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Dietary inflammatory index and its impact on severity and recurrence of Tourette syndrome in children

World Journal of Psychiatry 2024年第8期14卷 1208-1215页

作者： Xiao-ping Wu Rong-Rong Fang Ting-Ting ji Department of Pediatrics Qingdao Chengyang People’s HospitalQingdao 266109Shandong ProvinceChina

BACKGROUND Tourette syndrome(TS)is a neurodevelopmental disorder characterized by the presence of motor and vocal tics,typically beginning in *** signifi-cant research efforts,the exact pathophysiology of TS remains incompletely *** studies suggest that inflammation may play a role in the severity and progression of TS,pointing to the potential influence of dietary and lifestyle factors on the ***,research on the specific connection between dietary inflammatory index(DII)and TS is still in its early stages,requir-ing additional clinical and epidemiological studies to validate the strength and specific mechanisms of this *** A total of 207 children diagnosed with TS in the pediatric department of Qingdao Chengyang People’s Hospital from January 2022 to January 2023 were *** were divided into stable and unstable groups based on follow-up *** enrollment,general information of the children[age,gender,body mass index(BMI),guardian’s education level,DII score,medical history,family history,academic stress,electronic device usage,medication,and disease progression]was assessed,and serum inflammatory levels were measured during follow-up *** scores and Yale Global Tic Severity Scale(YGTSS)scores were ***,based on YGTSS scores,the children were classified into mild,moderate,and severe *** DII,interleukin-6(IL-6),C-reactive protein(CRP),and tumor necrosis factor-alpha(TNF-α)levels in each group were *** Follow-up surveys were completed by 207 children and their *** them,117 children were in the stable group,and 90 were in the recurrent *** found no statistically significant differences in age,gender,comorbidities,BMI,and disease duration between the two groups(P>0.05).However,academic stress,electronic device usage,medication,guardian’s education level,and DII scores showed statistically significant differences between the groups(P

关键词： Dietary inflammation index Tourette's syndrome Correlation analysis Pro-inflammatory foods Inflammation levels Impact on severity and recurrence

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An improved installation of 2-hydroxy-4-methoxybenzyl(iHmb)method for chemical protein synthesis

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Chinese Chemical Letters 2024年第5期35卷 145-150页

作者： Ying Li Long-jie Wang Yong-Kang Zhou Jun Liang Bin Xiao ji-shen Zheng The First Affiliated Hospital of USTC MOE Key Laboratory for Membraneless Organelles and Cellular DynamicsDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001China Department of Chemistry University of Science and Technology of ChinaHefei 230027China

The 2-hydroxy-4-methoxybenzyl(Hmb)backbone modification can prevent amide bond-mediated sidereactions(e.g.,aspartimide formation,peptide aggregation)by installing the removable Hmb group into a peptide bond,thus improving the synthesis of long and challenging peptides and ***,its use is largely precluded by the limited Hmb’s installation *** this report,an improved installation of Hmb(iHmb)method was developed to achieve the flexible installation and the convenient removal of *** iHmb method involves two critical steps:(1)oxidative diazotization of the readily installed 2-hydroxy-4-methoxy-5-amino-benzyl(Hmab)to give 2-hydroxy-4-methoxy-5-diazonium-benzyl(Hmdab)by combining soamyl nitrite(IAN)/HBF_(4),and(2)reductive elimination of Hmdab to give the desired Hmb by 1,2-ethanedithiol(EDT).The iHmb method enables the installation of Hmb at any primary amino acid including the highly sterically hindered amino acids(e.g.,valine and isoleucine).The practicality and utility of the iHmb method was demonstrated by one-shot solid-phase synthesis of a challenging aspartimide-prone peptide,the mirror-image version of a hydrophobic peptide and a long-chain peptide up to ***,the iHmb method can be utilized to facilitate chemical protein ligation,as exemplified by the synthesis of the single-spanning membrane protein *** iHmb method expands the toolkit for peptide synthesis and ligation and facilitates the preparation of peptides/proteins.

