84卷 178-193页

作者： Yanhao ye ji Xu Wei Ge State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China Innovation Academy for Green Manufacture Chinese Academy of SciencesBeijing100190China

By modeling a group of neighboring real particles as a single coarse-grained particle(CGP),discrete particle method(DPM)is now capable of simulating industrial-scale particle-fluid ***,a systematic approach to determine the CGP properties and develop their interaction models is still lacking,which casts uncertainty on the predictivity of the *** this study,collisions between predefined particle groups are analyzed to construct kernel functions for modeling the CGPs and then the model parameters are determined by equating the statistical properties of the CGPs and the real particles in the physical process *** approach is implemented for homogeneous cooling of granular gas,then demonstrated effective in simulating experimental fluidized beds.

关键词： Coarse-grain(CG) Discrete particle method(DPM) Fluidized bed Multi-scale simulation

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3D coarse-grained DPM simulation of the MIP reaction-regeneration loop

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Particuology 2024年第6期89卷 57-66页

作者： Yanhao ye Shuai Zhang ji Xu Wei Ge State Key Laboratory of Mesoscience and Engineering(formerly State Key Laboratory of Multiphase Complex Systems) Institute of Process EngineeringChinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

The reactor-regenerator loop is the core facility of the maximizing iso-paraffin(MIP)*** the discrete particle method(DPM)simulation can provide detailed information at the particle scale,it has been unable to simulate such a complex loop system due to limitations of coarse-grained(CG)models,computing software,and *** this study,a newly proposed soft-shell CG-DPM model with a CG ratio of up to 800 is used to simulate a 3.5 Mt/a industrial-scale MIP reactor-regenerator *** solid fraction distribution obtained is found to agree well with in-situ *** properties including the distribution of solid fraction,gas and solid velocity,standard derivation of solid fraction with time,temporal distribution of the flow field,and particle residence time distribution are measured in the simulation,which are meaningful to better design and operate such systems in the future.

关键词： Discrete particle method Coarse-grain Maximizing iso-paraffins Full-loop Reaction-regeneration system

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Boeravinone B ameliorates allergic nasal inflammation by modulating the GATA-3/T-bet signaling pathway in a mouse model of allergic rhinitis

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Asian Pacific Journal of Tropical Biomedicine 2024年第6期14卷 245-252页

作者： Ben ye ji-Zhe Wang Department of Otorhinolaryngology Second Hospital of Dalian Medical UniversityDalian116000China Department of Otorhinolaryngology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan250000China

Objective:To evaluate the anti-allergic effect of boeravinone B against ovalbumin-induced allergic rhinitis in mice and explore its possible ***:For the induction of allergic rhinitis,mice were intraperitoneally sensitized and intranasally challenged with ovalbumin,as well as orally received various concentrations of boeravinone *** mucosal inflammation,and the levels of nitric oxide,β-hexosaminidase,IFN-γ,LTC-4,myeloperoxidase,Nrf2,HO-1,GATA-3,ROR-γ,T-bet,antioxidant parameters,and allergen-specific cytokines were ***:Boeravinone B markedly reduced ovalbumin-induced increase in the number of episodes of nasal sneezing,rubbing,and discharge,as well as the levels of IgE,IgG1,andβ-hexosaminidase(Pyeloperoxidase,oxide-nitrosative stress,and the levels of IL-1β,IL-4,IL-5,IL-6,IL-13,IL-17,tumor necrosis factor-α,GATA-3,and ROR-γwhile enhancing the level of ***:Boeravinone B is a potential therapeutic agent for allergic rhinitis by modulating various inflammatory mediators and immune responses.

关键词： Allergic reaction Boeravinone B Oxidative stress Inflammation Ovalbumin

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VKFQ:A Verifiable Keyword Frequency Query Framework with Local Differential Privacy in Blockchain

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Computers, Materials & Continua 2024年第3期78卷 4205-4223页

作者： Youlin ji Bo yin Ke Gu School of Computer and Communication Engineering Changsha University of Science and TechnologyChangsha410114China

