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Journal of Reproduction and Contraception 2013年第2期24卷 121-125页

作者： Pin-xiu HUANG ji-hong wei Li-hong wei Department of Reproductive Medicine Maternal and Child Health Care Hospital of Guangxi Liuzhou City

Pregnancies in the same side tube after the same side ovary ovulation are more common. We report an unusual case of contralateral tubal ectopic pregnancy after ovulation of another side ovary in spontaneous cycles. A 32-year-old woman underwent laparoscopic left fallopian tube conservative surgery because of left tubal pregnancy two years ago. She returned to our hospital with a positive pregnancy test and lower abdominal pain 28 d after the dominant follicle discharged in the right side ovary detected by transvaginal ultrasound in spontaneous cycles. Transvaginal ultrasonography revealed no intrauterine gestational sac but a left adnexal mass measuring 2.6 cm X2.5 cm. Videolaparoscopy was performed, and the diagnosis of an ectopic pregnancy in the let fallopian tube was confirmed by pathologic report. Tubal damage is the most important risk factor for tubal ectopic pregnancy. Embryos can be reversely migrated toward fallopian tubes, due to retrograde action of endometrial waves and uterine contractions, that is another necessary reason which contributes to such tubal pregnancy. Total salpingectomy or tubal sterilization is necessary for avoiding repeated tubal ectopic pregnancy.

关键词： ectopic pregnancy repeated ectopic pregnancy tubal pregnancy ovary

Mechanism of counterattack of colorectal cancer cell by Fas/Fas ligand system

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World Journal of Gastroenterology 2005年第39期11卷 6125-6129页

作者： Qiang Zhu ji-Yong Liu hong-wei Xu Chong-Mei Yang An-Zhong Zhang Yi Cui hong-Bo Wang Department of Gastroenterology Shandong Provincial Hospital Jing 5 Wei 7 Road 324# Jinan 250021 Shandong Province China

AIM： To determine the role of Fas/Fas ligand （FasL） in the immune escape of colon cancer cells. METHODS： Immunohistochemistry was used to observe the expression of Fas and FasL in the tissues of colon cancer patients. In situ hybridization was used to detect the localization of FasL mRNA expression in cancer tissues. Terminal deoxynucleotide transferase-mediated dUTP nick end labeling （TUNEL） assay and CD45 staining were performed to detect the apoptosis of tumor-infiltrating lymphocytes （TILs）. Co-culture assays of colon cancer cells （SW480） and Jurkat cells （Fas-sensitive cells） were performed to observe the counterattack of colon cancer cells to lymphocytes. RESULTS： Of 53 cases of colon carcinomas, 23 cases （43.4%） expressed Fas which was significantly lower as compared to the normal colonic mucosa （73.3%, P〈0.01）, and 45 cases （84.9%） of colon carcinomas expressed FasL, whereas only two cases （3.75%） in normal mucosa expressed FasL. FasL expression in the colon cancer cells was found to be associated with increased cell death of TIEs. The apoptotic rate of TIL in the FasL-positive staining regions of tumor cells was significantly higher than that in the FasL-negative staining region （54.84±2.79% vs 25.73±1.98%, P〈0.01）. The co-culture of SW480 cells and Jurkat cells confirmed the function of FasL on the SW480 cells. The apoptotic rates of Jurkat cells were found to be related with the amount of SW480 cells. CONCLUSION： Colon cancer cells can escape the immune surveillance and killing via decreasing Fas expression, and can counterattack the immune system via increasing FasL expression. Fas/FasL can serve as potential targets for effective antitumor therapy.

关键词： Colon neoplasm Fas system Immune counterattack

Highly metabolic thrombus of the portal vein:^(18)F fluorodeoxyglucose positron emission tomography/computer tomography demonstration and clinical significance in hepatocellular carcinoma

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World Journal of Gastroenterology 2008年第8期14卷 1212-1217页

作者： Long Sun Yong-Song Guan wei-Ming Pan Gui-Bing Chen Zuo-Ming Luo ji-hong wei Hua Wu Minnan PET: Center The First Hospitalof Xiamen Fujian Medical University Xiamen 316003 FujianProvince China West China Hospital of Sichuan University Chengdu China 610041 State Key Laboratory of Biotherapy West China Medical School Sichuan University Gaopeng StreetKeyuan Road 4 Chengdu 610041 Sichuan Province China

