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A pilot clinical study to evaluate feasibility of using single patient classifier as a prognostic test in stage Ⅱ-Ⅲ gastric cancer patients

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Chinese Journal of Cancer Research 2024年第4期36卷 368-378页

作者： ji Yeong An Sung Eun Oh Soomin Ahn Hyoung-II Kim Yoo Min Kim Minah Cho Keun Won Ryu Hong man Yoon Young Kyu park In Gyu Kwon Sung Hoon Noh Kyung Hee Lee In Cho Myoung Won Son Jong Won Kim Young-Woo Kim Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Department of Pathology and Translational Genomics Samsung Medical Center Sungkyunkwan University School of Medicine Department of Surgery Yonsei University College of Medicine Gastric Cancer Center Yonsei Cancer CenterYonsei University Health System Center for Gastric Cancer National Cancer Center Department of Surgery Chonnam National University Hwasun Hospital Chonnam National University College of Medicine Department of Surgery Gangnam Severance Hospital Yonsei University College of Medicine Department of Hematology-Oncology Yeungnam University Medical Center Department of Surgery Soonchunhyang University College of Medicine Department of Surgery Soonchunhyang University Cheonan Hospital Soonchunhyang University College of Medicine Department of Surgery Chung-Ang University Hospital Chung-Ang University College of Medicine

Objective: Precision medicine approaches emphasize the importance of reliable prognostic tools for guiding individualized therapy decisions. In this study, we evaluated the clinical feasibility of the single patient classifier(SPC) test, a new clinical-grade prognostic assay, in stage Ⅱ-Ⅲ gastric cancer ***: A prospective multicenter study was conducted, involving 237 patients who underwent gastrectomy between September 2019 and August 2020 across nine hospitals. The SPC test was employed to stratify patients into risk groups, and its feasibility and performance were evaluated. The primary endpoint was the proportion of the cases in which the test results were timely delivered before selecting postoperative treatment. Furthermore, 3-year disease-free survivals of risk groups were ***: The SPC test met the primary endpoint criteria. The 99.5% of SPC tests were timely delivered to hospitals before the postoperative treatment started. In a clinical setting, the median time from the specimen transfer to laboratory to the result delivery to hospital was 4 d. Furthermore, 3-year disease-free survivals were significantly different between risk groups classified with SPC ***: This study highlights the SPC test's feasibility in offering crucial information timely delivered for making informed decisions regarding postoperative treatment strategies. It also provides evidence to support the implementation of a future prospective clinical trial aimed at evaluating the clinical utility of the SPC test in guiding personalized treatment decisions for gastric cancer patients.

关键词： Prognostic test adjuvant chemotherapy advanced gastric cancer feasibility gastrectomy

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国产神怪片银幕叙事的历史文化意涵探析

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四川戏剧 2024年第1期 82-86页

作者：罗曼虞吉西南大学历史文化学院西南大学新闻传媒学院

作为国产类型电影独特存在的类型片种,神怪片早在20世纪20年代的商业类型电影潮流中就以极具标识性的类型程式与神怪元素完成了类型演进,开启了第一次“神怪”热潮。随着21世纪商业大片时代的来临,神怪片作为独立创生的大片类型接续古... 详细信息

作为国产类型电影独特存在的类型片种,神怪片早在20世纪20年代的商业类型电影潮流中就以极具标识性的类型程式与神怪元素完成了类型演进,开启了第一次“神怪”热潮。随着21世纪商业大片时代的来临,神怪片作为独立创生的大片类型接续古装大片并作为持续主打不断拓展与创新。跨越80年重复出现的类型热潮不仅是本土商业类型电影自主发展的使然性结果,更为重要的显然是两者间有着深层的历史性关联。立足于中国电影主向度对神怪片银幕叙事的深掘,不仅能探寻其类型实质与审美机制,同时能够深入揭示其美学意蕴与文化内涵。

关键词：国产神怪片传奇叙事叙事策略神怪传统美学理念

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Study on the effect of Shixiang plaster on the expression of CD31,serum FN,and VEGF in a rat model with chronic wounds

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Traditional Medicine Research 2024年第12期9卷 31-40页

