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Herb-partitioned moxibustion alleviates colon injuries in ulcerative colitis rats

World Journal of Gastroenterology 2018年第30期24卷 3384-3397页

作者： Dan Zhang Yan-Bo Ren Kai Wei Jue Hong Yan-Ting Yang Li-jie Wu ji Zhang Zheng shi Huan-Gan Wu Xiao-Peng Ma Laboratory of Acupuncture-moxibustion and Immunology Shanghai Research Institute of Acupuncture and MeridianShanghai University of Traditional Chinese Medicine Department of Integrated Traditional Chinese Medicine and Western Medicine North Branch of Huashan HospitalFudan University Key Laboratory of Systems Biomedicine (Ministry of Education) Shanghai Center for Systems BiomedicineShanghai Jiao Tong University Yueyang Clinical Medicine School Shanghai University of Traditional Chinese Medicine

AIM To observe the effect of herb-partitioned moxibustion(HPM) on expression of colonic cytokines in ulcerative colitis(UC) *** A UC rat model was established by protein immunization in combination with topical chemical *** in the HPM group(n = 8) received HPM at bilateral Tianshu(ST25) *** gross injury and pathological scores of the colon were *** expression profile of colonic cytokines was assayed using the protein microarray *** differential cytokines were selected and verified by *** corresponding Uni Prot Accessions of the differentially expressed cytokines were retrieved in the Uni Prot *** pathways involved were analyzed with the help of the KEGG PATHWAY *** DAVID database was used for functional cluster and pathway *** HPM improved colon injuries in UC rats,manifested by accelerated repair of ulcers and alleviation of inflammation,and the gross injury and pathological scores both significantly decreased(P 1.3 or < 0.77 was taken as the screening *** were 77 down-regulated and 9 up-regulated differentially expressed colonic cytokines in the HPM group compared with the model group,and expression of 20 differed significantly(P < 0.05).Twelve of the 20 significantly differentially expressed cytokines [β-catenin,interleukin-1 receptor 6(IL-1 R6),IL-1β,B7-1,nerve growth factor receptor,AMP-activated protein kinase-α1,neuropilin-2,orexin A,adipocyte differentiation-related protein,IL-2,Fas and Fas L] were up-regulated in the model group(n = 3,compared with the normal group) but downregulated in the HPM group(n = 3,compared with the model group).Functional cluster analysis showed that the differentially expressed colonic cytokines in the HPM group regulated apoptosis and protein *** pathway analysis showed that 52 down-regulated and 7 up-regulated differentially expressed colonic cytokines in the HPM group had *** pathw

关键词： Cytokine expression profile Ulcerative colitis Protein microarray Rats Herb-partitioned moxibustion

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Exploring differentially expressed genes associated with fertility instability of S-type cytoplasmic male-sterility in maize by RNA-seq

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Journal of Integrative Agriculture 2017年第8期16卷 1689-1699页

作者： SU Ai-guo SONG Wei shi Zi Zhao Yan-xin XING jin-feng ZHANG Ru-yang LI Chun-hui LUO Mei-jie WANG ji-dong Zhao jiu-ran Maize Research Center Beijing Academy of Agriculture and Forestry Sciences/Beijing Key Laboratory of Maize DNA Fingerprinting and Molecular BreedingBeijing 100097P.R.China