AIM： To assess the ability of ^18F-fluorodeoxyglucose positron emission tomography/computer tomography （^18F-FDG PET/CT） to differentiate between benign and malignant portal vein thrombosis in hepatocellular carcinoma （HCC） patients.METHODS： Five consecutive patients who had HBV cirrhosis, biopsy-proven HCC, and thrombosis of the main portal vein and/or left/right portal vein on ultrasound （US）, computer tomography （CT） or magnetic resonance imaging （MRI） were studied with ^18F-FDG PET/CT. The presence or absence of a highly metabolic thrombus on ^18F-FDG PET/CT was considered diagnostic for malignant or benign portal vein thrombosis, respectively. All patients were followed-up monthly with US, CT or MRI. Shrinkage of the thrombus or recanalization of the vessels on US, CT or MRI during follow-up was considered to be definitive evidence of the benign nature of the thrombosis, whereas enlargement of the thrombus, disruption of the vessel wall, and parenchymal infiltration over follow-up were considered to be consistent with malignancy. ^18SF-FDG PET/CT, and US, CT or MRI results were compared.RESULTS： Follow-up （1 to 10 mo） showed signs of malignant thrombosis in 4 of the 5 patients. US, CT or MRI produced a true-positive result for malignancy in 4 of the patients, and a false-positive result in 1. ^18F-FDG PET/CT showed a highly metabolic thrombus in 4 of the 5 patients. ^18F-FDG PET/CT achieved a true-positive result in all 4 of these patients, and a true-negative result in the other patient. No false-positive result was observed using ^18F-FDG PET/CT.CONCLUSION： ^18F-FDG PET/CT may be helpful in discriminating between benign and malignant portal vein thrombi. Patients may benefit from ^18F-FDG PET/CT when portal vein thrombi can not be diagnosed exactly by US, CT or MRI.

关键词： ^ 18F-fluorodeoxyglucose Positron emission tomography/computer tomography Hepatocellular carcinoma Portal vein tumor thrombus Portal vein blood thrombus

Clinical role of (18)~F-fluorodeoxyglucose positron emission tomography/computed tomography in post-operative follow up of gastric cancer: Initial results

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World Journal of Gastroenterology 2008年第29期14卷 4627-4632页

作者： Long Sun Xin-Hui Su Yong-Song Guan wei-Ming Pan Zuo-Ming Luo ji-hong wei Hua Wu Minnan PET Center and department of nuclear medicine the First Hospital of Xiamen Fujian Medical UniversiW Xiamen 316003 Fuiian Province China State Key Laboratory of Biotherapy West China Medical School Sichuan University Gaopeng Street Keyuan Road 4 Chengdu 610041 Sichuan Province China

AIM: To evaluate the clinical role of 18F-fluorodeo-xyglucose positron emission and computed tomography (18F-FDG PET/CT) in detection of gastric cancer recurrence after initial surgical resection. METHODS: In the period from January 2007 to May 2008, 23 patients who had previous surgical resection of histopathologically diagnosed gastric cancer underwent a total of 25 18F-FDG PET/CT scans as follow-up visits in our center. The standard of reference for tumor recurrence consisted of histopathologic confirmation or clinical follow-up information for at least 5 mo after PET/CT examinations. RESULTS: PET/CT was positive in 14 patients (61%) and negative in 9 (39%). When correlated with final diagnosis, which was confirmed by histopathologic evidence of tumor recurrence in 8 of the 23 patients (35%) and by clinical follow-up in 15 (65%), PET/CT was true positive in 12 patients, false positive in 2, true negative in 8 and false negative in 2. Overall, the accuracy of PET/CT was 82.6%, the negative predictive value (NPV) was 77.7%, and the positive predictive value (PPV) was 85.7%. The 2 false positive PET/CT findings were actually chronic inflammatory tissue lesions. For the two patients with false negativePET/CT, the f inal diagnosis was recurrence of mucinous adenocarcinoma in the anastomosis in one patient and abdominal wall metastasis in the other. Importantly, PET/CT revealed true-positive findings in 11 (47.8%) patients who had negative or no definite findings by CT. PET/CT revealed extra-abdominal metastases in 7 patients and additional esophageal carcinoma in one patient. Clinical treatment decisions were changed in 7 (30.4%) patients after introducing PET/CT into their conventional post-operative follow-up program. CONCLUSION: Whole body 18F-FDG PET/CT was highly effective in discriminating true recurrence in post-operative patients with gastric cancer and had important impacts on clinical decisions in a considerable portion of patients.

