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Acupuncture ameliorates atopic dermatitis by modulating gut barrier function in a gut microbiota-dependent manner in mice

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Journal of Integrative Medicine 2024年第5期22卷 600-613页

作者： Mijung Yeom Sora Ahn Dae-Hyun Hahm Sun-Young Jang Se Hoon Jang Su-Yang Park Jae-Hwan Jang jihan Park Ju-Young Oh In-Seon Lee Kyuseok Kim Soon-Kyeong kwon Hi-Joon Park Acupuncture and Meridian Science Research Center College of Korean MedicineKyung Hee UniversitySeoul 02447Republic of Korea Department of Physiology School of MedicineKyung Hee UniversitySeoul 02447Republic of Korea BioNanocomposite Research Center Kyung Hee UniversitySeoul 02447Republic of Korea Department of Science in Korean Medicine College of Korean MedicineGraduate SchoolKyung Hee UniversitySeoul 02447Republic of Korea College of Korean Medicine Kyung Hee UniversitySeoul 02447Republic of Korea Department of Ophthalmology Otorhinolaryngology and Dermatology of Korean MedicineCollege of Korean MedicineKyung Hee UniversitySeoul 02447Republic of Korea Division of Applied Life Science(BK21) Gyeongsang National UniversityJinju 52828Republic of Korea Department of Anatomy&Information Sciences College of Korean MedicineKyung Hee UniversitySeoul 02447Republic of Korea

Objective Atopic dermatitis(AD)is a chronic inflammatory skin disease that may be linked to changes in the gut *** has been proven to be effective in reducing AD symptoms without serious adverse events,but its underlying mechanism is not completely *** purpose of this study was to investigate whether the potential effect of acupuncture on AD is gut *** AD-like skin lesions were induced by applying MC903 topically to the cheek of the *** was done at the Gok-ji(LI11)***-like symptoms were assessed by lesion scores,scratching behavior,and histopathological changes;intestinal barrier function was measured by fecal output,serum lipopolysaccharide levels,histopathological changes,and mRNA expression of markers involved in intestinal permeability and *** microbiota was profiled using 16S rRNA gene sequencing from fecal *** Acupuncture effectively improved chronic itch as well as the AD-like skin lesions with epidermal thickening,and also significantly altered gut microbiota structure as revealed byβ-diversity indices and analysis of *** beneficial effects were eliminated by antibiotic depletion of gut microbiota,but were reproduced in gut microbiota-depleted mice that received a fecal microbiota transplant from acupuncture-treated ***,AD mice had intestinal barrier dysfunction as indicated by increased intestinal permeability,atrophy of the mucosal structure(reduced villus height and crypt depth),decreased expression of tight junctions and mucus synthesis genes,and increased expression of inflammatory mediators in the *** attenuated these abnormalities,which was gut *** Acupuncture ameliorates AD-like phenotypes in a gut microbiota-dependent manner and some of these positive benefits are explained by modulation of the intestinal barrier,providing new perspective for non-pharmacological strategies for

关键词： Atopic dermatitis Acupuncture Gut microbiota Intestinal barrier function

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Amine axial ligand-coordinated cobalt phthalocyanine-based catalyst for flow-type membraneless hydrogen peroxide fuel cell or enzymatic biofuel cell

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Journal of Energy Chemistry 2021年第7期30卷 463-471页

作者： Heeyeon An Hyewon Jeon Jungyeon ji Yongchai kwon Yongjin Chung Department of Chemical and Biological Engineering Korea National University of Transportation50 Daehak-roChungjuChungbuk 27469Republic of Korea Graduate School of Energy and Environment Seoul National University of Science and Technology 232 Gongneung-roNowon-guSeoul 01811Republic of Korea Department of Chemical and Biomolecular Engineering Seoul National University of Science and Technology232 Gongneung-roNowon-guSeoul 01811Republic of Korea Department of ITÁEnergy Convergence(BK21 FOUR) Korea National University of Transportation50 Daehak-roChungjuChungbuk 27469Republic of Korea

