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Graft cholangiopathy: etiology, diagnosis, and therapeutic strategies

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Hepatobiliary & Pancreatic Diseases International 2014年第1期13卷 10-17页

作者： Ying Luo Wen-Bin ji Wei-dong Duan Sheng Ye jia-hong dong Department of Hepatobiliary Surgery Chinese PLA General Hospital

BACKGROUND: Graft cholangiopathy has been recognized as a significant cause of morbidity, graft loss, and even mortality in patients after orthotopic liver transplantation. The aim of this review is to analyze the etiology, pathogenesis, diagnosis and therapeutic strategies of graft cholangiopathy after liver transplantation. DATA SOURCE: A PubMed database search was performed to identify articles relevant to liver transplantation, biliary complications and cholangiopathy. RESULTS: Several risk factors for graft cholangiopathy after liver transplantation have been identified, including ischemia/ reperfusion injury, cytomegalovirus infection, immunological injury and bile salt toxicity. A number of strategies have been attempted to prevent the development of graft cholangiopathy, but their efficacy needs to be evaluated in large clinical studies. Non-surgical approaches may offer good results in patients with extrahepatic lesions. For most patients with complex hilar and intrahepatic biliary abnormalities, however, surgical repair or re-transplantation may be required. CONCLUSIONS: The pathogenesis of graft cholangiopathy after liver transplantation is multifactorial. In the future, more efforts should be devoted to the development of more effective preventative and therapeutic strategies against graft cholangiopathy.

关键词： liver transplantation bile ducts complications ischemia/reperfusion injury therapy

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化工基础物性数据库—实现与利用

计算机与应用化学 1985年第1期 23-33页

作者：杨冀宏董玲丁巨元杨道沅麻德贤北京化工学院

在系统分析和逻辑结构设计的基础上[1],建成了大型的、主要用于检索的化工基础物性数据库,并开发了为该库服务的利用系统。目前该库存储了3400余种纯物质的55种物性数据。该库的检索采用人机会话方式,具有灵活、直观、易于掌握等特点。

关键词：物性数据库物性估算关联式化工基础分类代码

Wavelet Analysis and Nonparametric Test for Climate Change in Tarim River Basin of Xinjiang During 1959-2006

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Chinese Geographical Science 2009年第4期19卷 306-313页

作者： XU jianhua CHEN Yaning LI Weihong ji Minhe dong Shan hong Yulian The Research Center for East-West Cooperation in China East China Normal University Shanghai 200062 China Key Laboratory of Geographic Information Science Ministry of Education Shanghai 200062 China Key Laboratory of Oasis Ecology and Desert Environment Xinjiang Institute of Ecology and Geography Chinese Academy of Sciences Urumqi 830011 China

Using wavelet analysis,regression analysis and the Mann-Kendall test,this paper analyzed time-series(1959-2006) weather data from 23 meteorological stations in an attempt to characterize the climate change in the Tarim River Basin of Xinjiang Uygur Autonomous Region,*** findings are as follows:1) In the 48-year study period,average annual temperature,annual precipitation and average annual relative humidity all presented nonlinear trends.2) At the 16-year time scale,all three climate indices unanimously showed a rather flat before 1964 and a detectable pickup *** the 8-year time scale,an S-shaped nonlinear and uprising trend was revealed with slight fluctuations in the entire process for all three ***,they all showed similar pattern of a slight increase before 1980 and a noticeable up-swing *** 4-year time scale provided a highly fluctuating pattern of periodical oscillations and spiral increases.3) Average annual relative humidity presented a negative correlation with average annual temperature and a positive correlation with annual precipitation at each time scale,which revealed a close dynamic relationship among them at the confidence level of 0.001.4) The Mann-Kendall test at the 0.05 confidence level demonstrated that the climate warming trend,as represented by the rising average annual temperature,was remarkable,but the climate wetting trend,as indicated by the rising annual precipitation and average annual relative humidity,was not obvious.

关键词： climate change nonlinear trend wavelet analysis Mann-Kendall test Tarim River Basin

Interaction of major facilitator superfamily domain containing 2A with the blood-brain barrier

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Neural Regeneration Research 2025年第8期20卷 2133-2152页

作者： Yilun Ma Taiwei dong Fei Luan Juanjuan Yang Feng Miao Peifeng Wei College of Pharmacy and First Clinical Medical College Shaanxi University of Chinese MedicineXianyangShaanxi ProvinceChina National Drug Clinical Trial Agency The Second Affiliated Hospital of Shaanxi University of Chinese Medicine/Xixian New District Central HospitalXi′anShaanxi ProvinceChina

