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Correlation and Pathway Analysis of the Carbon,Nitrogen,and Phosphorus in Soil-Microorganism-Plant with Main Quality Components of Tea(Camellia sinensis)

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Phyton-International Journal of Experimental Botany 2024年第3期93卷 487-502页

作者： Chun Mao ji He Xuefeng wen Yangzhou Xiang jihong Feng Yingge Shu College of Agriculture Guizhou UniversityGuiyangChina School of Geography and Resources Guizhou Education UniversityGuiyangChina

The contents of carbon(C),nitrogen(N),and phosphorus(P)in soil-microorganisms-plant signiﬁcantly affect tea quality by altering the main quality components of tea,such as tea polyphenols,amino acids,and ***,few studies have quantiﬁed the effects of these factors on the main quality components of *** study aimed to explore the interactions of C,N,and P in soil-microorganisms-plants and the effects of these factors on the main quality components of tea by using the path analysis *** results indicated that(1)The contents of C,N,and P in soil,microorganisms,and tea plants were highly correlated and collinear,and showed signiﬁcant correlations with the main quality components of tea.(2)Optimal regression equations were established to esti-mate tea polyphenol,amino acid,catechin,caffeine,and water extract content based on C,N,and P contents in soil,microorganisms,and tea plants(R^(2)=0.923,0.726,0.954,0.848,and 0.883,respectively).(3)Pathway analysis showed that microbial biomass phosphorus(MBP),root phosphorus,branch nitrogen,and microbial biomass carbon(MBC)were the largest direct impact factors on tea polyphenol,catechin,water extracts,amino acid,and caffeine content,*** carbon,root phosphorus,and leaf nitrogen were the largest indirect impact factors on tea polyphenol,catechin,and water extract content,*** carbon indirectly affected tea polyphenol content mainly by altering MBP *** phosphorus indirectly affected catechin content mainly by altering soil organic carbon *** nitrogen indirectly affected water extract content mainly by altering branch nitrogen *** research results provide the scientiﬁc basis for reasonable fertilization in tea gardens and tea quality improvement.

关键词： Soil-microorganisms-plant system carbon nitrogen phosphorus tea quality path analysis

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Bayesian network-based survival prediction model for patients having undergone post-transjugular intrahepatic portosystemic shunt for portal hypertension

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World Journal of Gastroenterology 2024年第13期30卷 1859-1870页

作者： rong Chen Ling Luo Yun-Zhi Zhang Zhen Liu An-Lin Liu Yi-wen Zhang Department of Infectious Diseases Second Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Portal hypertension(PHT),primarily induced by cirrhosis,manifests severe symptoms impacting patient *** transjugular intrahepatic portosystemic shunt(TIPS)is a critical intervention for managing PHT,it carries risks like hepatic encephalopathy,thus affecting patient survival *** our knowledge,existing prognostic models for post-TIPS survival in patients with PHT fail to account for the interplay among and collective impact of various prognostic factors on ***,the development of an innovative modeling approach is essential to address this *** To develop and validate a Bayesian network(BN)-based survival prediction model for patients with cirrhosis-induced PHT having undergone *** The clinical data of 393 patients with cirrhosis-induced PHT who underwent TIPS surgery at the Second Affiliated Hospital of Chongqing Medical University between January 2015 and May 2022 were retrospectively *** were selected using Cox and least absolute shrinkage and selection operator regression methods,and a BN-based model was established and evaluated to predict survival in patients having undergone TIPS surgery for *** Variable selection revealed the following as key factors impacting survival:age,ascites,hypertension,indications for TIPS,postoperative portal vein pressure(post-PVP),aspartate aminotransferase,alkaline phosphatase,total bilirubin,prealbumin,the Child-Pugh grade,and the model for end-stage liver disease(MELD)*** on the above-mentioned variables,a BN-based 2-year survival prognostic prediction model was constructed,which identified the following factors to be directly linked to the survival time:age,ascites,indications for TIPS,concurrent hypertension,post-PVP,the Child-Pugh grade,and the MELD *** Bayesian information criterion was 3589.04,and 10-fold cross-validation indicated an average log-likelihood loss of 5.55 with a standard deviation of *** model’s acc

关键词： Bayesian network Cirrhosis Portal hypertension Transjugular intrahepatic portosystemic shunt Survival prediction model

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Floquet-Engineering Topological Phase Transition in Graphene Nanoribbons by Light

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Chinese Physics Letters 2024年第9期41卷 69-87页