With its untameable and traceable properties,blockchain technology has been widely used in the field of data *** to preserve individual privacy while enabling efficient data queries is one of the primary issues with secure data *** this paper,we study verifiable keyword frequency(KF)queries with local differential privacy in *** the numerical and the keyword attributes are present in data objects;the latter are sensitive and require privacy ***,prior studies in blockchain have the problem of trilemma in privacy protection and are unable to handle KF *** propose an efficient framework that protects data owners’privacy on keyword attributes while enabling quick and verifiable query processing for KF *** framework computes an estimate of a keyword’s frequency and is efficient in query time and verification object(VO)size.A utility-optimized local differential privacy technique is used for privacy *** data owner adds noise locally into data based on local differential privacy so that the attacker cannot infer the owner of the keywords while keeping the difference in the probability distribution of the KF within the privacy *** propose the VB-cm tree as the authenticated data structure(ADS).The VB-cm tree combines the Verkle tree and the Count-Min sketch(CM-sketch)to lower the VO size and query *** VB-cm tree uses the vector commitment to verify the query *** fixed-size CM-sketch,which summarizes the frequency of multiple keywords,is used to estimate the KF via hashing *** conduct an extensive evaluation of the proposed *** experimental results show that compared to theMerkle B+tree,the query time is reduced by 52.38%,and the VO size is reduced by more than one order of magnitude.

关键词： Security data sharing blockchain data query privacy protection

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DEGREE ELEVATION AND KNOT INSERTION FOR GENERALIZED BEZIER SURFACES AND THEIR´APPLICATION TO ISOGEOMETRIC ANALYSIS

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Journal of Computational Mathematics 2024年第5期42卷 1197-1225页

作者： Mengyun Wang ye ji Chungang Zhu School of Mathematical Sciences Dalian University of TechnologyDalian 116024China Key Laboratory for Computational Mathematics and Data Intelligence of Liaoning Province Dalian 116024China

Generalized B´ezier surfaces are a multi-sided generalization of classical tensor product B´ezier surfaces with a simple control structure and inherit most of the appealing properties from B´ezier ***,the original degree elevation changes the geometry of generalized B´ezier surfaces such that it is undesirable in many applications,*** *** this paper,we propose an improved degree elevation algorithm for generalized B´ezier surfaces preserving not only geometric consistency but also parametric *** on the knot insertion of B-splines,a novel knot insertion algorithm for generalized B´ezier surfaces is also *** the proposed algorithms are employed to increase degrees of freedom for multi-sided computational domains parameterized by generalized B´ezier surfaces in isogeometric analysis,corresponding to the traditional p-,h-,and *** examples demonstrate the effectiveness and superiority of our method.

关键词： Generalized B´ezier surface Degree elevation Knot insertion Isogeometric analysis Refinement

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Copper-catalyzed enantioselective desymmetrizing C(sp^(2))-H functionalization of azide-ynamides via α-imino copper carbenes

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Science China Chemistry 2024年第9期67卷 2982-2988页

作者： En-He Huang Li-Gao Liu You-Wei yin Hao-Xuan Dong ji-jia Zhou Xin Lu Bo Zhou Long-Wu ye Key Laboratory for Chemical Biology of Fujian Province and State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

α-Imino metal carbenes are versatile intermediates in organic synthesis,and have broad applications in the assembly of divergent ***,the catalytic enantioselective desymmetrization based onα-imino metal carbenes has not been developed to ***,we disclose an enantioselective desymmetrizing C(sp^(2))-H functionalization of azide-ynamides viaα-imino copper carbenes,leading to the efficient assembly of divergent chiral indoloazepines in generally moderate to excellent yields with high ***,this reaction represents the first enantioselective desymmetrization based onα-imino metal *** synthetic transformations and biological tests show the potential utility of this ***,computational studies are employed to elucidate the reaction mechanism and the origin of enantioselectivity.

关键词： enantioselective desymmetrization metal carbenes copper catalysis nitrene transfer alkynes

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A robust viscoelastic surfactant tolerating 20% HCl up to 150℃ for oil well stimulation

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Petroleum Science 2024年第3期21卷 1865-1874页

作者： ji Wang Ning Qi Hong-Yao yin Yu-Jun Feng Polymer Research Institute State Key Laboratory of Polymer Materials EngineeringSichuan UniversityChengdu610065SichuanPR.China Tianfu Yongxing Laboratory New Theory and Technology of CO_(2) Capture Research CenterChengdu610065SichuanPR China School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongPR China