In this study,an amine-coordinated cobalt phthalocyanine(CoPc)-based anodic catalyst was fabricated by a facile process,to enhance the performance of hydrogen peroxide fuel cells(HPFCs) and enzymatic biofuel cells(EBCs).For this purpose,polyethyleneimine(PEI) was added onto the reduced graphene oxide and CoPc composite(RGO/CoPc) to create abundant NH2 axial ligand groups,for anchoring the Co core within the *** to the PEI addition,the onset potential of the hydrogen peroxide oxidation reaction was shifted by 0.13 V in the negative direction(0.02 V) and the current density was improved by 1.92 times(1.297 mA cm^(-2)),compared to those for RGO/CoPc(0.15 V and 0.676 mA cm^(-2),respectively),due to the formation of donor-acceptor dyads and the prevention of CoPc from leaching *** biocatalyst using glucose oxidase(GOx)([RGO/CoPc]/PEI/GOx) showed a better onset potential and catalytic activity(0.15 V and 318.7 μA cm^(-2)) than comparable structures,as well as significantly improved operational durability and long-term *** is also attributed to PEI,which created a favorable microenvironment for the *** maximum power densities(MPDs) and open-circuit voltages(OCVs) obtained for HPFCs and EBCs using the suggested catalyst were 105.2±1.3 μW cm^(-2)(0.317±0.003 V) and 25.4±0.9 μW cm^(-2)(0.283±0.007 V),*** shows that the amine axial ligand effectively improves the performance of the actual driving HPFCs and EBCs.

关键词： Hydrogen peroxide fuel cell Enzymatic biofuel cell Amine axial ligand Hydrogen peroxide oxidation reaction Membraneless

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On the factors of Bitcoin’s value at risk

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Financial Innovation 2021年第1期7卷 1855-1885页

作者： ji Ho kwon College of Business Gachon University1342 Seongnam‑daeroSujeong‑guSeongnam‑siGyeonggi‑doRepublic of Korea

This study investigates the factors of Bitcoin’s tail risk,quantified by Value at Risk(VaR).Extending the conditional autoregressive VaR model proposed by Engle and Manganelli(2004),I examine 30 potential drivers of Bitcoin’s 5%and 1%*** the 5%VaR,quantity variables,such as Bitcoin trading volume and monetary policy rate,were positively significant,but these effects were attenuated when new samples were *** 5%VaR responds positively to the Internet search index and negatively to the fluctuation of returns on commodity variables and the Chinese stock market *** the 1%VaR,variables related to the macroeconomy play a key *** consumer sentiment index exerts a strong positive effect on the 1%VaR.I also find that the 1%VaR has positive relationships with the US economic policy uncertainty index and the fluctuation of returns on the corporate bond index.

关键词： Bitcoin Value at risk CAViaR

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Performance and genetic diversity of 23 provenances of northern red oak(Quercus rubra L.)after 25 years of growth in South Korea

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Journal of Forestry Research 2021年第5期32卷 2181-2188页

作者： Ki-won Kim Kyoung-Mi Lee Soon-Ho kwon ji-Min Park Yang-Gil Kim Hye-In Kang Da-Bin Yum Kyu-Suk Kang Department of Agriculture Forestry and BioresourcesSeoul National UniversitySeoul 08826Republic of Korea Department of Forest Bioresources National Institute of Forest ScienceSuwon 16631Republic of Korea Department of Plant Resource Research Korea National ArboretumPocheon 11186Republic of Korea Research Institute of Agriculture and Life Sciences CALS_SNUSeoul 08826Republic of Korea

