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Real-world cost-effectiveness associated with infliximab maintenance therapy for moderate to severe Crohn's disease in China

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World Journal of Gastroenterology 2020年第41期26卷 6455-6474页

作者： ji-hao shi Liang Luo Xiao-Li Chen Yi-Peng Pan Zhou Zhang hao Fang Ying Chen Wen-Dong Chen Qian Cao Department of Gastroenterology Sir Run Run Shaw HospitalCollege of MedicineZhejiang UniversityHangzhou 310016Zhejiang ProvinceChina Department of Project Changsha Normin Health Technology LtdChangsha 410013Hunan ProvinceChina Department of HEOR Normin Health Consulting LtdToronto L5R 0E9OntarioCanada Inflammatory Bowel Disease Center Sir Run Run Shaw HospitalHangzhou 310016Zhejiang ProvinceChina

BACKGROUND Infliximab was the first approved biologic treatment for moderate to severe Crohn's disease(MS-CD) in China. However, the cost-effectiveness of infliximab maintenance therapy(IMT) for MS-CD relative to conventional maintenance therapy remained *** To assess the cost-effectiveness of IMT for MS-CD in Chinese patients from the perspective of Chinese public insurance *** A cohort of MS-CD patients managed in a Chinese tertiary care hospital was created to compare IMT with conventional maintenance therapy(CMT) for clinical outcomes and direct medical costs over a 1-year observation time using conventional regression analyses. A decision-analytic model with the generated evidence was constructed to assess the cost-effectiveness of IMT relative to CMT using reimbursed medical *** Based on the included 389 patients, IMT was associated with significantly higher disease remission chance [odds ratio: 4.060, P = 0.003], lower risk of developing new complications(odds ratio: 0.527, P = 0.010), higher utility value for quality of life(coefficient 0.822, P = 0.008), and lower total hospital costs related to disease management(coefficient-0.378, P = 0.008) than CMT. Base-case cost-effectiveness analysis estimated that IMT could cost Chinese health insurance payers $55260 to gain one quality-adjusted life year(QALY). The cost-effectiveness of IMT was mainly driven by the estimate of quality of life, treatment efficacy of maintenance therapy, mortality risk associated with active disease, and unit price of infliximab. The probability that IMT was cost-effective at a willingness-to-pay threshold of three times gross domestic product [2018 Chinese gross domestic product per capita(GDPPC)] was 86.4%.CONCLUSION IMT significantly improved real-world health outcomes and cost the Chinese public health insurance payers less than one GDPPC to gain one QALY in Chinese MS-CD patients.

关键词： Infliximab Crohn's disease Maintenance therapy Cost-effectiveness Outcomes Direct medical costs

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Matrix orthogonal polynomials,non-abelian Toda lattices,and Bäcklund transformations

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Science China Mathematics 2024年第9期67卷 2071-2090页

作者： shi-hao Li Department of Mathematics Sichuan UniversityChengdu 610064China

A connection between matrix orthogonal polynomials and non-abelian integrable lattices is investigated in this *** normalization factors of matrix orthogonal polynomials expressed using quasideterminants are shown to be the solutions to the non-abelian Toda lattice in semi-discrete and full-discrete ***,with a moment modification method,we demonstrate that the B¨acklund transformation of the non-abelian Toda lattice given by Popowicz(1983)is equivalent to the non-abelian Volterra lattice,whose solutions can be expressed using quasi-determinants as well.

