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Chinese Chemical Letters 2011年第4期22卷 473-476页

作者： chun Xia wu Qiu Hua wu chun Wang Zhi Wang Key Laboratory of Bioinorganic Chemistry College of SciencesAgricultural University of HebeiBaoding 071001China

A novel,simple,rapid,efficient and environment-friendly method for the determination of trace copper in cereal samples was developed by using dispersive liquid-liquid microextraction based on solidification of floating organic drop（DLLME-SFO） followed by flame atomic absorption *** the DLLME-SFO,copper was complexed with 8-hydroxy quinoline and extracted into a small volume of 1-dodecanol,which is of low density,low toxicity and proper melting point near room temperature. The experimental parameters affecting the extraction efficiency were investigated and *** the optimum conditions, the calibration graph exhibited linearity over the range of 0.5—500 ng/mL with the correlation coefficient（r） of *** enrichment factor was 122 and the limit of detection was 0.1 ng/*** method was applied to the determination of copper in the complex matrix samples such as rice and millet with the recoveries for the spiked samples at 5.0 and 10.0 u,g/g falling in the range of 92.0-98.0%and the relative standard deviation of 3.9-5.7%.

关键词： Dispersive liquid-liquid microextraction based on solidification of floating organic droplet Flame atomic absorption spectrometry Copper Cereal samples

Unusual case of digestive hemorrhage: Celiac axis-portal vein arteriovenous fistula

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World Journal of Gastroenterology 2015年第4期21卷 1362-1364页

作者： Yi-Ren Liu Bin Huang Ding Yuan Zhou-Peng wu ji-chun Zhao Department of vascular surgery West China HospitalSichuan University

A case of intractable upper gastrointestinal-hemorrhage was reported in a patient with portal hypertension caused by an arterioportal fistula(APF), namely, celiac axis-portal vein arteriovenous fistula. Portal hypertension caused by extrahepatic-APFs is extremely rare. Trauma, malignancy, and hereditary causes are the common etiology of APFs; but were absent in our patient. Our patient represents an unusualcase of unexplained APF who presented with portal hypertension and was successfully managed through endovascular aortic repair.

关键词： Arterioportal fistula Portal hypertension Endovasc

Network pharmacology: A new approach to unveiling Traditional Chinese Medicine

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Chinese Journal of Natural Medicines 2015年第1期13卷 1-2页

作者： wu Xiao-Ming wu chun-Fu School of Pharmacy China Pharmaceutical Uninersity School of Life Science and Biopharmaceutics Shenyang Pharmaceutical University

Traditional Chinese medicine(TCM)has thousandsyears of history in using herbal formulae(Fang-ji in Chinese)that consist of many medicinal herbs for holistic treatment of various *** to the complex nature rooted in bot... 详细信息

关键词：传统医药药理学网络中国药物发现生物制药生物医学生物系统

Dynamic relay access for D2D-aided low-latency and high-reliability communications

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Science China(Information Sciences) 2021年第2期64卷 72-85页

作者： chun wu Mingming wu Yulan GAO Yue XIAO Xiaojian YOU School of National Defense Science and Technology Southwest University of Science and Technology National Key Laboratory of Science and Technology on Communications University of Electronic Science and Technology of China

Device-to-device(D2D) communications allow direct connections among devices to lower transmission latency and network loads of the existing cellular mobile networks. To fully exploit the benefits of D2D communications, relay access is one of the critical challenges upon employing the optimal cooperative relay user equipments(UEs) for data forwarding. The existed relay access approaches usually neglect the inherent motivation that whether the relay is reluctant to forward the information of other UEs based on its status, such as limited battery, service cost and social ties. In this paper, we jointly investigate both the transmission delay and the reliability performance for designing a relay access scheme combined with the impacts of the physical layer and the social layer. Meanwhile, considering the user mobility and status, a dynamic relay access model is constructed with the utility function of the weighted average of latency and social trust level under the long-term constraints. To solve this problem, Lyapunov framework is proposed for converting it into a renewal-reward system towards infinite time horizon, and numerical results show the benefits of the proposed scheme compared with other schemes under dynamic scenarios, as it can lower the latency while guaranteeing the reliability of relay access.