关键词： Chemical protein synthesis Solid-phase peptide synthesis Removable backbone modification 2-Hydroxy-4-methoxybenzyl(Hmb)group Aspartimide-prone peptides Difficult peptides Membrane proteins

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An Aerial–Wall Robotic Insect That Can Land, Climb, and Take Off from Vertical Surfaces

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Research 2024年第1期2023卷 149-163页

作者： Qian Li Haoze Li Huan shen Yangguang Yu Haoran He Xincheng Feng Yi Sun Zhiyuan Mao Guangming Chen Zongjun Tian Lida shen Xiangming Zheng Aihong ji College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and AstronauticsNanjingChina College of Aerospace Engineering Nanjing University of Aeronautics and AstronauticsNanjingChina State Key Laboratory of Mechanics and Control for Aerospace Structures Nanjing University of Aeronautics and AstronauticsNanjingChina

Insects that can perform flapping-wing flight,climb on a wall,and switch smoothly between the 2 locomotion regimes provide us with excellent biomimetic ***,very few biomimetic robots can perform complex locomotion tasks that combine the 2 abilities of climbing and ***,we describe an aerial–wall amphibious robot that is self-contained for flying and climbing,and that can seamlessly move between the air and *** adopts a flapping/rotor hybrid power layout,which realizes not only efficient and controllable flight in the air but also attachment to,and climbing on,the vertical wall through a synergistic combination of the aerodynamic negative pressure adsorption of the rotor power and a climbing mechanism with bionic adhesion *** the basis of the attachment mechanism of insect foot pads,the prepared biomimetic adhesive materials of the robot can be applied to various types of wall surfaces to achieve stable *** longitudinal axis layout design of the rotor dynamics and control strategy realize a unique cross-domain movement during the flying–climbing transition,which has important implications in understanding the takeoff and landing of ***,it enables the robot to cross the air–wall boundary in 0.4 s(landing),and cross the wall–air boundary in 0.7 s(taking off).The aerial–wall amphibious robot expands the working space of traditional flying and climbing robots,which can pave the way for future robots that can perform autonomous visual monitoring,human search and rescue,and tracking tasks in complex air–wall environments.

关键词： robot smoothly Vertical

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Failure mechanism and simulation for long run-out of the catastrophic rock landslide in the Shanyang Vanadium Mine,China

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Journal of Mountain Science 2024年第9期21卷 2905-2917页

作者： LIU Yinpeng Mumtaz HAIDER David-darnor LAWRENCE LI Tonglu shen Wei LI ping College of Geological Engineering and Geomatics Chang’an UniversityXi’an 710054China Observation and Research Station of Water Cycle and Geological Environment for the Chinese Loess Plateau Ministry of EducationZhengning 745399China

On 12th August 2015,a massive rapid long run-out rock landslide occurred in the Shanyang Vanadium Mine in Shaanxi Province,China,which claimed the lives of 65 *** heavy rainfalls,earthquakes,and mining blasts were recorded before the ***,the failure mechanism and the cause of the long run-out movement are always in *** this paper,we conducted a detailed field investigation,laboratory tests,block theory analysis,and numerical simulation to investigate the failure and long run-out mechanisms of the *** field investigation results show that the source material of the rock landslide is a huge dolomite wedge block bedding on siliceous shale *** compression tests indicate that the uniaxial compression strength of the intact dolomite is 130-140MPa and the dolomite shows a brittle failure *** to the progressive downward erosion of the gully,the dolomite rock bridge at the slope toe became *** the compression stress in the dolomite bridge increased to surpass its strength,the brittle failure of the bridge *** huge potential energy was released following the disintegration of the landslide,which led to the high acceleration of this rock *** 3D discrete element simulation results suggest that the low intergranular friction contributes to the long run-out movement of this rock landslide.

