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Bone morphogenetic protein-6 suppresses TGF-β_(2)-induced epithelial-mesenchymal transition in retinal pigment epithelium

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 646-652页

作者： Xuan liu Ming liu Meng ji Bo Ma Yu-Cen Hou Xin-Yue Yao Qiao-Chu Cheng Li Chen Department of Ophthalmology the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina Department of Ophthalmology Xi’an No.1 HospitalXi’an 710000Shaanxi ProvinceChina Shaanxi Institute of Ophthalmology Xi’an 710000Shaanxi ProvinceChina Department of Ophthalmology Ankang Hospital of Traditional Chinese MedicineAnkang 725000Shaanxi ProvinceChina

AIM:To evaluate the effect of bone morphogenetic protein-6(BMP-6)on transforming growth factor(TGF)-β_(2)-induced epithelial-mesenchymal transition(EMT)in retinal pigment epithelium(RPE).METHODS:Adult retinal pigment epithelial cell line(ARPE-19)were randomly divided into control,TGF-β_(2)(5μg/L),and BMP-6 small interfering RNA(siRNA)*** cell morphology was observed by microscopy,and the cell migration ability were detected by Transwell *** EMT-related indexes and BMP-6 protein levels were detected by Western ***,a BMP-6 overexpression plasmid was constructed and RPE cells were divided into the control group,TGF-β_(2)+empty plasmid group,BMP-6 overexpression group,and TGF-β_(2)+BMP-6 overexpression *** EMT-related indexes and extracellular regulated protein kinases(ERK)protein levels were ***:Compared with the control group,the migration of RPE cells in the TGF-β_(2) group was significantly ***-β_(2) increased the protein expression levels ofα-smooth muscle actin(α-SMA),fibronectin and vimentin but significantly decreased the protein levels of E-cadherin and BMP-6(P2) and prevented TGF-β_(2) from affecting EMT-related biomarkers(P2),which may provide a theoretical basis for the prevention and treatment of proliferative vitreoretinopathy.

关键词： bone morphogenetic protein-6 epithelialmesenchymal transition transforming growth factor-β_(2) retinal pigment epithelial cells cell migration

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The Effect and Mechanism of Fructus lycii on Improvement of Exercise Fatigue Using a Network Pharmacological Approach with in vitro Experimental Verification

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Biomedical and Environmental Sciences 2024年第1期37卷 42-53页

作者： ji Xiao Ning liu Zhao Ping ZHANG Chao Zheng CHEN Min LIANG jiang LU jiang ZHANG Lei National Resource Center for Chinese Materia Medica China Academy of Chinese Medical SciencesBeijing 100700China China National Center for Food Safety Risk Assessment Beijing 100022China Chinese Center for Disease Control and Prevention Beijing 102206China

Objective This study aimed to investigate the effect and underlying mechanism of Fructus lycii in improving exercise *** A network pharmacological approach was used to explore potential mechanisms of action of Fructus *** muscle C2C12 cells and immunofluorescence were employed to verify the effect and mechanism of the representative components in Fructus lycii predicted by network pharmacological *** Six potential active components,namely quercetin,β-sitosterol,stigmasterol,7-Omethylluteolin-6-C-beta-glucoside_qt,atropine,and glycitein,were identified to have potency in improving exercise fatigue via multiple pathways,such as the PI3K-Akt,neuroactive ligand-receptor interaction,IL-17,TNF,and MAPK signaling *** immunofluorescence results indicated that quercetin,a significant active component in Fructus lycii,increased the mean staining area of 2-NBDG,TMRM,and MitoTracker,and decreased the area of CellRox compared to the ***,the protein expression levels of p-38 MAPK,p-MAPK,p-JNK,p-PI3K,and p-AKT markedly increased after quercetin *** Fructus lycii might alleviate exercise fatigue through multiple components and *** these,quercetin appears to improve exercise fatigue by enhancing energy metabolism and reducing oxidative *** PI3K-AKT and MAPK signaling pathways also appear to play a role in this process.

关键词： Fructus lycii Exercise fatigue Network pharmacology

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Adaptive Predefined-Time Backstepping Control for Grid Connected Photovoltaic Inverter

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Energy Engineering 2024年第8期121卷 2065-2083页

作者： jiarui Zhang Dan liu Kan Cao Ping Xiong Xiaotong ji Yanze Xu Yunfei Mu Key Laboratory of Smart Grid of Ministry of Education Tianjin UniversityTianjin300072China State Grid Hubei Electric Power Research Institute Wuhan430077China State Grid Hubei Electric Power Co. Ltd.Wuhan430077China

The system performance of grid-connected photovoltaic(PV)has a serious impact on the grid *** improve the control performance and shorten the convergence time,a predefined-time controller based on backstepping technology and dynamic surface control is formulated for the inverter in the grid-connected *** time-varying tuning functions are introduced into state-tracking errors to realize the predefined-time control *** address the“computational explosion problem”in the design process of backstepping control,dynamic surface control is adopted to avoid the analytical calculations of virtual *** disturbances of the PV system are estimated and compensated by adaptive *** control parameters are chosen and the global stability of the closed-loop is ensured by Lyapunov *** results confirm the effectiveness of the proposed controller and ensure the predefined time control in the photovoltaic inverter.