Viscoelastic surfactants(VES)are often used as viscous diverters in acidizing stimulation to prolong the acid consumption time and maximize zonal coverage of the acid for improving well ***,the ceiling temperature of commercial VES cannot exceed 120℃in practical use because of the poor thermal stability and fragile molecular structure,hindering their implementation in hightemperature oil reservoirs,i.e.,≥150℃.Here we synthesized a novel C22-tailed diamine,N-erucaminopropyl-N,N-dimethylamine(EDPA),and examined comparatively its rheological behavior,assemblies morphology and molecular stability in 20 wt%HCl with a commercial VES,erucyl dimethyl amidopropyl betaine(EDAB).The feasibility of EDPA for acidizing stimulation was assessed by acid etching of carbonate rock with its HCl solution at 150℃.Rheological results showed that the 2.5 wt%EDPA—20 wt%HCl solution maintains stable viscosity of 90 m Pa s at 150℃for 60 min,while that of 2.0 wt%EDAB HCl solution is just 1 m Pa s under identical conditions.1H NMR spectra and cryo-TEM observations revealed that the chemical structure and self-assembled architectures of EDPA remained intact in such context,but the EDAB suffered from degradation due to the hydrolysis of the amide group,accounting for the poor heat-resistance and *** reaction rate of 2.5 wt%EDPA HCl solution with carbonate rock was one order of magnitude lower than that of 20 wt%HCl solution at 150℃,underpinning the potential of EDPA to be used in the high-temperature reservoirs *** work improved the thermal tolerance of VES in highly concentrated HCl solution,paving a feasible way for the acidization of high-temperature reservoir environments(~150℃).

关键词： Viscoelastic surfactants Thermal stability Self-diverting acid Wormlike micelles Acidizing stimulation

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Rapid chemical recycling of waste polyester plastics catalyzed by recyclable catalyst

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Green Chemical Engineering 2024年第2期5卷 257-265页

作者： Yu-ji Luo jia-yin Sun Zhi Li School of Physical Science and Technology ShanghaiTech UniversityShanghai201210China

Waste plastics are serious environmental threats due to their low degradability and low recycling *** and efficient waste plastics recycling technologies are urgently demanded for a sustainable ***,we report a rapid,closed-loop,and streamlined process to convert polyesters such as poly(ethylene terephthalate)(PET)back to its purified *** trifluoromethanesulfonic acid or metal triflates as the recyclable catalyst,polyesters such as PET can be completely depolymerized by simple carboxylic acids within 1 *** coupling this acidolysis with a subsequent hydrogenolysis process,the consumed carboxylic acid was recovered and the closed-loop of PET depolymerization could be *** catalysts and depolymerization agents are fully recycled while only PET and hydrogen are consumed.

关键词： Chemical recycling Waste polyester plastics Acidolysis Recyclable catalyst

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Insight into the Role and Evidence of Oxygen Vacancies in Porous Single-Crystalline Oxide to Enhance Catalytic Activity and Durability

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Research 2024年第2期2023卷 675-683页

作者： Lingting ye jiaming Ma jie Zhang Wen yin Yuanguang Xia Kui Xie Key Laboratory of Optoelectronic Materials Chemistry and Physics Fujan Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouFujian 350002China Fujian Science&Technology Innovation Laboratory for Optoelectronic Information of China FuzhouFujian 350108China Advanced Energy Science and Technology Guangdong Laboratory 29 Sanxin North RoadHuizhouGuangdong 116023China Spallation Neutron Source Science Center DongguanGuangdong 523803China

Introducing and stabilizing oxygen vacancies in oxide catalysts is considered to be a promising strategy for improving catalytic activity and ***,we quantitatively create oxygen vacancies in the lattice of porous single-crystallineβ-Ga_(2)O_(3)monoliths by reduction treatments and stabilize them through the long-range ordering of crystal lattice to enhance catalytic activity and *** combination analysis of time-of-flight neutron powder diffraction and extended x-ray absorption fine structure discloses that the preferential generation of oxygen vacancy tends to occur at the site of tetrahedral coordination oxygen ions(O_(Ⅲ)sites),which contributes to the formation of unsaturated Ga-O coordination in the monoclinic *** oxygen vacancies are randomly distributed in lattice even though some of them are present in the form of domain defect in the PSC Ga_(2)O_(3)monoliths after the reduction *** number of oxygen vacancies in the reduced monoliths gives 2.32×10^(13),2.87×10^(13),and 3.45×10^(13)mg^(-1)for the Ga_(2)O_(2.952),Ga_(2)O_(2.895),and Ga_(2)O_(2.880),*** therefore demonstrate the exceptionally high C_(2)H_(4)selectivity of~100%at the C_(2)H_(6)conversion of~37%for nonoxidative dehydrogenation of C_(2)H_(6)to C_(2)H_(4).We further demonstrate the excellent durability even at 620℃for 240 h of continuous operation.

关键词： durability coordination Oxygen

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