关键词： matrix orthogonal polynomial non-abelian Toda lattice Backlund transformation quasideterminant technique

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Adaptive neural dynamic-based hybrid control strategy for stable retrieval of tethered satellite systems

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Astrodynamics 2024年第2期8卷 261-269页

作者： Zhixiong ji Gefei shi School of Aeronautics and Astronautics Sun Yat-sen UniversityGuangzhou 510275China Shenzhen Campus of Sun Yat-sen University Shenzhen 518107China Shenzhen Key Laboratory of Intelligent Microsatellite Constellation Shenzhen 518107China

This study proposes a novel adaptive neural dynamic-based hybrid control strategy for stable subsatellite retrieval of two-body tethered satellite *** retrieval speed is given analytically,ensuring a libration-free steady *** mitigate the potential libration motion,a general control input signal is generated by an adaptive neural-dynamic(AND)algorithm and executed by adjusting the retrieval speed and thruster on the *** address the limited retrieval speed and improve the control performance,the thruster controller is manipulated according to a novel advanced state fuzzy control law based on higher-order libration states,whereas the remaining control input is allocated to the speed *** Lyapunov stability of the control strategy is demonstrated *** simulations validate the proposed control strategy,demonstrating well-allocated control inputs for both controllers and good control performance.

关键词： tethered satellite system(TSS) stable retrieval hybrid control adaptive neural-dynamic (AND)control fuzzy control

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Simultaneous Bulk-and Surface-initiated Living Polymerization Studied with a Heterogeneous Stochastic Reaction Model

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Chinese Journal of Polymer Science 2024年第3期42卷 364-372,I0008页

作者： jia-Shu Ma Zhi-Ning Huang jia-hao Li Bang-Ping jiang Yan-Da Liao shi-Chen ji Xing-Can Shen State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources(Ministry of Education of China)School of Chemistry and Pharmaceutical SciencesGuangxi Normal UniversityGuilin 541004China School of Computer Science and Engineering&School of Software Guangxi Normal UniversityGuilin 541004China

To better characterize the properties of surface-initiated polymers, simultaneous bulk-and surface-initiated polymerizations are usually carried out by assuming that the properties of the surface-initiated polymers resemble those of the bulk-initiated polymers. Through a Monte Carlo simulation using a heterogeneous stochastic reaction model, it was discovered that the bulk-initiated polymers exhibit a higher molecular weight and a lower dispersity than the corresponding surface-initiated polymers, which indicates that the equivalent assumption is invalid. Furthermore, the molecular weight distributions of the two types of polymers are also different, suggesting different polymerization mechanisms. The results can be simply explained by the heterogeneous distributions of reactants in the system. This study is helpful to better understand surface-initiated polymerization.

关键词： Surface-initiated polymerization Polymer brush Stochastic reaction model Heterogeneous polymerization Simultaneous polymerization

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Restricted Arc-Connectivity of Harary Digraphs

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Journal of the Operations Research Society of China 2024年第2期12卷 540-547页

作者： Jun-hao Zhang ji-Xiang Meng College of Mathematics and System Science Xinjiang UniversityUrumqi 830046XinJiangChina

The h-restricted arc-connectivity of a digraph is an important parameter to measure fault-tolerance of interconnection *** paper determines that the h-restricted arc-connectivity of the Harary digraph D=G(n;1,2,.:,k)i... 详细信息

关键词： Restricted arc-connectivity λ_(h)(D) Super-λ_(h) λ_(h)-Atom λ_(h)-Superatom

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Role of catalyst surface-active sites in the hydrogenation ofα,β-unsaturated aldehyde

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Frontiers of Chemical Science and Engineering 2024年第6期18卷 41-69页

作者： Haixiang shi Tongming Su Zuzeng Qin Hongbing ji School of Chemistry and Chemical Engineering Guangxi Key Laboratory of Petrochemical Resource Processing and Process Intensification TechnologyGuangxi UniversityNanning 530004China Zhejiang Green Petrochemical and Light Hydrocarbon Transformation Research Institute Zhejiang University of TechnologyHangzhou 310014China

