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哈尔滨啤酒历史沿革

酿酒 2016年第6期43卷 5-11页

作者：季树太赵彤黑龙江省酒业协会黑龙江哈尔滨150001 黑龙江省轻工科学研究院黑龙江哈尔滨150010

在回顾了啤酒进入中国的历史背景、啤酒工业在中国的兴起及建国后我国啤酒工业发展过程的基础上,重点介绍了作为中国啤酒发源地的哈尔滨自1900年建立中国第一家啤酒厂以来的一百多年,哈尔滨啤酒的发展历程和历史沿革,主要包括哈尔滨啤... 详细信息

在回顾了啤酒进入中国的历史背景、啤酒工业在中国的兴起及建国后我国啤酒工业发展过程的基础上,重点介绍了作为中国啤酒发源地的哈尔滨自1900年建立中国第一家啤酒厂以来的一百多年,哈尔滨啤酒的发展历程和历史沿革,主要包括哈尔滨啤酒业的初创阶段(1900-1932)、动荡时期(1932-1950)、地方国营(1950-1996)、合资外资(1996-2015)等阶段。百年历史的啤酒文化深深溶入了哈尔滨人的血液之中,也赋予了哈尔滨人灵性和豪爽,更为这座中西文化交汇并融的城市增添了独特的魅力。

关键词：哈尔滨啤酒历史沿革

Hydrogen sulfide reduces oxidative stress in Huntington's disease via Nrf2

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Neural Regeneration Research 2025年第6期20卷 1776-1788页

作者： Zige jiang Dexiang Liu Tingting Li Chengcheng Gai Danqing Xin Yijing zhao Yan Song Yahong Cheng tong Li Zhen Wang Department of Physiology School of Basic Medical SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Medical Psychology and Ethics School of Basic Medicine SciencesCheeloo College of MedicineShandong UniversityJinanShandong ProvinceChina Department of Neurosurgery Surgery Qingdao Municipal HospitalQingdaoShandong ProvinceChina

The pathophysiology of Huntington's disease involves high levels of the neurotoxin quinolinic acid. Quinolinic acid accumulation results in oxidative stress, which leads to neurotoxicity. However, the molecular and cellular mechanisms by which quinolinic acid contributes to Huntington's disease pathology remain unknown. In this study, we established in vitro and in vivo models of Huntington's disease by administering quinolinic acid to the PC12 neuronal cell line and the striatum of mice, respectively. We observed a decrease in the levels of hydrogen sulfide in both PC12 cells and mouse serum, which was accompanied by down-regulation of cystathionine β-synthase, an enzyme responsible for hydrogen sulfide production. However, treatment with NaHS(a hydrogen sulfide donor) increased hydrogen sulfide levels in the neurons and in mouse serum, as well as cystathionine β-synthase expression in the neurons and the mouse striatum, while also improving oxidative imbalance and mitochondrial dysfunction in PC12 cells and the mouse striatum. These beneficial effects correlated with upregulation of nuclear factor erythroid 2-related factor 2 expression. Finally, treatment with the nuclear factor erythroid 2-related factor 2inhibitor ML385 reversed the beneficial impact of exogenous hydrogen sulfide on quinolinic acid-induced oxidative stress. Taken together, our findings show that hydrogen sulfide reduces oxidative stress in Huntington's disease by activating nuclear factor erythroid 2-related factor 2,suggesting that hydrogen sulfide is a novel neuroprotective drug candidate for treating patients with Huntington's disease.

关键词： apoptosis cystathionine-β-synthase nuclear factor erythroid 2-related factor 2 Huntington's disease hydrogen sulfide mitochondrion neuroplasticity oxidative stress quinolinic acid reactive oxygen species

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun zhao De-En Xu Ming-Lei Wu ji-Chuan Liu Zi-Ling Shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

新疆本土企业国际化发展SWOT—CLPV矩阵分析

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广西职业技术学院学报 2018年第2期11卷 65-69页

作者：李季鹏赵彤刘丹新疆财经大学工商管理学院新疆乌鲁木齐830012

运用SWOT—CLPV理论,结合定性和定量分析的方法,分析新疆本土企业在国际化发展过程中所处环境、优势、机遇、威胁与不足,从而实现更好地发展。

关键词：新疆企业国际化 SWOT—CLPV

Study on the prediction and inverse prediction of detonation properties based on deep learning