Growth traits and genetic diversity of 23 provenances of Quercus rubra introduced from North America were analyzed in a provenance trial established with a randomized block design in Hwaseong,Gyeonggi,South Korea in *** variables and survival at age 25 were compared with results from early ***,DBH,volume and stem straightness of *** was better than those of the domestic oak(Quercus accutissima).Growth of the Dunham Island provenance from New York was the best among the 23 provenances that of the Eagle River provenance from Wisconsin was *** rate at age25 was on average 52%.The longitude of seed origin and growth of provenance were consistently significantly negatively correlated at all *** of coastal provenances was superior to that of the inland provenances,which were separated by the Appalachian *** diversity and genetic distance among the provenances were evaluated using micro satellite *** allelic frequencies showed high polymorphism in 10 microsatellite loci,and 292 alleles were *** 10 loci,two were commonly found in the 23 *** mean allelic diversity and heterozygosity observed among the provenances were similar to those from the native populations of *** in North ***’s genetic distance among the 23 was estimated and showed that a clear trend between geographic and genetic distances,indicating that some provenances have high genetic diversity with superior growth performance.

关键词： Introduction breeding Provenance test Adaptation Microsatellite marker Genetic distance

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Flexible and transparent thin-film light-scattering photovoltaics about fabrication and optimization for bifacial operation

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npj Flexible Electronics 2023年第1期7卷 388-397页

作者： Soo-won Choi Jae-Ho Park ji-Woo Seo Chaewon Mun Yonghun Kim Pungkeun Song Myunghun Shin Jung-Dae kwon Surface&Nano Materials Division Korea Institute of Materials ScienceChangwonGyeongnam 51508Republic of Korea Department of Materials Science and Engineering Pusan National UniversityBusan 46241Republic of Korea Cell R&D Team Hanhwa QCells202 Sansusandan 2-roLwol-myeonJincheon-gunChungcheongbuk-do 27816Republic of Korea School of Electronics and Information Engineering Korea Aerospace UniversityGoyangGyeonggi 10540Republic of Korea Department of Advance Materials Engineering University of Science and Technology(UST)217 Gajeong-roYuseong-guDaejeon 34113Republic of Korea

Flexible and transparent thin-film silicon solar cells were fabricated and optimized for building-integrated photovoltaics and bifacial operation.A laser lift-off method was developed to avoid thermal damage during the transfer of light-scattering structures onto colorless polyimide substrates and thus enhance front-incidence photocurrent,while a dual n-type rear window layer was introduced to reduce optical losses,facilitate electron transport for rear incidence,and thus enhance performance during bifacial *** introduction of the window layer increased the rear-to-front power conversion efficiency ratio to~86%.The optimized bifacial power conversion efficiency for front and rear irradiances of 1 and 0.3 sun,respectively,equaled 6.15%,and the average transmittance within 500–800 nm equaled 36.9%.Additionally,the flexible and transparent solar cells fabricated using laser lift-off exhibited good mechanical reliability(i.e.,sustained 500 cycles at a bending radius of 6 mm)and were therefore suitable for building-integrated photovoltaics.

关键词： transparent scattering film

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Effect of gastric acid suppressants and prokinetics on peritoneal dialysis-related peritonitis

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World Journal of Gastroenterology 2014年第25期20卷 8187-8194页

作者： ji Eun kwon Seong-Joon Koh Jaeyoung Chun ji won Kim Byeong Gwan Kim Kook Lae Lee Jong Pil Im Joo Sung Kim Hyun Chae Jung Department of Internal Medicine and Liver Research Institute Seoul National University College of MedicineSeoul 110-799South Korea Department of Internal Medicine Seoul National University Boramae HospitalSeoul 156-707South Korea

AIM: To investigate the effect of gastric acid suppressants and prokinetics on peritonitis development in peritoneal dialysis(PD) ***: This was a single-center, retrospective study. The medical records of 398 PD patients were collected from January 2000 to September 2012 and analyzed to compare patients with at least one episode of peritonitis(peritonitis group, group A) to patients who never had peritonitis(no peritonitis group, group B). All peritonitis episodes were analyzed to compare peritonitis caused by enteric organisms and peritonitis caused by non-enteric ***: Among the 120 patients who met the inclusion criteria, 61 patients had at least one episode ofperitonitis and 59 patients never experienced peritonitis. Twenty-four of 61 patients(39.3%) in group A and 15 of 59 patients(25.4%) in group B used gastric acid suppressants. Only the use of H2-blocker(H2B) was associated with an increased risk of PD-related peritonitis; the use of proton pump inhibitors, other antacids, and prokinetics was not found to be a significant risk factor for PD-related peritonitis. A total of 81 episodes of peritonitis were divided into enteric peritonitis(EP) or non-enteric peritonitis, depending on the causative organism, and gastric acid suppressants and prokinetics did not increase the risk of EP in PD ***: The use of H2B showed a trend for an increased risk of overall PD-related peritonitis, although further studies are required to clarify the effects of drugs on PD-related peritonitis.