As an important technology in fine chemical production,the selective hydrogenation ofα,β-unsaturated aldehydes has attracted much attention in recent *** the process ofα,β-unsaturated aldehyde hydrogenation,a conjugated system is formed between>C=CC=O,leading to hydrogenation at both ends of the conjugated system,which competes with each other and results in more complex ***,improving the reaction selectivity is also difficult in industrial ***,many researchers have reported that surface-active sites on catalysts play a crucial role inα,β-unsaturated aldehyde *** review attempts to summarize recent advances in understanding the effects of surface-active sites(SASs)over metal catalysts for enhancing the process of *** construction strategies and roles of SASs for hydrogenation catalysts are *** attention has been given to the adsorption configuration and transformation mechanism ofα,β-unsaturated aldehydes on catalysts,which contributes to understanding the relationship between SASs and hydrogenation *** addition,recent advances in metal-supported catalysts for the selective hydrogenation ofα,β-unsaturated aldehydes to understand the role of SASs in hydrogenation are briefly ***,the opportunities and challenges will be highlighted for the future development of the precise construction of SASs.

关键词： α,β-unsaturatedd aldehydes hydrogenation active site cinnamaldehyde

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Systematic study of the synthesis of heavy and superheavy nuclei in 48Ca-induced fusion-evaporation reactions

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Nuclear Science and Techniques 2024年第7期35卷 157-172页

作者： shi-hao Zhu Tian-Liang Zhao Xiao-Jun Bao Department of Physics Collaborative Innovation Center for Quantum EffectsKey Laboratory of Low Dimensional Quantum Structures and Quantum Control of Ministry of EducationHunan Normal UniversityChangsha410081China School of Nuclear Science and Technology Lanzhou UniversityLanzhou730000China School of Physics Xi’an Jiaotong UniversityXi’an710049China

We systematically studied the evaporation residue cross sections of ^(48)Ca-induced reactions on lanthanide and actinide target nuclei under the Dinuclear System(DNS)model framework to check the reliability and applicability of the *** produce new proton-rich Fl and Lv isotopes through hot fusion reactions in the superheavy element region with Z≥104,we utilized the reactions ^(48)Ca+^(236,238,239) Pu and ^(48)Ca+^(242,243,244,250) ***,owing to the detection limit of available equipment(0.1 pb),only 283Fl and 287−289Lv,which have the maximum evaporation residue cross section values of 0.149,0.130,9.522,and 0.309 pb,respectively,can be ***,to produce neutron-deficient isotopes of actinides near the proton drip line with Z=93−100,we attempted to generate the new isotopes(224−227Pu,228−232,237Cm)using the reactions ^(48)Ca+180,182,183 W and ^(48)Ca+^(184,186,187,192) *** maximum evaporation residue cross section values are 0.07,0.06,0.26,and 0.30 nb for the former set of reactions,and 1.96 pb,5.73 pb,12.16 pb,19.39 pb,54.79 pb,and 6.45 nb for the latter,*** results are expected to provide new information for the future synthesis of unknown neutron-deficient isotopes.

关键词： Dinuclear system(DNS)model Evaporation residue cross section Neutron-deficient isotopes

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Kinetic scale magnetic holes in the terrestrial magnetosheath:A review

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Science China Earth Sciences 2024年第9期67卷 2739-2771页

作者： Quanqi shi Shutao YAO Maria HAMRIN ji LIU Shandong Provincial Key Laboratory of Optical Astronomy and Solar-Terrestrial Environment Institute of Space SciencesShandong UniversityWeihai 264209China Department of Physics UmeåUniversityUmeå90746Sweden Department of Physics University of AlbertaEdmonton T6K 2P6Canada

