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Slowβrelaxation in La-based metallic glasses based on mechanical spectroscopy measurements

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Journal of Iron and Steel Research International 2017年第4期24卷 397-401页

作者： ji-chao qiao Jean-marc Pelletier Ning Li Daniel Crespo Yao Yao School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi'an 710072ShaanxiChina Universite de Lyon MATEISUMR-CNRS5510Bat.B.PascalINSA LyonF-69621 Villeurbanne cedexFrance Department of Materials Science and Engineering State Key Laboratory for Materials Processing and Die&Mould TechnologyHuazhong University of Science and TechnologyWuhan 430074HubeiChina Departament de Fisica EETACUniversitat Politecnica de CatalunyaCastelldfels 08860BarcelonaSpain

Dynamic mechanical relaxations of La-based metallic glasses were investigated by mechanical *** the framework of the mixing enthalpy of constituent atoms,it was found thatβrelaxation was less evident by the addition of Cu to replace Ni in the LaCuNiAl glassy *** introducing Cu into the LaNiAl metallic glass,the mixing enthalpy was less negative,which led to weakerβrelaxation of the metallic ***αrelaxation of the La-based metallic glasses could be described by a Kohlrausch-Williams-Watts（KWW）function with a Kohlrausch exponentβKWW around *** should be noted that physical aging above the glass transition temperature Tginduced a decrease ofβrelaxation intensity in the La-based metallic glass.

关键词： Metallic glass Mechanical relaxation βrelaxation Mixing enthalpy

Fast secondary relaxation and plasticity initiation in metallic glasses

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National Science Review 2018年第5期5卷 616-618页

作者： ji chao qiao Xiao Di Liu Qing Wang Chain Tsuan Liu jian Lu Yong Yang School of Mechanics and Civil & Architecture Northwestern Polytechnic University Centre for Advanced Structural Materials Department of Mechanical and Biomedical EngineeringCity University of Hong Kong Laboratory for Structures Institute of MaterialsShanghai University

Metallic glasses (MGs) are a promising engineering material with superb strength. However, their ‘Achilles’ heel’is their poor ductility in ambient conditions, particularly under tension. Unlike their crystalline c... 详细信息

关键词： MG Fast secondary relaxation and plasticity initiation in metallic glasses

Thermal effects and evolution of the defect concentration based on shear modulus relaxation data in a Zr-based metallic glass

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Chinese Physics B 2020年第8期29卷 133-136页

作者： Qi Hao ji-chao qiao E V Goncharova G V Afonin Min-Na Liu Yi-Ting Cheng V A Khonik School of Mechanics Civil Engineering and ArchitectureNorthwestern Polytechnical UniversityXi'an 710072China Department of General Physics Voronezh State Pedagogical UniversityLenin Street 86Voronezh 394043Russia

A relationship between thermal effects and relaxation of the high-frequency shear modulus upon heat treatment of bulk Zr48(Cu5/6Ag1/6)44Al8 metallic glass is *** relationship is attributed to the relaxation of a interstitial-type defect system frozen-in from the melt upon glass *** data show that thermal effects occurring on heating include heat release below the glass transition temperature,heat absorption above it and heat release caused by *** equation derived within the Interstitialcy theory can be used to calculate the shear modulus relaxation using the calorimetric *** obtained results are used to trace the defect concentration as functions of temperature and thermal prehistory.

关键词： shear modulus metallic glass structural relaxation interstitialcy theory

Exploring gut microbiota as a novel therapeutic target in Crohn’s disease: Insights and emerging strategies

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World Journal of Gastroenterology 2025年第2期31卷 147-156页

作者： Tong qiao Xian-Hui Wen Department of Clinical Medicine Jinan UniversityGuangzhou 510632Guangdong ProvinceChina College of Life Science and Technology Jinan UniversityGuangzhou 510632Guangdong ProvinceChina

