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ASF1A-dependent P300-mediated histone H3 lysine 18 lactylation promotes atherosclerosis by regulating EndMT

Acta Pharmaceutica Sinica B 2024年第7期14卷 3027-3048页

作者： Mengdie Dong Yunjia Zhang Minghong chen Yongkang Tan jiao Min Xian He Fuhao Liu jiaming Gu Hong jiang Longbin Zheng jiajing chen Quanwen Yin Xuesong Li xiang chen Yongfeng Shao Yong ji Hongshan chen Department of Cardiovascular Surgery the First Affiliated Hospital of Nanjing Medical Universityand Key Laboratory of Cardiovascular and Cerebrovascular MedicineSchool of PharmacyNational Vaccine Innovation PlatformNanjing Medical UniversityNanjing 211166China Key Laboratory of Cardiovascular and Cerebrovascular Medicine School of PharmacyNanjing Medical UniversityNanjing 211166China Department of Clinical Medicine Nanjing Medical University TIANYUAN Honors SchoolNanjing Medical UniversityNanjing 211166China Department of Anesthesiology Sir Run Run HospitalNanjing Medical UniversityNanjing 211166China Department of Cardiovascular Surgery the First Affiliated Hospital of Nanjing Medical UniversityNanjing 211166China Key Laboratory of Cardiovascular and Cerebrovascular Medicine Key Laboratory of Targeted Intervention of Cardiovascular DiseaseCollaborative Innovation Center for Cardiovascular Disease Translational MedicineState Key Laboratory of Reproductive MedicineSchool of Pharmacythe Affiliated Suzhou Hospital of Nanjing Medical UniversityGusu SchoolNanjing Medical UniversityNanjing 211166China National Key Laboratory of Frigid Zone Cardiovascular Diseases(NKLFZCD) Department of Pharmacology(State-Province Key Laboratories of Biomedicine-Pharmaceutics of China)College of PharmacyKey Laboratory of Cardiovascular Medicine Research and Key Laboratory of Myocardial IschemiaChinese Ministry of EducationNHC Key Laboratory of Cell Transplantationthe Central Laboratory of the First Affiliated HospitalHarbin Medical UniversityHarbin 150081China Key Laboratory of Targeted Intervention of Cardiovascular Disease Collaborative Innovation Center for Cardiovascular Disease Translational MedicineNanjing Medical UniversityNanjing 211166China Department of Cardiology Huai’an First People’s Hospital Affiliated with Nanjing Medical UniversityHuai’an 223399China

Endothelial-to-mesenchymal transition(EndMT)is a key driver of *** glycolysis is increased in the endothelium of atheroprone areas,accompanied by elevated lactate *** lactylation,mediated by lactate,can regulate gene expression and participate in disease ***,whether histone lactylation is involved in atherosclerosis remains ***,we report that lipid peroxidation could lead to EndMT-induced atherosclerosis by increasing lactatedependent histone H3 lysine 18 lactylation(H3K18la)in vitro and in vivo,as well as in atherosclerotic patients’***,the histone chaperone ASF1A was first identified as a cofactor of P300,which precisely regulated the enrichment of H3K18la at the promoter of SNAI1,thereby activating SNAI1 transcription and promoting *** found that deletion of ASF1A inhibited EndMT and improved endothelial *** analysis based on Apoe^(KO)Asf1a^(ECKO) mice in the atherosclerosis model confirmed the involvement of H3K18la in atherosclerosis and found that endotheliumspecific ASF1A deficiency inhibited EndMT and alleviated atherosclerosis *** of glycolysis by pharmacologic inhibition and advanced PROTAC attenuated H3K18la,SNAI1 transcription,and EndMT-induced *** study illustrates precise crosstalk between metabolism and epigenetics via H3K18la by the P300/ASF1A molecular complex during EndMT-induced atherogenesis,which provides emerging therapies for atherosclerosis.