Magnetic holes at the ion-to-electron kinetic scale(KSMHs)are one of the extremely small intermittent structures generated in turbulent magnetized *** recent years,the explorations of KSMHs have made substantial strides,driven by the ultra-high-precision observational data gathered from the Magnetospheric Multiscale(MMS)*** review paper summarizes the up-to-date characteristics of the KSMHs observed in Earth’s turbulent magnetosheath,as well as their potential impacts on space *** review starts by introducing the fundamental properties of the KSMHs,including observational features,particle behaviors,scales,geometries,and distributions in terrestrial *** have discovered that KSMHs display a quasi-circular electron vortex-like structure attributed to electron diamagnetic *** electrons exhibit noticeable non-gyrotropy and undergo *** occurrence rate of KSMH in the Earth’s magnetosheath is significantly greater than in the solar wind and magnetotail,suggesting the turbulent magnetosheath is a primary source ***,KSMHs have also been generated in turbulence simulations and successfully reproduced by the kinetic equilibrium ***,KSMHs have demonstrated their ability to accelerate electrons by a novel non-adiabatic electron acceleration mechanism,serve as an additional avenue for energy dissipation during magnetic reconnection,and generate diverse wave phenomena,including whistler waves,electrostatic solitary waves,and electron cyclotron waves in space *** results highlight the magnetic hole’s impact such as wave-particle interaction,energy cascade/dissipation,and particle acceleration/heating in space *** end this paper by summarizing these discoveries,discussing the generation mechanism,similar structures,and observations in the Earth’s magnetotail and solar wind,and presenting a future extension perspective in this active field.

关键词： Magnetic hole Magnetic dip/cavity Electron vortex Magnetosheath Turbulence Coherent structure Mirror mode Kinetic scale Electron acceleration Whistler

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Limited Social Support,but Comparable Health Literacy and Service Utilization,Among Elderly People Living Alone—Six PLADs,China,May-September 2020

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China CDC weekly 2024年第39期6卷 1011-1016页

作者： hao Lin Meijun Chen Yuhui shi Ying ji Yuting Lin Wangnan Cao Chun Chang Department of Social Medicine and Health Education School of Public HealthPeking University Health Science CenterBeijingChina Center for Healthy Aging Peking University Health Science CenterBeijingChina School of Public Health The University of Hong KongHong Kong Special Administrative RegionChina

What is already known about this topic?The proportion of elderly living alone in China is approximately 10%.Living away from family poses enormous challenges for older *** is added by this report?Compared to those living with family,elderly individuals living alone exhibit a lower registration rate with general practitioners and have less social *** are the implications for public health practice?While the current health service system for elderly people living alone is working relatively well,there is a need for additional programs to enhance social support and improve their social well-being.

关键词： alone elderly service

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Impact of frailty on outcomes of elderly patients undergoing percutaneous coronary intervention: A systematic review and metaanalysis

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World Journal of Clinical Cases 2024年第1期12卷 107-118页

作者： shi-shi Wang Wang-hao Liu Department of Emergency Medicine Huzhou Third Municipal HospitalThe Affiliated Hospital of Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina Department of Geriatrics Huzhou Third Municipal Hospitalthe Affiliated Hospital of Huzhou UniversityHuzhou 313000Zhejiang ProvinceChina

BACKGROUND Frailty is a common condition in elderly patients who receive percutaneous coronary intervention(PCI).However,how frailty affects clinical outcomes in this group is *** To assess the link between frailty and the outcomes,such as in-hospital complic-ations,post-procedural complications,and mortality,in elderly patients *** The PubMed/MEDLINE,EMBASE,Cochrane Library,and Web of Science databases were screened for publications up to August *** primary outcomes assessed were in-hospital and all-cause mortality,major adverse cardiovascular events(MACEs),and major *** Newcastle-Ottawa Scale was used for quality *** Twenty-one studies with 739693 elderly patients undergoing PCI were *** was consistently associated with adverse *** patients had significantly higher risks of in-hospital mortality[risk ratio:3.45,95%confidence interval(95%CI):1.90-6.25],all-cause mortality[hazard ratio(HR):2.08,95%CI:1.78-2.43],MACEs(HR:2.92,95%CI:1.85-4.60),and major bleeding(HR:4.60,95%CI:2.89-7.32)compared to non-frail *** Frailty is a pivotal determinant in the prediction of risk of mortality,development of MACEs,and major bleeding in elderly individuals undergoing percutaneous coronary intervention.

关键词： Frailty Elderly Percutaneous coronary intervention Systematic review Meta-analysis

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