Extensive research has investigated the etiology of Crohn’s disease(CD),encompassing genetic predisposition,lifestyle factors,and environmental ***,the gut microbiome,recognized as the human body’s second-largest gene pool,has garnered significant attention for its crucial role in the patho-genesis of *** paper investigates the mechanisms underlying CD,focusing on the role of‘creeping fat’in disease progression and exploring emerging therapeutic strategies,including fecal microbiota transplantation,enteral nutri-tion,and therapeutic *** fat has been identified as a unique patho-logical feature of CD and has recently been found to be associated with dysbiosis of the gut *** characterize this dysbiotic state by identi-fying key microbiome-bacteria,fungi,viruses,and archaea,and their contributions to CD ***,this paper reviews contemporary therapies,empha-sizing the potential of biological therapies like fecal microbiota transplantation and dietary *** elucidating the complex interactions between host-microbiome dynamics and CD pathology,this article aims to advance our under-standing of the disease and guide the development of more effective therapeutic strategies for managing CD.

关键词： Crohn’s disease Gut microbiome Dysbiosis Creeping fat Fecal microbiota transplantation

Heterogeneity of mature oligodendrocytes in the central nervous system

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Neural Regeneration Research 2025年第5期20卷 1336-1349页

作者： chao Weng Adam M.R.Groh Moein Yaqubi qiao-Ling Cui Jo Anne Stratton G.R.Wayne Moore Jack P.Antel Neuroimmunology Unit Montreal Neurological Institute-HospitalDepartment of Neurology and NeurosurgeryMcGill UniversityMontrealQCCanada Department of Neurology Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina

Mature oligodendrocytes form myelin sheaths that are crucial for the insulation of axons and efficient signal transmission in the central nervous *** evidence has challenged the classical view of the functionally static mature oligodendrocyte and revealed a gamut of dynamic functions such as the ability to modulate neuronal circuitry and provide metabolic support to *** the recognition of potential heterogeneity in mature oligodendrocyte function,a comprehensive summary of mature oligodendrocyte diversity is *** delve into early 20th-century studies by Robertson and Río-Hortega that laid the foundation for the modern identification of regional and morphological heterogeneity in mature ***,recent morphologic and functional studies call into question the long-assumed homogeneity of mature oligodendrocyte function through the identification of distinct subtypes with varying myelination ***,modern molecular investigations,employing techniques such as single cell/nucleus RNA sequencing,consistently unveil at least six mature oligodendrocyte subpopulations in the human central nervous system that are highly transcriptomically diverse and vary with central nervous system *** and disease related mature oligodendrocyte variation denotes the impact of pathological conditions such as multiple sclerosis,Alzheimer's disease,and psychiatric ***,caution is warranted when subclassifying mature oligodendrocytes because of the simplification needed to make conclusions about cell identity from temporally confined *** studies leveraging advanced techniques like spatial transcriptomics and single-cell proteomics promise a more nuanced understanding of mature oligodendrocyte *** research avenues that precisely evaluate mature oligodendrocyte heterogeneity with care to understand the mitigating influence of species,sex,central nervous system region,age,and disease,

关键词： aging central nervous system diseases electron microscopy heterogeneity immunohistochemistry myelin sheath natural history neuroglia oligodendroglia single-cell gene expression analysis

The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li Wei Zhang jian Wu Hui Hong Wei Quan Xinyu qiao Chun Cui Chenmeng qiao Weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

Association between intra-pancreatic fat deposition and diseases of the exocrine pancreas: A narrative review

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World Journal of Gastroenterology 2025年第2期31卷 27-41页

作者： jing Ye jian-Guo Wang Rong-Qiang Liu qiao Shi Wei-Xing Wang Department of General Surgery Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina Department of Pancreatic Surgery Renmin Hospital of Wuhan UniversityWuhan 430060Hubei ProvinceChina

Intrapancreatic fat deposition(IPFD)has garnered increasing attention in recent *** prevalence of IPFD is relatively high and associated with factors such as obesity,age,and ***,the pathophysiological mechanisms underlying IPFD remain unclear,with several potential contributing factors,including oxida-tive stress,alterations in the gut microbiota,and hormonal *** was found to be highly correlated with the occurrence and prognosis of exocrine pan-creatic *** imaging techniques remain the primary diagnostic approach for IPFD,an expanding array of biomarkers and clinical scoring systems have been identified for screening ***,effective treatments for IPFD are not available;however,existing medications,such as glucagon-like peptide-1 receptor agonists,and new therapeutic approaches explored in animal models have shown considerable potential for managing this *** paper reviews the pathogenesis of IPFD,its association with exocrine pancreatic disea-ses,and recent advancements in its diagnosis and treatment,emphasizing the significant clinical relevance of IPFD.

