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Sarcomatoid intrahepatic cholangiocarcinoma with good patient prognosis after treatment with Huaier granules following hepatectomy:A case report

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World Journal of Clinical Cases 2022年第9期10卷 2829-2835页

作者： ji-ye feng Xian-Peng Li Zong-Yang Wu Li-Ping Ying Chang Xin Zhen-Zhen Dai Yao Shen Yi-feng Wu Department of Hepatobiliary&Pancreas Surgery The Affiliated People’s Hospital of Ningbo UniversityNingbo 315040Zhejiang ProvinceChina Department of Infectious Disease The Affiliated People’s Hospital of Ningbo UniversityNingbo 315040Zhejiang ProvinceChina Department of Pathology The Affiliated People’s Hospital of Ningbo UniversityNingbo 315040Zhejiang ProvinceChina Department of Radiology The Affiliated People’s Hospital of Ningbo UniversityNingbo 315040Zhejiang ProvinceChina

BACKGROUND Sarcomatoid intrahepatic cholangiocarcinoma(SICC)is an extremely rare and highly invasive malignant tumor of the *** precise pathologic mechanism of SICC has not been clearly identified,and the prognosis is very *** effectiveness of the treatment strategy of radical hepatectomy combined with Huaier granules has not yet been *** SUMMARY The patient was a 69-year-old male who presented with intermittent right upper abdominal pain for one month and 4-pound weight loss before *** magnetic resonance imaging and magnetic resonance cholangiopancreatography showed multiple stones in the bile ducts accompanied by dilatation of the intrahepatic and extrahepatic bile *** preoperative diagnoses were right intrahepatic bile duct stones and extrahepatic bile duct stones;thus,surgical resection was *** showed that the bile duct wall of the right anterior lobe was thickened,and a mass was visible in the ***,a biopsy was performed,and rapid frozen-section biopsy analysis indicated that the tumor was *** final diagnosis was SICC(T1a N0M0).Huaier granules were taken by the patient as anticancer therapy after *** patient attended follow-up for 72 mo with no tumor recurrence or *** Sarcomatous intrahepatic cholangiocarcinoma is an extremely rare,aggressive malignancy,and the diagnostic gold standard is pathological *** reported the first case of successful treatment with Huaier granules as anticancer therapy after surgery,which indicated that Huaier granules are safe and *** studies are needed to study the anticancer molecular mechanisms of Huaier granules in sarcomatous intrahepatic cholangiocarcinoma.

关键词： Sarcomatous intrahepatic cholangiocarcinoma Hepatectomy Huaier granules Diagnose Therapy Case report

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基于PCA和PLS-DA算法的不同生长阶段贯叶金丝桃药材HPLC指纹图谱研究

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药物分析杂志 2020年第3期40卷 568-576页

作者：项锋叶继锋侯齐书温州医科大学附属第二医院药学部温州325000

目的:建立不同生长阶段贯叶金丝桃HPLC指纹图谱,并结合相似度计算和化学模式识别技术对其进行质量评价。方法:采用Waters Sunfire ODS(250 mm×4.6 mm,5μm)色谱柱;乙腈-0.05%磷酸水溶液为流动相,梯度洗脱,流速1.0 mL·min-1,检测波长25... 详细信息

目的:建立不同生长阶段贯叶金丝桃HPLC指纹图谱,并结合相似度计算和化学模式识别技术对其进行质量评价。方法:采用Waters Sunfire ODS(250 mm×4.6 mm,5μm)色谱柱;乙腈-0.05%磷酸水溶液为流动相,梯度洗脱,流速1.0 mL·min-1,检测波长254 nm,建立18批贯叶金丝桃的指纹图谱。采用相似度分析、主成分分析(PCA)及偏最小二乘法-判别分析(PLS-DA)对其总体质量进行分析评价。结果:建立了贯叶金丝桃指纹图谱且共标定16个共有峰,经过与对照品比对,指认并鉴定出其中的6个色谱峰。18批样品的相似度为0.712~0.933,PCA分析出不同生长阶段的贯叶金丝桃药材的最佳采收阶段为盛开期;PLS-DA可将不同生长阶段的样品显著分类,并筛选出导致不同生长阶段质量差异的6个差异标志物。结论:该研究建立的指纹图谱分析方法科学、准确,结合PCA和PLS-DA化学模式识别技术,可系统、全面地评价贯叶金丝桃的质量。