The germplasm resources for the S-type male sterility is rich in maize and it is resistant to Bipolaris maydis race T and CI, but the commercial application of S-type cytoplasmic male sterility （CMS-S） in maize hybrid industry is greatly compromised because of its common fertility instability. Currently, the existence of multiple minor effect loci in specific nuclear genetic backgrounds was considered as the molecular mechanism for this phenomenon. In the present study, we evaluated the fertility segregation of the different populations with the fertility instable material FIL-H in two environments of Beijing and Hainan, China. Our results indicated that the fertility instability of FIL-H was regulated by multiple genes, and the expression of these genes was sensitive to environmental factors. Using RNA sequencing （RNA-seq） technology, transcriptomes of the sterile plants and partially fertile plants resulted from the backcross of FIL-Hxjing 724 in Hainan were analyzed and 2 108 genes with different expression were identified, including 1 951 up-regulated and 157 down-regulated genes. The cluster analysis indicated that these differentially expressed genes （DEGs） might play roles in many biological processes, such as the energy production and conversion, carbohydrate metabolism and signal transduction. In addition, the path- way of the starch and sucrose metabolism was emphatically investigated to reveal the DEGs during the process of starch biosynthesis between sterile and partially fertile plants, which were related to the key catalytic enzymes, such as ADP-G pyrophosphorylase, starch synthase and starch branching enzyme. The up-regulation of these genes in the partially fertile plant may promote the starch accumulation in its pollen. Our data provide the important theoretical basis for the further exploration of the molecular mechanism for the fertility instability in CMS-S maize.

关键词： CMS-S fertility instability RNA-seq DEGs

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基于医疗保健生态学模型的人群医疗照护行为及慢性病共病状况研究

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现代预防医学 2024年第8期51卷 1460-1466页

作者：张峥岩张伋陈玉倩尹学珺赵艺皓王振中王捷谭方琴宫恩莹邵瑞太中国医学科学院北京协和医学院群医学及公共卫生学院上海政法学院经济管理学院上海市卫生和健康发展研究中心(上海市医学科学技术情报研究所)卫生政策研究部

目的应用医疗保健生态学模型描述人群医疗照护行为情况，分析共病与各类型医疗照护行为的关联，为合理配置医疗保健资源提供理论证据。方法 2023年7—9月间，采用多阶段分层抽样，纳入来自北京市房山区和江西省婺源县20岁及以上的居民... 详细信息

目的应用医疗保健生态学模型描述人群医疗照护行为情况，分析共病与各类型医疗照护行为的关联，为合理配置医疗保健资源提供理论证据。方法 2023年7—9月间，采用多阶段分层抽样，纳入来自北京市房山区和江西省婺源县20岁及以上的居民开展横断面调查。基于医疗保健生态模型开展描述性分析，计算以每千人月为单位医疗照护行为情况，绘制医疗保健生态图。采用多因素logistic回归分析探讨共病与医疗照护行为的关系。结果研究回收了来自6 004名调查对象的有效问卷(女性：56.4%,平均年龄50.4±14.7岁)。平均每月每千人，约有382人报告有不适症状或外伤、162人有医疗机构门诊就诊行为(61人在基层医疗机构就诊、47人在三级医院门诊就诊)、62人自行用药、10人住院、5人急诊就诊、4人接受手术治疗、1人接受远程诊疗。约31.9%的调查对象自报患有共病，其寻求医疗照护的比例相较于未患病和患单病人群更高。多因素logistic回归分析结果显示，与无慢性病的个体相比，患有一种慢性病或多种疾病的患者就诊的可能性更高[(OR=1.67,95%CI:1.38～2.02)和(OR=3.40,95%CI:2.83～4.08)],其住院可能性也相应更高[(OR=2.60,95%CI:2.04～3.32)和(OR=5.17,95%CI:4.10～6.51)]。结论在有潜在健康照护需求的人群中，仅有不到一半的人群有就诊行为，其中患有慢性病共病人群寻求医疗照护的比例更高。需开展群医学领域研究，加强各层级机构对共病人群的协同及有效健康照护，从而减少未满足的健康需求。

关键词：医疗保健生态学模型慢性病共病群医学就医行为初级卫生保健

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Triboelectric nanogenerators for human-health care

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Science Bulletin 2021年第5期66卷 490-511,M0004页

作者： hao Wang jia Cheng Zhaozheng Wang Linhong ji Zhong Lin Wang State Key Laboratory of Tribology Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 100083China School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332-0245USA

Since the world’s first triboelectric nanogenerator(TENG) was proposed in 2012, numerous TENG-based devices and equipment have sprung up in various fields. In particular, TENG has great potential in the field of human-health care due to its small size, self-powered and low cost. With the continuous deepening of TENG research, its structure, function and technical concept are becoming more and more abundant. In order to summarize the progress and development status of TENG in health care, based on the different types of applications subdirection, this paper reviews the TENG-based research work of this field in recent eight years. The characteristics of various types of TENG-based applications and their corresponding technologies are introduced and analyzed, under the comparison of their structure and performance. This review is dedicated to provide reference and inspiration for the future development and innovation of TENG for health care.

