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Autophagy-targeting modulation to promote peripheral nerve regeneration

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Neural Regeneration Research 2025年第7期20卷 1864-1882页

作者： Yan chen Hongxia Deng Nannan Zhang Department of Obstetrics and Gynecology West China Second HospitalSichuan UniversityChengduSichuan ProvinceChina Key Laboratory of Birth Defects and Women and Children’s Diseases Ministry of EducationSichuan UniversityChengduSichuan ProvinceChina Laboratory of Reproductive Endocrinology and Reproductive Regulation Sichuan UniversityChengduSichuan ProvinceChina National Center for Birth Defect Monitoring West China Second University HospitalSichuan UniversityChengduSichuan ProvinceChina

Nerve regeneration following traumatic peripheral nerve injuries and neuropathies is a complex process modulated by diverse factors and intricate molecular *** studies have focused on factors that stimulate axonal outgrowth and myelin ***,recent studies have highlighted the pivotal role of autophagy in peripheral nerve regeneration,particularly in the context of traumatic ***,autophagy-targeting modulation has emerged as a promising therapeutic approach to enhancing peripheral nerve *** current understanding suggests that activating autophagy facilitates the rapid clearance of damaged axons and myelin sheaths,thereby enhancing neuronal survival and mitigating injury-induced oxidative stress and *** actions collectively contribute to creating a favorable microenvironment for structural and functional nerve regeneration.A range of autophagyinducing drugs and interventions have demonstrated beneficial effects in alleviating peripheral neuropathy and promoting nerve regeneration in preclinical models of traumatic peripheral nerve *** review delves into the regulation of autophagy in cell types involved in peripheral nerve regeneration,summarizing the potential drugs and interventions that can be harnessed to promote this *** hope that our review will offer novel insights and perspectives on the exploitation of autophagy pathways in the treatment of peripheral nerve injuries and neuropathies.

关键词： autophagy autophagy related genes Charcot–Marie–Tooth diseases diabetic peripheral neuropathy metformin myelination peripheral nerve injury Schwann cells sciatic nerve Wallerian degeneration

DYNAMICS OF A NONLINEAR NON-AUTONOMOUS n-PATCHES PREDATOR-PREY DISPERSION-DELAY MODEL

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Applied Mathematics(A Journal of Chinese Universities) 2007年第4期22卷 393-404页

作者： chen Chao ji kun School of Sciences Jimei University Xiamen 361021 China.

In this paper, a nonlinear nonautonomous predator-prey dispersion model with continuous distributed delay is studied, where all parameters are time-dependent. In this system consisting of n-patches the prey species can disperse among n-patches, but the predator species is confined to one patch and cannot disperse. It is proved that the system is uniformly persistent under any dispersion rate effect. Furthermore~ some sufficient conditions are established for the existence of a unique almost periodic solution of the system. The example shows that the criteria in the paper are new, general and easily verifiable.

关键词： nonlinear almost periodic solution dispersion continuous time delay global asymptotic stable.

Selective laser melting of magnesium alloys: Necessity, formability, performance, optimization and applications

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Journal of Materials Science & Technology 2023年第23期154卷 65-93页

作者： kun Li chen ji Shengwen Bai Bin jiang Fusheng Pan State Key Laboratory of Mechanical Transmission Chongqing University Chongqing 400044 China Chongqing Key Laboratory of Metal Additive Manufacturing (3D Printing) Chongqing University Chongqing 400044 China College of Mechanical and Vehicle Engineering Chongqing University Chongqing 400044 China National Engineering Research Center for Magnesium Alloys College of Materials Science and Engineering Chongqing University Chongqing 400044 China

Selective laser melting (SLM), as a rapid prototyping technology, has been widely used to manufacture high-performance metal components with complex structures, which vitally provides a broad platform for the development and application of magnesium alloys. However, the poor laser formability of magnesium alloys has deleterious consequences in the application of SLM processing. This paper discusses the defect formation mechanisms during the SLM process and summarizes characteristics in terms of mechanical properties, oxidation and corrosion resistance. Current optimization schemes are reviewed from both macro and micro perspectives. Firstly, the relationship between process parameters and formability and material properties is clarified, and advanced optimization methods of the design of experiments, physical models, and machine learning are evaluated. Secondly, the effects of alloying elements, composite reinforcement, and post-treatment on the microstructure and properties of the SLMed magnesium alloy are reviewed. Finally, the future application development prospects are envisaged based on the comprehensive review. This work is significantly helpful to a better scientific understanding of SLMed magnesium alloy and puts forward some meaningful guiding opinions for the future work of magnesium alloy manufacturing.