关键词：贯叶金丝桃 HPLC指纹图谱相似度主成分分析偏最小二乘法-判别分析

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High-dense nanocrystalline W-based alloy prepared by hot isostatic pressing with uniform microstructure, ultrahigh hardness and good thermal stability

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Tungsten 2025年第1期7卷 120-136页

作者： Zao-Ming Wu Lin He Lin-Sen ye Xiao-feng Yang jia-jia Zhang Hong-Bo Lei Institute of Materials China Academy of Engineering Physics

High-density uniform microstructure nanocrystalline W-10wt.% Cr-5wt.% Y（W-10Cr-5Y） alloy with an average grain size of 85 nm and a relative density of 99.8% was successfully prepared.W-Cr-Y alloys with different amounts of second-phase particles were prepared by high-energy ball milling and hot isostatic pressing *** effects of composition design,ball milling parameters,and sintering parameters on the microstructure of W-Cr-Y alloys were studied.A feasible technology for controlling the synthesis of high-density nanocrystalline W-based alloys has been *** microstructure analysis of nanocrystalline W-10Cr-5Y alloy shows that there are two types of doping in the second phase:intergranular doping and intragranular *** "uniform distribution YOx-rich particles" effectively suppresses the grain growth of W and leads to the formation of nanocrystalline W-10Cr-5Y alloy.W-10Cr-5Y has an ultra-high hardness,with a Vickers hardness of 1312±12 kgf·***-temperature annealing treatment shows that W-10Cr-5Y has good thermal stability at 1000 and1100℃,as demonstrated by the comparison of Vickers hardness and grain size between annealed and unannealed alloys.

关键词： Hot isostatic pressing Microstructure Nanocrystalline tungsten Thermal stability Vickers hardness

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肿瘤坏死因子-α、白细胞介素-6和脂联素与2型糖尿病胰岛素抵抗的关系

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中国基层医药 2011年第10期18卷 1308-1309页

作者：叶继锋聊城市第二人民医院内分泌科山东省临清252600

目的研究2型糖尿病（T2DM）患者肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和脂联素与胰岛素抵抗的关系.方法选择80例T2DM患者（T2DM组）和40例健康体检者（对照组）,测定各组空腹血清TNF-α,IL-6和脂联素水平,同时分别测定各... 详细信息

目的研究2型糖尿病（T2DM）患者肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）和脂联素与胰岛素抵抗的关系.方法选择80例T2DM患者（T2DM组）和40例健康体检者（对照组）,测定各组空腹血清TNF-α,IL-6和脂联素水平,同时分别测定各组患者体质量指数（BMI）、空腹血糖、血清胰岛素水平,计算胰岛素抵抗指数（HOMA-IR）.结果 T2DM组TNF-α、IL-6水平均明显高于对照组,脂联素水平明显低于对照组（均P＜0.05）.在T2DM组中,TNF-α和IL-6均与HOMA-IR呈正相关（P＜0.01,P＜0.05）,脂联素与HOMA-IR呈负相关（P＜0.01）.结论 IL-6、TNF-α及脂联素参与了2型糖尿病的发病过程,与胰岛素抵抗密切相关.