The functional and structural integrity of the blood-brain barrier is crucial in maintaining homeostasis in the brain microenvironment;however,the molecular mechanisms underlying the formation and function of the blood-brain barrier remain poorly *** major facilitator superfamily domain containing 2A has been identified as a key regulator of blood-brain barrier *** plays a critical role in promoting and maintaining the formation and functional stability of the blood-brain barrier,in addition to the transport of lipids,such as docosahexaenoic acid,across the blood-brain ***,an increasing number of studies have suggested that major facilitator superfamily domain containing 2A is involved in the molecular mechanisms of blood-brain barrier dysfunction in a variety of neurological diseases;however,little is known regarding the mechanisms by which major facilitator superfamily domain containing 2A affects the blood-brain *** paper provides a comprehensive and systematic review of the close relationship between major facilitator superfamily domain containing 2A proteins and the blood-brain barrier,including their basic structures and functions,cross-linking between major facilitator superfamily domain containing 2A and the blood-brain barrier,and the in-depth studies on lipid transport and the regulation of blood-brain barrier *** comprehensive systematic review contributes to an in-depth understanding of the important role of major facilitator superfamily domain containing 2A proteins in maintaining the structure and function of the blood-brain barrier and the research progress to *** will not only help to elucidate the pathogenesis of neurological diseases,improve the accuracy of laboratory diagnosis,and optimize clinical treatment strategies,but it may also play an important role in prognostic *** addition,the effects of major facilitator superfamily domain containing 2A on blood-brain barrier lea

关键词： blood-brain barrier(BBB) caveolin-1 central nervous system docosahexaenoic acid endothelial cells lysophosphatidylcholine major facilitator superfamily domain containing 2A(MFSD2A) transcytosis

Force and impulse multi-sensor based on flexible gate dielectric field effect transistor

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 214-220页

作者： Chao Tan Junling Lü Chunchi Zhang dong Liang Lei Yang Zegao Wang College of Materials Science and Engineering Sichuan UniversityChengdu 610065China The 54th Research Institute of China Electronics Technology Group Corporation Shijiazhuang 050081China

Nowadays,force sensors play an important role in industrial production,electronic information,medical health,and many other ***-dimensional material-based filed effect transistor(2D-FET)sensors are competitive with nano-level size,lower power consumption,and accurate ***,few of them has the capability of impulse detection which is a path function,expressing the cumulative effect of the force on the particle over a period of *** we fabricated the flexible polymethyl methacrylate(PMMA)gate dielectric MoS_(2)-FET for force and impulse sensor *** systematically investigated the responses of the sensor to constant force and varying forces,and achieved the conversion factors of the drain current signals(I_(ds))to the detected impulse(I).The applied force was detected and recorded by I_(ds)with a low power consumption of~30 *** sensitivity of the device can reach~8000%and the 4×1 sensor array is able to detect and locate the normal force applied on ***,there was almost no performance loss for the device as left in the air for two months.

关键词： flexible gate dielectric transistor force sensor impulse sensor force sensor array

^(18)F-FDG-PET-CT引导胶质瘤三维适形放疗的研究

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中国现代医学杂志 2010年第8期20卷 1193-1196,1199页

作者：洪继东莫逸钟美佐申良方刘海峰杨振黄军韩再德潘孝智中南大学湘雅医院肿瘤科湖南长沙410008 湖南省肿瘤医院PET-CT中心湖南长沙410008 中南大学湘雅医院神经外科湖南长沙410008 中南大学湘雅医院放射科湖南长沙410008

目的探讨18F脱氧葡萄糖正电子发射断层扫描-计算机断层扫描(18F-FDG-PET-CT)在胶质瘤三维适形放疗中的应用价值。方法本院从2008年1月~2009年12月收治的20例胶质瘤病人,均行三维适形放疗,手术前后均行磁共振T1 WI平扫和增强扫描,T2 WI... 详细信息

目的探讨18F脱氧葡萄糖正电子发射断层扫描-计算机断层扫描(18F-FDG-PET-CT)在胶质瘤三维适形放疗中的应用价值。方法本院从2008年1月~2009年12月收治的20例胶质瘤病人,均行三维适形放疗,手术前后均行磁共振T1 WI平扫和增强扫描,T2 WI平扫扫描,术后行18F-FDG-PET脑显像,根据磁共振和18F-FDG-PET显示的病变范围勾画显在肿瘤区、临床肿瘤区及计划肿瘤区。计划肿瘤区DT:54～60Gy。结果放疗后3月复查磁共振,根据RECIST标准评价疗效,完全缓解率(CR):10.0%(2/20),部分缓解率(PR):35.0%(7/20),稳定(SD):40%(8/20),进展(PD):15%(3/20)。胶质瘤残灶标准摄取值(SUV)与对侧白质SUV值比值(RT/WM SUV)与病理分级呈显著正相关,r=0.770,P=0.001。结论 18F-FDG-PET脑显像对于胶质瘤三维适形放疗的靶区勾画具有一定的临床价值。

关键词： 18F-FDG-PET 胶质瘤三维适形放疗磁共振

Induced neural stem cells regulate microglial activation through Akt-mediated upregulation of CXCR4 and Crry in a mouse model of closed head injury

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Neural Regeneration Research 2025年第5期20卷 1416-1430页

