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基于Falcon的盲签名方案

密码学报（中英文） 2024年第4期11卷 911-923页

作者：李子臣郑惠敏北京印刷学院数字版权保护技术研究中心北京102600

基于格的密码体系是后量子密码时代的重要研究方向,构造格上的盲签名方案具有重要意义.本文结合NIST后量子密码标准化项目的优胜算法Falcon,设计了一个NTRU格上紧凑型的盲签名方案.消息盲化时,用户先将签名者产生的320 bit均匀分布的随... 详细信息

基于格的密码体系是后量子密码时代的重要研究方向,构造格上的盲签名方案具有重要意义.本文结合NIST后量子密码标准化项目的优胜算法Falcon,设计了一个NTRU格上紧凑型的盲签名方案.消息盲化时,用户先将签名者产生的320 bit均匀分布的随机比特串和一个本地均匀生成的等长随机比特串进行异或运算,得到真实签名组合中的320 bit长的随机值,实现该部分签名的盲性.接着用户计算原始消息拼接上新生成的随机向量的哈希值,然后将一个任意选取的整数和两个离散高斯分布随机选择的向量作为盲因子对哈希值进行盲化,实现消息对签名者的盲性.将原始消息与上述生成的均匀随机比特串做拼接的操作可以使得一个消息拥有多个合法签名.在“先哈希再签名”范式下,签名者利用快速傅里叶陷门采样器从NTRU格上寻找离其陪集上一点最近的格点,计算出符合要求的盲签名.用户对盲签名去盲后可以得到消息的合法签名.在随机谕言机模型下,基于NTRU格上SIS问题的困难性假设,证明本文方案满足强不可伪造性.依据效率分析,本文方案产生的公钥和签名组合尺寸较小,可以有效节约带宽资源.

关键词： Falcon 盲签名强不可伪造性

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螺杆马达过盈量对输出性能影响研究

机械科学与技术 2024年第9期43卷 1477-1484页

作者：钟辉况雨春钟良春西南石油大学机电工程学院成都610500 中石化石油机械股份有限公司湖北荆州434007

螺杆马达是螺杆钻具的动力来源,其定转子之间的过盈量对螺杆马达的工作性能和使用寿命起着至关重要的作用。文中提出了螺杆马达性能评价准则,建立了螺杆马达流固耦合三维有限元模型,基于显式非线性瞬态动力学对0.1 mm、0.2 mm和0.3 mm这... 详细信息

螺杆马达是螺杆钻具的动力来源,其定转子之间的过盈量对螺杆马达的工作性能和使用寿命起着至关重要的作用。文中提出了螺杆马达性能评价准则,建立了螺杆马达流固耦合三维有限元模型,基于显式非线性瞬态动力学对0.1 mm、0.2 mm和0.3 mm这3种过盈量螺杆马达的接触力值、机械效率、容积效率、密封腔成腔稳定性进行了有限元分析。结果表明:随着过盈量的增加,定转子接触力值逐渐增大,螺杆马达容积效率逐渐升高,机械效率逐渐降低,高负载情况下0.2 mm过盈量螺杆马达密封腔稳定性较好,并且马达整体性能最好,在较低负载情况下,0.1 mm过盈量螺杆马达密封腔稳定性较好,其整体性能较好。研究结果可为螺杆马达的过盈量设计以及优选提供一定的参考。

关键词：螺杆马达过盈量流固耦合性能优选

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Toxoplasma ROP16Ⅰ/Ⅲ ameliorated inflammatory bowel diseases via inducing M2 phenotype of macrophages

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World Journal of Gastroenterology 2019年第45期25卷 6634-6652页

作者： Yong-Wei Xu Rui-Xin Xing wen-hui Zhang Lu Li Yi Wu jing Hu Cong Wang Qing-Li Luo ji-Long Shen Xi Chen Department of Gastroenterology the First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Pathogen Biology Provincial Laboratory of Pathogen Biology and Zoonoses AnhuiAnhui Medical UniversityHefei 230032Anhui ProvinceChina