作者： ji Fei Ling-Li Wang man Liu Peng Liu jing-Hua Ruan Kai-Wei Zhang College of Chinese Orthopedics and Traumatology Guizhou University of Traditional Chinese MedicineGuiyang 550001China Pharmaceutic Preparation Centre The First Affiliated Hospital of Guizhou University of Traditional Chinese MedicineGuiyang 550001China

Background:Chronic wounds pose a significant surgical challenge,often requiring traditional treatments with limited *** study explores the promising impact of Shixiang plaster,a classic Chinese ointment,on wound *** investigated the cluster of differentiation 31(CD31)expression,serum fibronectin(FN),and vascular endothelial growth factor(VEGF)levels in SPF rats with induced wounds to elucidate the mechanism behind Shixiang plaster’s *** investigated the effect and explored the role of Shixiang plaster on the expression of CD31,serum FN,and VEGF in chronic ***:The study involved 36 SPF rats divided into model,rb-bFGF,and Shixiang plaster *** was injected into the rats before modelling for 3 days to prevent *** skin was excised 2 cm below the horizontal line of the inferior border of the shoulder bone in the middle of the rat column up to the deep fascial layer and inoculated with a certain concentration of Staphylococcus aureus;the wound was covered aseptically for 3 *** trauma area of the rats was observed at 3,7,and 14 days,*** was observed using haematoxylin eosin and Masson ***31 expression was detected using immunohistochemistry *** and VEGF expression was detected using serum *** analyses were carried out by the method of ***:Regarding wound morphology,at 3 days,the recovery area of the Shixiang plaster group was larger than that of the other two groups,at 7 days,the wound healing rate of the Shixiang plaster group was significantly higher,and at 14 days,the wounds of the Shixiang plaster group had been mostly healed,with a healing rate of 98.3%.Haematoxylin eosin staining revealed a large amount of granulation tissue at 3 days in the Shixiang plaster group,and the epidermal scales disappeared at 14 days,with thinner epidermal thickness at 1 lesion and a large reduction in inflammatory cell *** staining showed that

关键词： Shixiang plaster chronic wounds CD31 FN VEGF

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Sexual Dimorphism and Female Reproductive Characteristics in the Hainan Water Skink(Tropidophorus hainanus)from Hainan,South China

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Asian Herpetological Research 2024年第1期15卷 49-58页

作者： Yu DU Xiaming ZHU Chixian LIN Yuntao YAO Xiang ji Hainan Key Laboratory for Herpetological Research College of Fisheries and Life SciencesHainan Tropical Ocean UniversitySanya 572022HainanChina Zhejiang Provincial Key Laboratory for Water Environment and Marine Biological Resources Protection College of Life and Environmental SciencesWenzhou UniversityWenzhou 325035ZhejiangChina Institute for Eco-environmental Research of Sanyang Wetland Wenzhou UniversityWenzhou 325014ZhejiangChina

We studied sexual dimorphism in body size and shape and female reproductive characteristics in the Hainan Water Skink(Tropidophorus hainanus)from Hainan,South *** our sample the largest female and male were 61.1 and 55.2 mm snout-vent length(SVL),*** mean SVL was larger in adult females(52.0 mm)than in adult males(48.3 mm).Juveniles were sexually dimorphic in head length but not in other examined morphological *** males were longer in head length and shorter in abdomen length and fore-limb length than adult females of the same *** shifts in sexual dimorphism in body shape were evident,as revealed by the fact that morphological differences between the sexes were more pronounced in adults than in *** produced a single litter of 3–6 offspring per season from early August to early *** size,litter mass and offspring(neonate)mass were positively related to female *** mass was independent of relative *** the above findings we draw three main ***,females are the larger sex in ***,and sexual dimorphism in body shape is more pronounced in adults than in ***,larger female *** produce more and larger offspring and thus heavier litters than smaller ***,the offspring size-number trade-off does is not evident in ***.

