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Nano-Micro Letters 2025年第2期17卷 169-186页

作者： Bitgaram Kim Myeong‑Chang sung Gwang‑Hee Lee Byoungjoon Hwang Sojung Seo ji‑Hun Seo Dong‑Wan Kim Department of Materials Science and Engineering Korea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea School of Civil Environmental and Architectural EngineeringKorea University145 Anam‑RoSeongbuk‑GuSeoul 02841Republic of Korea Materials Science and Chemical Engineering Center Institute for Advanced Engineering(IAE)Yongin 17180Republic of Korea

A critical challenge hindering the practical application of lithium–oxygen batteries(LOBs)is the inevitable problems associated with liquid electrolytes,such as evaporation and safety *** study addresses these problems by proposing a modified polyrotaxane(mPR)-based solid polymer electrolyte(SPE)design that simultaneously mitigates solvent-related problems and improves ***-SPE exhibits high ion conductivity(2.8×10^(−3)S cm^(−1)at 25℃)through aligned ion conduction pathways and provides electrode protection ability through hydrophobic chain *** this mPR-SPE into solid-state LOBs resulted in stable potentials over 300 *** situ Raman spectroscopy reveals the presence of an LiO_(2)intermediate alongside Li_(2)O_(2)during oxygen *** situ X-ray diffraction confirm the ability of the SPE to hinder the permeation of oxygen and moisture,as demonstrated by the air permeability *** present study suggests that maintaining a low residual solvent while achieving high ionic conductivity is crucial for restricting the sub-reactions of solid-state LOBs.

关键词： Solid polymer electrolyte Lithium-oxygen batteries Polyrotaxane ion conductivity Hydrophobic chain

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社区支持农业模式下绿色互动对消费者价值共创行为的影响

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中国流通经济 2025年第1期39卷 86-99页

作者：张蓓黄薏翰朱吉婵华南农业大学经济管理学院广东广州510642 广东省哲学社会科学重点实验室--乡村振兴实验室广东广州510642 广东省哲学社会科学重点实验室--农业农村政策与改革创新实验室广东广州510642

引导消费者参与价值共创有助于促进社区支持农业高质量发展,推动农业现代化转型升级。基于双系统理论,探讨两种不同形式的绿色互动对消费者价值共创行为的影响,以及数字信任与绿色信任的并行中介作用和社区氛围的调节效应。采用偏最小... 详细信息

引导消费者参与价值共创有助于促进社区支持农业高质量发展,推动农业现代化转型升级。基于双系统理论,探讨两种不同形式的绿色互动对消费者价值共创行为的影响,以及数字信任与绿色信任的并行中介作用和社区氛围的调节效应。采用偏最小二乘结构方程模型(PLS-SEM)对收集的472份有效调查数据进行分析。研究发现:绿色情感互动和绿色信息互动正向促进消费者价值共创行为,且前者的作用更显著,表明绿色情感互动通过触发消费者对社区支持农业绿色生产理念的价值共振,对消费者价值共创行为的正向作用更大;数字信任和绿色信任在其中起并行中介作用,即绿色情感互动与绿色信息互动通过数字信任和绿色信任两条并行的心理机制路径间接影响消费者价值共创行为。值得关注的是,社区氛围不仅削弱数字信任与消费者价值共创行为间的关系,还会弱化绿色情感互动与绿色信息互动通过数字信任和绿色信任影响消费者价值共创行为的间接效应,较强的社区氛围或许引发信息超载和虚假舆论等负面影响,导致绿色互动通过消费者信任对价值共创行为的间接影响减弱。鉴于此,为更好促进消费者价值共创行为,社区支持农业实践者应为消费者打造沉浸式交互场景,强化成员间绿色价值情感纽带;开发可视化溯源系统,筑牢消费者对社区支持农业的数字信任与绿色信任基础;畅通多元化交流渠道,营造理性自由社区氛围。研究结论从理论上厘清绿色互动如何促进消费者价值共创行为,从实践上为优化社区支持农业经营策略,推进农业农村现代化提供有益借鉴。

关键词：绿色互动信任价值共创行为社区氛围社区支持农业

FSD1 inhibits glioblastoma diffuse infiltration through restriction of HDAC6-mediated microtubule deacetylation

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Science China Life Sciences 2025年

作者： Dake Xiao Haowen Ran Lishu Chen Yuanyuan Li Yan Cai Songyang Zhang Qinghui Qi Huiran Wu Cheng Zhang Shuailiang Cao Lanjuan Mi Haohao Huang ji Qi Qiuying han Haiqing Tu Huiyan Li Tao Zhou Fangye Li Ailing Li jianghong Man Nanhu Laboratory National Center of Biomedical Analysis School of Traditional Chinese Medicine Capital Medical University Department of Neurosurgery General Hospital of Central Theater Command of Chinese PLA School of Life and Health Sciences Huzhou College Department of Neurosurgery Beijing Fengtai Hospital Department of Neurosurgery First Medical Center of PLA General Hospital