关键词： Triboelectric nanogenerator Medical Health care Self-powered

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Sp1 contributes to overexpression of stanniocalcin 2 through regulation of promoter activity in colon adenocarcinoma

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World Journal of Gastroenterology 2019年第22期25卷 2776-2787页

作者： ji-Bin Li Zhe-Xian Liu Rui Zhang Si-Ping Ma Tao Lin Yan-Xi Li shi-Hua Yang Wan-Chuan Zhang Yong-Peng Wang Department of Colorectal Surgery Cancer Hospital of China Medical University Liaoning Cancer Hospital & Institute

BACKGROUND Aberrant expression of stanniocalcin 2 (STC2) is implicated in colon adenocarcinoma (COAD). A previous study identified that STC2 functions as a tumor promoter to drive development of some cancers, but the role of its overexpression in the development of COAD remains unclear. AIM To evaluate the regulation mechanism of STC2 overexpression in COAD. METHODS The expression of STC2 in COAD was assessed by TCGA COAD database and GEO (GSE50760). Methylation level of the STC2 promoter was evaluated with beta value in UALCAN platform, and the correlation between STC2 expression and survival rate was investigated with TCGA COAD. Transcription binding site prediction was conducted by TRANSFAC and LASAGNA, and a luciferase reporter system was used to identify STC2 promoter activity in several cell lines, including HEK293T, NCM460, HT29, SW480, and HCT116. Western blotting was performed to evaluate the role of Sp1 on the expression of STC2. RESULTS The central finding of this work is that STC2 is overexpressed in COAD tissues and positively correlated with poor prognosis. Importantly, the binding site of the transcription factor Sp1 is widely located in the promoter region of STC2. A luciferase reporter system was successfully constructed to analyze the transcription activity of STC2, and knocking down the expression of Sp1 significantly inhibited the transcription activity of STC2. Furthermore, inhibition of Sp1 remarkably decreased protein levels of STC2. CONCLUSION Our data provide evidence that the transcription factor Sp1 is essential for the overexpression of STC2 in COAD through activation of promoter activity. Taken together, our finding provides new insights into the mechanism of oncogenic function of COAD by STC2.

关键词： Transcription factor Sp1 Stanniocalcin 2 Overexpression Promoter activity Colon adenocarcinoma

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Biologic therapy for Crohn’s disease over the last 3 decades

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World Journal of Clinical Cases 2022年第2期10卷 594-606页

作者： ji-Liang Shen Zheng Zhou jia-Sheng Cao Bin Zhang jia-hao Hu jia-Ying Li Xiao-Ming Liu Sarun Juengpanich Ming-Song Li Xu Feng Department of General Surgery Sir Run-Run Shaw HospitalZhejiang University School of MedicineHangzhou 310016Zhejiang ProvinceChina Department of Gastroenterology Nan Fang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Gastroenterology Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Despite the overload of publications on Crohn’s disease(CD),no comprehensive analysis of biologic therapy for CD has been *** To determine knowledge gaps and identify areas of interest of biologic therapy for *** The top 100 highest-cited original articles were identified from January 1991 to December 2020 in the Clarivate Analytics Web of Science Core Collection *** conducted a bibliometric analysis of biologic therapy for CD based on total citations,summarized the bibliographic information of the articles related to CD biologic therapy,and explored the research *** The top 100 highest-cited original articles were identified with total citations ranging from 307 to *** 2000s(Period II,n=66)yielded the most influential original articles and saw the most dramatic *** the top 10 countries,including 8 European countries and 2 North American countries,the United States(n=37)and Belgium(n=20)contributed the most *** the top 10 institutions,the University Hospital Gasthuisberg in Belgium(n=23),the University of Chicago in the United States(n=20),and the Mayo Clinic in the United States(n=17)published the most *** authors,Rutgeerts P in Belgium(n=32),Sandborn WJ in the United States(n=23),and Feagan BG in Canada(n=18)published the highest number of *** cooperation relationships between the United States and Europe were most ***(impact factor=22.682)published the most articles on biologic therapy for CD(n=32)with 17654 total ***-tumor necrosis factor biologics and monoclonal antibodies were the most studied *** The bibliometric analysis emphasized the key contributions to the development of the specialized *** data would provide useful research insights into biologic therapy for CD for clinicians and researchers.