关键词： fecundity morphology offspring size-number trade-off reproduction scincidae sexual dimorphism

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Capsosiphon fulvescens suppresses LPS-stimulated inflammatory responses by suppressing TLR4/NF-κB activation in RAW264.7 murine macrophages

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Asian Pacific Journal of Tropical Biomedicine 2024年第3期14卷 115-126页

作者： Seon Yeong ji Eunjin Bang Hyun Hwangbo Min Yeong Kim Da Hye Kim Su Hyun Hong Shin-Hyung park Chang-Young Kwon Gi-Young Kim You-jin Jeon Suengmok Cho Yung Hyun Choi Department of Biochemistry Dong-eui University College of Korean MedicineBusan 47227Republic of Korea Basic Research Laboratory for the Regulation of Microplastic-Mediated Diseases and Anti-Aging Research Center Dong-eui UniversityBusan 47227Republic of Korea Department of Pathology Dong-eui University College of Korean MedicineBusan 47227Republic of Korea Department of Oriental Neuropsychiatry Dong-eui University College of Korean MedicineBusan 47227Republic of Korea Department of Marine Life Science Jeju National UniversityJeju 63243Republic of Korea Department of Food Science and Technology/Institute of Food Science Pukyong National UniversityBusan 48513Republic of Korea

Objective:To evaluate the effects of Capsosiphon fulvescens(***)ethanolic extract on inflammation in lipopolysaccharide(LPS)-induced RAW296.7 ***:The protective effects of *** ethanolic extract on LPS-induced inflammation in RAW264.7 macrophages were assessed using biochemical analysis,including enzyme-linked immunosorbent assay,quantitative reverse transcription-polymerase chain reaction,and Western blot *** examine reactive oxygen species(ROS)production,flow cytometry analysis,and immunofluorescence staining were ***,the modulatory effect of *** ethanolic extract on NF-κB activation was ***:*** ethanolic extract significantly attenuated LPS-induced levels of pro-inflammatory cytokines and notably reduced the secretion and mRNA levels of LPS-mediated matrix *** addition,*** ethanolic extract decreased ROS production and suppressed the TLR4/NF-κB signaling ***:*** ethanolic extract alleviates inflammation as well as oxidative stress by modulating the TLR4/NF-κB signaling in LPS-induced RAW264.7 *** can be used as a potential therapeutic agent to suppress inflammation and oxidative stress-associated diseases.

关键词： Capsosiphon fulvescens Inflammation Oxidative stress NF-κB Nrf2 TLR4

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Superhydrophobic melamine sponge prepared by radiation-induced grafting technology for efficient oil–water separation

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Nuclear Science and Techniques 2024年第09期 18-29页

作者： Ying Sun Wen-Rui Wang Dan-Yi Li Si-Yi Xu Lin Lin man-Li Lu Kai Fan Chen-Yang Xing Lin-Fan Li ji-Hao Li Shanghai Institute of Applied Physics Chinese Academy of Sciences University of Chinese Academy of Sciences School of Architecture and Materials Chongqing College of Electronic Engineering Center for Stretchable Electronics and NanoSensors Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education College of Physics and Optoelectronic Engineering Shenzhen University

This paper presents a superhydrophobic melamine(ME) sponge(ME-g-PLMA) prepared via high-energy radiation-induced in situ covalent grafting of long-alkyl-chain dodecyl methacrylate(LMA) onto an ME sponge for efficient oil–water separation. The obtained ME-g-PLMA sponge had an excellent pore structure with superhydrophobic(water contact angle of 154?)and superoleophilic properties. It can absorb various types of oils up to 66–168 times its mass. The ME-g-PLMA sponge can continuously separate oil slicks in water by connecting a pump or separating oil underwater with a gravity-driven *** addition, it maintained its highly hydrophobic properties even after long-term immersion in different corrosive solutions and repeated oil adsorption. The modified ME-g-PLMA sponge exhibited excellent separation properties and potential for oil spill cleanup.

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Survival benefit of concurrent chemoradiotherapy for advanced ampulla of Vater cancer

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World Journal of Clinical Cases 2024年第2期12卷 267-275页

作者： Chae Hwa Kwon Hyung Il Seo Dong Uk Kim Sung Yong Han Suk Kim Nam Kyung Lee Seung Baek Hong ji Hyun Ahn Young Mok park Byeong Gwan Noh BioMedical Research Institute Pusan National University HospitalBusan 49241South Korea Department of Surgery Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Internal Medicine Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Radiology Pusan National University School of Medicine and Biomedical Research InstitutePusan National University HospitalBusan 49241South Korea Department of Pathology and Biomedical Research Institute Pusan National University HospitalBusan 49241South Korea

