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Water-soluble chitosan nanoparticles as a novel carrier system for protein delivery

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Chinese Science Bulletin 2007年第7期52卷 883-889页

作者： WANG chun FU xiong YANG LianSheng School of Light Industry and Food Sciences South China University of Technology Guangzhou 510640 China

High MW chitosan (CS) solutions have already been proposed as vehicles for protein delivery. The aim of the present work is to investigate the potential utility of water-soluble chitosan (WSC) as vehicles to load and deliver proteins. WSC nanoparticles (WSC NP) with various formations were prepared based on ionic gelation of WSC with pentasodium tripolyphosphate (TPP) anions. Bovine serum albumin (BSA) was used as a model protein drug incorporated into the WSC nanoparticles. Blank and BSA-loaded WSC nanoparticles were examined and determined to have a spherical shape with diameters between 35―190 nm, and zeta potential between 35―42 mV. FTIR confirmed that the tripolyphosphoric groups of TPP linked to the ammonium groups of WSC in the nanoparticles. Some factors affecting delivery properties of BSA have been investigated. Altering the concentration of BSA from 0.05 to 1 mg/mL enhanced the loading capacity of BSA but decreased loading efficiency simultaneously. Also, with the introduction of poly ethylene glycol (PEG), BSA release accelerated. Nanoparticle preparation from WSC with various deacetylation degrees (DDs) from 72.6% to 90% and MWs ranging from 3.5 to 15.8 kDa promoted loading efficiency and decreased the release rate. These results indicate that WSC nanoparticles are promising carriers for protein delivery.

关键词：水溶性壳聚糖纳米颗粒蛋白质输送载体系统药物赋形剂

A Novel Regeneration Method of Cu(0)-deposited TiO_2 Photocatalytic Film:Air-assisted Electrochemical Oxidation

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Chinese Chemical Letters 2002年第11期13卷 1127-1130页

作者： chun HE Ya xiong Xi Hai ZHU School of Chemistry and Chemical Engineering Zhongshan UniversityGuangzhou 510275 Department of Chemistry Zhaoqing CollegeZhaoqing 526061

A rapid deactivation of TiO2 film was observed in the process of the photocatalytic degradation of formic acid in the presence of Cu(II) due to the deposition of Cu(0). A novel regeneration method, air-assisted electrooxidation, could efficiently retrieve the photocatalytic activity of the deact ivated film. HNO3 medium has a regeneration extent of 97.2% for first run, much higher than that of HCl and H2SO4 mediums.

关键词： Photocatalysis electrooxidation regeneration TiO2 formic acid copper.

稀土元素Er、Yb和Y掺杂ZrO_(2)的第一性原理研究

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原子与分子物理学报 2025年第1期42卷 156-162页

作者：熊威任浩重庆交通大学航空学院重庆402247 重庆交通大学绿色航空技术研究院重庆401147

氧化锆具有声子能量低,介电常数高和带隙较宽等优良特性,并且立方相的氧化锆(cZrO_(2))透光率高,适合作为上转换发光材料的基质.采用基于密度泛函理论(DFT)的第一性原理平面波赝势法研究了稀土元素Er、Yb和Y掺杂cZrO_(2)的电子结构和光... 详细信息

氧化锆具有声子能量低,介电常数高和带隙较宽等优良特性,并且立方相的氧化锆(cZrO_(2))透光率高,适合作为上转换发光材料的基质.采用基于密度泛函理论(DFT)的第一性原理平面波赝势法研究了稀土元素Er、Yb和Y掺杂cZrO_(2)的电子结构和光学性质.计算结果显示,掺入Y元素后,cZrO_(2)转变为直接带隙材料,继续掺入Er和Yb原子后,费米能级移动到价带内,带隙显著减小.Y和Er混掺后,增强了cZrO_(2)在近红外波段的吸收能力.继续掺入Yb后,cZrO_(2)对近红外波段的吸收能力有了进一步地增加.