关键词：糖尿病,2型胰岛素抵抗细胞因子脂联素

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小半夏加茯苓汤单煎与合煎之间多糖含量及紫外扫描的差异

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光谱实验室 2011年第6期28卷 3083-3087页

作者：叶继锋戴伟伟侯齐书林奕沨温州医学院附属第二医院药剂科

比较小半夏加茯苓汤单煎与合煎之间的差异。采用水提醇沉法提取多糖,以葡萄糖标准品进行对照测定多糖含量,紫外检测波长为198nm。通过峰位和吸光度值比较单煎液与合煎液的紫外扫描差异。小半夏加茯苓汤合煎液提取的多糖量较单煎液多,单... 详细信息

比较小半夏加茯苓汤单煎与合煎之间的差异。采用水提醇沉法提取多糖,以葡萄糖标准品进行对照测定多糖含量,紫外检测波长为198nm。通过峰位和吸光度值比较单煎液与合煎液的紫外扫描差异。小半夏加茯苓汤合煎液提取的多糖量较单煎液多,单煎液与合煎液紫外扫描基本一致,合煎液吸光度值较高。小半夏加茯苓汤合煎较单煎为优,尚不能完全说明是否能用免煎颗粒调冲的小半夏加茯苓来替代传统汤剂。

关键词：紫外分光光度法多糖提取单煎合煎

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Overexpression of low-density lipoprotein receptor prevents neurotoxic polarization of astrocytes via inhibiting NLRP3 inflammasome activation in experimental ischemic stroke

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Neural Regeneration Research 2025年第2期20卷 491-502页

作者： Shuai feng Juanji Li Tingting Liu Shiqi Huang Xiangliang Chen Shen Liu Junshan Zhou Hongdong Zhao ye Hong Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina

Neurotoxic astrocytes are a promising therapeutic target for the attenuation of cerebral ischemia/reperfusion ***-density lipoprotein receptor,a classic cholesterol regulatory receptor,has been found to inhibit NLR family pyrin domain containing protein 3(NLRP3)inflammasome activation in neurons following ischemic stroke and to suppress the activation of microglia and astrocytes in individuals with Alzheimer’s ***,little is known about the effects of low-density lipoprotein receptor on astrocytic activation in ischemic *** address this issue in the present study,we examined the mechanisms by which low-density lipoprotein receptor regulates astrocytic polarization in ischemic stroke ***,we examined low-density lipoprotein receptor expression in astrocytes via immunofluorescence staining and western blotting *** observed significant downregulation of low-density lipoprotein receptor following middle cerebral artery occlusion reperfusion and oxygen-glucose deprivation/***,we induced the astrocyte-specific overexpression of low-density lipoprotein receptor using astrocyte-specific adeno-associated ***-density lipoprotein receptor overexpression in astrocytes improved neurological outcomes in middle cerebral artery occlusion mice and reversed neurotoxic astrocytes to create a neuroprotective ***,we found that the overexpression of low-density lipoprotein receptor inhibited NLRP3 inflammasome activation in oxygen-glucose deprivation/reoxygenation injured astrocytes and that the addition of nigericin,an NLRP3 agonist,restored the neurotoxic astrocyte *** findings suggest that low-density lipoprotein receptor could inhibit the NLRP3-meidiated neurotoxic polarization of astrocytes and that increasing low-density lipoprotein receptor in astrocytes might represent a novel strategy for treating cerebral ischemic stroke.

关键词： inflammation ischemia/reperfusion injury ischemic stroke low-density lipoprotein receptor neuroprotective astrocytes neurotoxic astrocytes NLRP3 inflammasome polarization

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Neuroprotective potential for mitigating ischemia-reperfusion-induced damage

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Neural Regeneration Research 2025年第8期20卷 2199-2217页

作者： Zi ye Runqing Liu Hangxing Wang Aizhen Zuo Cen jin Nan Wang Huiqi Sun Luqian feng Hua Yang The Clinical Medical College Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Infectious Diseases Department of Internal MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina School of Medical Imaging Guizhou Medical UniversityGuiyangGuizhou ProvinceChina Division of Gastroenterology First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina The Second Clinical Medical College Lanzhou UniversityLanzhouGansu ProvinceChina Department of Neurosurgery Affiliated Hospital of Guizhou Medical UniversityGuiyangGuizhou ProvinceChina

