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Corrosion characteristics of single-phase Mg-3Zn alloy thin film for biodegradable electronics

Journal of Magnesium and Alloys 2023年第9期11卷 3241-3254页

作者： ji-woo gu Jae-Young Bae guangzhe Li Hae Won Hwang So-Hyeon Lee Sung-Geun Choi Ju-Young Kim Myoung-Ryul Ok Yu-Chan Kim Seung-Kyun Kang Department of Materials Science and Engineering Seoul National University(SNU)Seoul 08826Republic of Korea Research Institute of Advanced Materials(RIAM) Seoul National UniversitySeoul 08826Republic of Korea Soft Foundry Nano Systems Institute(NSI) Seoul National UniversitySeoul 08826Republic of Korea Biomaterials Research Center Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul 34141Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolKorea University of Science and TechnologySeoul 02792Republic of Korea Department of Materials Science and Engineering Ulsan National Institute of Science and Technology(UNIST)Ulsan 44919Republic of Korea

Biodegradable metals as electrodes, interconnectors, and device conductors are essential components in the emergence of transient electronics, either for passive implants or active electronic devices, especially in the fields of biomedical electronics. Magnesium and its alloys are strong candidates for biodegradable and implantable conducting materials because of their high conductivity and biocompatibility, in addition to their well-understood dissolution behavior. One critical drawback of Mg and its alloys is their considerably high dissolution rates originating from their low anodic potential, which disturbs the compatibility to biomedical applications. Herein, we introduce a single-phase thin film of a Mg-Zn binary alloy formed by sputtering, which enhances the corrosion resistance of the device electrode, and verify its applicability in biodegradable electronics. The formation of a homogeneous solid solution of single-phase Mg-3Zn was confirmed through X-ray diffraction and transmission electron microscopy. In addition, the dissolution behavior and chemistry was also investigated in various biological fluids by considering the effect of different ion species. Micro-tensile tests showed that the Mg-3Zn alloy electrode exhibited an enhanced yield strain and elongation in relation to a pure Mg electrode. Cell viability test revealed the high biocompatibility rate of the Mg-3Zn binary alloy thin film. Finally, the fabrication of a wireless heater demonstrated the integrability of biodegradable electrodes and highlighted the ability to prolong the lifecycle of thermotherapy-relevant electronics by enhancing the dissolution resistance of the Mg alloy.

关键词： Biodegradable alloy Mg-3Zn binary alloy Solid-solution thin film electrode Biodegradable conductor Transient electronics

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VKFQ:A Verifiable Keyword Frequency Query Framework with Local Differential Privacy in Blockchain

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Computers, Materials & Continua 2024年第3期78卷 4205-4223页

作者： Youlin ji Bo Yin Ke gu School of Computer and Communication Engineering Changsha University of Science and TechnologyChangsha410114China

With its untameable and traceable properties,blockchain technology has been widely used in the field of data sharing.How to preserve individual privacy while enabling efficient data queries is one of the primary issues with secure data sharing.In this paper,we study verifiable keyword frequency(KF)queries with local differential privacy in blockchain.Both the numerical and the keyword attributes are present in data objects;the latter are sensitive and require privacy protection.However,prior studies in blockchain have the problem of trilemma in privacy protection and are unable to handle KF queries.We propose an efficient framework that protects data owners’privacy on keyword attributes while enabling quick and verifiable query processing for KF queries.The framework computes an estimate of a keyword’s frequency and is efficient in query time and verification object(VO)size.A utility-optimized local differential privacy technique is used for privacy protection.The data owner adds noise locally into data based on local differential privacy so that the attacker cannot infer the owner of the keywords while keeping the difference in the probability distribution of the KF within the privacy budget.We propose the VB-cm tree as the authenticated data structure(ADS).The VB-cm tree combines the Verkle tree and the Count-Min sketch(CM-sketch)to lower the VO size and query time.The VB-cm tree uses the vector commitment to verify the query results.The fixed-size CM-sketch,which summarizes the frequency of multiple keywords,is used to estimate the KF via hashing operations.We conduct an extensive evaluation of the proposed framework.The experimental results show that compared to theMerkle B+tree,the query time is reduced by 52.38%,and the VO size is reduced by more than one order of magnitude.