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Defence Technology（防务技术） 2023年第6期24卷 18-30页

作者： Zi-hang Yang ji-li Rong Zi-tong zhao Department of Mechanics School of Aerospace EngineeringBeijing Institute of TechnologyBeijing100081China

The accurate and efficient prediction of explosive detonation properties has important engineering significance for weapon *** methods for predicting detonation performance include empirical formulas,equations of state,and quantum chemical calculation *** recent years,with the development of computer performance and deep learning methods,researchers have begun to apply deep learning methods to the prediction of explosive detonation *** deep learning method has the advantage of simple and rapid prediction of explosive detonation ***,some problems remain in the study of detonation properties based on deep *** example,there are few studies on the prediction of mixed explosives,on the prediction of the parameters of the equation of state of explosives,and on the application of explosive properties to predict the formulation of *** on an artificial neural network model and a one-dimensional convolutional neural network model,three improved deep learning models were established in this work with the aim of solving these *** training data for these models,called the detonation parameters prediction model,JWL equation of state(EOS)prediction model,and inverse prediction model,was obtained through the KHT thermochemical *** training,the model was tested for overfitting using the validation-set *** the model-accuracy test,the prediction accuracy of the model for real explosive formulations was tested by comparing the predicted value with the reference *** results show that the model errors were within 10%and 3%for the prediction of detonation pressure and detonation velocity,*** accuracy refers to the prediction of tested explosive formulations which consist of TNT,RDX and *** the prediction of the equation of state for explosives,the correlation coefficient between the prediction and the reference curves was above *** the prediction of the inverse predi

关键词： Deep learning Detonation properties KHT thermochemical Code JWL equation of states Artificial neural network One-dimensional convolutional neural network

Investigation of Eccentric PM on High-frequency Vibration in FSCW PM Machine Considering Force Modulation Effect

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Chinese Journal of Electrical Engineering 2024年第2期10卷 59-69页

作者： jinghua ji Weizhi jiang Wenxiang zhao tong Liu School of Electrical and Information Engineering Jiangsu UniversityZhenjiang 212013China

This study investigates the negative influence of an eccentric permanent-magnet(PM)design on high-frequency electromagnetic vibration in fractional-slot concentrated-winding(FSCW)PM ***,an analytical expression for the sideband current harmonics was derived using the double Fourier series expansion ***,the characteristics of the flux-density harmonics are studied from the perspective of the space-time distribution and initial phase *** influence of the eccentric PM design on high-frequency electromagnetic and concentrated forces was studied based on the electromagnetic force modulation ***,an eccentric PM design is not conducive to reducing the 2pth-order high-frequency electromagnetic ***,two FSCW PM machines with conventional and eccentric PM designs are manufactured and tested to verify the theoretical *** results show that the eccentric PM design worsens high-frequency vibrations.

关键词： Eccentric permanent magnet machine sideband current harmonics electromagnetic force modulation effect fractional-slot concentrated-winding high-frequency vibration

Collaboratively enhancing electrochemical properties of LiNi_(0.83)Co_(0.11)Mn_(0.06)O_(2) through doping and coating of quadrivalent elements

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Rare Metals 2023年第12期42卷 4103-4114页

作者： zhao-Zhe Yu Gui-Quan zhao Fang-Li ji Hao tong Qi-Lin tong Hua-Cheng Li Yan Cheng Guangxi Key Laboratory of Manufacturing Systems and Advanced Manufacturing Technology Guilin University of Electronic TechnologyGuilin 541004China Engineering Research Center of Electronic Information Materials and Devices Ministry of EducationGuilin University of Electronic TechnologyGuilin 541004China Guangxi CNGR New Energy Science&Technology Co. Ltd.Qinzhou 535000China