关键词： Histone lactylation Atherosclerosis Endothelial-tomesenchymal transition ASF1A SNAI1 Endothelial dysfunction Lactate Epigenetic

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Integrating phosphorus management and cropping technology for sustainable maize production

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Journal of Integrative Agriculture 2024年第4期23卷 1369-1380页

作者： Haiqing Gong Yue xiang jiechen Wu Laichao Luo Xiaohui chen Xiaoqiang jiao chen chen State Key Laboratory of Nutrient Use and Management College of Resources and Environmental SciencesCollege of Resources and Environmental SciencesChina Agricultural UniversityBeijing 100193China Department of Sustainable Development Environmental Science and Engineering(SEED)KTH Royal Institute of TechnologyStockholm SE-10044Sweden Anhui Province Key Lab of Farmland Ecological Conservation and Pollution Prevention School of Resources and EnvironmentAnhui Agricultural UniversityHefei 230036China Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering National Observations and Research Station for Wetland Ecosystems of the Yangtze EstuaryInstitute of Biodiversity Science and Institute of Eco-ChongmingCollege of Life SciencesFudan UniversityShanghai 200438China

Achieving high maize yields and efficient phosphorus(P)use with limited environmental impacts is one of the greatest challenges in sustainable maize *** plant density is considered an effective approach for achieving high maize ***,the low mobility of P in soils and the scarcity of natural P resources have hindered the development of methods that can simultaneously optimize P use and mitigate the P-related environmental footprint at high plant *** this study,meta-analysis and substance flow analysis were conducted to evaluate the effects of different types of mineral P fertilizer on maize yield at varying plant densities and assess the flow of P from rock phosphate mining to P fertilizer use for maize production in China.A significantly higher yield was obtained at higher plant densities than at lower plant *** application of single superphosphate,triple super-phosphate,and calcium magnesium phosphate at high plant densities resulted in higher yields and a smaller environmental footprint than the application of diammonium phosphate and monoammonium *** scenario analyses suggest that combining the optimal P type and application rate with a high plant density could increase maize yield by 22%.Further,the P resource use efficiency throughout the P supply chain increased by 39%,whereas the P-related environmental footprint decreased by 33%.Thus,simultaneously optimizing the P type and application rate at high plant densities achieved multiple objectives during maize production,indicating that combining P management with cropping techniques is a practical approach to sustainable maize *** findings offer strategic,synergistic options for achieving sustainable agricultural development.

关键词： maize plant density mineral phosphorus fertilizer meta-analysis substance flow analysis

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Exploring multiple phases and first-order phase transitions in Kármán Vortex Street

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Science China(Physics,Mechanics & Astronomy) 2024年第11期67卷 47-54页

作者： Xu Li Xing xiang Tingting Xue Limin Wang Xiaosong chen School of Systems Science and Institute of Nonequilibrium Systems Beijing Normal UniversityBeijing 100875China State Key Laboratory of Multiphase Complex Systems Institute of Process EngineeringChinese Academy ofSciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

Kármán Vortex Street, a fascinating phenomenon of fluid dynamics, has intrigued the scientific community for a long time. Many researchers have dedicated their efforts to unraveling the essence of this intriguing flow pattern. Here, we apply the lattice Boltzmann method with curved boundary conditions to simulate flows around a circular cylinder and study the emergence of Kármán Vortex Street using the eigen microstate approach, which can identify phase transition and its order-parameter. At low Reynolds number, there is only one dominant eigen microstate W_(1) of laminar flow. At Re_(c)^(1)= 53.6, there is a phase transition with the emergence of an eigen microstate pair W^(2,3) of pressure and velocity fields. Further at Re_(c)^(2)= 56, there is another phase transition with the emergence of two eigen microstate pairs W^(4,5) and W^(6,7). Using the renormalization group theory of eigen microstate,both phase transitions are determined to be first-order. The two-dimensional energy spectrum of eigen microstate for W^(1), W^(2,3) after Re_(c)^(1), W^(4-7) after Re_(c)^(2) exhibit-5/3 power-law behavior of Kolnogorov's K41 theory. These results reveal the complexity and provide an analysis of the Kármán Vortex Street from the perspective of phase transitions.