BACKGROUND Inflammatory bowel disease（IBD） is characterized by chronic and non-specific inflammation of the intestinal mucosa and mainly includes ulcerative colitis and Crohn’s *** To explore the beneficial effect of Toxo ROP16Ⅰ/Ⅲ-induced M2 phynotype macrophages in homeostasis of IBDs through downregulation of M1 inflammatory *** RAW264.7 macrophages stimulated by lipopolysaccharide（LPS）（M1 cells） were co-cultured with Caco-2 cells as an inflammatory model of IBD in *** expression of Toxo ROP16Ⅰ/Ⅲ was observed in RAW264.7 macrophages that were transfected with p EGFP-rop16Ⅰ/Ⅲ.The phenotypes of M2 and M1 macrophage cells were assessed by quantitative real-time reverse transcriptase polymerase chain reaction and the expression of tumor necrosis factor（TNF）-α,interleukin（IL）-1β,IL-6,transforming growth factor（TGF）-β1,IL-10,inducible nitric oxide synthase（i NOS）,and arginase-1（Arg-1） was *** expression of i NOS,Arg-1,signal transducer and activator of transcription 3（Stat3）,p-Stat3,Stat6,pStat6,programmed death ligand-2（PD-L2）,caspase-3,-8,and-9 was analyzed by Western blotting,and Griess assays were performed to detect nitric oxide（NO）.TNF-α,IL-1β,IL-6,TGF-β1,and IL-10 expression in the supernatants was detected by enzyme-linked immunosorbent assay,and Caco-2 cell apoptosis was determined by flow cytometry after mixing M1 cells with M2 cells in a Caco-2 cell co-culture *** M1 cells exhibited significantly increased production of i NOS,NO,TNF-α,IL-1β,and IL-6,while Toxo ROP16Ⅰ/Ⅲ induced macrophage bias to M2 cells in vitro,showing increased expression of Arg-1,IL-10 and TGF-β1 and elevated production of p-Stat3 and *** mixed M1 and M2 cell culture induced by Toxo ROP16 Ⅰ/Ⅲ exhibited decreased production of NO and i NOS and upregulated expression of Arg-1 and ***,Caco-2 cells became apoptotic,and apoptosis-associated proteins such as caspase-3,-8 and-9 were dampened during co-culture of M1 and M2 ***

关键词： Toxoplasma ROP16Ⅰ/Ⅲ Caco-2 Inflammatory bowel disease Immunity Classically activated macrophages Alternatively activated macrophages

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山西祁县渠氏家族文化内涵探析

延安职业技术学院学报 2024年第2期38卷 80-83页

作者：朱慧慧西安翻译学院文学与传媒学院陕西西安710105

山西祁县渠氏家族是明清时期极具文化底蕴的儒商巨族,一代代族人在家族教育、经商治家、公共空间建设等方面有独到之处,构成了丰富的文化传统,就族人个体而言,能够修身立范;就家族来说,能够齐家治家;就社会而论,能够统一整合,长期积淀,... 详细信息

山西祁县渠氏家族是明清时期极具文化底蕴的儒商巨族,一代代族人在家族教育、经商治家、公共空间建设等方面有独到之处,构成了丰富的文化传统,就族人个体而言,能够修身立范;就家族来说,能够齐家治家;就社会而论,能够统一整合,长期积淀,形成了重要的地域文化景观。在建设和谐社会的当下,渠氏家族的优秀传统文化逐渐凸显,在家风文化涵育、社会主义文化建设方面具有借鉴作用。

关键词：渠氏家族文化底蕴家风构建

SYNTHESIS AND CATALYSTIC BEHAVIOR OF A HEW PHASE-TRANSFER CATALYST SUPPORTED ON SILICA GEL

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Chinese Chemical Letters 1993年第1期4卷 41-44页

作者： Ru Hong KANG jian Lu ZHAO hui Lan CHEN wen Juan QIE Wei Zhan ji Chemistry Department Of Hebei Normal University Shi.jiazhuang Hebei 050016