关键词： 18F-fluorodeoxyglucose Positron emissiontomography/computed tomography Gastric cancer Follow-up Recurrence

Clinical usefulness of ^(18) F-FDG PET/CT in the restaging of esophageal cancer after surgical resection and radiotherapy

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World Journal of Gastroenterology 2009年第15期15卷 1836-1842页

作者： Long Sun Xin-Hui Su Yong-Song Guan wei-Ming Pan Zuo-Ming Luo ji-hong wei Long Zhao Hua Wu Minnan PET Center andDepartment of Nuclear Medicine the First Hospital ofXiamenFujian Medical University Xiamen 316003 Fujian ProvinceChina State Key Laboratory of Biotherapy West China Medical School Sichuan University Gaopeng StreetKeyuan Road 4 Chengdu 610041 Sichuan Province China

AIM： To evaluate the clinical usefulness of lSF-fluorodeoxyglucose positron emission and computed tomography QSF-FDG PET/CT） in restaging of esophageal cancer after surgical resection and radiotherapy. METHODS： Between January 2007 and Aug 2008, twenty histopathologically diagnosed esophageal cancer patients underwent 25 PET/CT scans （three patients had two scans and one patient had three scans） for restaging after surgical resection and radiotherapy. The standard reference for tumor recurrence was histopathologic confirmation or clinical follow-up for at least ten months after ^18F-FDG PET/CT examinations. RESULTS： Tumor recurrence was confirmed histopathologically in seven of the 20 patients （35%） and by clinical and radiological follow-up in 13 （65%）. ^18F-FDG PET/CT was positive in 14 patients （68.4%） and negative in six （31.6%）. ^18F-FDG PET/CT was true positive in 11 patients, false positive in three and true negative in six. Overall, the accuracy of ^18F-FDG PET/CT was 85%, negative predictive value （NPV） was 100%, and positive predictive value （PPV） was 78.6%.The three false positive PET/CT findings comprised chronic inflammation of mediastinal lymph nodes （n = 2） and anastomosis inflammation （n = 1）. PET/ CT demonstrated distant metastasis in 10 patients. ^18F-FDG PET/CT imaging-guided salvage treatment in nine patients was performed. Treatment regimens were changed in 12 （60%） patients after introducing ^18F-FDG PET/CT into their conventional post-treatment follow-up program. CONCLUSION： Whole body ^18F-FDG PET/CT is effective in detecting relapse of esophageal cancer after surgical resection and radiotherapy. It could also have important clinical impact on the management of esophageal cancer, influencing both clinical restaging and salvage treatment of patients.

关键词： ^18F-fluorodeoxyglucose Positron emissiontomography/computed tomography Esophagealcancer Surgical resection Radiotherapy radiation Restaging

Influence of drug treatment on glucocorticoid receptor levels in patients with coronary heart disease

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Chinese Medical Journal 2010年第13期123卷 1685-1689页

作者： ji hong GUO wei-zao YAN Zhi-hong LI Di LU Cui-lian Department of Gereology Peking University Aerospace Medical College Beijing 100049 China

Background Glucocorticoid signaling exerts major roles in inflammation, metabolism and depression, which are three crucial factors accompanying or underlying coronary heart disease. Although accumulating evidence indicates the influence of glucocorticoids on the pathology and treatment of coronary heart disease, there is still a dearth of pharmaceutical mechanisms for this relationship. This study aimed to investigate the influence of drug treatment on glucocorticoid receptor levels in coronary heart disease. Methods Eighty hospitalized patients （average age （59.0＋7.5） years, 46 male and 34 female） with coronary heart disease were categorized into four groups with 20 members in each according to one of the four drugs they were treated with. The four drugs were： nitrated derivative isosorbide dinitrate, the beta-adrenergic receptor blocker metoprolol, the calcium antagonist nifedipine, and the HMG-CoA reductase inhibitor Iovastatin. Glucocorticoid receptor protein levels of peripheral blood lymphocytes were tested using immunoblotting analysis before and after one month of treatment. Results Immunoblotting analysis showed increased glucocorticoid receptor levels after treatment with metoprolol and nifedipine. There were no statistically significant changes of glucocorticoid receptor levels after treatment with isosorbide dinitrate or Iovastatin, although there were trends of up-regulation of glucocorticoid receptor expression after both treatments. Conclusions Both the beta-blocker and the calcium blocker can increase glucocorticoid receptor levels after chronic administration. This effect suggests a mechanism for their anti-inflammatory and other therapeutic roles for coronary heart disease and comorbid disorders.

