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Batch synthesis of rare-earth nickelates electronic phase transition perovskites via rare-earth processing intermediates

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Rare Metals 2022年第10期41卷 3495-3503页

作者： Xiao-Yu Li Zi-Ang Li Feng-Bo Yan Hao Zhang jia-Ou Wang Xin-You Ke Yong jiang Nuo-Fu chen ji-kun chen School of New Energy North China Electric Power UniversityBeijing102206China School of Materials Science and Engineering University of Science and Technology BeijingBeijing100083China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing100049China Department of Mechanical and Aerospace Engineering Case Western Reserve UniversityClevelandOH44106USA

The rare-earth nickelates(RENiO_(3)) exhibit an exceptional complex electronic phase diagram and multiple electronic phase transitions that enrich promising applications in correlated electronic devices beyond conventional ***,the practical applications of RENiO_(3) are challenged by their intrinsic thermodynamic metastability in material synthesis and high material ***,developing an economical strategy to achieve the batch synthesis of RENiO_(3) is of vital *** this work,we enlarged the synthesis amount of RENiO_(3) up to 20 g per batch using chloride(KCI) assisted molten salt *** optimizing the reaction conditions,the powder of RENiO_(3) with the cubic shape and average size of ~2μm was effectively synthesized,while their phase purity exceeded 95%.In addition,the cost to synthesize RENiO_(3) was further reduced by using rare-earth extraction intermediate products as the raw materials,instead of using the pure rare-earth *** also achieved wide adjustments in the metal-to-insulator-transition temperature from160 to 420 K without significantly reducing the transition *** enlarging the synthesis amount and the reducing the cost,it paves the way to the device application of RENiO_(3).

关键词： Quantum materials Rare-earth nickelates Metastable materials Perovskite oxides

Alterations of FHIT Gene and P16 Gene in Nickel Transformed Human Bronchial Epithelial Cells

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Biomedical and Environmental Sciences 2006年第4期19卷 277-284页

作者： WEI-DONG ji jiA-kun chen jiA-CHUN LU ZHONG-LIANG WU FEI YI SU-MEI FENG Institute for Chemical Carcinogenesis Guangzhou Medical College Guangzhou 510182 Guangdong China

Objective To study the alterations of FHIT gene and P16 gene in malignant transformed human bronchial epithelial cells induced by crystalline nickel sulfide using an immortal human bronchial epithelial cell line, and to explore the molecular mechanism of nickel carcinogenesis. Methods 16HBE cells were treated 6 times with different concentrations of NiS in vitro, and the degree of malignant transformation was determined by assaying the anchorage-independent growth and tumorigenicity. Malignant transformed cells and tumorigenic cells were examined for alterations of FHIT gene and P16 gene using RT-PCR, DNA sequencing, silver staining PCR-SSCP and Western blotting. Results NiS-treated cells exhibited overlapping growth. Compared wkh that of negative control cells, soft agar colony formation efficiency of NiS-treated cells showed significant increases （P〈0.01） and dose-dependent effects. NiS-treated cells could form tumors in nude mice, and a squamous cell carcinoma was confirmed by histopathological examination. No mutation of exon 2 and exons 2-3, no abnormal expression in pl6 gene and mutation of FHIT exons 5-8 and exons 1-4 or exons 5-9 were observed in transformed cells and tumorigenic cells. However, aberrant transcripts or loss of expression of the FHIT gene and Fhit protein was observed in transformed cells and tumorigenic cells. One of the aberrant transcripts in the FHIT gene was confirmed to have a deletion of exon 6, exon 7, exon 8, and an insertion of a 36 bp sequence replacing exon 6-8. Conclusions The FHIT gene rather than the P16 gene, plays a definite role in nickel carcinogenesis. Alterations of the FHIT gene induced by crystalline NiS may be a molecular event associated with carcinogen, chromosome fragile site instability and cell malignant transformation. FHIT may be an important target gene activated by nickel and other exotic carcinogens.