关键词： Kármán Vortex Street first-order phase transition eigen microstate approach renormalization group theory of eigen microstate

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How mesenchymal stem cells transform into adipocytes:Overview of the current understanding of adipogenic differentiation

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World Journal of Stem Cells 2024年第3期16卷 245-256页

作者： Shan-Shan Liu xiang Fang Xin Wen ji-Shan Liu Miribangvl Alip Tian Sun Yuan-Yuan Wang Hong-Wei chen Department of Reumatology and Immunology Nanjing Drum Tower HospitalThe Affiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008Jiangsu ProvinceChina Department of Emergency Nanjing Drum Tower HospitalThe Affiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008Jiangsu ProvinceChina Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical EngineeringBeihang UniversityBeijing 100191China Anhui Key Laboratory of Infection and Immunity Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina

Mesenchymal stem cells(MSCs)are stem/progenitor cells capable of self-renewal and differentiation into osteoblasts,chondrocytes and *** transformation of multipotent MSCs to adipocytes mainly involves two subsequent steps from MSCs to preadipocytes and further preadipocytes into adipocytes,in which the process MSCs are precisely controlled to commit to the adipogenic lineage and then mature into *** studies have shown that the master transcription factors C/enhancer-binding protein alpha and peroxisome proliferation activator receptor gamma play vital roles in ***,the mechanism underlying the adipogenic differentiation of MSCs is not fully ***,the current knowledge of adipogenic differentiation in MSCs is reviewed,focusing on signaling pathways,noncoding RNAs and epigenetic effects on DNA methylation and acetylation during MSC ***,the relationship between maladipogenic differentiation and diseases is briefly *** hope that this review can broaden and deepen our understanding of how MSCs turn into adipocytes.

关键词： Mesenchymal stem cell Adipogenic differentiation Signaling pathway Noncoding RNA Epigenetic regulation

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Electronic structural engineering of bimetallic Bi-Cu alloying nanosheet for highly-efficient CO_(2) electroreduction and Zn-CO_(2) batteries

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Nano Research 2024年第5期17卷 3684-3692页

作者： Wenbo Wu jiaye Zhu Yun Tong Shuangfei xiang Pengzuo chen School of Chemistry and Chemical Engineering Key Laboratory of Surface and Interface Science of Polymer Materials of Zhejiang ProvinceZhejiang Sci-Tech UniversityHangzhou 310018China

Regulating the electronic structure of Bi-based materials by alloying engineering is promising to promote the electrocatalytic activity,but it remains some challenges to be *** this study,a facile electrochemical co-deposition strategy is developed to synthesize the bimetallic Bi_(9)Cu_(1) alloy nanosheet on carbon cloth(Bi_(9)Cu_(1)/CC),which represents a novel self-supporting electrode for the electrocatalytic carbon dioxide(CO_(2))reduction reaction(CO_(2)RR).The Bi_(9)Cu_(1)/CC catalyst has achieved a remarkable catalytic performance with high Faradaic efficiencies(FE)of over 90%for formate at wide potentials from-0.7 to-1.2 V *** hydrogen electrode(RHE).Moreover,the reversible Zn-CO_(2) battery can be driven by Bi_(9)Cu_(1)/CC cathode with a largest power density of 1.4 mW·cm^(-2),and superior operating *** systematic characterizations and electrochemical results confirm that the improved catalytic active sites,the enhanced mass/charge transport and the optimal reaction kinetics of Bi nanosheet are realized for CO_(2)RR by Cu *** situ attenuated total reflection infrared(ATR-IR)result confirms the bimetallic Bi-Cu active sites prefer to follow the^(*)OCHO conversion *** density functional theory(DFT)calculations suggest that the Cu alloying contributes to the increased density of states near the Fermi surface of Bi and the optimized adsorption of^(*)OCHO intermediates on the Bi sites,resulting in the excellent catalytic performance.