关键词： glucocorticoid receptor coronary heart disease beta-adrenergic receptor blocker calcium antagonist

Multi-agent-based Approach for Determination of Time-quota in Integrated Environment

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厦门大学学报（自然科学版） 2002年第S1期41卷 156-157页

作者： LI Shu-juan, LI Yan, ZHENG jian-ming, XIAO ji-ming, hong wei (The Mechanical and Instrument Engineering School, Xi’an University of Technology, Xi’an 710048, China)

Time-quota is one of important factors in producti on system. It is affected by various factors. time-quota is studied in CAPP and p roduction schedule integration environment in this paper. An agent-based time- quota method is put forward and the structure model is established by means of i ntelligent agent in integrated environment. The method can map the influencing t ime-quota factors into part agent related to process state and machine method a gent, resorting to the function of agent rule-based reasoning, the agents can t ransform these factors into data mode that artificial neural network (ANN) can a ccept and recognize. As a tool, ANN agent can calculate time-quota quickly. A b lackboard method is used as the means of communication and collaborative control between agents. The experiments show that precise process time-quota can be obtained rapidly with proper samples selected, continuous self-study and self -organization in system, and multi-agent approach is an effective method for d etermination of time-quota.

关键词： multi-agent artificial neural network (ANN) ti me-quota integrated environment

基于高速图像测量技术的缓冲材料缓冲性能的表征

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振动与冲击 2011年第9期30卷 216-220页

作者：计宏伟王怀文天津商业大学包装工程系天津300134

有效表征缓冲材料的缓冲特性对于优化设计缓冲包装十分重要。采用动态缓冲系数表征材料的缓冲性能是一种非常有效方法。基于动态压缩实验和高速图像测量技术,测量了发泡聚乙烯缓冲材料冲击过程中的动态应力-应变曲线,由此得到不同应力... 详细信息

有效表征缓冲材料的缓冲特性对于优化设计缓冲包装十分重要。采用动态缓冲系数表征材料的缓冲性能是一种非常有效方法。基于动态压缩实验和高速图像测量技术,测量了发泡聚乙烯缓冲材料冲击过程中的动态应力-应变曲线,由此得到不同应力水平情况下单位体积的动态变形能和动态缓冲系数,从而直接表征了泡沫材料的动态缓冲性能,为缓冲包装设计提供了重要的基础数据。

关键词：缓冲性能动态压缩动态缓冲系数图像测量

一类非线性三阶微分方程边值问题多个解的存在性

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西南师范大学学报（自然科学版） 2020年第5期45卷 51-57页

作者：纪宏伟南通师范高等专科学校数学与科学教育系江苏南通226006

利用不动点指数理论和拓扑度理论研究非线性三阶微分方程边值问题{-u^m(t)=f(t,u(t)),t∈[0,1]u(0)=u′(0)=u′(1)=0}解的存在性,通过计算相应的线性问题的特征值与代数重数,获得了2个正解、2个负解及2个变号解的存在性结果.如果非线性... 详细信息

利用不动点指数理论和拓扑度理论研究非线性三阶微分方程边值问题{-u^m(t)=f(t,u(t)),t∈[0,1]u(0)=u′(0)=u′(1)=0}解的存在性,通过计算相应的线性问题的特征值与代数重数,获得了2个正解、2个负解及2个变号解的存在性结果.如果非线性项是奇函数,则所述问题至少存在2个正解、2个负解及4个变号解.

关键词：三阶微分方程边值问题变号解不动点指数 Leray-Schauder度

非线性Sturm-Liouville边值问题的变号解

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西南师范大学学报（自然科学版） 2018年第5期43卷 17-22页

作者：纪宏伟南通师范高等专科学校数理系江苏南通226010

讨论了Sturm-Liouville两点边值问题Lφ=fφ,0≤x≤1αφ(0)-βφ′(0)=0,γφ(1)+δφ′(1)=0变号解的存在性,并由此研究了Hammerstein型积分方程变号解更一般的情况,得出具有普遍性的结果,改进了之前工作.

关键词： Sturm-Liouville两点边值问题变号解 Hammerstein积分方程