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Preclinical Long-term Magnetic Resonance Imaging Study of Silymarin Liver-protective Effects

Journal of Clinical and Translational Hepatology 2022年第6期10卷 1167-1175页

作者： Yeon ji Chae Hwon Heo Chul-Woong Woo Sang-tae Kim Jae-Im kwon Monica Young Choi Yu Sub Sung Kyung Won Kim Jeong Kon Kim Yoonseok Choi Dong-Cheol Woo Department of Convergence Medicine Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea Convergence Medicine Research Center Asan Institute for Life SciencesAsan Medical CenterSeoulRepublic of Korea Clinical Research Center Asan Medical CenterSeoulRepublic of Korea Department of Radiology Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea Medical Research Institute Gangneung Asan HospitalGangneung-siGangwon-doRepublic of Korea

Background and Aims:Efficacy evaluations with preclini-cal magnetic resonance imaging(MRI)are uncommon,but MRI in the preclinical phase of drug development provides information that is useful for longitudinal *** study aim was to monitor the protective effectiveness of silymarin with multiparameter MRI and biomarkers in a thioacetamide(TAA)-induced model of liver injury in *** analysis was conducted to assess compare the monitoring of liver function by MRI and ***-ods:TAA was injected three times a week for 8 weeks to generate a disease model(TAA group).In the TAA and sily-marin-treated(TAA-SY)groups,silymarin was administered three times weekly from week *** images were acquired at 0,2,4,6,and 8 weeks in the control,TAA,and TAA-SY ***:The area under the curve to maximum time(AUCtmax)and T_(2)*values of the TAA group decreased over the study period,but the serological markers of liver abnormality increased significantly more than those in the control *** the TAA-SY group,MRI and serological biomarkers indicated attenuation of liver function as in the TAA ***,pattern changes were observed from week 6 to comparable levels in the control group with si-lymarin *** correlations between either AUCtmax or T_(2)*values and the serological biomarkers were ***:Silymarin had hepatoprotective effects on TAA-induced liver injury and demonstrated the usefulness of multiparametric MRI to evaluate efficacy in preclinical studies of liver drug development.

关键词： Liver fibrosis Magnetic resonance imaging Silymarin T1-weight-ed dynamic contrast-enhanced T_(2)*

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Oxygen vacancy engineering for tuning the catalytic activity of LaCoO_(3) perovskite

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Journal of Rare Earths 2024年第3期42卷 506-514,I0003页

作者： Jeong Hyun Cho Minjae Kim Inchan Yang Kyung tae Park Chang Houn Rhee Hai Woong Park ji Chul Jung Department of Chemical Engineering Myongji UniversityYongin 17058Republic of Korea Institute of Advanced Composite Materials Korea Institute of Science and TechnologyWanju-gunJeollabuk-do 55324Republic of Korea Iron&Steel Process Engineering Research Group POSCOPohang 37859Republic of Korea Hydrogen Research Center Research Institute of Industrial Science&Technology(RIST)Pohang 37673Republic of Korea

Herein, we attempted to engineer oxygen vacancies on the surface of LaCoO_(3) perovskite through simple post-treatments(acid or reductive thermal treatments). Acid treatment induces oxygen vacancies through the selective etching of the La cations, whereas thermal treatment in a reducing atmosphere generates oxygen vacancies by directly removing lattice oxygen. The characterization results confirm that the number of surface oxygen vacancies, which are crucial in various catalytic oxidation reactions,considerably increases in the LaCoO_(3) catalysts treated with acid or reducing gas. Acid treatment enriches the oxygen vacancies while maintaining the structure of the LaCoO_(3) catalysts, which can not be achieved through reductive thermal treatment. Therefore, the acid treatment is considered a promising technique for oxygen vacancy engineering of perovskite catalysts for tuning their catalytic activities. Furthermore,the catalytic activities of the posttreated LaCoO_(3) catalysts for CO oxidation were evaluated and are noted to be considerably better than those of the pristine LaCoO_(3) catalyst due to their abundant oxygen vacancies. Consequently, we conclude that the oxygen vacancies of perovskite catalysts can be effectively engineered via two simple methods and play a significant role in CO oxidation.

