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Neuroscience Bulletin 2014年第1期30卷 90-98页

作者： Rong-Yi Liu Jun-Jun Wang Xia Qiu ji-min wu Department of Neurology Second Affiliated Hospital College of Medicine Zhejiang University Department of Neurology Zhejiang Hospital

Recent evidence suggests that admission hypergly- cemia has deleterious effects on the survival and functional outcome of patients with intracerebral hemorrhage （ICH）. In this study, we first induced acute hyperglycemia in male adult Sprague-Dawley rats by intraperitoneal injection of 50% glucose （6 mL/kg）, and created the ICH model thereafter by delivering autologous whole blood or homologous normal- glucose blood into the right basal ganglia. Twenty- four hours later, we assessed the neurological injury, evaluated the hematoma and brain water content, and investigated autophagy. We found elevations of neurological deficit scores, brain water content, and microtubule-associated protein light chain-3 （LC3） and beclin-1 protein levels, and decreased SQSTM1/ p62 levels after ICH with normal-glucose blood （without hyperglycemia）. Acute hyperglycemia with ICH of high-glucose blood hematoma was associated with significantly increased forelimb-use asymmetry test scores, brain water content and SQSTM1/p62 protein levels, and evident decreases in the ratio of LC3-11/LC3-1 and beclin-1 protein levels. On the other hand, acute hyperglycemia and ICH with normal- glucose blood hematoma only slightly increased the neurological deficit scores and brain water content （P 〉0.05）. In conclusion, the autophagy pathway was activated after ICH, and acute hyperglycemia with hematoma of high-glucose blood exacerbates the neurological injury, and reduces autophagy around the hematoma.

关键词： intracerebral hemorrhage hyperglycemia autophagy

Comparison of Stretta procedure and toupet fundoplication for gastroesophageal reflux disease-related extra-esophageal symptoms

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World Journal of Gastroenterology 2015年第45期21卷 12882-12887页

作者： Chao Yan Wei-Tao Liang Zhong-Gao Wang Zhi-Wei Hu ji-min wu Chao Zhang Mei-Ping Chen Department of Gastroesophageal Reflux Disease Second Artillery General Hospital of Chinese People’s Liberation Army Department of Vascular Surgery Xuan Wu Hospital Capital Medical University

AIM: To compare the outcomes between the Stretta procedure and laparoscopic toupet fundoplication(LTF) in patients with gastroesophageal reflux disease(GERD)-related extra-esophageal ***: From January 2011 to February 2012, a total of 98 patients diagnosed with GERD-related extra-esophageal symptoms who met the inclusion criteria were enrolled in this study. All patients who either underwent the Stretta procedure or LTF treatment have now completed the 3-year follow-up. Primary outcome measures, including frequency and severity of extra-esophageal symptoms, proton pump inhibitor(PPI) use, satisfaction, and postoperative complications, were assessed. The results of the Stretta procedure and LTF therapy were analyzed and ***: There were 47 patients in the Stretta group and 51 patients in the LTF group. Ninety patients were available at the 3-year follow-up. The total of the frequency and severity scores for every symptom improved in both groups(P 0.05). However, the score for globus hysterics was different between the Stretta group and the LTF group(4.9 ± 2.24 vs 3.2 ± 2.63, P < 0.05). After the Stretta procedure and LTF treatment, 29 and 33 patients in each group achieved PPI therapy independence(61.7% vs 64.7%, P = 0.835). The patients in the LTF group were more satisfied with their quality of life than those in the Stretta procedure group(P < 0.05). Most complications resolved without intervention within two weeks; however, two patients in the LTF group still suffered from severe dysphagia 2 wk after the operation, and it improved after bougie dilation treatment in both ***: The Stretta procedure and LTF were both safe and effective for the control of GERD-related extra-esophageal symptoms and the reduction of PPI use.