关键词： Magnesium alloys Selective laser melting Defects Microstructure-property relationship Performance optimization

Construction of 3D porous Cu_(1.81)S/nitrogen-doped carbon frameworks for ultrafast and long-cycle life sodium-ion storage

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 191-200页

作者： chen chen Hongyu Xue Qilin Hu Mengfan Wang Pan Shang Ziyan Liu Tao Peng Deyang Zhang Yongsong Luo Key Laboratory of Microelectronics and Energy of Henan Province Henan Joint International Research Laboratory of New Energy Storage TechnologyCollege of Physics and Electronic EngineeringXinyang Normal UniversityXinyang 464000China School of Physics and Electronic Engineering Nanyang Normal UniversityNanyang 473061China

Transition metal sulfides have great potential as anode mterials for sodium-ion batteries(SIBs)due to their high theoretical specific ***,the inferior intrinsic conductivity and large volume variation during sodiation-desodiation processes seriously affect its high-rate and long-cyde performance,unbeneficial for the application as fast-charging and long-cycling SIBs ***,the three-dimensional porous Cu_(1.81)S/nitrogen-doped carbon frameworks(Cu_(1.81)S/NC)are synthesized by the simple and facile sol-gel and annealing processes,which can accommodate the volumetric expansion of Cu_(1.81)S nanoparticles and accelerate the transmission of ions and electrons during Na^(+)insertion/extraction processes,exhibiting the excellent rate capability(250.6 mA·g^(-1)at 20.0 A·g^(-1))and outstanding cycling stability(70% capacity retention for 6000 cycles at 10.0 A·g^(-1))for ***,the Na-ion full cells coupled with Na_(3)V_(2)(PO_(4))_(3)/C cathode also demonstrate the satisfactory reversible specific capacity of 330.5 mAh·g^(-1)at 5.0 A·g^(-1)and long-cycle performance with the 86.9% capacity retention at 2.0 A·g^(-1)after 750 *** work proposes a promising way for the conversionbased metal sulfides for the applications as fast-charging sodium-ion battery anode.

关键词： copper sulfide nanoparticles porous carbon framework fast charging long-cycle performance sodium-ion full batteries

Dynamic behaviors of graphene platelets-reinforced metal foam piezoelectric beams with velocity feedback control

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 63-80页

作者： jie chen Xinyue ZHANG Mingyang FAN School of Mathematics Statistics and Mechanics Beijing University of Technology College of Mechanical & Energy Engineering Beijing University of Technology

Graphene platelets(GPLs)-reinforced metal foam structures enhance the mechanical properties while maintaining the lightweight characteristics of metal foams. Further bonding piezoelectric actuator and sensor layers on the surfaces of GPLs-reinforced metal foam beams enables active vibration control, greatly expanding their applications in the aerospace industry. For the first time, this paper investigates the vibration characteristics and active vibration control of GPLs-reinforced metal foam beams with surfacebonded piezoelectric layers. The constant velocity feedback scheme is used to design the closed-loop controller including piezoelectric actuators and sensors. The effects of the GPLs on the linear and nonlinear free vibrations of the beams are numerically *** Newmark-β method combined with Newton's iteration technique is used to calculate the nonlinear responses of the beams under different load forms including harmonic loads,impact loads, and moving loads. Additionally, special attention is given to the vibration reduction performance of the velocity feedback control on the responses of the beam.

关键词： Piezoelectric actuators

Hourglass-GCN for 3D Human Pose Estimation Using Skeleton Structure and View Correlation

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Computers, Materials & Continua 2025年第1期82卷 173-191页

作者： Ange chen chengdong Wu Chuanjiang Leng Faculty of Robot Science and Engineering Northeastern UniversityShenyang110169China

Previous multi-view 3D human pose estimation methods neither correlate different human joints in each view nor model learnable correlations between the same joints in different views explicitly,meaning that skeleton structure information is not utilized and multi-view pose information is not completely ***,existing graph convolutional operations do not consider the specificity of different joints and different views of pose information when processing skeleton graphs,making the correlation weights between nodes in the graph and their neighborhood nodes *** Graph Convolutional Networks(GCNs)cannot extract global and deeplevel skeleton structure information and view correlations *** solve these problems,pre-estimated multiview 2D poses are designed as a multi-view skeleton graph to fuse skeleton priors and view correlations explicitly to process occlusion problem,with the skeleton-edge and symmetry-edge representing the structure correlations between adjacent joints in each viewof skeleton graph and the view-edge representing the view correlations between the same joints in different *** make graph convolution operation mine elaborate and sufficient skeleton structure information and view correlations,different correlation weights are assigned to different categories of neighborhood nodes and further assigned to each node in the *** on the graph convolution operation proposed above,a Residual Graph Convolution(RGC)module is designed as the basic module to be combined with the simplified Hourglass architecture to construct the Hourglass-GCN as our 3D pose estimation ***-GCNwith a symmetrical and concise architecture processes three scales ofmulti-viewskeleton graphs to extract local-to-global scale and shallow-to-deep level skeleton features *** results on common large 3D pose dataset Human3.6M and MPI-INF-3DHP show that Hourglass-GCN outperforms some excellent methods in 3D pose estimati

关键词： 3D human pose estimation multi-view skeleton graph elaborate graph convolution operation Hourglass-GCN

Optimal Scheduling of an Independent Electro-Hydrogen System with Hybrid Energy Storage Using a Multi-Objective Standardization Fusion Method

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Energy Engineering 2025年第1期122卷 63-84页