关键词： Proton pump inhibitors Histamine 2 receptor antagonists Gastrointestinal motility Peritoneal dialysis Peritonitis

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Anti-cancer effect of ethylacetate fraction from Orostachys japonicus on HT-29 human colon cancer cells by induction of apoptosis through caspase-dependent signaling pathway

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Asian Pacific Journal of Tropical Medicine 2018年第5期11卷 330-335页

作者： Deok-Seon Ryu Hyun-ji Lee ji-Hye kwon Dong-Seok Lee Department of Biomedical Laboratory Science Soonchunhyang University Department of Smart Foods and Drugs Graduate School of Inje University

Objective: To investigate the anti-colon cancer effects of ethylacetate fraction from Orostachys japonicus(0. japonicus) on HT-29 cancer cells. Methods: The viability of HT-29 cells was assayed by the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2 H-tetrazolium(MTS) method. Apoptosis induction and cell cycle inhibition were confirmed by fluorescein isothiocyanate and propidium iodide staining using flow *** changes in the nucleus were observed, using a fluorescence microscope with4',6-diamidino-2-phenylindole(DAPI) nuclear staining. The expression levels of the upstream and downstream proteins involved in the anti-cancer mechanism were confirmed by Western blotting. Results: After treating HT-29 cells with different concentrations of ethylacetate fraction from O. japonicus, the viability of cells decreased in a concentration-dependent manner,while apoptosis induction and apoptotic body formation increased. Cell cycle analysis showed that the arrest occurred at the sub-G_1 and S phase. Among the upstream and downstream proteins involved in anti-cancer activity, the level of B cell lymphoma-2 decreased, and the bcl-2-associated x protein increased. The level of pro-caspase-3, pro-caspase-8, and pro-caspase-9 decreased, while the level of cleaved-caspase-3, cleaved-caspase-8, and cleaved-caspase-9 increased. Moreover, the phosphorylation, that is, activation of extracellular signal regulated kinase 1/2, Jun-N-terminal kinase, and p38 increased. Conclusions: Combining the above results, it is thought that the survival of HT-29 cells is suppressed by ethylacetate fraction from0. japonicus through mitochondrial regulation-induced caspase cascade activation, induction of apoptosis and cell cycle arrest.

关键词： Orostachys japonicus HT-29 human colon cancer cells Anti-cancer activity Apoptosis Caspase cascade

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Preparation of AZ91D Slurries for Semi-Solid Forming Using Al8 ( Mn, Fe) 5 Precipitates

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Journal of Rare Earths 2004年第Z2期22卷 42-46页

作者： ji Young Byun Soon Il kwon Jeong Man Doh Heon Phil Ha Metal Processing Research Center Division of MaterialsKorea Institute of Science and Technology# 39-1 Haweolgok-DongSungbuk-KuSeoul 136-791Republic of Korea

During the solidification of the AZ91D-alloys, the Al8(Mn, Fe)5 phase is generally precipitated in the melt in advance of the precipitation of the primary α-Mg. The basic principle for manufacturing AZ91D-alloy slurries for semi solid forming is to use the Al8(Mn, Fe)5 precipitates as the heterogeneous nucleation sites for primary α-Mg phases. Microscopic analysis for the location of the Al8(Mn, Fe)5 precipitate explains that the Al8(Mn, Fe)5 precipitate is the effective heterogeneous nucleation site for the primary α-Mg phase. It was also observed that increase of the Mn content in the melt and the cooling rate below to the solid/liquid two-phase region resulted in smaller and more globular primary α-Mg due to the increase of heterogeneous nucleation sites. It was found that the average α-Mg diameter grew as a function of t0.278, where t is the holding time at the solid/liquid two-phase region. This would be attributed to the Ostwald type ripening and coalescence between primary α-Mg phases. The cooling rate below to the solid/liquid two-phase region, Mn content in AZ91D alloy, and the holding time and temperature affected on the quality of slurry.