关键词： Security data sharing blockchain data query privacy protection

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A study on carbon emission calculation in operation stage of residential buildings based on micro electricity usage behavior:Three case studies in China

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Building Simulation 2024年第1期17卷 147-164页

作者： Menghan Niu Ying ji Miao Zhao jiefan gu Aonan Li Beijing Key Laboratory of Green Built Environment and Energy Efficient Technology Beijing University of TechnologyBeijing 100124China College of Architecture and Urban Planning Tongji UniversityShanghai 201804China The Bartlett School of Architecture University College LondonWC1E 6BTUK

Along with the improvement of social productivity and living standard,residential buildings generate a growing portion of carbon emissions,especially during the operation stage.However,energy use behaviors are usually ignored in carbon emission calculation.This study focuses on calculating carbon emissions during the operation stage for residential buildings based on the characteristics of energy use behaviors in different regions.Firstly,we investigated energy use behaviors in dwellings across three cities in China:Xi'an,Shanghai and Fuzhou.Then,we established calibrated carbon emission models and optimization models with different green building measures for residential buildings.The results of this research reveal a significant disparity between the energy usage habits of residents in different climate regions.The carbon emissions of residential electricity bills in Xi'an,Shanghai and Fuzhou are 13.6 kgCO_(2)/(m^(2)·a)(excluding central heating),29.3 kgCO_(2)/(m^(2)·a)and 17.2 kgCO_(2)/(m^(2)·a),respectively.Equipment carbon emissions account for 32.2%-64.1% of the total.In comparison to the model based on internal standard setting,the accuracy of the models using actual internal has improved by 25.9%-37.4%.The three-star green building methods have the highest carbon reduction rate among different star buildings,the emission reduction rates are around 30%.This study's findings are useful for carbon emission calculation and green building design of residential buildings in the future.

关键词： residential building energy usage behavior energy simulation carbon emissions

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Quantitative discrimination of surface adsorbed NOx species on CeO_(2) via spectrophotometry for SCR denitration investigation

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Journal of Rare Earths 2024年第6期42卷 1066-1072,I0003页

作者： Songil Sin jiawei ji Lijun Cheng Zhiwen gu Chong Tan Kwangchol Ri Changjin Tang School of Environment Nanjing Normal UniversityNanjing210023China Department of Mining Engineering Kim Chaek University of TechnologyPyongyang999093Democratic People's Republic of Korea Laboratory of Mesoscopic Chemistry of MOE School of Chemistry and Chemical EngineeringNanjing UniversityNanjing20023China Institute of Chemical Engineering Hamhung University of Chemical EngineeringHamhungDemocratic People's Republic of Korea jiangsu Province Engineering Research Center of Environmental Risk Prevention and Emergency Response Technology Nanjing210023China

CeO_(2)-based catalysts are widely investigated for selective catalytic reduction(SCR)of NO with NH3.Interaction of NO/O_(2) with CeO_(2) generally produces two surface species,i.e.,nitrates and nitrites.However,the explicit quantification of these two species is still unresolved.Herein,we reported that spectrophotometry characterization was effective in determining surface adsorbed NOx species on CeO_(2) by measuring the corresponding ions(NO_(2)-and NO_(3)^(-))dissolved in aqueous solution.Experimental results show that both nitrate(-NO_(3))and nitrite(-NO_(2))species can be quantitatively evaluated and the accuracy is verified by calibrating with NOx-TPD result.Exclusive transfer of adsorbed NOx from catalyst surface to aqueous solution is confirmed and the dissolution process can be accelerated by ultrasonic treatment.Moreover,useful information related to evolution of surface NOx species under various conditions(O_(2) treatment,different adsorption temperature and duration)and over different catalysts(Fe_(2)O_(3),MnO_(2) and MnOx—CeO_(2))are provided.The result of present study demonstrates the potential of spectrophotometry for quantitative discrimination of surface NOx species on CeO_(2) and other oxide-based materials,which is conducive to mechanism analysis of SCR reaction.