关键词： Intrapancreatic fat deposition Pancreatic steatosis Nonalcoholic fatty pancreas disease Pancreatitis Pancreatic cancer

Enhanced Photothermal Selective Conversion of CO_(2)to CH4 in Water Vapor over Rod-Like Cu and N Co-Doped TiO_(2)

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Chinese Journal of Structural Chemistry 2022年第12期41卷 33-42页

作者： ji-chao Wang Xiu qiao Weina Shi Huiling Gao Lingchen Guo College of Chemistry and Chemical Engineering Henan Institute of Science and TechnologyXinxiang 453000China School of Chemistry and Materials Engineering Xinxiang UniversityXinxiang 453000China School of Ecology and Environment Zhengzhou UniversityZhengzhou 450052China

Enhancing catalytic efficiency and selectivity is critical issues for CO_(2) *** rod-like Cu/N co-doped TiO_(2) samples(Cu/N-TiO_(2)) were synthesized by the electrospinning-calcination *** substitutional Cu and interstitial N doping not only enhanced visible-light absorption ability,but also formed the Ti(Ⅲ)*** obviously synergistic effect between the photocatalysis and thermalcatalysis appeared for CO_(2) conversion over the 8-Cu/N-TiO_(2) *** 9 h visible-light-illumination at 160℃,the CO,CH4and O_(2) yields reached 49.7,1455.1 and 2910.2μmol/gcat,*** the 7thcycling,the yields of two main CH4and O_(2) products were slightly down by less than 11.5%,and the selectivity of CH_(4) product kept above 98%.Combined with the theoretical surface mode,Cu/N co-doping could promote the adsorption-ability for H_(2)O and CO_(2) molecules and reduce activation-energy for CO_(2)***,the co-doping construction showed a great significance of designing efficient photothermal catalysts for the CO_(2)conversion application.

关键词： CO_(2)conversion photothermal catalysis rod-like TiO_(2) co-doped

Stiffness-tunable biomaterials provide a good extracellular matrix environment for axon growth and regeneration

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Neural Regeneration Research 2025年第5期20卷 1364-1376页

作者： Ronglin Han Lanxin Luo Caiyan Wei Yaru qiao jiming Xie Xianchao Pan Juan Xing Department of Pathophysiology School of Basic Medical SciencesSouthwest Medical UniversityLuzhouSichuan ProvinceChina Department of Medicinal Chemistry School of PharmacySouthwest Medical UniversityLuzhouSichuan ProvinceChina

Neuronal growth, extension, branching, and formation of neural networks are markedly influenced by the extracellular matrix—a complex network composed of proteins and carbohydrates secreted by cells. In addition to providing physical support for cells, the extracellular matrix also conveys critical mechanical stiffness cues. During the development of the nervous system, extracellular matrix stiffness plays a central role in guiding neuronal growth, particularly in the context of axonal extension, which is crucial for the formation of neural networks. In neural tissue engineering, manipulation of biomaterial stiffness is a promising strategy to provide a permissive environment for the repair and regeneration of injured nervous tissue. Recent research has fine-tuned synthetic biomaterials to fabricate scaffolds that closely replicate the stiffness profiles observed in the nervous system. In this review, we highlight the molecular mechanisms by which extracellular matrix stiffness regulates axonal growth and regeneration. We highlight the progress made in the development of stiffness-tunable biomaterials to emulate in vivo extracellular matrix environments, with an emphasis on their application in neural repair and regeneration, along with a discussion of the current limitations and future prospects. The exploration and optimization of the stiffness-tunable biomaterials has the potential to markedly advance the development of neural tissue engineering.

关键词： alginate axon growth biomaterials extracellular matrix neural repair neurons neuroregeneration polyacrylamide polydimethylsiloxane stiffness