A new catalyst with quaternary ammonium cation activated polyether chains immobilized on silica gel was applied to promote the reations of KI with n-C_4H_9-Br and KSCH with n-C_4H_9Br. The new catalyst showed much sig... 详细信息

关键词： CI OB SILICA GEL SYNTHESIS AND CATALYSTIC BEHAVIOR OF A HEW PHASE-TRANSFER CATALYST SUPPORTEI PEG 一刁

Colonic vitamin D receptor expression is inversely associated with disease activity and jumonji domain-containing 3 in active ulcerative colitis

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World Journal of Gastroenterology 2020年第46期26卷 7352-7366页

作者： Hong-Qian Wang wen-hui Zhang Ya-Qi Wang Xiao-Pan Geng Ming-Wei Wang Yuan-Yuan Fan jing Guan ji-Long Shen Xi Chen Department of Gastroenterology The First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Pathogen Biology Anhui Medical UniversityHefei 230032Anhui ProvinceChina

BACKGROUND The expression of jumonji domain-containing 3(Jmjd3)and trimethylated H3 lysine 27(H3K27me3)in active ulcerative colitis(UC)and the correlation between vitamin D receptor(VDR)and the Jmjd3 pathway are *** To study the relationship between VDR,Jmjd3 and H3K27me3 in patients with active *** One hundred patients with active UC and 56 healthy controls were enrolled in this *** patients with active UC were divided into groups according to mild(n=29),moderate(n=32)and severe(n=29)disease activity based on the modified Mayo *** D levels were measured by *** mucosal tissues from UC patients and controls were collected by *** expression of VDR,Jmjd3 and H3K27me3 in the intestinal mucosa was determined by immunohistochemistry *** Patients with active UC had lower levels of serum vitamin D(13.7±2.8 ng/mL,P<0.001)than the controls(16.2±2.5 ng/mL).In the UC cohort,serum vitamin D level was negatively correlated with disease activity(r=-0.323,P=0.001).VDR expression in the mucosa of UC patients was reduced compared to that in normal tissues(P<0.001)and negatively correlated with disease activity(r=-0.868,P<0.001).Similar results for VDR expression were noted in the most serious lesion(defined as UC diseased)and 20 cm proximal to the anus(defined as UC normal)(P<0.05).Simultaneously,Jmjd3 expression significantly increased in UC patients(P<0.001),but no difference was found between the different sites in UC patients.H3K27me3 expression in UC patients was significantly down-regulated when compared with normal tissues(P<0.001),but up-regulated in the mild disease activity group in comparison with the moderate disease activity group of UC patients(P<0.05).Jmjd3 Level was negatively correlated with the level of VDR(r=-0.342,P=0.002)and H3K27me3(r=-0.341,P=0.002),while VDR level was positively correlated with H3K27me3(r=0.473,P<0.001).CONCLUSION Serum vitamin D and VDR were inversely correlated with

关键词： Vitamin D Ulcerative colitis Disease activity Vitamin D receptor Jumonji domain-containing 3 Trimethylated H3 lysine 27

Combined transarterial chemoembolization and tislelizumab for patients with unresectable hepatocellular carcinoma

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World Journal of Gastrointestinal Surgery 2024年第9期16卷 2829-2841页

作者： Bin-Bin Tan Ying Fu Ming-Hua Shao Hai-Lei Chen Ping Liu Chao Fan hui Zhang Department of Hepatobiliary Surgery First Affiliated Hospital of Third Military Medical University(Army Medical University)Chongqing 400038China Department of Hepatobiliary Surgery First Affiliated Hospital of Third Military Medical University(Army Medical University)Jiangbei Area(The 958th Hospital of Chinese People's Liberation Army)Chongqing 400020China