关键词：氧化锆第一性原理电子结构光学性质

Lipschitz Estimates for Commutators of p-adic Fractional Hardy Operators

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Communications in Mathematical Research 2015年第2期31卷 131-140页

作者： Li Liang xiong chun-yan Zhou jiang ji You-qing School of Mathematics and Statistics Yili Normal University College of Mathematics and System Sciences Xinjiang University

In this paper, the boundedness of commutators generated by the n- dimensional fractional Hardy operators and Lipschitz functions on p-adic function spaces are obtained. The authors show that these commutators are bounded on Herz space and Lebesgue space with suitable indexes. Moreover, the commutator of Hardy- Littlewood-Poly~ operator is also considered.

关键词： commutator the p-adic Hardy operator Lipschitz function Herz space

Monitoring the penetration and accumulation of gold nanoparticles in rat skin ex vivo using surface-enhanced Raman scattering spectroscopy

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Journal of Innovative Optical Health Sciences 2016年第5期9卷 71-81页

作者： Honglian xiong Zhouyi Guo Huiqing Zhong Yanhong ji Sun-Yat sen University Cancer Center Guangzhou 510060 P.R.China Institute of Laser Life Science College of Biophotonics South China Normal UniversityGuangzhou 510631P.R.China Guangdong Provincial Key Laboratory of Quantum Engineering and Quantum Materials School of Physics and Telecommunication Engineering South China Normal University Guangzhou 510006 P.R.China

Contamination by accidental cutaneous contact with the commercial products and the air pol-hutants raised a considerable health and safety *** study aimed to trace the dynamics of the 20 nm gold nanopartide(GNP)penetration and accumulation in rat skin tissues using a surface-enhanced Raman scattering(SERS)*** the topical application of GNPs on rat skin surface,the SERS spectra were recorded for every 15 pum to an overall depth of 75 pum from skin surface for 150 *** processes of GNP penetration in rat skin were accompanied by aggregation of GNPs,which affected SERS *** results revealed that 20 nm GNPs can penetrate through stratum corneum layer,viable epidermis layer,and then into dermis *** study demonstrated for the first time the potential of SERS spectroscopy to monitor the penetration and accumulation of GNPs in rat skin.

关键词： Surface enhanced Raman scattering spectroscopy rat skin gold nanopartide pene-tration aggregation.

End-to-end energy-efficient resource allocation in device-to-device communication underlaying cellular networks

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The Journal of China Universities of Posts and Telecommunications 2015年第1期22卷 24-30页

作者： Xu Quansheng ji Hong Li Xi xiong Danni Key Laboratory of Universal Wireless Communications Beijing University of Posts and Telecommunications

A proposed resource allocation （RA） scheme is given to device-to-device （D2D） communication underlaying cellular networks from an end-to-end energy-efficient perspective, in which, the end-to-end energy consumptions were taken into account. Furthermore, to match the practical situations and maximize the energy-efficiency （EE）, the resource units （RUs） were used in a complete-shared pattern. Then the energy-efficient RA problem was formulated as a mixed integer and non-convex optimization problem, extremely difficult to be solved. To obtain a desirable solution with a reasonable computation cost, this problem was dealt with two steps. Step 1, the RU allocation policy was obtained via a greedy search method. Step 2, after obtaining the RU allocation, the power allocation strategy was developed through quantum-behaved particle swarm optimization （QPSO）. Finally, simulation was presented to validate the effectiveness of the proposed RA scheme.

关键词： energy-efficiency resource allocation D2D communication mixed integer and non-convex optimization problem

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Efficacy of Acupuncture Combined with Local Anesthesia in Ischemic Stroke Patients with Carotid Artery Stenting:A Prospective Randomized Trial

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Chinese Journal of Integrative Medicine 2020年第8期26卷 609-616页

作者： xiong Wei ZHAO chun-mei AN Li-xin XIE Si-ning jiA chun-rong Department of Anesthesiology Beijing Tiantan HospitalCapital Medical UniversityBeijing 100015China Department of Anesthesiology Beijing Friendship HospitalCapital Medical UniversityBeijing 100050China Department of Traditional Chinese Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijing 100015China