关键词： Quantitative evaluation Spectrophotometry analysis Nitrate species Nitrite species CeO_(2)catalyst NH_(3)-SCR

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Suboptimal Feature Selection Techniques for Effective Malicious Traffic Detection on Lightweight Devices

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1669-1687页

作者： So-Eun Jeon Ye-Sol Oh Yeon-ji Lee Il-gu Lee Department of Future Convergence Technology Engineering Sungshin Women’s UniversitySeoul02844Korea Department of Convergence Security Engineering SungshinWomen’s UniversitySeoul02844Korea

With the advancement of wireless network technology,vast amounts of traffic have been generated,and malicious traffic attacks that threaten the network environment are becoming increasingly sophisticated.While signature-based detection methods,static analysis,and dynamic analysis techniques have been previously explored for malicious traffic detection,they have limitations in identifying diversified malware traffic patterns.Recent research has been focused on the application of machine learning to detect these patterns.However,applying machine learning to lightweight devices like IoT devices is challenging because of the high computational demands and complexity involved in the learning process.In this study,we examined methods for effectively utilizing machine learning-based malicious traffic detection approaches for lightweight devices.We introduced the suboptimal feature selection model(SFSM),a feature selection technique designed to reduce complexity while maintaining the effectiveness of malicious traffic detection.Detection performance was evaluated on various malicious traffic,benign,exploits,and generic,using the UNSW-NB15 dataset and SFSM sub-optimized hyperparameters for feature selection and narrowed the search scope to encompass all features.SFSM improved learning performance while minimizing complexity by considering feature selection and exhaustive search as two steps,a problem not considered in conventional models.Our experimental results showed that the detection accuracy was improved by approximately 20%compared to the random model,and the reduction in accuracy compared to the greedy model,which performs an exhaustive search on all features,was kept within 6%.Additionally,latency and complexity were reduced by approximately 96%and 99.78%,respectively,compared to the greedy model.This study demonstrates that malicious traffic can be effectively detected even in lightweight device environments.SFSM verified the possibility of detecting various attack traffic on lightweight devices.

关键词： Feature selection lightweight device machine learning Internet of Things malicious traffic

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Reducing the global cancer burden with gastrointestinal screening: China's 30 years practice

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Cancer Biology & Medicine 2024年第3期21卷 204-212页

作者： Lei Yang Li Feng Yong Zhu Ning Wang Xinpu Lu Fanghui gu Xiaotian Zhang jiafu ji Peking University Cancer Hospital(Inner Mongolia Campus)/Affiliated Cancer Hospital of Inner Mongolia Medical University Inner Mongolia Cancer CenterHohhot 010020China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Bejing) Bejing Office for Cancer Prevention and ControlPeking University Cancer Hospital&InstituteBejing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Peking University Cancer Hospital&InstituteBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Bejing) Department of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Bejing Key Laboratory of Carcinogenesis and Translational ResearchGastrointestinal Cancer CenterPeking University Cancer Hospital&InstituteBeijing 100142China

Gastrointestinal(GI) cancers include esophageal [EC(International Classification of Disease 10^(th) revision: C15)], gastric [GC(C16)], and colorectal [CRC(C18-C21)] cancers. China is a high-incidence country of GI ca... 详细信息

关键词： esophageal colorectal gastrointestinal

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Multifunctional AlPO_(4)reconstructed LiMn_(2)O_(4)surface for electrochemical lithium extraction from brine

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Journal of Energy Chemistry 2024年第2期89卷 410-421,I0010页

作者： Jun gu Linlin Chen Xiaowei Li guiling Luo Linjing Fan Yanhong Chao Haiyan ji Wenshuai Zhu School of Materials Science and Engineering Jiangsu UniversityZhenjiang 212013JiangsuChina School of Chemistry and Chemical Engineering Jiangsu UniversityZhenjiang 212013JiangsuChina College of Science State Key Laboratory of Heavy Oil ProcessingChina University of Petroleum-BeijingBeijing 102249China School of the Environment and Safety Engineering Jiangsu UniversityZhenjiang 212013JiangsuChina