Ni-rich layered oxides(Ni>80%)with high energy density have become a mainstream cathode material for Li-ion ***,irreversible phase transitions and interface instability are deep-seated challenges in commercializing Ni-rich *** study used a collaborative modification strategy involving doping and coating with quadrivalent elements to construct Ni-rich *** particular,introducing tetravalent Zr makes the valence change of Ni(2+to 4+)more accessible to complete spontaneously during the charging and discharging processes,which significantly suppresses the cationic mixing and irreversible phase transition(H2?H3).Combining the strategy of constructing CeO_(2) coatings on the surface and interfacial spinel-like phases improves the Li+diffusion kinetics and interfacial ***,part of the strongly oxidizing four-valence Ce^(4+)diffuses to the surface layer,further increasing the average valence state of ***,LiNi_(0.83)Co_(0.11)Mn_(0.06)O_(2)(NCM)-Zr@Ce achieves 78.5%outstanding retention at1.0C after 200 cycles within 3.0-4.3 V compared to unmodified NCM with 41.4%*** improved cyclic stability can be attributed to the collaborative modification strategy of the quadrivalent elements,which provides an effective synergistic modification strategy for developing high-performance Li-ion battery cathode materials.

关键词： Collaborative modification strategy Quadrivalent elements Phase transitions Structural degradation Ni-rich layered oxides

Understanding the local structure and thermophysical behavior of Mg-La liquid alloys via machine learning potential

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 439-449页

作者： jia zhao Taixi Feng Guimin Lu National Engineering Research Center for Integrated Utilization of Salt Lake Resource East China University of Science and TechnologyShanghai 200237China Joint International Laboratory for Potassium and Lithium Strategic Resources East China University of Science and TechnologyShanghai 200237China

The local structure and thermophysical behavior of Mg-La liquid alloys were in-depth understood using deep potential molecular dynamic(DPMD) simulation driven via machine learning to promote the development of Mg-La alloys. The robustness of the trained deep potential(DP) model was thoroughly evaluated through several aspects, including root-mean-square errors(RMSEs), energy and force data, and structural information comparison results;the results indicate the carefully trained DP model is reliable. The component and temperature dependence of the local structure in the Mg-La liquid alloy was analyzed. The effect of Mg content in the system on the first coordination shell of the atomic pairs is the same as that of temperature. The pre-peak demonstrated in the structure factor indicates the presence of a medium-range ordered structure in the Mg-La liquid alloy, which is particularly pronounced in the 80at% Mg system and disappears at elevated temperatures. The density, self-diffusion coefficient, and shear viscosity for the Mg-La liquid alloy were predicted via DPMD simulation, the evolution patterns with Mg content and temperature were subsequently discussed, and a database was established accordingly. Finally, the mixing enthalpy and elemental activity of the Mg-La liquid alloy at 1200 K were reliably evaluated,which provides new guidance for related studies.

关键词： magnesium-lanthanum liquid alloys local structure macroscopic properties thermodynamic behavior deep potential mo-lecular dynamic simulation

Insights into the multiple applications of modified polyacrylamide as oilfield corrosion inhibitor and water phase tackifier

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Petroleum Science 2022年第1期19卷 397-408页

作者： tong Han ji-Xiang Guo Qing zhao Tao Shen Shi-Ling Zhang Unconventional Natural Gas Institute China University of PetroleumChangpingBeijing102249People's Republic of China State Key Laboratory of Heavy Oil Processing and College of Science China University of PetroleumChangpingBeijing102249People's Republic of China

In order to obtain a multifunctional oilfield agent with both corrosion inhibition and oil displacement functions,a polymer with benzene ring structures is synthesized based on polyacrylamide(PAM)and used as inhibitor for the first *** including electrochemistry,weight loss and theoretical calculations are used to study the inhibition effect for P110 steel in 1.0 M *** experimental results show that the modified polymer poly-(Z)-N-benzylidenepropionamide(PBAM)has excellent inhibition effects,and the maximum efficiency can reach 90.62%in impedance spectroscopy *** benzene ring structure added in the modified polymer providesπelectrons for the adsorption of inhibitor on metal surface,strengthens the adsorption,and thus brings a better corrosion inhibition *** addition to the corrosion inhibition performance,the viscosity-increasing effect of PBAM is *** results show that the addition of benzene ring not only enhances the corrosion inhibition effect,but also brings temperature resistance to the ***,the salt tolerance of the polymer is affected,the synthesized PBAM which viscosity can above 500 m Pa s at 140℃ is suitable for high temperature and low salinity *** modified polyacrylamide has satisfactory corrosion inhibition and oil displacement performance,which provides a new idea for the development of oilfield chemistry.

关键词： Corrosion inhibitor Polymer Multifunctional pharmacy Computational study