Objective:To evaluate the efficacy of electro-acupuncture(EA)or transcutaneous electrical acupoint stimulation(TEAS)on perioperative cerebral blood flow(CBF)and neurological function in ischemic stroke(IS)patients undergoing carotid artery stenting(CAS).Methods:In total,124 consecutive IS patients were randomly allocated to the EA,TEAS,and sham groups(groups A,T,and S;41,42,and 41 cases,respectively)by softwarederived random-number *** A and T received EA and TEAS,respectively,at the Shuigou(GV 26)and Baihui(GV 20),Hegu(LI4)and Waiguan(TE 5)*** S received sham *** stimulation was started from 30 min before surgery until the end of the *** primary outcome was the CBF at 30 min after surgery,which was measured by transcranial Doppler *** secondary outcomes included hyperperfusion incidence and neurological *** Institutes of Health Stroke Scale(NIHSS)and General Evaluation Scale(GES)scores were recorded at 1 week,1 month,and 3 months ***:Mean CBF velocity at 30 min after surgery in groups A and T was much lower than that in Group S(P<0.05);the incidence of hyperperfusion in Groups A and T was also lower than that in group S(P<0.05).Acupuncture was an independent factor associated with reduced incidence of hyperperfusion(OR=0.042;95%CI:0.002–0.785;P=0.034).NIHSS and GES scores improved significantly at 1 week postoperatively in Groups A and T than in Group S(P<0.05).Relative to Group S,groups A and T exhibited significantly lower incidences of moderate pain,as well as higher incidences of satisfaction with anesthesia,at 1 day postoperatively(P<0.05).Conclusion:EA or TEAS administered in combination with local anesthesia during CAS can inhibit transient increases in CBF,reduce the incidence of postoperative hyperperfusion,and improve neurological function.

关键词： electro-acupuncture transcutaneous electrical acupoint stimulation carotid artery stenting cerebral blood flow neurological function

Multilinear commutators of BMO functions and multilinear singular integrals with non-smooth kernels

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Applied Mathematics(A Journal of Chinese Universities) 2011年第1期26卷 109-120页

作者： LIAN jia-li LI ji WU Huo-xiong Department of Mathematics and Computer Science Wuyi University Wuyi 354300 China Department of Mathematics Zhongshan University Guangzhou 510275 China School of Mathematical Sciences Xiamen University Xiamen 361005 China

This paper is concerned with certain multilinear commutators of BMO functions and multilinear singular integral operators with non-smooth kernels. By the sharp maximal functions estimates, the weighted norm inequaliti... 详细信息

关键词： Multilineav operator commutator non-smooth kernel sharp maximal function weighted norminequality.

Role of retained austenite in advanced high-strength steel:ductility and toughness

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Journal of Iron and Steel Research International 2024年第9期31卷 2079-2089页

作者： Vung Lam Nuam Hao Zhang Ying-chun Wang Zhi-ping xiong National Key Laboratory of Science and Technology on Materials under Shock and Impact School of Materials Science and EngineeringBeijing Institute of TechnologyBeijing100081China Tangshan Key Laboratory of High-Performance Metals and Ceramics Tangshan Research Institute BITTangshan063000HebeiChina

Enhancing the ductility and toughness of advanced high-strength steels is essential for the wide range of promising *** retained austenite(RA)is a key phase due to the austenite-to-martensite transformation and its transformation-induced plasticity *** is commonly accepted that slow RA-to-martensite transformation is beneficial to ductility;therefore,the RA fraction and stability should be carefully *** RA stability is related to its morphology,size,carbon content,neighboring phase and ***,these factors are *** is noteworthy that the influence of RA on ductility and fracture toughness is not consistent because of their difference in stress *** is no clear relationship between fracture toughness and tensile ***,it is important to understand the role of RA in *** toughness is enhanced during the RA-to-martensite transformation,while the fracture toughness is decreased due to the formation of fresh and brittle *** a result,the findings regarding to the effect of RA on fracture toughness are *** investigations should be conducted in order to fully understand the effects of RA on ductility and fracture toughness,which can optimize the combination of ductility and toughness in AHSSs.

关键词： Retained austenite Ductility Toughness TRIP effect Steel