关键词： Crystalline nickel sulfide Human bronchial epithelial cell line Malignant transformation P16 gene FHIT gene

Robust interface-induced unusual anomalous Hall effect in Mn_(3)Sn/Pt bilayers

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Rare Metals 2022年第9期41卷 3012-3018页

作者： Jun-jie Liu Kang-Kang Meng ji-kun chen Yong Wu Jun Miao Xiao-Guang Xu Yong jiang School of Materials Science and Engineering University of Science and Technology BeijingBeijing100083China

Interface-driven magnetic phenomena related to spin-orbit coupling and intrinsic symmetry breaking are of great significance to the development of spintronics materials and ***_(3)Sn is a natural antiferromagnetic material with a non-collinear magnetic structure,and its anomalous Hall effect(AHE)has been reported to have high crystal anisotropy and temperature dependent ***,a large unusual anomalous Hall effect(UAHE)in the(0001)c-axis orientation Mn_(3)Sn/Pt bilayers in the whole temperature range from 5 to 300 K is reported,which is absent in single MnSn film.

关键词： film. unusual effect

Melanoma differentiation-associated gene-7, MDA-7/IL-24, selectively induces growth suppression, apoptosis in human hepatocellular carcinoma cell line HepG2 by replication-incompetent adenovirus vector

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World Journal of Gastroenterology 2006年第11期12卷 1774-1779页

作者： Cong-Jun Wang Xin-Bo Xue ji-Lin Yi kun chen jian-WeiZheng jian Wang jian-Ping Zeng Rong-Hua Xu Department of Biliary and Pancreatic Surgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 Hubei Province China

AIM： To investigate the effect of replication-incompetent adenovirus vector expressing MDA-7/IL-24 on tumor growth and apoptosis in human hepatocellular carcinoma （HCC） cell line HepG2 and normal liver cell line L02. METHODS： We constructed the recombinant replication-incornpetent ***-7 virus vector and infected it into the human HCC cell line HepG2 and normal liver cell line L02. RT-PCR was performed to detect the rnRNA expressing in cells, by ELISA was used to detect MDA-7/IL-24 protein expression in the culture supernatant. The effect of apoptosis induced by ***-7 was confirmed by Hoechst staining and flow cytometry assay with Annexin-V and PI staining. MTT assay was used to determine growth inhibition of HepG2 cells, and cell-cycle and hypodiploidy analyses were performed by flow cytometry. RESULTS： Recombinant replication-defective virus expressing MDA-7/IL-24 was constructed successfully. RTPCR showed that the ***-7 could mediate the expression of the exogenous gene MDA-7/IL-24 into HepG2 and L02. The concentration of MDA-7/IL-24 protein in supernatant was 130 pg/mL and 110 pg/mL in ***-7-infected L02 and HepG2 ceils, respectively. ***-7 infection obviously induced apoptosis （from 2.604±0.72% to 33.64±13.2%, P=0.00012） and growth suppression in HepG2 （inhibition ratio IR=68%） and an increase in the percentage of specific cancer cell types at the G2/M phase of the cell cycle （from 6.44% to 32.29%, P〈 0.01）, but not in L02 ***： These results confirm selectively induction of apoptosis and growth suppression by the mda-7/ IL-24 gene with replication-incompetent adenovirus vector in human hepatocellular carcinoma cell line HepG2.

关键词： Cancer gene therapy Hepatocellular carcinoma (HCC) Apoptosis Growth suppression MDA-7/IL-24

Influence of thickness on current-induced magnetization switching in𝐿L1_(0)-FePt single layer

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Chinese Physics B 2021年第10期30卷 500-505页

作者： Shi-Qi Zheng Kang-Kang Meng Zhen-Guo Fu ji-kun chen Jun Miao Xiao-Guang Xu Yong jiang School of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Institute of Applied Physics and Computational Mathematics Beijing 100083China