作者： Anhua Huang Shasha Ke ji-Huan Guan Jun Li wen-Kai Lou SKLSM Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China College of Materials Science and Opto-electronic Technology Center of Materials Science and Optoelectronics EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China Department of Physics School of Physical Science and TechnologyXiamen UniversityXiamen 361005China

Quasi-one-dimensional(1D)graphene nanoribbons(GNRs)play a crucial role in advancement of nextgeneration *** studies have suggested their potential to exhibit unique symmetry-protected topological phases defined by a𝑍2 *** employing both the tight-binding model and the Floquet theory,our investigation demonstrates the effective control of the topological phase within quasi-1D armchair GNRs(AGNRs)using elliptically polarized light,unveiling rich topological phase ***,we observe that varying the amplitude of the light can induce transitions in the band gap(𝐸g)of AGNRs,leading to multiple changes in the system’s𝑍2 ***,for heterojunctions composed of different AGNR segments,the junction state can be either created or eliminated by the application of elliptically polarized light.

关键词： topological polarized Transition

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Comprehensive analysis of the gut microbiome and posttranslational modifications elucidates the route involved in microbiota-host interactions

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Zoological Research 2024年第1期45卷 95-107页

作者： Hai-Yang Wang Lan-Xiang Liu Xue-Yi Chen Yang-Dong Zhang wen-Xia Li wen-wen Li Lian Wang Xiao-Long Mo Hong Wei Ping ji Peng Xie NHC Key Laboratory of Diagnosis and Treatment on Brain Functional Diseases First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China College of Stomatology and Affiliated Stomatological Hospital of Chongqing Medical University Chongqing 401147China Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences Chongqing 401147China Department of Neurology Yongchuan Hospital of Chongqing Medical UniversityChongqing 402160China Department of Pathology Faculty of Basic MedicineChongqing Medical UniversityChongqing 400016China Department of Neurology First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Yu-Yue Pathology Scientific Research Center Chongqing 401329China

The gut microbiome interacts with the host to maintain body homeostasis,with gut microbial dysbiosis implicated in many ***,the underlying mechanisms of gut microbe regulation of host behavior and brain functions remain *** study aimed to elucidate the influence of gut microbiota on brain functions via post-translational modification mechanisms in the presence or absence of bacteria without any *** conducted succinylome analysis of hippocampal proteins in germ-free(GF)and specific pathogen-free(SPF)mice and metagenomic analysis of feces from SPF *** results were integrated with previously reported hippocampal acetylome and phosphorylome data from the same batch of *** bioinformatics analyses revealed 584 succinylation sites on 455 proteins,including 54 up-regulated succinylation sites on 91 proteins and 99 down-regulated sites on 51 proteins in the GF mice compared to the SPF *** constructed a panoramic map of gut microbiota-regulated succinylation,acetylation,and phosphorylation,and identified cross-talk and relative independence between the different types of post-translational modifications in modulating complicated intracellular *** correlation analysis indicated that 13 taxa,predominantly belonging to the Bacteroidetes phylum,were correlated with the biological functions of post-translational *** correlations between these taxa and succinylation and negative correlations between these taxa and acetylation were identified in the modulation of intracellular *** study highlights the hippocampal physiological changes induced by the absence of gut microbiota,and proteomic quantification of succinylation,phosphorylation,and acetylation,contributing to our understanding of the role of the gut microbiome in brain function and behavioral phenotypes.

关键词： Gut microbiota Hippocampal protein Post-translational modifications Succinylation Acetylation Phosphorylation

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Research Advance of Chinese Medicine in Treating Atherosclerosis:Focus on Lipoprotein-Associated Phospholipase A2

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Chinese Journal of Integrative Medicine 2024年第3期30卷 277-288页

作者： WANG Lu-ming ZHANG wen-lan LYU Nuan SUO Yan-rong YANG Lin YU Bin jiANG Xi-juan School of Integrative Medicine Tianjin University of Traditional Chinese MedicineTianjin301617China Department of Traditional Chinese Medicine Ganzhou People’s HospitalGanzhouJiangxi Province341000China School of Medical Technology Tianjin University of Traditional Chinese MedicineTianjin301617China

As a serious cardiovascular disease,atherosclerosis(AS)causes chronic inflammation and oxidative stress in the body and poses a threat to human ***-associated phospholipase A2(Lp-PLA2)is a member of the phospholipase A2(PLA2)family,and its elevated levels have been shown to contribute to ***-PLA2 is closely related to a variety of lipoproteins,and its role in promoting inflammatory responses and oxidative stress in AS is mainly achieved by hydrolyzing oxidized phosphatidylcholine(ox PC)to produce lysophosphatidylcholine(lyso PC).Moreover,macrophage apoptosis within plaque is promoted by localized Lp-PLA2 which also promotes plaque *** paper reviews those researches of Chinese medicine in treating AS via reducing Lp-PLA2 levels to guide future experimental studies and clinical applications related to AS.