关键词： LaCoO_(3)perovskite Acid treatment Reductive thermal treatment Oxygen vacancy CO oxidation Rare earths

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Brassinosteroids enhance salicylic acid-mediated immune responses by inhibiting BIN2 phosphorylation of clade I TGA transcription factors in Arabidopsis

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Molecular Plant 2022年第6期15卷 991-1007页

作者： Yeong-Woo Kim ji-Hyun Youn Jeehee Roh Jeong-Mok Kim Seong-Ki Kim tae-Wuk Kim Department of Life Science Hanyang UniversitySeoul 04763Republic of Korea Department of Life Science Chung-Ang UniversitySeoul 06973Republic of Korea Research Institute for Convergence of Basic Science Hanyang UniversitySeoul 04763Republic of Korea Hanyang Institute of Bioscience and Biotechnology Hanyang UniversitySeoul 04763Republic of Korea

Salicylic acid (SA) plays an important role in plant immune response, including resistance to pathogens and systemic acquired resistance. Two major components, NONEXPRESSOR OF PATHOGENESIS-RELATED GENES (NPRs) and TGACG motif-binding transcription factors (TGAs), are known to mediate SA signaling, which might also be orchestrated by other hormonal and environmental changes. Nevertheless, the molecular and functional interactions between SA signaling components and other cellular signaling pathways remain poorly understood. Here we showed that the steroid plant hormone brassinosteroid (BR) promotes SA responses by inactivating BR-INSENSITIVE 2 (BIN2), which inhibits the redox-sensitive clade I TGAs in Arabidopsis. We found that both BR and the BIN2 inhibitor bikinin synergistically increase SA-mediated physiological responses, such as resistance to Pst DC3000. Our genetic and biochemical analyses indicated that BIN2 functionally interacts with TGA1 and TGA4, but not with other TGAs. We further demonstrated that BIN2 phosphorylates Ser-202 of TGA4, resulting in the suppression of the redox-dependent interaction between TGA4 and NPR1 as well as destabilization of TGA4. Consistently, transgenic Arabidopsis overexpressing TGA4-YFP with a S202A mutation displayed enhanced SA responses compared to the wild-type TGA4-YFP plants. Taken together, these results suggest a novel crosstalk mechanism by which BR signaling coordinates the SA responses mediated by redox-sensitive clade I TGAs.

关键词： brassinosteroid salicylic acid immune responses BIN2 clade I TGA

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Influence of tool plunge depth and welding distance on friction stir lap welding of AA5454-O aluminum alloy plates with different thicknesses

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中国有色金属学会会刊：英文版 2012年第S3期22卷 624-628页

作者： Jun-Won kwon Myoung-Soo KANG Sung-Ook YOON Yong-Jai kwon Sung-tae HONG Dae-Il KIM Kwang-Hak LEE Jong-Dock SEO jin-Soo MOON Kyung-Sik HAN School of Materials Science and Engineering University of Ulsan School of Mechanical Engineering University of Ulsan Technical Research Laboratories Shin Young Co.Ltd. Automotive Parts Innovation Center Ulsan Technopark

AA5454-O aluminum alloy plates with thicknesses of 1.4 and 1.0 mm were friction-stir-lap-welded (FSLWed).The influences of the tool plunge depth and welding distance on surface appearance,macrostructure and mechanical properties of the FSLWed plates were experimentally *** tensile shear load of the FSLWed plates was compared with that of the adhesive-bonded ***-free FSLWed zones were successfully obtained in all the tool plunge depths and the welding *** FSLWed zones exhibited the relatively smooth surface *** all the FSLWed conditions,the FSLWed zone exhibited higher average hardness than the base *** addition,the upper plate exhibited a higher average hardness than the lower plate,although there was no special tendency in spite of the change in the tool plunge depth and the welding *** maximum tensile shear load of the FSLWed plates was much higher than that of the adhesive-bonded aluminum alloy ***,under the FSLW condition of the plunge depth of 1.8 mm and the welding distance of 40 mm,the tensile shear load of the FSLWed plate reached a level about 41% greater than that of the adhesive-bonded aluminum alloy *** addition,the maximum tensile shear load of the FSLWed plate was increased with the increase of the welding distance.