The thickness dependent spin-orbit torque(SOT)in an L1_(0)-FePt single layer is investigated in this *** the thickness increases from 8 nm to 16 nm,the magnetization switching ratio in the L1_(0)-FePt film with higher chemical ordering becomes *** is noted that compared with 3-nm-thick L1_(0)-FePt film,8-nm-thick L1_(0)-FePt film can switch much magnetization with the increase of chemical *** the FePt film is thick enough,the SOT in FePt is closely related to the L10-ordered structure,which indicates a bulk ***,the disordering plays an important role in the magnetization switching only for the ultra-thin FePt films,while the structural gradient may play an important role for thicker ***,both of the two mechanisms cannot fully explain the process of magnetization switching and the spin current *** many factors influence SOT,here in this work we emphasize only the bulk nature of strong SOC in L1_(0)-FePt through density functional theory calculations,which should generate large spin current due to spin Hall effect.

关键词： spin-orbit coupling magnetic anisotropy spin transport effects

Magneto‑Dielectric Synergy and Multiscale Hierarchical Structure Design Enable Flexible Multipurpose Microwave Absorption and Infrared Stealth Compatibility

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Nano-Micro Letters 2025年第2期17卷 401-416页

作者： chen Li Leilei Liang Baoshan Zhang Yi Yang Guangbin ji School of Electronic Science and Engineering Nanjing UniversityNanjing 210093People’s Republic of China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

Developing advanced stealth devices to cope with radar-infrared(IR)fusion detection and diverse application scenarios is increasingly demanded,which faces significant challenges due to conflicting microwave and IR cloaking mechanisms and functional integration ***,we propose a multiscale hierarchical structure design,integrating wrinkled MXene IR shielding layer and flexible Fe_(3)O_(4)@C/PDMS microwave absorption *** top wrinkled MXene layer induces the intensive diffuse reflection effect,shielding IR radiation signals while allowing microwave to pass ***,the permeable microwaves are assimilated into the bottom Fe_(3)O_(4)@C/PDMS layer via strong magneto-electric *** theoretical and experimental optimization,the assembled stealth devices realize a near-perfect stealth capability in both X-band(8–12 GHz)and long-wave infrared(8–14μm)wavelength ***,it delivers a radar cross-section reduction of−20 dB m^(2),a large apparent temperature modulation range(ΔT=70℃),and a low average IR emissivity of ***,the optimal device demonstrates exceptional curved surface conformability,self-cleaning capability(contact angle≈129°),and abrasion resistance(recovery time≈5 s).This design strategy promotes the development of multispectral stealth technology and reinforces its applicability and durability in complex and hostile environments.

关键词： Microwave absorption Radar-infrared compatible stealth Wrinkled MXene Magneto-dielectric synergy Multifunction

Exploring the potential of extrachromosomal DNA as a novel oncogenic driver

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Science China Life Sciences 2025年第1期68卷 144-157页

作者： Huanbo Zhu Longtao Huangfu Junbing chen jiafu ji Xiaofang Xing Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Division of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital & Institute Department of Gastrointestinal Cancer Center Peking University Cancer Hospital & Institute Department of Liver Surgery & Transplantation Liver Cancer InstituteZhongshan HospitalFudan University Key Laboratory of Carcinogenesis and Cancer Invasion Ministry of Education State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDivision of Gastrointestinal Cancer Translational Research LaboratoryPeking University Cancer Hospital & Institute

Extrachromosomal DNA(ecDNA) is a form of circular DNA mostly found in tumor cells. Unlike the typical chromosomal DNA, ecDNA is circular, self-replicating, and carries complete or partial gene fragments. Although ecDNA occurrence remains a rare event in cancer, recent studies have shown that oncogene amplification on ecDNA is widespread throughout many types of cancer, implying that ecDNA plays a central role in accelerating tumor evolution. ecDNA has also been associated with increased tumor mutation burden, chromosomal instability, and even tumor microenvironment remodeling. ecDNA may be crucial in influencing tumor heterogeneity, drug sensitivity,oncogenic senescence, and tumor immunogenicity, leading to a worsening prognosis for tumor patients. In this way, several clinical trials have been conducted to investigate the importance of ecDNA in clinical treatment. In this review, we summarize the biogenesis, characteristics, and current research methods of ecDNA, discuss the vital role of ecDNA-caused tumor heterogeneity in cancers, and highlight the potential role of ecDNA in cancer therapy.