Reperfusion following cerebral ischemia causes both structural and functional damage to brain tissue and could aggravate a patient's condition;this phenomenon is known as cerebral ischemia-reperfusion *** studies have elucidated the neuroprotective role of the sirtuin protein family(Sirtuins)in modulating cerebral ischemia-reperfusion ***,the potential of utilizing it as a novel intervention target to influence the prognosis of cerebral ischemia-reperfusion injury requires additional *** this review,the origin and research progress of Sirtuins are summarized,suggesting the involvement of Sirtuins in diverse mechanisms that affect cerebral ischemia-reperfusion injury,including inflammation,oxidative stress,blood-brain barrier damage,apoptosis,pyroptosis,and *** therapeutic avenues related to Sirtuins that may improve the prognosis of cerebral ischemia-reperfusion injury were also investigated by modulating Sirtuins expression and affecting representative pathways,such as nuclear factor-kappa B signaling,oxidative stress mediated by adenosine monophosphate-activated protein kinase,and the forkhead box *** review also summarizes the potential of endogenous substances,such as RNA and hormones,drugs,dietary supplements,and emerging therapies that regulate Sirtuins *** review also reveals that regulating Sirtuins mitigates cerebral ischemia-reperfusion injury when combined with other risk *** Sirtuins show promise as a potential target for the treatment of cerebral ischemiareperfusion injury,most recent studies are based on rodent models with circadian rhythms that are distinct from those of humans,potentially influencing the efficacy of Sirtuinstargeting drug ***,this review provides new insights into the role of Sirtuins in the pathology and treatment of cerebral ischemia-reperfusion injury.

关键词： apoptosis autophagy blood-brain barrier dietary supplements drug hormones inflammation neuroprotection oxidative stress prognosis pyroptosis reperfusion injury risk factors RNA therapeutics

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早发型与晚发型新生儿败血症临床特点及病原学比较

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中国消毒学杂志 2017年第7期34卷 657-659,663页

作者：侯齐书叶继锋杨莲华温州医科大学附属第二医院、育英儿童医院浙江温州325000

目的研究早发型和晚发型新生儿败血症临床特点、病原菌分布及菌株耐药状况。方法对2015年1-12月收治的83例早发型与晚发型新生儿败血症病例的临床和病原学资料进行回顾性分析。结果晚发型患儿常为足月儿,早发型常为早产或低出生体重儿;... 详细信息

目的研究早发型和晚发型新生儿败血症临床特点、病原菌分布及菌株耐药状况。方法对2015年1-12月收治的83例早发型与晚发型新生儿败血症病例的临床和病原学资料进行回顾性分析。结果晚发型患儿常为足月儿,早发型常为早产或低出生体重儿;早发型患儿反应低下、硬肿、喂养困难发生率明显高于晚发型;晚发型组肺炎和化脓性脑膜炎发生率高于早发型组;早发型败血症病原以肺炎克雷伯菌、大肠埃希菌主,晚发型败血症病原以凝固酶阴性葡萄球菌为主。结论应根据早发型和晚发型新生儿败血症在临床特点及病原分布差异指导临床诊断和治疗。

关键词：新生儿早发型晚发型败血症

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Spatiotemporal evolution of Ediacaran-Cambrian(ca. 551–523 Ma)sponges in South China and their simulated contributions to marine oxygenation

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Science China Earth Sciences 2025年