关键词： D2D communications relay access low-latency high-reliability social ties

Infinitesimal dividing modeling method for dual suppliers inventory model with random lead times

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Journal of Systems Engineering and Electronics 2009年第3期20卷 527-536页

作者： ji Pengcheng Song Shiji wu Cheng Dept. of Automation Tsinghua Univ. Beijing 100084 P. R. China

As one of the basic inventory cost models, the （Q, τ）inventory cost model of dual suppliers with random procurement lead time is mostly formulated by using the concepts of ＂effective lead time＂ and ＂lead time demand＂, which may lead to an imprecise inventory cost. Through the real-time statistic of the inventory quantities, this paper considers the precise （Q, τ） inventory cost model of dual supplier procurement by using an infinitesimal dividing method. The traditional modeling method of the inventory cost for dual supplier procurement includes complex procedures. To reduce the complexity effectively, the presented method investigates the statistics properties in real-time of the inventory quantities with the application of the infinitesimal dividing method. It is proved that the optimal holding and shortage costs of dual supplier procurement are less than those of single supplier procurement respectively. With the assumption that both suppliers have the same distribution of lead times, the convexity of the cost function per unit time is proved. So the optimal solution can be easily obtained by applying the classical convex optimization methods. The numerical examples are given to verify the main conclusions.

关键词： inventory precise model random lead times dual supplier infinitesimal dividing method optimiza- tion.

Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang Zeng Wei Tan Xingxing Chen Shuyuan Bai Qiong wu Yushan Chen Zhen Wei Yufei Mei Yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

Moxibustion combined with acupuncture increases tight junction protein expression in Crohn's disease patients

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World Journal of Gastroenterology 2015年第16期21卷 4986-4996页

作者： Hai-Xia Shang An-Qi Wang chun-Hui Bao Huan-Gan wu Wei-Feng Chen Lu-Yi wu Rong ji ji-Meng Zhao Yin Shi Shanghai University of Traditional Chinese Medicine Shanghai Institute of Acupuncture-Moxibustion and Meridian Zhongshan Hospital affiliated to Fudan University

AIM:To investigate the effect of herb-partitioned moxibustion combined with acupuncture on the expression of intestinal epithelial tight junction(TJ) ***:Sixty patients diagnosed with mild to moderate Crohn’s disease(CD)were allocated into the herb-partitioned moxibustion combined with acupuncture(HMA)group(n=30)or the mesalazine(MESA)group(n=30)using a parallel control *** were 2 sets of acupoints used alternately for HMA *** following points were included in Set A:ST25(Tianshu),RN6(Qihai),and RN9(Shuifen)for herb-partitioned moxibustion and ST36(Zusanli),ST37(Shangjuxu),LI11(Quchi),and LI4(Hegu)for *** points for Set B included BL23(Shenshu)and BL25(Dachangshu)for herb-partitioned moxibustion and EX-B2 of T6-T1(jiajixue)fo r *** patients received the same treatment6 times a week for 12 consecutive *** MESA group received 1 g of mesalazine enteric coated tablets4 times daily for 12 consecutive *** were stained and examined to compare the morphological and ultrastructural changes before and after the treatment *** and in situ hybridization assays were used to detect the expression of intestinal epithelial TJ proteins zonula occludens-1(ZO-1),occludin,and *** m RNA levels were also ***:After the treatment,both herb-partitioned moxibustion combined with acupuncture and mesalazine improved intestinal morphology and ultrastructure of CD patients;the patients treated with HMA showed better *** significantly increased the expression of ZO-1(P=0.000),occludin(P=0.021),and claudin-1(P=0.016).MESA significantly increased the expression of ZO-1(P=0.016)and occludin(P=0.026).However,there was no significant increase in the expression of claudin-1(P=0.935).There was no statistically significant difference between the two groups for the expression of occludin and claudin-1(P>0.05).The HMA group showed a significant improvement in ZO-1 exp

关键词： Crohn's disease Herb-partitioned moxibustion Acupuncture Intestinal epithelial cells Tight junctionproteins

Thermodynamic analysis and modification of Gibbs–Thomson equation for melting point depression of metal nanoparticles

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Chinese Journal of Chemical Engineering 2021年第3期34卷 198-205页

作者： Nanhua wu Xiaohua Lu Rong An Xiaoyan ji Division of Energy Science/Energy Engineering LuleåUniversity of Technology97187 LuleåSweden State Key Laboratory of Materials-Oriented and Chemical Engineering Nanjing Tech UniversityNanjing 211816China Key Laboratory of Advanced Catalytic Materials and Technology School of Petrochemical EngineeringChangzhou UniversityChangzhou 213164China Herbert Gleiter Institute of Nanoscience Nanjing University of Science&TechnologyNanjing 210094China