关键词： Biologic therapy Crohn’s disease Bibliometric analysis Most influential Insight

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区域协调发展中县(市)域发展规划的实践与启示——论陈烈的县域发展规划的实践特点

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经济地理 2007年第2期27卷 275-278,284页

作者：王世豪广东外语外贸大学区域与城市经济研究所中山大学城市与区域规划系中国广东广州510275

对陈烈的县域发展规划的实践特点作了归纳总结。同时认为,县(市)域发展规划是解决区域发展问题的重要切入点,有利于促进区域内及区域之间的协调发展。县(市)域发展规划的核心是调控人地关系,实现县域可持续发展。县(市)域发展规划论证... 详细信息

对陈烈的县域发展规划的实践特点作了归纳总结。同时认为,县(市)域发展规划是解决区域发展问题的重要切入点,有利于促进区域内及区域之间的协调发展。县(市)域发展规划的核心是调控人地关系,实现县域可持续发展。县(市)域发展规划论证了“人地关系地域系统”理论的实践价值;使区域发展理论的应用价值得到提高。

关键词：县(市)域规划区域协调发展可持续发展人地关系

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溴化锂溶液竖管内降膜蒸发传热性能分析

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重庆大学学报（自然科学版） 2010年第9期33卷 113-118页

作者：石程名王洋宫世吉重庆大学动力工程学院重庆400044 济南钢铁公司山东济南250101

为了直接高效利用低温烟气余热驱动制冷,对不同热流密度、不同浓度溴化锂水溶液竖管内层流降膜蒸发的传热性能进行了实验研究。结果表明,降膜传热系数随溶液进口浓度升高而减小,随热流密度增加而显著增大。对实验数据进行多元线性回归计... 详细信息

为了直接高效利用低温烟气余热驱动制冷,对不同热流密度、不同浓度溴化锂水溶液竖管内层流降膜蒸发的传热性能进行了实验研究。结果表明,降膜传热系数随溶液进口浓度升高而减小,随热流密度增加而显著增大。对实验数据进行多元线性回归计算,得到实验范围内降膜传热系数关联式。用该关联式设计降膜蒸发传热的降膜式发生器,并对相同传热量的沉浸式发生器进行设计,性能对比表明,降膜式发生器在传热系数、换热组件重量和体积上有十分显著的优势。

关键词：溴化锂溶液降膜蒸发传热系数关联式

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The dopamine receptor D4 regulates the proliferation of pulmonary arteries smooth muscle in broilers by downregulating AT1R

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Animal Diseases 2021年第2期1卷 95-107页

作者： Xiaoqi Yang Yang Fu Lianfeng Wu Antong Li Luyao ji hao Li Yuxuan Peng jiabin Zhang Donghai Zhou Huiping Zhou Veterinary Clinical Medicine Laboratory College of Veterinary MedicineHuazhong Agricultural UniversityShizishan StreetWuhanCA 0070People's Republic of China School of Basic Medical Hubei University of Science&TechnologyWuhan 0070People's Republic of China School of Basic Medical Hubei University of Science&TechnologyXianning 7100HubeiPeople's Republic of China