关键词： Gastroesophageal reflux disease Extraesophageal sy

Nissen fundoplication vs proton pump inhibitors for laryngopharyngeal reflux based on p H-monitoring and symptom-scale

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World Journal of Gastroenterology 2017年第19期23卷 3546-3555页

作者： Chao Zhang Zhi-Wei Hu Chao Yan Qiong wu ji-min wu Xing Du Dian-Gang Liu Tao Luo Fei Li Zhong-Gao Wang Department of General Surgery Xuanwu HospitalCapital Medical University Department of Gastroesophageal Reflux Disease Second Artillery General Hospital of Chinese People’s Liberation Army Department of Nutrition Xuanwu HospitalCapital Medical University

AIM To compare the outcomes between laparoscopic Nissen fundoplication(LNF)and proton pump inhibitors(PPIs)therapy in patients with laryngopharyngeal reflux(LPR)and typeⅠhiatal hernia diagnosed by oropharyngeal p H-monitoring and symptom-scale *** From February 2014 to January 2015,70 patients who were diagnosed with LPR and type I hiatal hernia and referred for symptomatic assessment,oropharyngeal p H-monitoring,manometry,and gastrointestinal endoscopy were enrolled in this *** of the patients met the inclusion *** of the patients underwent LNF or PPIs administration,and completed a2-year ***’baseline characteristics and primary outcome measures,including comprehensive and single symptoms of LPR,PPIs independence,and satisfaction,and postoperative complications were *** outcomes of LNF and PPIs therapy were analyzed and compared. RESULTS There were 31 patients in the LNF group and 39patients in the PPI ***-three patients(25 in the LNF group and 28 in the PPI group)completed reviews and *** p H-monitoring parameters were all abnormal with high acid exposure,a large amount of reflux,and a high Ryan score,associated reflux symptom index(RSI)*** was a significant improvement in the RSI and LPR symptom scores after the 2-year follow-up in both groups(P<0.05),as well as typical symptoms of gastroesophageal reflux *** in the RSI(P<0.005)and symptom scores of cough(P=0.032),mucus(P=0.011),and throat clearing(P=0.022)was significantly superior in the LNF group to that in the PPI *** LNF and PPIs therapy,13 and 53 patients achieved independence from PPIs therapy(LNF:44.0%vs PPI:7.14%,P<0.001)during follow-up,*** in the LNF group were more satisfied with their quality of life than those in the PPI group(LNF:62.49±28.68 vs PPI:44.36±32.77,P=0.004).Body mass index was significantly lower in the LNF group than in the PPI group(LNF:22.2±3.1kg/m^2 vs

关键词： Laryngopharyngeal reflux Hiatal hernia Laparoscopic Nissen fundoplication Proton pump inhibitor p H-monitoring Gastroesophageal reflux disease

Effect of laparoscopic fundoplication treatment on gastroesophageal reflux disease-related respiratory symptoms

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Frontiers of Medicine 2010年第2期4卷 254-258页

作者： Zhong-Gao WANG Feng ji ji-min wu Yun-Gang LAI Xiang GAO Cheng-Chao ZHANG Xiu CHEN Ibrahim M.IBRAHIM Cardiovascular Surgery Xuan Wu HospitalCapital University of Medical ScienceBeijing 100053China Center for GERD Second Artillery General HospitalBeijing 100088China Department of Surgery Hospital&Medical Center EnglewoodEnglewoodNJ 07631USA

Gastroesophageal reﬂux disease(GERD)was diagnosed and fundoplication was performed,which relieved the *** paper explores the effect of fundoplication on GERD-related respiratory *** January 2007 to October 2008,64 patients with respiratory symptoms related to GERD were consecutively enrolled for laparoscopic *** these,60 patients had respiratory symptoms mainly combined with gastroesophageal reﬂux,while four had respiratory symptoms *** patients had GERD conﬁrmed,and medical treatment provided before surgery resulted in an insufﬁciently favorable effect or even producing further *** the patients were requested toﬁll a questionnaire form regarding the severity of symptoms and their medication so as to make an evaluation score for the *** outcome of respiratory symptoms after surgery was as follows:excellent in 23 cases(35.9%);good in 28(43.8%);fair in 5(7.8%);poor in 8(12.5%).The mean respiratory symptom score decreased from 6.3�2.65 to 2.33�*** fundoplication can be an effective treatment for the majority of patients with GERD-related respiratory symptoms.