作者： Mou Gao Qin dong Dan Zou Zhijun Yang Lili Guo Ruxiang Xu Department of Neurosurgery Sichuan Academy of Medical Sciences and Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Department of Neurosurgery Chinese PLA General HospitalBeijingChina Department of Neurology Fu Xing HospitalCapital Medical UniversityBeijingChina

Microglial activation that occurs rapidly after closed head injury may play important and complex roles in neuroinflammation-associated neuronal damage and *** previously reported that induced neural stem cells can modulate the behavior of activated microglia via CXCL12/CXCR4 signaling,influencing their activation such that they can promote neurological ***,the mechanism of CXCR4 upregulation in induced neural stem cells remains *** this study,we found that nuclear factor-κB activation induced by closed head injury mouse serum in microglia promoted CXCL12 and tumor necrosis factor-αexpression but suppressed insulin-like growth factor-1 ***,recombinant complement receptor 2-conjugated Crry(CR2-Crry)reduced the effects of closed head injury mouse serum-induced nuclear factor-κB activation in microglia and the levels of activated microglia,CXCL12,and tumor necrosis factor-α.Additionally,we observed that,in response to stimulation(including stimulation by CXCL12 secreted by activated microglia),CXCR4 and Crry levels can be upregulated in induced neural stem cells via the interplay among CXCL12/CXCR4,Crry,and Akt signaling to modulate microglial *** agreement with these in vitro experimental results,we found that Akt activation enhanced the immunoregulatory effects of induced neural stem cell grafts on microglial activation,leading to the promotion of neurological recovery via insulin-like growth factor-1 secretion and the neuroprotective effects of induced neural stem cell grafts through CXCR4 and Crry upregulation in the injured cortices of closed head injury ***,these beneficial effects of Akt activation in induced neural stem cells were positively correlated with the therapeutic effects of induced neural stem cells on neuronal injury,cerebral edema,and neurological disorders post–closed head *** conclusion,our findings reveal that Akt activation may enhance the immunoregulatory effects of induced neura

关键词： Akt signaling cerebral edema closed head injury Crry CXCR4 induced neural stem cell microglia neuroinflammation

Poles Extraction Based LiDAR Localization for Autonomous Robot Systems

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Journal of Systems Science & Complexity 2024年第4期37卷 1413-1424页

作者： hong Xin dong Yi College of Electronic and Information Engineering Tongji UniversityShanghai 201800China

With the development of intelligent technology,the problem of Li DAR-based localization has played an increasingly important role in the localization of robots in unmanned *** the dense point clouds from the environment requires a large amount of memory,specific and stable structural features,such as pole-like objects in the environment,can serve as the ideal landmarks for localization in unmanned systems,which can effectively reduce the memory usage and mitigate the effects of dynamic environment *** this paper,the authors propose a pole-like objects extraction approach and then,it is applied into the localization system of mobile *** the same experimental conditions,the proposed method can extract more pole-like objects and achieve better long-term localization accuracy than some existing methods in different urban environmental datasets.

关键词： Pole-like landmark extraction robot localization

Refractive index of ionic liquids under electric field:Methyl propyl imidazole iodide and several derivatives

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Chinese Physics B 2020年第4期29卷 477-487页

作者： ji Zhou Shi-Kui dong Zhi-hong He Yan-Hu Zhang Beijing Institute of Space Mechanics&Electricity Beijing 100094China School of Energy Science and Engineering Harbin Institute of TechnologyHarbin 150001China Advanced Manufacturing&Equipment Institute Jiangsu UniversityZhenjiang 212013China

Ionic liquids have received wide attention due to their novel optoelectronic structures and devices as an optical means of regulating ***,the quantitative testing and analysis of refractive index of ionic liquids under electric field are rarely carried *** the present study,an experimental apparatus including a hollow prism is designed to measure the refractive indices of ionic liquids under different electric *** groups of imidazole ionic liquids are experimentally investigated and an inversion is performed to determine the refractive indices under electric *** error propagation analysis of the apex angle and the minimum deflection angle are conducted,and the machining accuracy requirements of the hollow prism are *** results show that the refractive indices of imidazole ionic liquids change with the light wavelength,following a downward convex ***,the refractive index decreases with the carbon chain length of ionic liquid at a given wavelength,presenting an order of C3MImI>C4MImI>C5MImI>C3MImBr>***,the refractive index of imidazole ionic liquid exhibits a nonlinear change with the applied voltage at 546 nm and a monotonical decrease at 1529 ***,the variation of refractive index at 1529 nm with the applied voltage is larger than that at 546 nm and 1013 ***,the variation of refractive index is contrary to that of absorption coefficient under electric *** study illustrates that the theory of electrode and carrier transport can be used to explain the law of variation of n–k value of ionic liquid under the electric field,and provides the support for the evaluation of physical properties of ionic liquids,the measurement of optical functional parameters and the regulation of electric–optic performances of optical devices.

关键词： ionic liquid refractive index electro-optical property uncertainty propagation analysis