作者： Yan ye Lei ZHANG Can CHEN Shan CHANG Yuhao YI Qinglai feng State Key Laboratory of Geological Processes and Mineral Resources China University of Geosciences(Wuhan) School of Earth Science China University of Geosciences(Wuhan) Department of Geology Lund University Institute of Sedimentary Geology Chengdu University of Technology Key Laboratory of Deep-time Geography and Environment Reconstruction and Applications of Ministry of Natural Resources Chengdu University of Technology Second Geological Brigade of Hubei Geological Bureau College of Urban and Environmental Sciences Hubei Normal University Exploration and Development Research Institute SINOPEC Jianghan Oilfield Company

The origin and evolution of sponges have attracted interest, not only because they are among the most basal metazoans, but also because they act as important ecological engineers in the ocean. Previous research suggested that sponge groups diversified quickly during the Cambrian Series 2, while Terreneuvian sponge fossils are conspicuously rare and poorly substantiated. yet, an increasing number of sponge spicules have been reported from the Ediacaran-Cambrian(E-C, ca.551–523 Ma) transitional carbonates/cherts worldwide, particularly in South China, which calls for updated discussions. Ocean oxygenation has been widely proposed to play a critical role in organismal evolution, but its relationship with sponges is unclear and falls into a “chicken-egg” dilemma. In this study, we summarize reported sponge spicule distributions from five E-C sections in South China to investigate the early evolutionary pattern of siliceous sponges. According to current stratigraphic correlation,monaxons first appear in the late Ediacaran in the intrashelf basin-slope area, and then potentially expand to the continental shelf and deep basin in the lower Cambrian. In these sections, the abundance, size, and diversity of monaxons increase upwards,followed by the appearance of diaxons, triaxons and then polyactines. Despite the uncertain affinity of the sponge fossils, it is possible that siliceous hexactinellids evolved later than siliceous demosponges, given that the earliest spicule assemblages are exclusively composed of monaxons, which commonly form bundles comparable to modern demosponges. New geochemical data from the Sifangjing section, Guizhou Province and the Yanziqiao section, Hunan Province, South China show that the appearance of sponges usually corresponds to anoxic environment. In addition, we applied the recently proposed Biological Pump, Oxygen and Phosphorus(BPOP) model to trace the evolution of oceanic oxygen concentrations with the radiation of sponges. The results indic

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儿童重症肺炎患者病原菌分布特点及药敏结果分析

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中国消毒学杂志 2016年第8期33卷 752-755页

作者：叶继锋陈瑞杰侯齐书温州医科大学附属第二医院育英儿童医院浙江温州325000

目的研究儿童重症肺炎常见病原菌及药敏特点。方法对温州医科大学附属第二医院育英儿童医院2014年1-12月,159例重症肺炎患儿血培养和痰培养标本中分离出的病原菌和药敏结果进行统计分析。结果224份阳性标本中,分离出革兰阴性菌109株,占4... 详细信息

目的研究儿童重症肺炎常见病原菌及药敏特点。方法对温州医科大学附属第二医院育英儿童医院2014年1-12月,159例重症肺炎患儿血培养和痰培养标本中分离出的病原菌和药敏结果进行统计分析。结果224份阳性标本中,分离出革兰阴性菌109株,占48.66%;革兰阳性菌28株,占12.50%;病毒60株,占26.79%,其他27株,占12.05%。分离菌株前4位的细菌依次为肺炎克雷伯菌、大肠埃希菌、鲍曼不动杆菌、铜绿假单胞菌。药敏试验结果显示,对革兰阴性菌较敏感的药物有阿米卡星、头孢哌酮/舒巴坦、环丙沙星、美罗培南、亚胺培南;对革兰阳性菌较敏感的药物有万古霉素、利奈唑胺、左氧氟沙星。结论肺炎克雷伯菌、大肠埃希菌、鲍曼不动杆菌、铜绿假单胞菌、肺炎链球菌、金黄色葡萄球菌是引起该院儿童重症肺炎的常见病原菌,应根据病原菌培养及药敏试验结果合理选用抗菌药物。

关键词：重症肺炎儿童病原体药物敏感性

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