关键词： Photovoltaic inverter system backstepping technology predefined-time control adaptive control

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Insights into photocatalytic mechanism over a novel Cu_(2)WS_(4)/MoS_(2) S-scheme heterojunction

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Rare Metals 2024年第7期43卷 3118-3133页

作者： Wei Zhao ji-Hui Cao Jun-jie Liao Yun liu Xiao-Jun Zeng Jun-Yu Shen Xue-Kun Hong Yang Guo He-Hua Zeng Ya-Zi liu School of Materials Engineering Jiangsu Key Laboratory of Advanced Functional MaterialsSchool of Electronic and Information EngineeringChangshu Institute of TechnologyChangshu215500China School of Chemistry and Chemical Engineering Changji UniversityChangji 831100China State Environmental Protection Key Laboratory of Soil Environmental Management and Pollution Control Ministry of Ecology and EnvironmentNanjing Institute of Environmental SciencesNanjing 210023China School of Environment Jiangsu Engineering Lab of Water and Soil Eco-RemediationNanjing Normal UniversityNanjing 210023China Department of Chemical Engineering Curtin UniversityPerthWA6845Australia

A novel efficient Cu_(2)WS_(4)/MoS_(2) step-scheme(S-scheme)heterojunction photocatalyst was constructed for the first time and applied in the removal of environmental *** the as-prepared photocatalysts,the Cu_(2)WS_(4)/MoS_(2)-8%heterojunc tion photoc atalyst demonstrates the optimal photocatalytic performance,with the catalytic oxidation efficiency of tetracycline(TC)and the catalytic reduction efficiency of Cr^(6+)reaching 93.3%and 82.1%,*** excellent catalytic properties of Cu_(2)WS_(4)/MoS_(2) heterojunction photocatalysts are attributed to the effective separation pathways of charges and the presence of S-scheme heterojunctions,together with stronger redox *** is speculated that the photogenerated carrier migration path of the Cu_(2)WS_(4)/MoS_(2) catalyst follows the typical S-scheme photocatalytic mechanism,which is verified by the in-depth experimental study and simulated calculations including the electron paramagnetic resonance(EPR)analysis,free radical quenching experiments,charge density distribution,and simulated built-in electric field formation at the interface,which acts as driving force to promote the separation of photoinduced electrons and ***,the photocatalytic mechanism of S-scheme photogenerated carrier migration for the Cu_(2)WS_(4)/MoS_(2) catalyst is revealed based on the systematic experimental techniques and simulated calculations,accounting for its superior photocatalytic oxidation and reduction *** study provides inspiring implications to develop high-efficient S-scheme photocatalytic systems for versatile applications in solarenergy conversion.

关键词： Cu_(2)WS_(4)/MoS_(2) S-scheme Heterojunction Photocatalysis

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Advances in the study of gastric organoids as disease models

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1725-1736页

作者： Yi-Yang liu De-Kun Wu ji-Bing Chen You-Ming Tang Feng jiang Graduate School Guangxi University of Chinese MedicineNanning 530011Guangxi Zhuang Autonomous RegionChina Teaching Experiment and Training Center Guangxi University of Chinese MedicineNanning 530011Guangxi Zhuang Autonomous RegionChina Central Laboratory Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese MedicineNanning 530011Guangxi Zhuang Autonomous RegionChina Department of Digestive Disease Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese MedicineNanning 530011Guangxi Zhuang Autonomous RegionChina AIDS Research Center Ruikang Hospital Affiliated to Guangxi University of Traditional Chinese MedicineNanning 530011Guangxi Zhuang Autonomous RegionChina

Gastric organoids are models created in the laboratory using stem cells and sophisticated three-dimensional cell culture *** models have shown great promise in providing valuable insights into gastric physiology and advanced disease *** review comprehensively summarizes and analyzes the research advances in culture methods and techniques for adult stem cells and induced pluripotent stem cell-derived organoids,and patient-derived *** potential value of gastric organoids in studying the pathogenesis of stomach-related diseases and facilitating drug screening is initially *** construction of gastric organoids involves several key steps,including cell extraction and culture,three-dimensional structure formation,and functional *** the structure and function of the human stomach by disease modeling with gastric organoids provides a platform to study the mechanism of gastric cancer induction by Helicobacter *** addition,in drug screening and development,gastric organoids can be used as a key tool to evaluate drug efficacy and toxicity in preclinical *** can also be used for precision medicine according to the specific conditions of patients with gastric cancer,to assess drug resistance,and to predict the possibility of adverse ***,despite the impressive progress in the field of gastric organoids,there are still many unknowns that need to be addressed,especially in the field of regenerative ***,the reproducibility and consistency of organoid cultures are major challenges that must be *** challenges have had a significant impact on the development of gastric ***,as technology continues to advance,we can foresee more comprehensive research in the construction of gastric *** research will provide better solutions for the treatment of stomach-related diseases and personalized medicine.