关键词： electronic regulation bismuth nanosheet copper alloying CO_(2)electroreduction Zn-CO_(2)batteries

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In situ generation of oxyanions-decorated cobalt(nickel)oxyhydroxide catalyst with high corrosion resistance for stable and efficient seawater oxidation

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Journal of Energy Chemistry 2024年第7期94卷 508-516页

作者： Fengting Luo Pei Yu Jueting xiang Junjie jiang Shijian chen Chongqing Key Laboratory of Interface Physics in Energy Conversion College of PhysicsChongqing UniversityChongqing 401331China Center of Modern Physics Institute for Smart City of Chongqing University in LiyangLiyang 213300JiangsuChina

The development of efficient and robust anode materials for stable alkaline seawater electrolysis is severely limited by chlorine evolution reaction and chloride ***,the sulfur-doped cobalt-nickel bimetallic phosphides(CoNiPS)are specifically designed as a pre-catalyst for navigating a surface reconstruction to fabricate the anions(PO^(3-)_(4) and SO^(2-)_(4))-decorated Co(Ni)OOH catalyst(R-CoNiPS)with exceptional durability and high activity for stable alkaline seawater oxidation(ASO).Various experiment techniques together with theoretical simulations both demonstrate that the in situ-generated PO^(3-)_(4) and SO^(2-)_(4) anions on catalyst surface can improve the oxygen evolution reaction(OER)activity,regulating and stabilizing the catalytic active species Co(Ni)OOH,as well as make a critical role in inhibiting the adsorp-tion of chloride ions and extending the service life of ***,this R-CoNiPS electrode exhi-bits superb OER activity toward AsO and stands out among the non-precious ASO electrocatalysts reported recently,requiring low overpotentials of 420 and 440 mV to attain large current densities of 500 and 1000 mA cm^(-2) in an alkaline natural seawater electrolyte,***,the catalyst displays a negligible chloride corrosion at room temperature during ASO operation(>200 h)at 500 mA cm^(-2).This work opens up a new viewpoint for designing high-activity and durable electrocata-lystsforseawaterelectrolysis.

关键词： Seawater electrolysis Anions Oxygen evolution reaction Chloride corrosion

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Single-atom Co alloyed Ru for electrocatalytic nitrite reduction to ammonia

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Nano Research 2024年第5期17卷 3660-3666页

作者： Fuzhou Wang jiaqi xiang Guike Zhang Kai chen Ke Chu School of Materials Science and Engineering Lanzhou Jiaotong UniversityLanzhou 730070China

Electrochemical converting NO_(2)^(-)into NH_(3)(NO_(2)RR)holds an enormous prospect to attain efficient NH_(3) electrosynthesis and polluted NO_(2)^(-)***,we report single-atom Co alloyed Ru(Co_(1)Ru)as an efficient and durable NO_(2)RR *** experimental and theoretical investigations reveal that single-atom Co alloying of Ru enables the construction of Co_(1)-Ru heteronuclear active sites to synergistically promote NO_(2)^(-)activation/hydrogenation while suppressing the competitive H_(2) evolution,rendering the greatly enhanced activity and selectivity of Co_(1)Ru towards the NO_(2)***,Co_(1)Ru assembled within a flow cell exhibits an impressive NH_(3) yield rate of 2379.2μmol·h^(-1)·cm^(-2) with an NH_(3)-Faradaic efficiency of 92%at a high current density of 415.9 mA·cm^(-2),which is among the highest NO_(2)RR performances reported to date.