关键词： extrachromosomal DNA cancer therapy tumor heterogeneity drug resistance tumor evolution

Preparation and Performance of Ternary Early Strength Agent and Quercetin Composite Cement Sealing Material

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Journal of Wuhan University of Technology(Materials Science) 2025年第1期40卷 130-140页

作者： LIU jian chen Meiting ji Xiaoli XU Chao WANG Chunmei Department of Safety Science and Engineering Anhui University of Science and TechnologyHuainan 232001China Key Laboratory of Mine Safety and High Efficient Mining Jointly Built by Province and Education Ministry Anhui University of Science and TechnologyHuainan 232001China Department of Chemical Engineering and Explosives Anhui University of Science and TechnologyHuainan 232001China

A ternary early-strengthening agent consisting of calcium formate+triethanolamine+lithium sulfate was compounded with quercetin to shorten the setting time of cementitious materials while ensuring their early *** optimum ratio of the three early-strengthening agents was determined as 0.5%calcium formate+0.04%triethanolamine+0.4%lithium sulfate by response surface *** effects of the ternary early-strengthening agent composed of calcium formate+triethanolamine(TEA)+lithium sulfate on cementitious pore sealing materials under the synergistic effect of quercetin were studied by means of the performance tests of compressive strength,fluidity,and setting time,and the microstructural characterizations of X-ray powder diffractometer(XRD),thermogravimetry(TG-DSC)and scanning electron microscopy(SEM).The study shows that the synergistic effect of ternary early-strengthening agent and quercetin forms a multi-performance composite admixture for cementitious *** best performance was obtained with the compounding scheme of 0.5%calcium formate+0.04%triethanolamine+0.4%lithium sulfate ternary early-strengthening agent and 0.05%*** compressive strength of 1,3,7,and 28 d are 94.8%,39.8%,42%,and 28%higher than those of the blank group,*** initial time and final setting time are 41 and 57 minutes,*** to the microscopic analysis,the network and fibrous C-S-H gels generated by ternary early-strengthening agents are attached to the surface promoted by quercetin,which forms skeleton support while thickening and solidifying the cement slurry,which enhances the early compressive strength of the cement-based materials.

关键词： sealing material ternary early-strengthening agent quercetin synergetic effect response surface methodology

Modular assembly of Co4-thiacalix[4]arene units and Keggin-type SiW12O40 for visible-light photothermal conversion

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Tungsten 2025年第1期7卷 112-119页

作者： jia-Hui Li Qing Zhao Dong-Ao Mao kun Zhou Bao-Kuan chen Yan-Feng Bi School of Petrochemical Engineering Liaoning Petrochemical University

The construction of metal-organic coordination clusters（MCCs） using modular secondary building units is an important method for preparing functional *** this study,two new MCCs modularly assembled from Keggin-type {SiW12O40}H4TC4A=p-tert-Butylthiacalix[4]arene(SiW12) units and thiacalixarene-supported Co4-thiacalix[4]arene(Co4-TC4A polynuclear second-building units（PSBUs,H4TC4A=p-tert-Butylthiacalix[4]arene） are *** two MCCs,abbreviated as Co4-SiW12and Co8-SiW12,were structurally characterized by single-crystal X-ray *** Co4-SiW12is a supramolecular structure involving cation-anion interactions between Co4-TC4A PSBUs and ***8-SiW12features "barbell-like" shapes with two Co4-TC4A coordinatively linked to a Keggin-type SiW12unit on opposite via W-O_t-Co *** coordination of Co4-TC4A to SiW12in Co8-SiW12resulted in significantly improved photothermal conversion performances compared with Co4-SiW12and pure SiW12or ***-gap determination and photophysical analysis combined with density functional theory calculations indicated the binding mode between Co4-TC4A PSBUs and SiW12,which considerably influences the way of electron transport and the conversion ability of visible light to heat.

关键词： Modular construction Photothermal conversion Polyoxometalate Thiacalixarene