LiMn_(2)O_(4)(LMO)electrochemical lithium-ion pump has gained widespread attention due to its green,high efficiency,and low energy consumption in selectively extracting lithium from brine.However,collapse of crystal structure and loss of lithium extraction capacity caused by Mn dissolution loss limits its industrialized application.Hence,a multifunctional coating was developed by depositing amorphous AlPO_(4)on the surface of LMO using sol-gel method.The characterization and electrochemical performance test provided insights into the mechanism of Li^(+)embedment and de-embedment and revealed that multifunctional AlPO_(4)can reconstruct the physical and chemical state of LMO surface to improve the interface hydrophilicity,promote the transport of Li^(+),strengthen cycle stability.Remarkably,after 20 cycles,the capacity retention rate of 0.5AP-LMO reached 93.6%with only 0.147%Mn dissolution loss.The average Li^(+)release capacity of 0.5AP-LMO//Ag system in simulated brine is 28.77 mg/(g h),which is 90.4%higher than LMO.Encouragingly,even in the more complex Zabuye real brine,0.5AP-LMO//Ag can still maintain excellent lithium extraction performance.These results indicate that the 0.5AP-LMO//Ag lithium-ion pump shows promising potential as a Li^(+)selective extraction system.

关键词： LiMn_(2)O_(4) Multifunctional AlPO_(4)coating Li^(+)embedment and de-embedment mechanism Stability Hydrophilicity Various solution

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Thyroid-stimulating hormone-thyroid hormone signaling contributes to circadian regulation through repressing clock2/npas2 in zebrafish

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Journal of Genetics and Genomics 2024年第1期51卷 61-74页

作者： Cheng ji Yue Ou Wangjianfei Yu jiaxin Lv Fanmiao Zhang Huashan Li Zeyun gu jiayuan Li Zhaomin Zhong Han Wang Center for Circadian Clocks Soochow UniversitySuzhouJiangsu 215123China School of Biology and Basic Medical Sciences Suzhou Medical CollegeSoochow UniversitySuzhouJiangsu 215123China

Thyroid-stimulating hormone(TSH)is important for the thyroid gland,development,growth,and metabolism.Defects in TSH production or the thyrotrope cells within the pituitary gland cause congenital hypothyroidism(CH),resulting in growth retardation and neurocognitive impairment.While human TSH is known to display rhythmicity,the molecular mechanisms underlying the circadian regulation of TSH and the effects of TSH-thyroid hormone(TH)signaling on the circadian clock remain elusive.Here we show that TSH,thyroxine(T4),triiodothyronine(T3),and tshba display rhythmicity in both larval and adult zebrafish and tshba is regulated directly by the circadian clock via both E′-box and D-box.Zebrafish tshba^(−/−)mutants manifest congenital hypothyroidism,with the characteristics of low levels of T_(4)and T_(3)and growth retardation.Loss or overexpression of tshba alters the rhythmicity of locomotor activities and expression of core circadian clock genes and hypothalamic-pituitary-thyroid(HPT)axis-related genes.Furthermore,TSH-TH signaling regulates clock2/npas2 via the thyroid response element(TRE)in its promoter,and transcriptome analysis reveals extensive functions of Tshba in zebrafish.Together,our results demonstrate that zebrafish tshba is a direct target of the circadian clock and in turn plays critical roles in circadian regulation along with other functions.

关键词： Thyroid-stimulating hormone subunitβa (tshba) Thyroid hormone Circadian rhythm TALEN Zebrafish

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Ceria nanoparticles: biomedical applications and toxicity

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第5期25卷 361-388页

作者： Xiaoxuan FU Peng LI Xi CHEN Yuanyuan MA Rong WANG Wenxuan ji jiakuo gu Bowen SHENG Yizhou WANG Zhuhong ZHANG School of Pharmacy Key Laboratory of Molecular Pharmacology and Drug Evaluation(Yantai University)Ministry of EducationCollaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of ShandongYantai UniversityYantai 264005China Department of Nephrology Yantai Yuhuangding HospitalQingdao UniversityYantai 264005China Institute of Crop Science College of Agriculture and BiotechnologyZhejiang UniversityHangzhou 310058China