关键词： friction stir lap welding AA5450-O aluminum alloy tool plunge depth welding distance mechanical properties

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Protective effect of decursin and decursinol angelate-rich Angelica gigas Nakai extract on dextran sulfate sodium-induced murine ulcerative colitis

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Asian Pacific Journal of Tropical Medicine 2017年第9期10卷 864-870页

作者： Sa-Rang Oh Seon Ok tae-Sung Jung Sang-Ok Jeon ji-Min Park ji-wook Jung Deok-Seon Ryu Department of Wellbeing Products Co. LtdGimhaeGyeongnam 50969Republic of Korea Department of Herbal Medicinal Pharmacology College of Herbal Bio-industryDaeguHaany UniversityKyungsanRepublic of Korea Department of Biomedical Laboratory Science College of Medical SciencesSoonchunhyang UniversityAsanRepublic of Korea

Objective: To investigate the anti-inflammatory effects of decursin and decursinol angelate-rich Angelica gigas Nakai(AGNE) on dextran sulfate sodium(DSS)-induced murine ulcerative colitis(UC).Methods: The therapeutic effect of an AGNE was analyzed in a mouse model of UC induced by DSS. Disease activity index values were measured by clinical signs such as a weight loss, stool consistency, rectal bleeding and colon length. A histological analysis was performed using hematoxylin and eosin staining. Key inflammatory cytokines and mediators including IL-6, TNF-a, PGE2, COX-2 and HIF-1 a were assayed by enzymelinked immunosorbent assay or western ***: Treatment with the AGNE at 10, 20, and 40 mg/kg alleviated weight loss,decreased disease activity index scores, and reduced colon shortening in mice with DSSinduced UC. AGNE inhibited the production of IL-6 and TNF-a in serum and colon tissue. Moreover, AGNE suppressed the increased expression of COX-2 and HIF-1 a and the increased production of PGE2 in colon tissue were observed in mice with DSSinduced UC. Additionally, histological damage was also alleviated by AGNE ***: The findings of this study verified that AGNE significantly improves clinical symptoms and reduces the activity of various inflammatory mediators. These results indicate the AGNE has the therapeutic potential in mice with DSS-induced UC.

关键词： Angelica gigas Nakai Ulcerative colitis Dextran sulfate sodium Anti-inflammatory effects Cytokine

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The association of stromal antigen 3(STAG3) sequence variations with spermatogenic impairment in the male Korean population

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Asian Journal of Andrology 2020年第1期22卷 106-111页

作者： Yeojung Nam Kyung Min Kang Se Ra Sung ji Eun Park Yun-Jeong Shin Seung Hun Song Ju tae Seo tae Ki Yoon Sung Han Shim Department of Biomedical Science College of Life ScienceCHA UniversitySeongnam 13488Korea Genetics Laboratory Fertility Center of CHA Gangnam Medical CenterCHA UniversitySeoul 06135Korea Department of Urology CHA Gangnam Medical CenterCHA UniversitySeoul 06135Korea Department of Urology Cheil General HospitalSeoul 04619Korea Department of Obstetrics and Gynecology CHA Gangnam Medical CenterSeoul 04637Korea