BACKGROUND Hepatocellular carcinoma(HCC)often presents as unresectable,necessitating effective treatment *** transarterial chemoembolization(TACE)with immunotherapy and targeted therapy has shown promise,yet real-world evidence is *** To investigate effectiveness and safety of TACE with tislelizumab±targeted therapy for unresectable HCC in real-world *** This retrospective study included patients with unresectable HCC receiving combined treatment of TACE and *** clinical outcomes included progression-free survival(PFS),overall survival(OS),objective response rate(ORR),and disease control rate(DCR).All patients were evaluated according to the mRECIST *** adverse event(AE)was also *** In this study of 56 patients with median follow-up of 10.9 months,7 had previous *** was administered before TACE in 21(37.50%)and after in 35(62.50%)patients,with 91.07%receiving concurrent targeted *** PFS was 14.0(95%CI:7.0-18.00)months,and OS was 28(95%CI:2.94-53.05)*** with prior immunotherapy had shorter PFS(6 vs.18 months,P=0.006).Overall ORR and DCR were 82.14%and 87.50%.Grade≥3 treatment-related AEs included increased alanine aminotransferase(8.93%),aspartate aminotransferase(10.71%),and total bilirubin(3.57%).CONCLUSION The combination of TACE and tislelizumab,with or without targeted therapy,demonstrated promising efficacy and safety in unresectable HCC,especially in immunotherapy-naive patients,warranting further prospective validation studies.

关键词： Hepatocellular carcinoma Transarterial chemoembolization,Therapeutic Immunotherapy Prognosis

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基于等效模型的砖石古塔有限元模型修正方法

振动与冲击 2024年第3期43卷 105-109页

作者：杨庆山张源浩刘纲王晖重庆大学土木工程学院重庆400045

针对砖石古塔实体有限元模型节点众多导致修正效率低下问题,提出了一种将实体模型和杆系模型相结合的有限元模型快速修正方法。基于古塔结构的测试输出信号,使用随机子空间法识别了塔的自振频率。使用整体连续式方法建立了ABAQUS有限元... 详细信息

针对砖石古塔实体有限元模型节点众多导致修正效率低下问题,提出了一种将实体模型和杆系模型相结合的有限元模型快速修正方法。基于古塔结构的测试输出信号,使用随机子空间法识别了塔的自振频率。使用整体连续式方法建立了ABAQUS有限元模型,基于实测结果,使用萤火虫算法修正了塔的弹性模量、密度。修正后的有限元模型的计算结果与实测结果对比,能够较好吻合,说明修正后的模型可靠,可以作为后续抗震性能分析的基础。

关键词：砖石古塔有限元模型模型修正等效模型萤火虫算法

Growth and applications of graphene on copper

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cMat 2024年第1期1卷 45-50页

作者： Chong Zhao Meng-Ze Zhao Zhi-Bin Zhang En-Ge Wang Kai-hui Liu Mu-Hong Wu Songshan Lake Materials Laboratory Institute of PhysicsChinese Academy of SciencesDongguanChina State Key Laboratory for Mesoscopic Physics Frontiers Science Center for Nano-OptoelectronicsSchool of PhysicsPeking UniversityBeijingChina International Center for Quantum Materials Collaborative Innovation Center of Quantum MatterPeking UniversityBeijingChina School of Physics Liaoning UniversityShenyangChina Interdisciplinary Institute of Light-Element Quantum Materials and Research Center for Light-Element Advanced Materials Peking UniversityBeijingChina

Since the first isolation of graphene by Geim and Novoselov in 2004,this two-dimensional(2D)material has attracted significant attention from the scientific and engineering communities.^(1)Due to its structure with a single layer of covalently bonded sp^(2)-hybridized carbon atoms,graphene has superior mechanical,electrical,optical,and thermal properties.^(2-4)Although mechanical exfoliation remains an ideal method for obtaining highquality graphene,its scalability is severely limited;thus,it is impractical for industrial *** pursuit of a method suitable for large-scale production,research has been performed using chemical vapor deposition(CVD)methods for synthesizing graphene on metal substrates.

关键词： graphene copper method