The infiltration of glioblastoma multiforme(GBM) is predominantly characterized by diffuse spread, contributing significantly to therapy resistance and recurrence of GBM. In this study, we reveal that microtubule deacetylation, mediated through the downregulation of fibronectin type III and SPRY domain-containing 1(FSD1), plays a pivotal role in promoting GBM diffuse infiltration. FSD1 directly interacts with histone deacetylase 6(HDAC6) at its second catalytic domain, thereby impeding its deacetylase activity on α-tubulin and preventing microtubule deacetylation and depolymerization. This inhibitory interaction is disrupted upon phosphorylation of FSD1 at its Ser317 and Ser324 residues by activated CDK5, leading to FSD1 dissociation from microtubules and facilitating HDAC6-mediated α-tubulin deacetylation. Furthermore, increased expression of FSD1 or interference with FSD1 phosphorylation reduces microtubule deacetylation, suppresses invasion of GBM stem cells, and ultimately mitigates tumor infiltration in orthotopic GBM xenografts. Importantly, GBM tissues exhibit diminished levels of FSD1 expression, correlating with microtubule deacetylation and unfavorable clinical outcomes in GBM patients. These findings elucidate the mechanistic involvement of microtubule deacetylation in driving GBM cell invasion and offer potential avenues for managing GBM infiltration.

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Effects of ethanol on the tonicity of corporal tissue and the intracellular Ca^2＋ concentration of human corporal smooth muscle cells

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Asian Journal of Andrology 2010年第6期12卷 890-898页

作者： sung Chul Kam Mee Ree Chae ji Young Kim Seol Ho Choo Deok Hyun han sung Won Lee Department of Urology Samsung Medical Center Sungkyunkwan University School of Medicine Seoul 135-710 Korea

Heavy alcohol consumption is associated with an increased risk of erectile dysfunction （ED）; however, the acute effects of ethanol （EtOH） on penile tissue are not fully understood. We sought to investigate the effects of EtOH on corporal tissue tonicity, as well as the intracellular Ca^2＋ concentration （[Ca^2＋]i） and potassium channel activity of corporal smooth muscle. Strips of corpus cavernosum （CC） from rabbits were mounted in organ baths for isometric tension studies. Electrical field stimulation （EFS） was applied to strips precontracted with 10 μmol L^-1 phenylephrine as a control. EtOH was then added to the organ bath and incubated before EFS. The [Ca^2＋]i levels were monitored by the ratio of fura-2 fluorescence intensities using the fura-2 loading method. Single-channel and whole-cell currents were recorded by the conventional patch-clamp technique in short-term cultured smooth muscle cells from human CC tissue. The corpus cavernosal relaxant response of EFS was decreased in proportion to the concentration of EtOH. EtOH induced a sustained increase in [Ca^2＋]i in a dose-dependent manner, Extracellular application of EtOH significantly increased whole-cell K^＋ currents in a concentration-dependent manner （P 〈 0.05）. EtOH also increased the open probability in cell-attached patches; however, in inside-out patches, the application of EtOH to the intracellular aspect of the patches induced slight inhibition of Ca^2＋-activated potassium channel （KCa） activity. EtOH caused a dose-dependent increase in cavemosal tension by alterations to [Ca^2＋]i. Although EtOH did not affect KCa channels directly, it increased the channel activity by increasing [Ca^2＋]i. The increased corpus cavemosal tone caused by EtOH might be one of the mechanisms of ED after heavy drinking.

关键词： alcohol Ca^2+-activated potassium channel corporal smooth muscle penile erection

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信息化视角下的电子档案四性检测研究与探索

办公自动化 2025年第1期30卷 75-77页

作者：郎吉韩洁中国航空工业集团公司第一飞机设计研究院西安710089

真实性、完整性、可用性、安全性是电子文件能成为档案的本质特征,也是电子档案具备法律效力的前提。文章分析电子档案四性检测的研究现状,梳理电子档案的归档、移交与接收、长期保存等三个环节的四性检测要求,并以电子档案四性检测功... 详细信息

真实性、完整性、可用性、安全性是电子文件能成为档案的本质特征,也是电子档案具备法律效力的前提。文章分析电子档案四性检测的研究现状,梳理电子档案的归档、移交与接收、长期保存等三个环节的四性检测要求,并以电子档案四性检测功能开发与应用实例为依据开展实践研究,以期为四性检测嵌入电子档案档案管理流程提供借鉴和参考。

关键词：电子档案四性检测应用

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TWO-STEP SCHEME FOR BACKWARD STOCHASTIC DIFFERENTIAL EQUATIONS

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Journal of Computational Mathematics 2023年第2期41卷 287-304页

作者： Qiang han Shaolin ji Zhongtai Securities Institute for Financial Studies Shandong UniversityJinan 250100China

In this paper,a stochastic linear two-step scheme has been presented to approximate backward stochastic differential equations(BSDEs).A necessary and sufficient condition is given to judge the L 2-stability of our numerical *** stochastic linear two-step method possesses a family of 3-order convergence schemes in the sense of strong *** coefficients in the numerical methods are inferred based on the constraints of strong stability and n-order accuracy(n∈N^(+)).Numerical experiments illustrate that the scheme is an efficient probabilistic numerical method.