The stromal antigen 3(STAG3)gene,encoding a meiosis-specific cohesin component,is a strong candidate for causing male infertility,but little is known about this gene so *** identified STAG3 in patients with nonobstructive azoospermia(NOA)and normozoospermia in the Korean *** coding regions and their intron boundaries of STAG3 were identified in 120 Korean men with spermatogenic impairments and 245 normal controls by using direct sequencing and haplotype analysis.A total of 30 sequence variations were identified in this *** the total,seven were exonic variants,18 were intronic variants,one was in the 5’-UTR,and four were in the 3'-*** variations that directly caused NOA were not ***,two variants,c.3669+35C>G(rs1727130)and+198A>T(rs1052482),showed significant differences in the frequency between the patient and control groups(P=0.021,odds ratio[OR]:1.79,95%confidence interval[Cl]:1.098-2.918)and were tightly linked in the linkage disequilibrium(LD)*** pmir-rs1052482A was cotransfected with miR-3162-5p,there was a substantial decrease in luciferase activity,compared with *** result suggests that rsl052482 was located within a binding site of miR-3162-5p in the STAG33'-UTR,and the minor allele,the rs1052482T polymorphism,might offset inhibition by *** are the first to identify a total of 30 single-nucleotide variations(SNVs)of STAG3 gene in the Korean *** found that two SNVs(rs1727130 and rsl052482)located in the 3'-UTR region may be associated with the NOA *** findings contribute to understanding male infertility with spermatogenic impairment.

关键词： linkage disequilibrium meiotic-specific gene single-nucleotide variations spermatogenic impairment stromal antigen 3 gene

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Photoluminescence of Nominally Undoped Heavy n-Type ZnO Nanowires

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Chinese Physics Letters 2011年第2期28卷 200-203页

作者： TANG Hai-Ping HE Hai-Ping LIU Chao kwon Bong-Jun YE Zhi-Zhen LEE Soonil PARK ji-Yong Division of Energy Systems Research Ajou UniversitySuwon443-749Korea Baoji University of Arts and Sciences Baoji 721007 State Key Laboratory of Silicon Materials Department of Materials Science and EngineeringZhejiang UniversityHangzhou 310027

We report the identification of a donor band and the correlation between n-type conductivity and the green emission in ZnO ***-dependent photoluminescence is used to investigate nominally undoped ZnO nanowires with high n-type *** the whole temperature range,a dominant free-to-bound transition with a donor band of about 150meV below the conduction band minimum is *** nanowires show very strong green emission,which is quenched with activation energy of about 220 *** correlation between the high n-type conductivity and the strong green emission is discussed in detail,and we suggest that they may have different origins.

关键词： nanowires conductivity conductivity

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Assimilating OSTIA SST into regional modeling systems for the Yellow Sea using ensemble methods

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Acta Oceanologica Sinica 2017年第3期36卷 37-51页

作者： ji Xuanliang kwon Kyung Man CHOI Byoung-Ju LIU Guimei PARK Kwang-Soon WANG Hui BYUN Do-Seong LI Yun ji Qiyan ZHU Xueming National Marine Environmental Forecasting Center State Oceanic AdminstrationBeijing 100081China Key Laboratory of Research on Marine Hazards Forecasting National Marine Environmental Forecasting CenterState Oceanic AdminstrationBeijing 100081China Department of Oceanography Kunsan National UniversityGunsan 54150Republic of Korea Department of Oceanography Chonnam National UniversityGwangju 61186Republic of Korea Korea Institute of Ocean Science and Technology Ansan 15627Republic of Korea Korea Hydrographic and Oceanographic Agency Busan 49111Republic of Korea Marine Acoustics and Remote Sensing Laboratory Zhejiang Ocean UniversityZhoushan 316000China

The effects of sea surface temperature（SST） data assimilation in two regional ocean modeling systems were examined for the Yellow Sea（YS）. The SST data from the Operational Sea Surface Temperature and Sea Ice Analysis（OSTIA） were assimilated. The National Marine Environmental Forecasting Center（NMEFC） modeling system uses the ensemble optimal interpolation method for ocean data assimilation and the Kunsan National University（KNU） modeling system uses the ensemble Kalman filter. Without data assimilation, the NMEFC modeling system was better in simulating the subsurface temperature while the KNU modeling system was better in simulating SST. The disparity between both modeling systems might be related to differences in calculating the surface heat flux, horizontal grid spacing, and atmospheric forcing data. The data assimilation reduced the root mean square error（RMSE） of the SST from 1.78°C（1.46°C） to 1.30°C（1.21°C） for the NMEFC（KNU） modeling system when the simulated temperature was compared to Optimum Interpolation Sea Surface Temperature（OISST） SST dataset. A comparison with the buoy SST data indicated a 41%（31%） decrease in the SST error for the NMEFC（KNU） modeling system by the data assimilation. In both data assimilative systems, the RMSE of the temperature was less than 1.5°C in the upper 20 m and approximately 3.1°C in the lower layer in October. In contrast, it was less than 1.0°C throughout the water column in February. This study suggests that assimilations of the observed temperature profiles are necessary in order to correct the lower layer temperature during the stratified season and an ocean modeling system with small grid spacing and optimal data assimilation method is preferable to ensure accurate predictions of the coastal ocean in the YS.