关键词： Rock landslide Gully erosion Long run-out Wedge block Discrete element method

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Detachment Behavior of Gecko Toe in Functional Strategies for Bionic Toe

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Journal of Bionic Engineering 2024年第2期21卷 707-717页

作者： Qingfei Han Wei Wang Huan shen Xincheng Feng Haoran Zhang Qian Li Yi Sun Huapeng Wu Aihong ji Lab of Locomotion Bioinspiration and Intelligent Robots College of Mechanical and Electrical EngineeringNanjing University of Aeronautics and AstronauticsNanjing210016China Laboratory of Intelligent Machines School of Energy SystemsLappeenranta-Lahti University of Technology53850LappeenrantaFinland State Key Laboratory of Mechanics and Control for Aerospace Structures Nanjing University of Aeronautics and AstronauticsNanjing210016China

Geckos can efficiently navigate complex terrains due to their multi-level adhesive system that is present on their *** setae are responsible for the gecko’s extraordinary adhesion and have garnered wide attention from the scientific *** majority of the reported works in the literature that have dealt with the peeling models mainly focus on the gecko hierarchical adhesive system,with limited attention given to investigating the influence of gecko toe structure on the *** these lines,to gain a deeper understanding of the rapid and effortless detachment abilities of gecko toes,the peeling behavior of gecko toes on vertical surfaces was primarily investigated in this *** specifically,the detachment time of a single toe on a smooth acrylic plate was measured to be 0.41±0.21 ***,it was observed that the toe assumed a"U"-shaped structure upon complete ***,Finite Element Analysis(FEA)models for three different types of gecko toes were developed to simulate both the displacement-peel and the moment-peel *** the segmentation of the adhesive layer led to a gradual decrease in the resultant force,as well as the normal and tangential ***,a gecko-inspired toe model was constructed and powered by Shape Memory Alloy(SMA).A systematic comparison between the vertical drag separation and the outward flip separation was also *** our analysis,it was clearly demonstrated that outward peel separation significantly necessitated the reduction of the peeling force,thus confirming the advantageous nature of the outward motion in gecko toe *** data not only contribute to a deeper understanding of the gecko detachment behavior but also offer valuable insights for the advancement of the wall-climbing robot feet.

关键词： Gecko toes Detachment behavior Finite element analysis Gecko-inspired toe

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Correlation Study on Grain Size Characteristics and Geotechnical Properties of Surface Sediments in Qingdao Offshore Area

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Journal of Ocean University of China 2024年第3期23卷 721-730页

作者： LI Anlong WANG Panpan GUO Xijun ji Xiangkun shen Kunming LIN Lin YAN Zhichao YUAN Lin Key Laboratory of Submarine Geosciences and Prospecting Techniques Ministry of Education and College of Marine GeosciencesOcean University of ChinaQingdao 266100China College of Marine Geoscience Ocean University of ChinaQingdao 266100China China Construction Second Engineering Bureau Co. LTDYueyang 414000China Tianjin Research Institute for Water Transport Engineering M.O.T.Tianjin 3000456China Lianyungang Xuwei Port Holding Group Co. Ltd.Lianyungang 222042China

The comprehension of sediment grain size parameters and the corresponding sedimentary environment holds paramount importance in elucidating the engineering geological attributes of the subaqueous *** study delineated the sedimentary environment zoning in the northern sea area of Qingdao through cluster analysis of grain size parameters derived from 123 surface sediment *** study analyzed the correlation between sediment geotechnical indices and grain size parameters across diverse sedimentary environments.A correlation equation was established for samples exhibiting a strong *** study found four distinct sedimentary environments in the study area:coastal,transitional,shallow sea,and *** the same sedimentary environment,the average grain size and sorting coefficient exhibit significant correlations with geotechnical indices such as water content,density,shear strength,plastic limit,liquid limit,and plastic ***,notable disparities in the correlation between grain size parameters and geotechnical indices emerge across different sedimentary environments.