BACKGROUND Currently,there is no standard adjuvant therapy for patients with resected ampulla of Vater(AoV)*** To evaluate the effectiveness of adjuvant concurrent chemoradiotherapy(CCRT)in patients with advanced AoV cancer who underwent curative *** This single-centered,retrospective study included 29 patients with advanced AoV cancer who underwent pancreaticoduodenectomy between 2006 and *** impact of CCRT on advanced AoV cancer was *** The 1-,3-,and 5-yr recurrence-free survival(RFS)rates for patients with advanced AoV cancer were 82.8%,48.3%,and 40.8%,respectively,and the overall survival(OS)rates were 89.7%,62.1%,and 51.7%,***-cular invasion was found to be a significant risk factor for RFS and OS in patients with advanced AoV cancer in the univariate analysis,whereas T stage and lymph node metastasis were significantly associated with OS in the multivariate *** to the patients who did not receive adjuvant CCRT,those who received adjuvant CCRT did not show statistically significant improvements in the RFS and OS,although they had a significantly lower average age and significantly higher platelet-to-lymphocyte *** Adjuvant CCRT did not improve survival outcomes in patients with advanced AoV *** findings contribute to existing knowledge on the effectiveness of CCRT in this patient population and provide important insights for clinical decision-making.

关键词： Advanced ampulla of Vater cancer Adjuvant concurrent chemoradiotherapy Recurrence Survival Vater cancer

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sTREM-1 as promising prognostic biomarker for acute-on-chronic liver failure and mortality in patients with acute decompensation of cirrhosis

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World Journal of Gastroenterology 2024年第9期30卷 1177-1188页

作者： Song-man Yu Hai Li Guo-Hong Deng Xian-Bo Wang Xin Zheng jin-Jun Chen Zhong-ji Meng Yu-Bao Zheng Yan-Hang Gao Zhi-Ping Qian Feng Liu Xiao-Bo Lu Yu Shi jia Shang Ruo-Chan Chen Yan Huang Department of Infectious Diseases Xiangya HospitalCentral South UniversityChangsha 410000Hunan ProvinceChina Department of Gastroenterology Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Infectious Diseases Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100020China Department of Infectious Diseases Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430020Hubei ProvinceChina Department of Infectious Diseases Nanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Infectious Disease Taihe HospitalHubei University of MedicineShiyan 442009Hubei ProvinceChina Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina Department of Hepatology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Liver Intensive Care Unit Shanghai Public Health Clinical CentreFudan UniversityShanghai 200093China Tianjin Institute of Hepatology Nankai University Second People's HospitalTianjin 300192China Infectious Disease Center The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina The State Key Laboratory for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital of School of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvineChina Department of Infectious Diseases Henan Provincial People's HospitalZhengzhou 463599Henan ProvineChina Department of Infectious Diseases Hunan Key Laboratory of Viral HepatitisXiangya HospitalCentral South UniversityChangsha 110051Hunan ProvineChina

BACKGROUND Acute decompensation(AD)of cirrhosis is associated with high short-term mortality,mainly due to the development of acute-on-chronic liver failure(ACLF).Thus,there is a need for biomarkers for early and accurate identification of AD patients with high risk of development of ACLF and *** triggering receptor expressed on myeloid cells-1(sTREM-1)is released from activated innate immune cells and correlated with various inflammatory *** To explore the prognostic value of sTREM-1 in patients with AD of *** A multicenter prospective cohort of 442 patients with cirrhosis hospitalized for AD was divided into a study cohort(n=309)and validation cohort(n=133).Demographic and clinical data were collected,and serum sTREM-1 was measured at *** enrolled patients were followed-up for at least 1 *** In patients with AD and cirrhosis,serum sTREM-1 was an independent prognosis predictor for 1-year survival and correlated with liver,coagulation,cerebral and kidney failure.A new prognostic model of AD(P-AD)incorporating sTREM-1,blood urea nitrogen(BUN),total bilirubin(TBil),international normalized ratio(INR)and hepatic encephalopathy grades was established and performed better than the model for end-stage liver disease(MELD),MELD-sodium(MELD-Na),chronic liver failure-consortium(CLIF-C)ACLF and CLIF-C AD ***,sTREM-1 was increased in ACLF and predicted the development of ACLF during first 28-d *** ACLF risk score incorporating serum sTREM-1,BUN,INR,TBil and aspartate aminotransferase levels was established and significantly superior to MELD,MELD-Na,CLIF-C ACLF,CLIF-C AD and P-AD in predicting risk of ACLF *** Serum sTREM-1 is a promising prognostic biomarker for ACLF development and mortality in patients with AD of cirrhosis.