关键词： Organoids Stomach neoplasms Helicobacter pylori Drug evaluation Preclinical Precision

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Electrosynthesis of H_(2)O_(2)via two-electron oxygen reduction over carbon-based catalysts:From microenvironment control to electrode/reactor design

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Energy Reviews 2024年第2期3卷 117-135页

作者： jingjing jia Zhenxin Li Yunrui Tian Xia Li Rui Chen jiachen liu ji Liang Key Laboratory of Advanced Ceramics and Machining Technology Ministry of EducationSchool of Materials Science and EngineeringTianjin UniversityTianjinChina

The electrochemical production of hydrogen peroxide(H_(2)O_(2))by the two-electron oxygen reduction(2e^(-)ORR)process has the advantages of high safety,low energy consumption,and environmental *** 2e^(-)ORR,the catalyst/electrode is the key component as it strongly affects catalytic performance and *** materials have the advantages of high electronic conductivity,good structural stability,easy control of nanostructures,and low ***,it has been regarded as a promising catalyst/electrode material for the electrosynthesis of H_(2)O_(2)via 2e^(-)*** addition,studies have also considered the optimization of the liquid/gas interface by tuning the electrode surface,electrolyte pH,and reactor configurations for further improving the activity and selectivity of *** this review,we provide an in-depth discussion of the recent research on the carbon-based electrocatalysts for 2e^(-)ORR,especially in terms of microenvironment tuning,catalyst/electrode interface engineering,and reactor design for achieving stable and efficient production of H_(2)O_(2).The challenges that we are still facing and the future development prospects will then be concluded,which we believe should help the future development in this field.

关键词： Oxygen reduction Hydrogen peroxide Carbon-based catalyst Electrode surface Reactor design

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Extraordinary stability of surfactant-free bubbles suspended in ultrasound

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Droplet 2024年第2期3卷 146-152页

作者： Xiaoliang ji Wenxuan Zhong Kangqi liu Yichen jiang Hongyue Chen Wei Zhao Duyang Zang School of Physical Science and Technology Northwestern Polytechnical UniversityXi'anChina Shaanxi Liquid Physics Research Center Xi'anChina School of Marine Science and Technology Northwestern Polytechnical UniversityXi'anChina State Key Laboratory of Photon-Technology in Western China Energy International Scientific and Technological Cooperation Base of Photoelectric Technology and Functional Materials and ApplicationInstitute of Photonics and Photon-TechnologyNorthwest UniversityXi'anChina

Gravity-induced drainage is one of the main destabilizing mechanisms for soap bubbles and *** we show that solely through acoustic levitation without introducing any chemical stabilizers,liquid drainage in the bubble film can be completely inhibited,therefore leading to a significant enhancement of bubble lifetime by more than two orders of magnitude and enabling the bubble to survive puncturing by a *** on sound simulation and force analysis,it has been found that acoustic radiation force,exerted on both the inner and outer surfaces of the levitated bubble,acts in opposite directions,thus providing a squeezing effect to the bubble *** hydrostatic pressure that induces drainage has been balanced by the acoustic radiation pressure exerted on both sides of the film,which is at the origin of the sound stabilization *** study provides new insights into the interplay between sound and soap bubbles or films,thus stimulating a wide range of fundamental research concerning bubble films and expanding their applications in bio/chemical reactors.

关键词： bubble sound ordinary

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Case Retrieval Strategy of Turning Process Based on Grey Relational Analysis

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Computer Modeling in Engineering & Sciences 2024年第2期138卷 1663-1678页

作者： jianfeng Zhao Yunliang Huo ji Xiong Junbo liu Zhixing Guo Qingxian Li School of Mechanical Engineering Sichuan UniversityChengdu610065China Sichuan Engineering Technology Research Center of Intelligent Design and Service for Cutting Tools Yibin R&D Park of Sichuan UniversityYibin644000China Department of R&D Pengxi Heye High-Tech Co.Ltd.Suining629000China

To solve the problem of long response time when users obtain suitable cutting parameters through the Internet based platform,a case-based reasoning framework is ***,a Hamming distance and Euclidean distance combined method is designed to measure the similarity of case features which have both numeric and category *** addition,AHP(Analytic Hierarchy Process)and entropy weight method are integrated to provide features weight,where both user preferences and comprehensive impact of the index have been *** relation analysis is used to obtain the similarity of a new problem and alternative ***,a platform is also developed on Visual Studio 2015,and a case study is demonstrated to verify the practicality and efficiency of the proposed *** method can obtain cutting parameters which is suitable without iterative *** with the traditional PSO(Particle swarm optimization algorithm)and GA(Genetic algorithm),it can obtain faster response *** method can provide ideas for selecting processing parameters in industrial *** guaranteeing the characteristic information is similar,this approach can select processing parameters which is the most appropriate for the production process and a lot of time can be saved.