作者： SuliangMa ZeqingMeng Mingxuan chen Yuan jiang School of Electrical and Control Engineering North China University of TechnologyBeijing100144China ChinaThree Gorges Technology Co. Ltd.Beijing100032China School of Automation and Electrical Engineering University of Science and Technology BeijingBeijing100083China

In the independent electro-hydrogen system(IEHS)with hybrid energy storage(HESS),achieving optimal scheduling is ***,it presents a challenge due to the significant deviations in values ofmultiple optimization objective functions caused by their physical *** deviations seriously affect the scheduling process.A novel standardization fusion method has been established to address this issue by analyzing the variation process of each objective function’s *** optimal scheduling results of IEHS with HESS indicate that the economy and overall energy loss can be improved 2–3 times under different optimization *** proposed method better balances all optimization objective functions and reduces the impact of their *** the cost of BESS decreases by approximately 30%,its participation deepens by about 1 ***,if the price of the electrolyzer is less than 15￥/kWh or if the cost of the fuel cell drops below 4￥/kWh,their participation will increase *** study aims to provide a more reasonable approach to solving multi-objective optimization problems.

关键词： Electro-hydrogen system multi-objective optimization standardization method hybrid energy storage system

Experimental study on slope sliding and debris flow evolution with and without barrier

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Water Science and Engineering 2015年第1期8卷 68-77页

作者： ji-kun Zhao Dan Wang jia-hong chen College of Engineering Nanjing Agricultural University jiangsu Key Laboratory for Intelligent Agricultural Equipment Nanjing Agricultural University College of Civil Engineering Tongji University

A constitutive model on the evolution of debris flow with and without a barrier was established based on the theory of the Bingham model. A certain area of the Laoshan Mountain in Nanjing, jiangsu Province, in China was chosen for experimental study, and the slope sliding and debris flow detection system was utilized. The change curve of the soil moisture content was attained, demonstrating that the moisture content of the shallow soil layer increases faster than that of the deep soil layer, and that the growth rate of the soil moisture content of the steep slope is large under the first weak rainfall, and that of the gentle slope is significantly affected by the second heavy rainfall. For the steep slope, slope sliding first occurs on the upper slope surface under heavy rainfall and further develops along the top platform and lower slope surface, while under weak rainfall the soil moisture content at the lower part of the slope first increases because of the high runoff velocity, meaning that failure occurring there is more serious. When a barrier was placed at a high position on a slope, debris flow was separated and distributed early and had less ability to carry solids, and the variation of the greatest depth of erosion pits on soil slopes was not significant.

关键词： Debris flow Slope sliding Geological disaster Time domain reflectometry (TDR) technique Detection system Constitutive model

一种基于柱面镜聚焦系统的高灵敏度全谱光谱仪

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光谱学与光谱分析 2025年第1期45卷 222-230页

作者：陈吉文陈作儿赵迎北方工业大学电气与控制工程学院北京100144

很多元素的最灵敏谱线主要分布在紫外波段。一些常被作为检测对象的重要元素,例如C、P和S,其谱线甚至位于200 nm以下的真空紫外波段。然而真空紫外波段内的辐射极易受空气吸收而无法在空气中传输。因此为了适用于紫外波段各谱线的检测,... 详细信息

很多元素的最灵敏谱线主要分布在紫外波段。一些常被作为检测对象的重要元素,例如C、P和S,其谱线甚至位于200 nm以下的真空紫外波段。然而真空紫外波段内的辐射极易受空气吸收而无法在空气中传输。因此为了适用于紫外波段各谱线的检测,常使用光程短、系统精简的罗兰圆光学系统作为光谱仪的色散系统,并且在进行检测分析时,还需对设备腔体内部建立相对真空的环境进行实验,进而减小实验环境对真空紫外波段内各谱线强度的削弱作用。然而即使在该条件下,P和S这两种元素在真空紫外波段的谱线灵敏度仍然较弱。为此为了实现真空紫外波段范围内的高灵敏度,本研究在距离像面前30 mm处位置设计了一个柱面镜聚焦系统。其采用了材料为CaF_(2)、中心厚度为5 mm以及弧矢面曲率半径为22.06 mm的柱面镜作为核心部件。并利用仿真软件Zemax对设计的光学系统进行仿真与优化,以及从非序列模式下的辐射照度仿真结果可知,柱面镜聚焦系统在几乎不影响分辨率的情况下对各波长成像灵敏度有较大的提升。最后以中低合金钢为检测样品,使用电火花激发光源对样品中各元素在紫外波段内的各谱线进行激发,进而验证光谱仪的各项性能:通过一次拟合、参比拟合以及二次拟合,建立每个元素谱峰强度和实际含量之间的数学模型,并算得各元素的拟合优度R^(2)均在0.99以上;柱面镜聚焦系统显著提高了设备在真空紫外波段的灵敏度,响应提高了1倍以上。实验结果表明,柱面镜聚焦系统的设计方法对于提升罗兰圆色散系统的灵敏度具有一定的参考价值。

关键词：紫外光谱罗兰圆光学系统柱面镜灵敏度拟合优度