关键词： Soluble triggering receptor expressed on myeloid cell-1 Acute decompensation Cirrhosis Acute-on-chronic liver failure Prognostic biomarker

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基于MobileViT-CA模型的营运车辆驾驶人分心行为检测

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中国公路学报 2024年第1期37卷 194-204页

作者：贺宜鲁曼可高嵩曹博李继朴武汉理工大学智能交通系统研究中心湖北武汉430063

营运车辆驾驶人因其职业特殊性,驾驶过程中易产生分心驾驶行为从而引发重大交通事故。为提高营运车辆驾驶人分心驾驶行为的检测准确性和泛化性,提出一种基于改进MobileViT网络的驾驶人分心行为检测方法。首先,基于自然驾驶实车试验,构... 详细信息

营运车辆驾驶人因其职业特殊性,驾驶过程中易产生分心驾驶行为从而引发重大交通事故。为提高营运车辆驾驶人分心驾驶行为的检测准确性和泛化性,提出一种基于改进MobileViT网络的驾驶人分心行为检测方法。首先,基于自然驾驶实车试验,构建包含安全驾驶、使用手机、喝水、整理仪容和与副驾驶交谈5类行为的营运车辆驾驶人分心行为数据集。其次,将注意力机制引入轻量型MobileViT网络,通过选择有效的网络主干MobileViT、注意力模块CA、网络嵌入位置从而设计出最优分类模型MobileViT-CA。研究结果表明:所提出的MobileViT-CA分类模型可以有效提升分类网络的性能,在正常光照条件下的营运车辆驾驶人分心行为数据集和State Farm数据集上分别达到了96.57%和99.89%的准确率,且模型具有体积小、检测精度高的优势,有较高的可靠性和泛化能力。

关键词：交通工程营运车辆分心驾驶行为检测 MobileViT网络注意力机制

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Controlling electrodeposited Ni layers by different-sized graphene oxides enables conductive e-textiles for the highly sensitive electrochemical detection of glucose

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Nano Research 2024年第7期17卷 6258-6264页

作者： Zhen Li Zibo Chen Xiaodong ji Huihui jin Yunfa Si jingwei Zhang Cheng Chen Daping He Sanya Science and Education Innovation park of Wuhan University of Technology Sanya 572000China School of Science Wuhan University of TechnologyWuhan 430070China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China Hubei Engineering Research Center of RF-Microwave Technology and Application Wuhan University of TechnologyWuhan 430070China

With the increasing popularity of wearable electronic devices,there is an urgent demand to develop electronic textiles(e-textiles)for device ***,the difficulty in reconciliation between conductivity and manufacturing costs hinders their large-scale practical ***,we reported a facile and economic method for preparing conductive ***,nonconductive polypropylene(PP)was wrapped by reduced graphene oxide(rGO),followed by the electrodeposition of Ni nanoparticles(NPs).Notably,modulating the sheet size of graphene oxide(GO)resulted in controllable deposition of Ni NPs with adjustable size,allowing for controlled manipulations over the structures,morphologies,and conductivity of the obtained e-textiles,which influenced their performance in electrochemical glucose detection *** optimal material,denoted as Ni/rGO+(0.2)/PP,exhibited an impressive conductivity of 7.94×10^(4)S·m^(−1).With regard to the excellent conductivity of the as-prepared e-textiles and the high electrocatalytic activity of Ni for glucose oxidation,the asprepared e-textiles were subjected to glucose *** was worth emphasizing that the Ni/rGO_(0.2)/PP-based electrode demonstrated promising performance for nonenzymatic/label-free glucose detection,with a detection limit of 0.36μM and a linear response range of 0.5μM to 1 *** study paves the way for further development and application prospects of conductive etextiles.

关键词： conductive e-textiles nonenzymatic/label-free glucose detection controllable Ni deposition graphene oxides sizedependent effect

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