关键词： lipoprotein-associated phospholipase A2 atherosclerosis inflammation oxidative stress apoptosis Chinese medicine

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Early monitoring values of oncogenic signalling molecules for hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2350-2361页

作者： Min Yao rong-Fei Fang Qun Xie Min Xu wen-Li Sai Deng-Fu Yao Department of Immunology Medical School of Nantong University and Research Center of Clinical MedicineThe Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Gastroenterology The Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina Department of Infectious Diseases Haian People’s HospitalHaian 226600Jiangsu ProvinceChina Research Center of Clinical Medicine The Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina

The prevention and early diagnosis of liver cancer remains a global medical *** the malignant transformation of hepatocytes,a variety of oncogenic cellular signalling molecules,such as novel high mobility group-Box 3,angiopoietin-2,Golgi protein 73,glypican-3,Wnt3a(a signalling molecule in the Wnt/β-catenin pathway),and secretory clusterin,can be expressed and secreted into the *** signalling molecules are derived from different signalling pathways and may not only participate in the malignant transformation of hepatocytes but also become early diagnostic indicators of hepatocarcinogenesis or specific targeted molecules for hepatocellular carcinoma *** article reviews recent progress in the study of several signalling molecules as sensitive biomarkers for monitoring hepatocarcinogenesis.

关键词： Hepatocarcinogenesis Cell signals Specific biomarkers Early diagnosis

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Asymmetric radical allylation of β-keto esters with vinyl cyclopropanes by dual photoredox/nickel catalysis

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Science China Chemistry 2024年

作者： wen-Yuan Qu Xue-Song Zhou wen-jing Xiao jia-rong Chen Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction Ministry of EducationCollege of Chemistry Central China Normal University Wuhan Institute of Photochemistry and Technology Key Laboratory of Organo-Pharmaceutical Chemistry of jiangxi Province Gannan Normal University

Radical-involved allylation reactions have emerged as a powerful platform for construction of carbon-carbon and carbonheteroatom bonds, facilitating the strategic incorporation of diverse allyl moieties. Nevertheless, this burgeoning field still faces ongoing challenges, including limitations of radical precursors and coupling partners, and difficulties in achieving enantiocontrol. Herein, we report for the first time a highly enantioselective radical allylation involving β-keto esters with vinyl cyclopropanes utilizing a synergistic dual photoredox/nickel catalysis under visible light irradiation. The mild and redox-neutral catalytic protocol demonstrates an extensive substrate compatibility and good functional tolerance, providing access to enantioenriched β-keto esters featuring quaternary α-stereocenter with good yields and high enantioselectivities. Preliminary mechanistic studies have uncovered that the success of the reaction hinges on the dual roles of nickel catalyst, including in situ formation of photoredox sensitive substrate/Ni complex and the ensuing asymmetric radical addition step.

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Predictive visual field outcomes after optic chiasm decompressive surgery by retinal vessels parameters using optical coherence tomography angiography

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 365-373页

作者： wen-Juan Yu jin Xiao Guang-Xin Wang Chang jiang Wei Zha rong-Feng Liao Department of Ophthalmology the First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Neurosurgery the First Affiliated Hospital of Anhui Medical UniversityHefei 230022Anhui ProvinceChina Department of Ophthalmology the First People’s Hospital of HefeiHefei 230061Anhui ProvinceChina

AIM:To evaluate the predictive value of superficial retinal capillary plexus(SRCP)and radial peripapillary capillary(RPC)for visual field recovery after optic cross decompression and compare them with peripapillary nerve fiber layer(pRNFL)and ganglion cell complex(GCC).METHODS:This prospective longitudinal observational study included patients with chiasmal compression due to sellar region mass scheduled for decompressive *** estimating equations were used to compare retinal vessel density and retinal layer thickness preand post-operatively and with healthy *** regression models were used to assess the relationship between preoperative GCC,pRNFL,SRCP,and RPC parameters and visual field recovery after ***:The study included 43 eyes of 24 patients and 48 eyes of 24 healthy *** RPC and SRCP vessel density and pRNFL and GCC thickness were lower than healthy controls and higher than postoperative *** best predictive GCC and pRNFL models were based on the superior GCC[area under the curve(AUC)=0.866]and the tempo-inferior pRNFL(AUC=0.824),and the best predictive SRCP and RPC models were based on the nasal SRCP(AUC=0.718)and tempo-inferior RPC(AUC=0.825).There was no statistical difference in the predictive value of the superior GCC,tempo-inferior pRNFL,and tempo-inferior RPC(all P>0.05).CONCLUSION:Compression of the optic chiasm by tumors in the saddle area can reduce retinal thickness and blood *** reduction persists despite the recovery of the visual field after decompression ***,pRNFL,and RPC can be used as sensitive predictors of visual field recovery after decompression surgery.