Abnormal melting point depression of metal nanoparticles often occurs in heterogeneous catalytic reactions,which leads to a reduction in the stability of reactive *** study this abnormal phenomenon,the original and surface-energy modified Gibbs-Thomson equations were analyzed in this work and further modified by considering the effect of the *** results revealed that the original Gibbs-Thomson equation was not suitable for the particles with radii smaller than 10 ***,the performance of the surface-energy modified Gibbs-Thomson equation was improved,and the deviation was reduced to(-350-100)K,although further modification of the equation by considering the interfacial effect was necessary for the small particles(r<5 nm).The new model with the interfacial effect improved the model performance with a deviation of approximately-50 to 20 K,where the interfacial effect can be predicted quantitatively from the thermodynamic properties of the metal and ***,the micro-wetting parameterα_W can be used to qualitatively study the overall impact of the substrate on the melting point depression.

关键词： Melting point depression Metal nanoparticle Gibbs–Thomson equation Substrate Interfacial effect

Alterations of FHIT Gene and P16 Gene in Nickel Transformed Human Bronchial Epithelial Cells

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Biomedical and Environmental Sciences 2006年第4期19卷 277-284页

作者： WEI-DONG ji jiA-KUN CHEN jiA-chun LU ZHONG-LIANG wu FEI YI SU-MEI FENG Institute for Chemical Carcinogenesis Guangzhou Medical College Guangzhou 510182 Guangdong China

Objective To study the alterations of FHIT gene and P16 gene in malignant transformed human bronchial epithelial cells induced by crystalline nickel sulfide using an immortal human bronchial epithelial cell line, and to explore the molecular mechanism of nickel carcinogenesis. Methods 16HBE cells were treated 6 times with different concentrations of NiS in vitro, and the degree of malignant transformation was determined by assaying the anchorage-independent growth and tumorigenicity. Malignant transformed cells and tumorigenic cells were examined for alterations of FHIT gene and P16 gene using RT-PCR, DNA sequencing, silver staining PCR-SSCP and Western blotting. Results NiS-treated cells exhibited overlapping growth. Compared wkh that of negative control cells, soft agar colony formation efficiency of NiS-treated cells showed significant increases （P〈0.01） and dose-dependent effects. NiS-treated cells could form tumors in nude mice, and a squamous cell carcinoma was confirmed by histopathological examination. No mutation of exon 2 and exons 2-3, no abnormal expression in pl6 gene and mutation of FHIT exons 5-8 and exons 1-4 or exons 5-9 were observed in transformed cells and tumorigenic cells. However, aberrant transcripts or loss of expression of the FHIT gene and Fhit protein was observed in transformed cells and tumorigenic cells. One of the aberrant transcripts in the FHIT gene was confirmed to have a deletion of exon 6, exon 7, exon 8, and an insertion of a 36 bp sequence replacing exon 6-8. Conclusions The FHIT gene rather than the P16 gene, plays a definite role in nickel carcinogenesis. Alterations of the FHIT gene induced by crystalline NiS may be a molecular event associated with carcinogen, chromosome fragile site instability and cell malignant transformation. FHIT may be an important target gene activated by nickel and other exotic carcinogens.

关键词： Crystalline nickel sulfide Human bronchial epithelial cell line Malignant transformation P16 gene FHIT gene

A Fully Actuated System Approach for Stabilization of Discrete-Time Multiple-Input Nonlinear Systems with Distinct Input Delays

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Journal of Systems Science & Complexity 2022年第2期35卷 670-687页

作者： wu Ai-Guo ZHANG jie ji Youzhou Harbin Institute of Technology(Shenzhen) Shenzhen 518055China HIT wuhu Robot Technology Research Institute Wuhu 241008China

In this paper,the problem of stabilization is considered for discrete-time multiple-input nonlinear systems with distinct input delays law based on the fully actuated system *** order to compensate the input delays,a prediction scheme is presented to predict future states based on the closed-loop linear ***,a stabilizing law is constructed for nonlinear delayed systems by replacing the future states in the control law for the corresponding delay-free systems with their ***,numerical examples are given to verify the effectiveness of the proposed approach.

关键词： Fully actuated system approach input delays nonlinear systems prediction scheme