关键词： grain size parameters cluster analysis sedimentary environment correlations geotechnical indexes

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Federated Dynamic Client Selection for Fairness Guarantee in Heterogeneous Edge Computing

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Journal of Computer Science & Technology 2024年第1期39卷 139-158页

作者：毛莺池沈莉娟吴俊平萍吴杰 Key Laboratory of Water Big Data Technology of Ministry of Water Resources Hohai UniversityNanjing 211100China College of Computer and Information Hohai UniversityNanjing 211100China Center of Networked Computing Temple UniversityPhiladelphiaPA 19122-6096U.S.A

Federated learning has emerged as a distributed learning paradigm by training at each client and aggregat-ing at a parameter *** heterogeneity hinders stragglers from responding to the server in time with huge com-munication *** client grouping in federated learning can solve the straggler problem,the stochastic selection strategy in client grouping neglects the impact of data distribution within each ***,current client grouping ap-proaches make clients suffer unfair participation,leading to biased performances for different *** order to guaran-tee the fairness of client participation and mitigate biased local performances,we propose a federated dynamic client selec-tion method based on data representativity(FedSDR).FedSDR clusters clients into groups correlated with their own lo-cal computational *** estimate the significance of client datasets,we design a novel data representativity evalua-tion scheme based on local data ***,the two most representative clients in each group are selected to optimize the global ***,the DYNAMIC-SELECT algorithm updates local computational efficiency and data representativity states to regroup clients after periodic average *** on real datasets show that FedS-DR improves client participation by 27.4%,37.9%,and 23.3%compared with FedAvg,TiFL,and FedSS,respectively,tak-ing fairness into account in federated *** addition,FedSDR surpasses FedAvg,FedGS,and FedMS by 21.32%,20.4%,and 6.90%,respectively,in local test accuracy variance,balancing the performance bias of the global model across clients.

关键词： federated learning fairness computational efficiency data distribution client selection client grouping

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Refining the Factors Affecting N_(2)O Emissions from Upland Soils with and without Nitrogen Fertilizer Application at a Global Scale

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Advances in Atmospheric Sciences 2024年第9期41卷 1804-1820页

作者： Wenqian jiANG Siqi LI Yong LI Meihui WANG Bo WANG ji LIU jianlin shen Xunhua ZHENG State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Key Laboratory for Agro-ecological Processes in Subtropical Regions Institute of Subtropical AgricultureChinese Academy of SciencesChangsha 410125China Changsha Research Station for Agricultural&Environmental Monitoring Chinese Academy of SciencesChangsha 410125China University of Chinese Academy of Sciences Beijing 100049China State Environmental Protection Key Laboratory of Formation and Prevention of the Urban Air Pollution Complex Shanghai Academy of Environment SciencesShanghai 200233China Institute of Carbon Neutrality Qilu ZhongkeJinan 251699China Hubei Province Key Laboratory for Geographical Process Analysis and Simulation Central China Normal UniversityWuhan 430079China Department of Ecohydrology Leibniz Institute of Freshwater Ecology and Inland FisheriesBerlin 12587Germany Key laboratory of Environment Change and Resources Use in Beibu Gulf Ministry of EducationNanning Normal UniversityNanning 530001China Golden Mantis school of Architecture Soochow UniversitySuzhou 215123China

Nitrous oxide(N_(2)O)is a long-lived greenhouse gas that mainly originates from agricultural *** and more studies have explored the sources,influencing factors and effective mitigation measures of N_(2)O in recent ***,the hierarchy of factors influencing N_(2)O emissions from agricultural soils at the global scale remains *** this study,we carry out correlation and structural equation modeling analysis on a global N_(2)O emission dataset to explore the hierarchy of influencing factors affecting N_(2)O emissions from the nitrogen(N)and non-N fertilized upland farming systems,in terms of climatic factors,soil properties,and agricultural *** results show that the average N_(2)O emission intensity in the N fertilized soils(17.83 g N ha^(-1)d^(-1))was significantly greater than that in the non-N fertilized soils(5.34 g N ha^(−1) d^(−1))(p<0.001).Climate factors and agricultural practices are the most important influencing factors on N_(2)O emission in non-N and N fertilized upland soils,*** different climatic zones,without fertilizer,the primary influence factors on soil N_(2)O emissions are soil physical properties in subtropical monsoon zone,whereas climatic factors are key in the temperate *** fertilizer,the primary influence factors for subtropical monsoon and temperate continental zones are soil physical properties,while agricultural measures are the main factors in the temperate monsoon *** enhanced agricultural practices,such as reduced N fertilizer rate combined with the addition of nitrification and urease inhibitors can potentially mitigate N_(2)O emissions by more than 60%in upland farming systems.