关键词： sellar region mass retinal vessels optic chiasm optical coherence tomography angiography visual field decompressive surgery

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Ultra-high-temperature application of MXene: Stabilization of 2D Ti_(3)C_(2)T_(x) for cross-scale strengthening and toughening of 3D TiC

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Journal of Advanced Ceramics 2024年第1期13卷 1-10页

作者： Lu Liu Guobing Ying Quanguo jiang Dong wen Peng Wang Meng Wu Ziying ji Yongting Zheng Xiang Wang Department of Materials Science and Engineering College of Mechanics and MaterialsHohai UniversityNanjing 211100China Key Laboratory of Superlight Materials&Surface Technology Ministry of EducationHarbin Engineering UniversityHarbin 150001China Shenzhen Key Laboratory for Advanced Materials School of Materials Science and EngineeringHarbin Institute of Technology(Shenzhen)Shenzhen 518055China Center for Composite Materials and Structures Harbin Institute of TechnologyHarbin 150001China

Transition metal carbide/nitride cores within MXenes make them considerably useful for ultra-high-temperature ***,extensive research on Ti_(3)C_(2)T_(x) MXene has revealed its tendency to undergo a phase transition to TiCy at temperatures above 800℃due to high activity of a superficial Ti atomic ***,spark plasma sintering of Ti_(3)C_(2)T_(x) and TiC is performed to prevent the Ti_(3)C_(2)T_(x) phase transition at temperatures up to 1900℃through the fabrication of composites at a pressure of 50 *** a focused ion beam scanning electron microscope to separate layered substances in the composites and examining selected area diffraction spots in a transmission electron microscope enabled identification of non-phase-transitioned ***-principles calculations based on density functional theory indicated the formation of strong chemical bonding interfaces between Ti_(3)C_(2)T_(x) and TiC,which imposed a stability constraint on the Ti atomic layer at the Ti_(3)C_(2)T_(x) *** performance tests,such as three-point bending and fracture toughness analysis,demonstrated that the addition of Ti_(3)C_(2)T_(x) can effectively improve the cross-scale strengthening and toughening of the TiC matrix,providing a new path for designing and developing two-dimensional(2D)carbides cross-scale-enhanced three-dimensional(3D)carbides with the same elements relying on a wide variety of MXenes.

关键词： MXene ultra-high-temperature phase stability interface bonding cross-scale strengthening and toughening structural ceramic composites

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Diabetes and susceptibility to COVID-19:Risk factors and preventive and therapeutic strategies

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World Journal of Diabetes 2024年第8期15卷 1663-1671页

作者： jing-wen Liu Xiao Huang Ming-Ke Wang ji-Shun Yang School of Pharmacy Bengbu Medical UniversityBengbu 233000Anhui ProvinceChina Naval Medical Center Naval Medical UniversityShanghai 200052China

Coronavirus disease 2019(COVID-19)is a highly infectious disease caused by a novel human coronavirus called severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Diabetes is a well-known risk factor for infectious diseases with high prevalence and increased ***,we elucidated the possible factors for the increased vulnerability of diabetic patients to SARS-CoV-2 infection and the more severe COVID-19 *** worsened prognosis of patients with both COVID-19 and diabetes may be attributable to host receptor angiotensinconverting enzyme 2-assisted viral ***,insulin resistance is often associated with impaired mucosal and skin barrier integrity,resulting in microbiota dysbiosis,which increases susceptibility to viral *** may also be associated with higher levels of pro-inflammatory cytokines resulting from an impaired immune system in diabetics,inducing a cytokine storm and excessive *** review describes diabetes mellitus and its complications,explains the risk factors,such as disease characteristics and patient lifestyle,which may contribute to the high susceptibility of diabetic patients to COVID-19,and discusses preventive and therapeutic strategies for COVID-19-positive diabetic patients.

关键词： Diabetes mellitus SARS-CoV-2 COVID-19 Susceptibility Prevention Treatment

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