关键词： electrochemical converting NO_(2)-into NH3 single-atom alloys theoretical computations industrial-level current density

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On the Surface Helium Abundance of B-type Hot Subdwarf Stars from the WD+MS Channel of Type Ia Supernovae

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Research in Astronomy and Astrophysics 2024年第5期24卷 21-27页

作者： Rui-jie ji xiang-Cun Meng Zheng-Wei Liu Yunnan Observatories Chinese Academy of SciencesKunming 650216Kunming 650216China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory for the Structure and Evolution of Celestial Objects Chinese Academy of SciencesKunming 650216China International Centre of Supernovae(ICESUN) Yunnan Key LaboratoryKunming 650216China

The origin of intermediate helium (He)-rich hot subdwarfs is still *** studies have suggested that some surviving Type Ia supernovae (SNe Ia) companions from the white dwarf+main-sequence (WD+MS)channel may contribute to the intermediate He-rich hot ***,previous studies ignored the impact of atomic diffusion on the post-explosion evolution of surviving companion stars of SNe Ia,leading to the aspect that they could not explain the observed surface He abundance of intermediate He-rich hot *** this work,by taking the atomic diffusion and stellar wind into account,we trace the surviving companions of SNe Ia from the WD+MS channel using the one-dimensional stellar evolution code MESA until they evolve into hot *** find that the surface He-abundances of our surviving companion models during their core He-burning phases are in a range of-1■log(N_(He) N_(H))■0,which are consistent with those observed in intermediate He-rich hot *** seems to further support the notion that it is possible for surviving companions of SNe Ia in the WD+MS channel to form some intermediate He-rich hot subdwarfs.

关键词： (stars:)subdwarfs-atomic processes-diffusion

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From atomistic modeling to materials design:computation-driven material development in lithium-ion batteries

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Science China Chemistry 2024年第1期67卷 276-290页

作者： xiangrong Li xiang chen Qiang Bai Yifei Mo Yizhou Zhu Research Center for Industries of the Future and School of Engineering Westlake UniversityHangzhou 310030China Department of Chemical Engineering Tsinghua UniversityBeijing 100084China College of Materials Science and Engineering Taiyuan University of TechnologyTaiyuan 030024China Department of Materials Science and Engineering University of MarylandCollege Park 20742United States

As an advanced energy storage system,lithium-ion batteries play an essential role in modern *** their ubiquitous success,there is a great demand for continuous improvements of the battery performance,including higher energy density,lower safety risk,longer cycling life,and lower *** performance improvement requires the design and development of novel electrode and electrolyte materials that exhibit desirable properties and satisfy strict *** modeling can provide a unique perspective to fundamentally understand and rationally design battery *** this paper,we review a few recent successful examples of computation-driven discovery and design in electrode and electrolyte ***,we highlight how atomistic modeling can reveal the underlying mechanisms,predict the important properties,and guide the design and engineering of electrode and electrolyte *** have a conclusion with a discussion of the unique capability of atomistic modeling in battery material development and provide a perspective on future challenges and directions for computation-driven battery material developments.

关键词： materials design computation modeling batteries electrolyte electrode

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A review on g-C_(3)N_(4)decorated with silver for photocatalytic energy conversion

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Chinese Chemical Letters 2024年第2期35卷 187-196页

作者： Ziyu Pan Wufan Ding Hanchun chen Haodong ji Eco-environment and Resource Efficiency Research Laboratory School of Environment and EnergyPeking University Shenzhen Graduate SchoolShenzhen 518055China

Artificial photocatalytic energy conversion is considered as the most potential strategy for solving the increasingly serious energy crisis and environmental pollution problems by directly capturing solar ***,high efficiency photocatalyst has drawn significant research attention in recent *** to the excellent electronic,optical,structural,and physicochemical performances,silver-based g-C_(3)N_(4)have become promising *** review emphasizes the recent progresses and challenges on g-C_(3)N_(4)decorated with silver for photocatalytic energy *** extensive use of g-C_(3)N_(4)decorated with silver in diverse photocatalytic reactions,including hydrogen evolution,pollutant degradation and carbon dioxide reduction,is also fully *** addition,we propose the perspectives of g-C_(3)N_(4)decorated with silver on photocatalytic *** hope that this review will shed some light on the photocatalytic energy conversion of g-C_(3)N_(4)decorated with silver.

关键词： g-C_(3)N_(4) Silver-modified g-C_(3)N_(4) Photocatalytic energy conversion H_(2)evolution Pollutant degradation CO_(2)reduction

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