Ceria nanoparticles(CeO_(2) NPs)have become popular materials in biomedical and industrial fields due to their potential applications in anti-oxidation,cancer therapy,photocatalytic degradation of pollutants,sensors,etc.Many methods,including gas phase,solid phase,liquid phase,and the newly proposed green synthesis method,have been reported for the synthesis of CeO_(2) NPs.Due to the wide application of CeO_(2) NPs,concerns about their adverse impacts on human health have been raised.This review covers recent studies on the biomedical applications of CeO_(2) NPs,including their use in the treatment of various diseases(e.g.,Alzheimer's disease,ischemic stroke,retinal damage,chronic inflammation,and cancer).CeO_(2) NP toxicity is discussed in terms of the different systems of the human body(e.g.,cytotoxicity,genotoxicity,respiratory toxicity,neurotoxicity,and hepatotoxicity).This comprehensive review covers both fundamental discoveries and exploratory progress in CeO_(2) NP research that may lead to practical developments in the future.

关键词： Ceria nanoparticle Synthetic method Biomedical application Oxidative stress Toxicity

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GRK2-YAP signaling is implicated in pulmonary arterial hypertension development

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中华医学杂志(英文版) 2024年第7期137卷 846-858页

作者： Ye Peng Deng Yunfei gu Yue Liu Pengfei Luo jie Pu jiangqin Chen jingyu Huang Yu Wang Nanping ji Yong Chen Shaoliang Wuxi People’s Hospital Wuxi jiangsu 300247 Institute of Vascular Medicine The Chinese University of Hong Kong Hongkong 999077 Health Science Center East China Normal University Shanghai 200241 School of Pharmacy Division of Cardiovascular Molecular Laboratory jiangsu 210004 Third Clinical College Nanjing Medical University Nanjing jiangsu 210006 China Division of Cardiovascular Laboratory Nanjing First Hospital Division of Pulmonary Surgery

Background: Pulmonary arterial hypertension (PAH) is characterized by excessive proliferation of small pulmonary arterial vascular smooth muscle cells (PASMCs), endothelial dysfunction, and extracellular matrix remodeling. G protein-coupled receptor kinase 2 (GRK2) plays an important role in the maintenance of vascular tone and blood flow. However, the role of GRK2 in the pathogenesis of PAH is unknown.Methods: GRK2 levels were detected in lung tissues from healthy people and PAH patients. C57BL/6 mice, vascular smooth muscle cell-specificGrk2-knockout mice (Grk2?SM22), and littermate controls (Grk2flox/flox) were grouped into control and hypoxia mice (n = 8). Pulmonary hypertension (PH) was induced by exposure to chronic hypoxia (10%) combined with injection of the SU5416 (cHx/SU). The expression levels of GRK2 and Yes-associated protein (YAP) in pulmonary arteries and PASMCs were detected by Western blotting and immunofluorescence staining. The mRNA expression levels ofGrk2 and Yes-associated protein (YAP) in PASMCs were quantified with real-time polymerase chain reaction (RT-PCR). Wound-healing assay, 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di-phenytetrazoliumromide (MTT) assay, and 5-Ethynyl-2′-deoxyuridine (EdU) staining were performed to evaluate the proliferation and migration of PASMCs. Meanwhile, the interaction among proteins was detected by immunoprecipitation assays.Results: The expression levels of GRK2 were upregulated in the pulmonary arteries of patients with PAH and the lungs of PH mice. Moreover, cHx/SU-induced PH was attenuated inGrk2?SM22 mice compared with littermate controls. The amelioration of PH inGrk2?SM22 mice was accompanied by reduced pulmonary vascular remodeling.In vitro study further confirmed thatGRK2 knock-down significantly altered hypoxia-induced PASMCs proliferation and migration, whereas this effect was severely intensified by overexpression ofGRK2. We also identified that GRK2 promoted YAP expression and nuclear translocation in PASMCs, resulting in excessive PASMCs proliferat

关键词： Pulmonary arterial hypertension GRK2 YAP Pulmonary artery smooth muscle cell Hypoxia

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