The major cause of pulmonary vascular remodeling in broilers is abnormal proliferation of vascular smooth muscle cells(VSMCs),and one of the main causes of pulmonary hypertension syndrome(PHS)in broilers is pulmonary artery vascular *** Arbor Acres(AA)broilers were randomly divided into four groups(n=10):a control group(deionized water,Og/L NaCl),a freshwater group(FW,deionized water+1 g/L NaCl),highly salinized freshwater group 1(H-SFW-1,deionized water+2.5 g/L NaCl)and highly salinized freshwater group 2(H-SFW-2,deionized water+5 g/L NaCl).The results of in vivo experiments showed that vascular smooth muscle of the broilers could be significantly proliferated by intake of high-salinity fresh water(H-SFW-1&H-SFW-2),which significantly increased the content of angiotensin II(Ang II)and the expression of angiotensin II type 1(AT1)receptor ***,it significantly decreased the expression of dopamine receptor D4(DRD4)*** results of in vitro experiments showed that exogenous Ang II induced the proliferation of primary VSMCs in broilers,which could be significantly inhibited by DRD4 agonists(D4A,HY-101384A)and enhanced by DRD4 inhibitors(D4I;HY-B0965).In addition,the results of immunoblotting and fluorescence quantitative PCR showed that AT1 receptors could be negatively regulated by DRD4 in VSMCs of broilers,either at the transcriptional or translational *** the same time,the expression of AT1 receptor could be increased by DRD4 inhibition by D4I and decreased by DRD4 activation by *** negative regulatory effect of DRD4 on AT1 receptor occurred in a dose-dependent *** results indicate that long-term intake of highly salinized fresh water can cause PHS in broilers,accompanied by varying degrees of proliferation of pulmonary artery smooth *** mechanism may involve response of its receptor being induced by increased Ang II,while DRD4 can negatively regulate it.

关键词： AT1 receptors Dopamine receptor D4 PHS Vascular smooth muscle AngiotensinⅡ

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Sedimentary environment and model for lacustrine organic matter enrichment:lacustrine shale of the Early Jurassic Da’anzhai Formation,central Sichuan Basin,China

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Journal of Palaeogeography 2021年第4期10卷 584-601页

作者： Zheng-Lu Xiao shi-jia Chen Shao-Ming Zhang Rui Zhang Zhi-Yong Zhu Jun-Gang Lu Yong Li Xiang-Dong Yin Long-Xiang Tang Zhang-hao Liu Zong-Hui Lin State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Chengdu 610500China School of Geoscience and Technology Southwest Petroleum UniversityChengdu 610500China PetroChina Southwest Oil&Gas Field Company Chengdu 610051China Xi'an Branch of PetroChina Materials Co. Ltd Xi'an 710000China State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing 102249China

Based on the analysis of element geochemistry and total organic carbon(TOC),this study investigates the main factors controlling organic matter(OM)enrichment,reconstructs the evolution process of the sedimentary environment,and proposes a dynamic OM enrichment model of the Jurassic Da’anzhai(D)Formation,Sichuan *** results indicate that the Sichuan Basin was generally dominated by a warm and oxidizing sedimentary environment,but with some peculiarities,such as a hotter climate in the D1 member and more anoxic lake water in the D2a *** sedimentary evolution of the Da’anzhai Formation can be divided into a fluctuating sedimentary stage,a stable sedimentary stage and a reef-building *** D2a member showed the strongest hypoxia,the weakest weathering,the largest amount of terrestrial inputs,and the highest TOC *** TOC is positively correlated with reducing conditions and terrestrial inputs,negatively correlated with *** on these findings,it is suggested that the global climate in the Early Jurassic period had a complex regional effect and the global oceanic anoxic events of the Toarcian did not spread to the Sichuan ***,the anoxic deep water,high terrestrial inputs,and weak weathering were conducive to rapid deposition and preservation of lacustrine OM.

关键词： Lacustrine shale Early Jurassic Toarcian Organic matter enrichment model Da’anzhai Formation Sichuan Basin

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