关键词： ensemble optimal interpolation ensemble Kalman filter SST Yellow Sea assimilation

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韩国高速列车防撞设计与评估

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中国铁道科学 2004年第1期25卷 1-7页

作者： Jeong-Seo Koo tae-Soo kwon Hyun-jik Cho KoreanRailroadResearshInstitute KoreanRailroadResearshInstituteKoreanRailroadResearshInstitute UiwangcityKyonggiDo437050KoreaUiwangcityKyonggiDo437050KoreaUiwangcityKyonggiDo437050Korea

针对韩国高速列车(KHST)的防撞性能进行深入地研究。选定行驶速度为110km·h-1的列车与一个15t重的刚性障碍物的撞击、两列行驶速度为30km·h-1的列车相撞作为严重撞击的事故场景,两列行驶速度为8km·h-1的列车相撞作为轻度撞击的事故... 详细信息

针对韩国高速列车(KHST)的防撞性能进行深入地研究。选定行驶速度为110km·h-1的列车与一个15t重的刚性障碍物的撞击、两列行驶速度为30km·h-1的列车相撞作为严重撞击的事故场景,两列行驶速度为8km·h-1的列车相撞作为轻度撞击的事故场景。用有限元方法对KHST的防撞性进行了数学评估。一维和二维的仿真分析表明该车整体上具有良好的耐撞性。同时,对动车的前端部分做了三维壳体单元的仿真分析。使用安全带的旅客伤亡试验的结果说明KHST的良好性能足以在设置的事故场景中保护旅客的安全。最后,用实比例的撞击试验对仿真方法进行了验证。

关键词：高速列车防撞性能有限元法铁路安全试验评估

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Decellularized sciatic nerve matrix as a biodegradable conduit for peripheral nerve regeneration

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Neural Regeneration Research 2018年第10期13卷 1796-1803页

作者： Jongbae Choi Jun Ho Kim ji Wook Jang Hyun Jung Kim Sung Hoon Choi Sung Won kwon R&D Center Genewel Co.Ltd. Department of Surgery CHA Bundang Medical CenterCHA University

The use of autologous nerve grafts remains the gold standard for treating nerve defects, but current nerve repair techniques are limited by donor tissue availability and morbidity associated with tissue loss. Recently, the use of conduits in nerve injury repair, made possible by tissue engineering, has shown therapeutic potential. We manufactured a biodegradable, collagen-based nerve conduit containing decellularized sciatic nerve matrix and compared this with a silicone conduit for peripheral nerve regeneration using a rat model. The collagen-based conduit contains nerve growth factor, brain-derived neurotrophic factor, and laminin, as demonstrated by enzyme-linked immunosorbent assay. Scanning electron microscopy images showed that the collagen-based conduit had an outer wall to prevent scar tissue infiltration and a porous inner structure to allow axonal growth. Rats that were implanted with the collagen-based conduit to bridge a sciatic nerve defect experienced significantly improved motor and sensory nerve functions and greatly enhanced nerve regeneration compared with rats in the sham control group and the silicone conduit group. Our results suggest that the biodegradable collagen-based nerve conduit is more effective for peripheral nerve regeneration than the silicone conduit.

关键词： nerve regeneration biodegradable decellularized collagen nerve conduit growth factor peripheral nerve injury regeneration silicone conduit rat model

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