关键词： CBR turning process grey relation AHP entropy weight

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How mesenchymal stem cells transform into adipocytes:Overview of the current understanding of adipogenic differentiation

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World Journal of Stem Cells 2024年第3期16卷 245-256页

作者： Shan-Shan liu Xiang Fang Xin Wen ji-Shan liu Miribangvl Alip Tian Sun Yuan-Yuan Wang Hong-Wei Chen Department of Reumatology and Immunology Nanjing Drum Tower HospitalThe Affiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008Jiangsu ProvinceChina Department of Emergency Nanjing Drum Tower HospitalThe Affiliated Hospital of Medical SchoolNanjing UniversityNanjing 210008Jiangsu ProvinceChina Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical EngineeringBeihang UniversityBeijing 100191China Anhui Key Laboratory of Infection and Immunity Bengbu Medical CollegeBengbu 233000Anhui ProvinceChina

Mesenchymal stem cells(MSCs)are stem/progenitor cells capable of self-renewal and differentiation into osteoblasts,chondrocytes and *** transformation of multipotent MSCs to adipocytes mainly involves two subsequent steps from MSCs to preadipocytes and further preadipocytes into adipocytes,in which the process MSCs are precisely controlled to commit to the adipogenic lineage and then mature into *** studies have shown that the master transcription factors C/enhancer-binding protein alpha and peroxisome proliferation activator receptor gamma play vital roles in ***,the mechanism underlying the adipogenic differentiation of MSCs is not fully ***,the current knowledge of adipogenic differentiation in MSCs is reviewed,focusing on signaling pathways,noncoding RNAs and epigenetic effects on DNA methylation and acetylation during MSC ***,the relationship between maladipogenic differentiation and diseases is briefly *** hope that this review can broaden and deepen our understanding of how MSCs turn into adipocytes.

关键词： Mesenchymal stem cell Adipogenic differentiation Signaling pathway Noncoding RNA Epigenetic regulation

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Modification strategies for non-aqueous, highly proton-conductive benzimidazole-based high-temperature proton exchange membranes

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Chinese Chemical Letters 2024年第4期35卷 43-51页

作者： Yunfa Dong Shijie Zhong Yuhui He Zhezhi liu Shengyu Zhou Qun Li Yashuai Pang Haodong Xie Yuanpeng ji Yuanpeng liu jiecai Han Weidong He National Key Laboratory of Science and Technology on Advanced Composites in Special Environments and Center for Composite Materials and StructuresHarbin Institute of TechnologyHarbin 150080China School of Petroleum Engineering Chongqing University of Science and TechnologyChongqing 401331China School of Physics University of Electronic Science and Technology of ChinaChengdu 610054China MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001China Chongqing Research Institute Harbin Institute of TechnologyChongqing 401151China School of Mechanical Engineering Chengdu UniversityChengdu 610106China

High-temperature proton exchange membranes(HT-PEMs) possess excellent thermal and outstanding electrochemical stability, providing an avenue to realize high-temperature proton exchange membranes fuel cells(HT-PEMFCs) with both superior power density and long-term durability. Unfortunately, polybenzimidazole(PBI), a typical material for conventional HT-PEMs, fails to compromise the high nonaqueous proton conductivity and high mechanical properties, thus hindering their practical *** efficient nonaqueous proton conduction is crucial for HT-PEMFC, and many insightful research works have been done in this area. However, there still lacks a report that integrates the host-guest interactions of phosphoric acid doping and the structural stability of polymers to systematically illustrate modification strategies. Here, we summarize recent advancements in enhancing the nonaqueous proton conduction of HT-PEMs. Various polymer structure modification strategies, including main chain and side group modification, cross-linking, blocking, and branching, are reviewed. Composite approaches of polymer, including compounding with organic porous polymers, filling the inorganic components and modifying with ionic liquids, etc., are also covered in this work. These strategies endow the HT-PEMs with more free volume, nanophase-separated structure, and multi-stage proton transfer channels, which can facilitate the proton transportation and improve their performance. Finally, current challenges and future directions for further enhancements are also outlined.

关键词： Benzimidazole Nonaqueous proton conduction Free volume Nanophase-separated structure Structure modification

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