关键词： N_(2)O emissions influencing factors nitrogen cycling upland farming systems

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Fracture sealing performance of granular lost circulation materials at elevated temperature:A theoretical and coupled CFD-DEM simulation study

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Petroleum Science 2024年第1期21卷 567-581页

作者： Chong Lin Qi-Cong Xu Lie-Xiang Han Gao Li Hai He Hong-Ling Zhou ji-ping She CCDC Drilling&Production Technology Research Institute Guanghan618300SichuanChina State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu610500SichuanChina College of Materials Science and Engineering Chongqing UniversityChongqing400044China State Key Lab of Oil and Gas Reservoir Geology and Exploitation(Chengdu University of Technology) Chengdu610059SichuanChina College of Energy Chengdu University of TechnologyChengdu610059SichuanChina

Lost circulation is a common downhole problem of drilling in geothermal and high-temperature,high-pressure(HTHP)*** circulation material(LCM)is a regular preventive and remedial measure for lost ***,conventional LCMs seem ineffective in high-temperature *** may be due to the changes in the mechanical properties of LCMs and their sealing performance under high-temperature *** understand how high temperature affects the fracture sealing performance of LCMs,we developed a coupled computational fluid dynamics-discrete element method(CFD-DEM)model to simulate the behavior of granular LCMs in *** summarized the literature on the effects of high temperature on the mechanical properties of LCMs and the rheological properties of drilling *** conducted sensitivity analyses to investigate how changing LCM slurry properties affected the fracture sealing efficiency at increasing *** results show that high temperature reduces the size,strength,and friction coefficient of LCMs as well as the drilling fluid ***,softer,and less frictional LCM particles have lower bridging probability and slower bridging *** particles tend to form dual-particle bridges rather than single-particle *** result in a deeper,tighter,but unstable sealing *** drilling fluid viscosity leads to faster and shallower sealing zones.

关键词： Geothermal well drilling HTHP formationLost circulation material CFD-DEM Fracture sealing

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Effect of solute Ce,Mn,and Si on mechanical properties of silicon steel:insights from DFT calculations

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Journal of Iron and Steel Research International 2024年第3期31卷 700-709页

作者： Xiang-jun Liu ji-chun Yang Hui-ping Ren Xiao-bin jia Ming-yi Zhang Chang-qiao Yang School of Materials and Metallurgy Inner Mongolia University of Science and TechnologyBaotou 014010Inner MongoliaChina Key Laboratory of Integrated Exploitation of Bayan Obo Multi-Metal Resource Inner Mongolia University of Science and TechnologyBaotou 014010Inner MongoliaChina Inner Mongolia North Heavy Industries Group Co. Ltd.Baotou 014010Inner MongoliaChina Inner Mongolia Metal Material Research Institute Baotou 014010Inner MongoliaChina

The influence of solute Ce,Mn,and Si on the mechanical properties of silicon steel was investigated by first-principles ***,Mn,and Si can all be solubilized in Fe *** significantly reduces the incompressibility and rigidity of the system but also significantly improves the toughness and *** effect of Mn on mechanical properties of the system is not *** has a significant effect on the improvement in incompressibility and rigidity but a limited effect on the improvement in toughness and *** metallic bond strength of Fe-Ce,Fe-Mn,and Fe-Si doped systems is weaker than that of the pure Fe system,which can be used to explain the reduction in the incompressibility and rigidity of these doped *** relatively high electron cloud density in the doped system may be responsible for the increase in toughness.

关键词： Silicon steel Rare earth First-principles calculation Elastic modulus Electronic structure

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