关键词： Backward stochastic differential equation Stochastic linear two-step scheme Local truncation error Stability and convergence

Failure modes of lattice sandwich plate by additive-manufacturing and its imperfection sensitivity

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Acta Mechanica Sinica 2020年第2期36卷 430-447页

作者： Bin ji han han Renbang Lin Hao Li Shanghai Key Laboratory of Spacecraft Mechanism Shanghai 201109China Aerospace System Engineering Shanghai Shanghai 201109China

Additive-manufacturing process has substantially promoted the development of lattice structure and makes it possible to fabricate complex lattice sandwich ***-plane compression load always appears in engineering,such as in the primary structure of *** order to reveal potential engineering application in future,this paper focuses on the lattice sandwich plate that is fabricated by additive-manufacturing and subjected to in-plane ***,five failure modes are proposed for lattice sandwich plate under in-plane compression,including Euler buckling,shear buckling,face sheet dimpling,face sheet wrinkling and face sheet ***,an optimization method is proposed to obtain the optimum sizes,including the panel thickness,the length of rod,the size of rod cross-section,the inclined angle of rod and the wideness ratio of ***,the in-plane compression experiment is operated after measuring the geometrical imperfection of the specimen by the optical *** method is adopted to illustrate the effect on failure behaviors caused by the imperfections of struts,face sheets and global *** introducing these imperfection,numerical result can be well agreed with experimental result and explain the failure mechanisms mostly derived from the radius imperfection for the struts.

关键词： Additive-manufacturing Lattice structure In-plane compression Failure mode Imperfection sensitivity

Clinical significance of CT-defined minimal ascites in patients with gastric cancer

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World Journal of Gastroenterology 2005年第42期11卷 6587-6592页

作者： Dong Kyung Chang ji Won Kim Byung Kwan Kim Kook Lae Lee Chi sung Song Joon Koo han In sung Song Department of Internal Medicine Seoul National University College of Medicine Seoul National University Hospital and Seoul Municipal Boramae Hospital Seoul Korea Department of Radiology Seoul National University College of Medicine Seoul National University Hospital and Seoul Municipal Boramae Hospital Seoul Korea

AIM： To study the clinical significance of minimal ascites, which was only defined by the CT and whose nature was not determined preoperatively, in the relationship with the peritoneal carcinomatosis. METHODS： The medical records and the dynamic CT films of 118 patients with gastric cancer were reviewed. Factors associated with peritoneal carcinomatosis were analyzed in 40 patients who had CT-defined ascites of which the nature was surgically confirmed, RESULTS： Only 12.5-25% of the CT-defined minimal ascites, whose volume was estimated to be less than 50 mL, were associated with peritoneal carcinomatosis. When the estimated CT-defined ascitic volume was 50 mL or more, peritoneal carclnomatosis was identified in 75-100%. When CT-defined lymph node enlargements were not found beyond the regional gastric area, perigastric invasions were not suspected, and the size of tumor was less than 3 cm, peritoneal carcinomatosis seemed significantly less accompanied at the univariate analysis. However, except for the minimal volume of CT- defined ascites in comparison with the mild or more, other factors were not confirmed multivariately. CONCLUSION： In the patients with gastric cancer, CT- defined minimal ascites alone is rarely associated with peritoneal carcinomatosis, if it does not accompany other signs suggestive of malignant seeding. Therefore, consideration of active curative resection should not be hesitated, if CT-defined minimal ascites is the only delusive sign.

关键词： Ascites Peritoneal carcinomatosis Gastriccancer

Geometry and Hardy spaces on spaces of homogeneous type in the sense of Coifman and Weiss

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Science China Mathematics 2017年第11期60卷 2199-2218页

作者： han YanChang han YongSheng LI ji School of Mathematical Sciences South China Normal University Department of Mathematics Auburn University Department of Mathematics Macquarie University

It is known that the space of homogeneous type introduced by Coifman and Weiss(1971) provides a very natural setting for establishing a theory of Hardy spaces. This paper concentrates on how the geometrical conditions of the space of homogeneous type play a crucial role in building a theory of Hardy spaces via the Littlewood-Paley functions.

关键词： spaces of homogeneous type Hardy space singular integrals Carleson measure space BMO

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COVID-19 Detection via a 6-Layer Deep Convolutional Neural Network

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Computer Modeling in Engineering & Sciences 2022年第2期130卷 855-869页

作者： Shouming Hou ji han School of Computer Science and Technology Henan Polytechnic UniversityJiaozuo454000China

Many people around the world have lost their lives due to *** symptoms of most COVID-19 patients are fever,tiredness and dry cough,and the disease can easily spread to those around *** the infected people can be detected early,this will help local authorities control the speed of the virus,and the infected can also be treated in *** proposed a six-layer convolutional neural network combined with max pooling,batch normalization and Adam algorithm to improve the detection effect of COVID-19 *** the 10-fold cross-validation methods,our method is superior to several state-of-the-art *** addition,we use Grad-CAM technology to realize heat map visualization to observe the process of model training and detection.

关键词： COVID-19 deep learning convolutional neural network max pooling batch normalization Adam Grad-CAM