关键词： AZ91D alloy semi-solid forming solidification heterogeneous nucleation

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Correction to:Memristive Devices Based on Two‑Dimensional Transition Metal Chalcogenides for Neuromorphic Computing

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Nano-Micro Letters 2022年第5期14卷 15-17页

作者： Ki Chang kwon ji Hyun Baek Kootak Hong Soo Young Kim Ho won Jang Department of Materials Science and Engineering Research Institute of Advanced MaterialsSeoul National UniversitySeoul 08826Republic of Korea Interdisciplinary Materials Measurement Institute Korea Research Institute of Standards and Science(KRISS)Daejeon 34133Republic of Korea Department of Materials Science and Engineering Institute of Green Manufacturing TechnologyKorea UniversitySeoul 02841Republic of Korea Advanced Institute of Convergence Technology Seoul National UniversitySuwon 16229Korea

The original version of this article,unfortunately,contained some mistakes and unintentional wrong description of Fig.6 and the caption of Figs.9,*** correct version of Fig.6 is *** mentioned figure name for the Fig.6 on the manuscript should be *** 2D vdW synaptic devices,the length of the tunneling barrier can be increased or decreased on the trapped or detrapped *** et *** memristive and neuromorphic devices composed of vertically grown WS2 layer and ZnO(Fig.6e)[149].The interlayer separation between WS2 and ZnO layers serves as an effective porous medium allowing the ZnO to grow with *** interfacial region of ZnO,the very contiguous to WS2 layer.

关键词： WS2 Transition separation

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Antimicrobial activity and synergism of Sami-Hyanglyun-Hwan with ciprofloxacin against methicillin-resistant Staphylococcus aureus

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Asian Pacific Journal of Tropical Medicine 2015年第7期8卷 536-540页

作者： Jang-Gi Choi ji-Young Choi Su-Hyun Mun Ok-Hwa Kang Preeti Bharaj Dong-won Shin Myong-Soo Chong Dong-Yeul kwon Department of Oriental Pharmacy College of Pharmacy Wonkwang University Wonkwang Oriental Medicines Research Institute Center of Excellence in Infectious Disease Research Department of Biomedical Sciences Paul L. Foster School of Medicine Texas Tech University Health Sciences Center Department of Third Medicine Professional Graduate School of Oriental Medicine Wonkwang University BK21 Plus Team Professional Graduate School of Oriental Medicine Wonkwang University Department of Oriental Medicine Resources Sunchon National University

Objective: To investigate the antibacterial activity of SHHextracted with either water or ethanol against methicillin-resistant Staphylococcus aureus(MRSA) and combinatory antimicrobial effect with ciprofloxacin(CIP) by time kill assay and checkerboard dilution test. Methods: The antibacterial activity determined by broth dilution method indicated that the antibacterial activity of Sami-Hyanglyun-Hwan(SHH) water extract(SHHW) and SHH ethanol extract(SHHE) ranged from 250 to 2000 μg/m L and 125 to 1000 μg/m L against MRSA, respectively. Results: In the checkerboard method, the combinations of SHHE with CIP had a partial synergistic or synergistic effect against MRSA. The time-kill curves showed that a combined SHHE and CIP treatment reduced the bacterial counts dramatically after 24 h. Conclusions: The present study demonstrates the therapeutic ability of SHHE against MRSA infections.

关键词： Sami-Hyanglyun-Hwan Methicillin-resistant Staphylococcus aureus Ciprofloxacin Synergy

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