关键词： gastroesophageal reﬂux disease pH monitor-ing laparoscopic fundoplication respiratory symptom

胃镜下胃食管反流病评估新方法-食管裂孔横径法

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世界华人消化杂志 2024年第8期32卷 576-583页

作者：田书瑞陈冬刘建军刘健男梁艳吴继敏中国人民解放军火箭军特色医学中心北京市100088

背景总结分析无法进行Hill分级因素,提出食管裂孔横径四级分级;收集胃镜、阻抗、测压等相关数据,通过与Hill胃食管阀瓣分级法比较,相关数据统计分析,证实胃镜下食管裂孔横径法在评估胃食管反流病中的价值.目的分析无法进行Hill分级因素... 详细信息

背景总结分析无法进行Hill分级因素,提出食管裂孔横径四级分级;收集胃镜、阻抗、测压等相关数据,通过与Hill胃食管阀瓣分级法比较,相关数据统计分析,证实胃镜下食管裂孔横径法在评估胃食管反流病中的价值.目的分析无法进行Hill分级因素及胃镜在胃食管反流病评估中的新方法.方法选择2019-03-07/2019-09-24在中国人民解放军火箭军特色医学中心胃食管外科就诊,考虑胃食管反流病并行胃镜检查患者749例.胃镜下进行Hill胃食管阀瓣分级,记录无法进行Hill分级因素,测量食管裂孔横径,收集反流性食管炎、下食管括约肌长度、压力,Demeester积分、反流次数等相关参数据,进行统计分析,比较Hill胃食管阀瓣分级法和胃镜下食管裂孔横径法在评估胃食管反流病中的价值.采用t检验、秩和检验、χ^(2)检验进行统计学比较.结果195例(195/749,26.03%)无法进行Hill分级.异常Hill胃食管阀瓣组和食管裂孔横径组,反流性食管炎发生率、食管裂孔横径、Demeester积分、反流次数增加,食管、食管下括约肌(lower esophageal sphincter,LES)、腹腔内LES长度均减短,LES静息压平均值、最小值均减低,差别有统计学意义(P<0.05);胃食管阀瓣组和食管裂孔横径组之间,在反流性食管炎发生率,Demeester积分、反流次数,食管、LES、腹腔内LES长度、压力差别均无统计学意义,有良好的一致性.结论客观存在一定无法进行Hill分级因素,胃镜下食管裂孔横径分级对胃食管反流病的评估有重要意义,简单易掌握,可以作为一种评价方法.

关键词：胃镜胃食管反流病胃食管阀瓣分级食管裂孔横径分级

Compound Product of Hypermatrices

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Journal of Systems Science & Complexity 2024年第1期37卷 169-183页

作者： CHENG Daizhan MENG min ZHANG Xiao ji Zhengping Key Laboratory of Systems and Control Academy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China Department of Control Science and Engineering School of Electronics and Information EngineeringTongji UniversityShanghai 201210China National Center for Mathematics and Interdisciplinary Sciences Chinese Academy of SciencesBeijing 100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100149China.

The semi-tensor product(STP)of matrices is generalized to multidimensional arrays,called the compound product of *** product is first defined for three-dimensional hypermatrices with compatible orders and then extended to general *** different types of hyperdeterminants are introduced and certain properties are *** Lie groups and Lie algebras corresponding to the hypermatrix products are ***,these results are applied to dynamical systems.

关键词： Compound semi-tensor product hyperdeterminants hypereigenvalues and hypereigenvectors hypergeneral linear groups hypermatrices.

A Room-Temperature Chloride-Conducting Metal-Organic Crystal[Al(DMSO)_(6)]Cl_(3) for Potential Solid-State Chloride-Shuttle Batteries

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Energy & Environmental Materials 2024年第1期7卷 107-113页

作者： Bing wu Jan Luxa jiří Šturala Shuangying Wei Lukáš Děkanovský Abhilash Karuthedath Parameswaran min Li Zdenek Sofer Department of Inorganic Chemistry University of Chemistry and Technology PragueTechnická 516628Prague Czech Republic

The growing demand for substitutes of lithium chemistries in battery leads to a surge in budding novel anion-based electrochemical energy storage,where the chloride ion batteries(CIBs)take over the *** application of CIBs is limited by the dissolution and side reaction of chloride-based electrode materials in a liquid *** the flipside,its solid-state electrolytes are scarcely reported due to the challenge in realizing fast Cl^(-)*** present study reports[Al(DMSO)_(6)]Cl_(3),a solid-state metal-organic material,allows chloride ion *** strong Al-Cl bonds in AlCl_(3)are broken down after coordinating of Al^(3+)by ligand DMSO,and Cl^(-)in the resulting compound is weakly bound to complexions[Al(DMSO)_(6)]^(3+),which may facilitate Cl^(-)*** partial replacement of Cl^(-)with PF_(6)^(-),the room-temperature ionic conductivity of as-prepared electrolyte is increased by one order of magnitude from 2.172×10^(-5)S cm^(-1)to 2.012×10^(-4)S cm^(-1).When they are assembled with Ag(anode)/Ag-AgCl(cathode)electrode system,reversible electrochemical redox reactions occur on both sides,demonstrating its potential for solid-state chloride ion *** strategy by weakening the bonding interaction using organic ligands between Cl^(-)and central metallic ions may provide new ideas for developing solid chloride-ion conductors.

关键词： [Al(DMSO)_(6)]Cl_(3) chloride-ion batteries ionic conductivity metal-organic solid-state electrolytes

Dietary selection of commensal protists:expanding host immunity by impacting trans-kindom competition with bacteria

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2344-2346页

作者： Bo Li min wu Huaqiong Li Department of Neonatology The Second Affliated Hospital of Wenzhou Medical University and Yuying Children’s HospitalWenzhou Medical UniversityWenzhouZhejiang 325027China Zhejiang Engineering Research Center for Tissue Repair Materials Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhouZhejiang 325000China

In a recent publication in Cell,1 Elias *** and colleagues identified novel commensal parabasalid protists(***,Parabasalia_sp_1653)with distinct metabolic traits,including diverse succinate excretion and dietary preference,which drives different trans-kingdom competition with specific commensal bacteria and results in divergent small intestine(SI)immune response,highlighting the significance of dietary interventions as a pivotal strategy for maintaining gut health(Fig.1).

关键词： immunity dietary intestine

Discovering deaminases using AlphaFold2:a strategy to search for tool proteins for gene editing

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Signal Transduction and Targeted Therapy 2024年第3期9卷 822-824页

作者： Yongye Huang jianxin jiang min wu Key Laboratory of Bioresource Research and Development of Liaoning Province College of Life and Health SciencesNortheastern UniversityShenyang 110169China Wound Trauma Medical Center State Key Laboratory of TraumaBurns and Combined InjuryDaping HospitalArmy Medical UniversityChongqing 400042China Wenzhou Traditional Chinese Medicine Hospital of Zhejiang Chinese Medical University WenzhouZhejiang 325000China Wenzhou Institute University of Chinese Academy of SciencesWenzhou 325000China The Joint Research Center Affiliated Xiangshan Hospital of Wenzhou Medical UniversityNingboChina

A recent study by Huang et *** in Cell reported the application of AlphaFold2 to forecast the structures of deaminase proteins and cluster them based on structural similarity,creating a truncated Sdd that can be used as a cytosine base editor(CBE)to be integrated into a single adeno-associated virus(AAV)1 This ground-breaking study aided by the artificial intelligence system would largely broaden the utility of tool proteins for gene editing.

关键词： CBE Alpha editor

Respiratory Distress Resulting from Gastroesophageal Reflux Is not Asthma,but Laryngotracheal Irritation,Spasm,even Suffocation

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Chinese Medical Sciences Journal 2009年第2期24卷 130-132页

作者： Zhong-gao Wang ji-min wu jian-jun Liu Li-yin Wang Yun-gang Lai Ibrahim M Ibrahim Xiu-jie Wang Herbert Dardik Department of Cardiothoracic ＆ Vascular Surgery Xuanwu Hospital Capital University of Medical Science Beijing 100053 China Center for Gastroesophageal Reflux the Second Artillery General Hospital Beijing 100088 China Department of Surgery Englewood Hospital ＆ Medical Center Englewood 07631 USA

ESPITE the strong association between gastroesophageal reflux disease （GERD） and asthma has been undisputedly established and widely recognized by experts in advanced countries. Yet few topics in medicine are as controversial as the causal relationship between GERD and asthma： some argue that GERD causes asthma, while others think the other way around is true, still quite a few believe that bronchodilator medications are to blame. This controversy continues to be a conundrum or more piece of the puzzle.1 We would like to share two thoughts which might be a belated revelation with scholars and experts and invite them for further cooperative studies： the GERD-derived respiratory distress is not asthma, but GERD pure and simple; and the pathogenesis of respiratory distress is not asthma, but laryngotracheal irritation/spasm/suffocation.

关键词： gastroesophageal reflux asthma Stretta radiofrequency fundoplication