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Clobenpropit enhances anti-tumor effect of gemcitabine in pancreatic cancer

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World Journal of Gastroenterology 2014年第26期20卷 8545-8557页

作者： Woo Hyun Paik ji Kon Ryu Kyoung-Sin Jeong jin Myung park Byeong Jun Song Sang Hyub Lee Yong-tae Kim Yong Bum Yoon Department of Internal Medicine Inje University Ilsan Paik Hospital Division of Gastroenterology Department of Internal Medicine and Liver Research InstituteSeoul National University College of Medicine

AIM: To evaluate the anti-tumor effect of clobenpropit, which is a specific H3 antagonist and H4 agonist, in combination with gemcitabine in a pancreatic cancer cell line.

关键词： Clobenpropit Epithelial-mesenchymal transition Histamine Histamine receptors Pancreatic neoplasm

Ampullary neuroendocrine tumor diagnosed by endoscopic papillectomy in previously confirmed ampullary adenoma

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World Journal of Gastroenterology 2016年第13期22卷 3687-3692页

作者： Seoung Ho Lee tae Hoon Lee Si-Hyong Jang Chi Young Choi Won Myung Lee ji Hey Min Hyun Deuk Cho Sang-Heum park Division of Gastroenterology Department of Internal Medicine Soonchunhyang University College of Medicine Cheonan Hospital Department of Pathology Soonchunhyang University College of Medicine Cheonan Hospital

Ampullary adenoma is a common indication for endoscopic papillectomy. Ampullary neuroendocrine tumor(NET) is a rare disease for which complete surgical resection is the treatment of choice. However, because of the morbidity and mortality associated with surgical resection, endoscopic papillectomy is increasingly used in selected cases of low grade, with no metastasis and no invasion of the pancreatic or bile duct. Also, confirmed and complete endoscopic resection of ampullary NET accompanied by adenoma has not been reported to date. We report herein a rare case of an ampullary NET accompanied with adenoma, which was successfully and completely resected via endoscopic papillectomy. Prior to papillectomy, this case was diagnosed as an ampullary adenoma.

关键词： Ampulla of Vater Neuroendocrine tumor Adenoma Papillectomy

Microforming of superplastic 5083 aluminum alloy

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中国有色金属学会会刊：英文版 2012年第S3期22卷 656-660页

作者： Md.Abu Mowazzem HOSSAIN Sung-tae HONG Kyu-Yeol park Young-Sang NA School of Mechanical Engineering University of Ulsan Korea Institute of Materials Science

The mechanical behavior of superplastic 5083 aluminum alloy during microforming process was investigated by finite element analysis.A micro V-groove die was modeled to analyze the effects of forming time,load and temperature on the microformability of the 5083 aluminum ***,the microformability of the 5083 aluminum alloy was estimated using a microformability *** simulation results show that the microformability increases with the forming load,time and temperature *** of the 5083 aluminum alloy during microforming using the V-groove die was also investigated in terms of the effective strain *** results show that the superplasticity of the 5083 aluminum alloy occurs in a specific part of the material for a specific period during the microforming process depending on the forming conditions and the microformability index.

关键词： microforming superplasticity 5083 aluminum alloy

Power-aware transceiver design for half-duplex bidirectional chip-to-chip optical interconnects

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Journal of Semiconductors 2013年第12期34卷 60-65页

作者： Jamshid Sangirov Ikechi Augustine Ukaegbu Gulomjon Sangirov tae-Woo Lee Hyo-Hoon park Electrical Engineering Department Korea Advanced Institute of Science and Technology (KAIST) Information and Communication Engineering Department Harbin Engineering University

A power-aware transceiver for half-duplex bidirectional chip-to-chip optical interconnects has been designed and fabricated in a 0.13 μm complementary metal-oxide-semiconductor （CMOS） technology. The transceiver can detect the presence and absence of received signals and saves 55% power in Rx enabled mode and 45% in Tx enabled mode. The chip occupies an area of 1.034 mm2 and achieves a 3-dB bandwidth of 6 GHz and 7 GHz in Tx and Rx modes, respectively. The disabled outputs for the Tx and Rx modes are isolated with 180 dB and 139 dB, respectively, from the enabled outputs. Clear eye diagrams are obtained at 4.25 Gbps for both the Tx and Rx modes.

关键词： optical transceiver power detector optical interconnect voltage regulator

Effect of Post-Rolling after ECAP on Superplastic Behavior of Commercial Al-Mg Alloy

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Journal of Rare Earths 2004年第Z2期22卷 53-56页

作者： Dong Hyuk Shin Byung Du Ahn Hyun Soo Woo Kyeom Kim Kyung-tae park Department of Metallurgy and Materials Science Hanyang UniversityAnsan 425-791Korea Department of Metallurgy and Materials ScienceHanyang UniversityAnsan 425-791Korea Department of Metallurgy and Materials ScienceHanyang UniversityAnsan 425-791Korea Department of Metallurgy and Materials ScienceHanyang UniversityAnsan 425-791Korea Division of Advanced Materials Science & EngineeringHanbat National UniversityTaejon 305-719Korea

A commercial Al-Mg alloy was subjected to equal channel angular pressing of 4 passes with and without postrolling, and the effects of post-rolling on the deformation characteristics of the alloy at 723 K were examined. Post-rolling was found to influence the deformation behavior significantly. The deformation behavior of the alloy processed only by equal channel angular pressing was characterized by (a) localized deformation indicated by severe surface prominence and depression, (b) the strain rate sensitivity of 0.33, and (c) moderate high strain rate superplastic elongations. By contrast, that of the alloy processed by equal channel angular pressing and post-rolling (70 % thickness reduction) was manifested by (a) uniform deformation associated with grain boundary sliding throughout the sample, (b) a sigmoidal behavior showing the strain rate sensitivity of 0.45 at the intermediate strain rates in the logarithmic stress-strain rate curve, and (c) very large high strain rate superplastic elongations.

关键词： high superplasticity equal channel angular pressing rolling deformation mechanisms rare earths

Do you have what it takes for challenging endoscopic submucosal dissection cases?

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World Journal of Gastroenterology 2011年第31期17卷 3580-3584页

作者： Kyoung-Oh Kim Sung Jung Kim tae Hyeon Kim Jong-Jae park Division of Gastroenterology and Hepatology Department of Internal MedicineHallym University Medical Center Division of Gastroenterology and Hepatology Department of Internal MedicineWonkwang University Hospital Division of Gastroenterology and Hepatology Department of Internal MedicineKorea University Guro Hospital Korea University College of Medicine

Endoscopic submucosal dissection(ESD) is a widely accepted treatment for early gastric cancer(EGC),especially in Korea and *** criteria for the therapeutic use of ESD for EGC have been expanded ***,attention should be drawn to the technical feasibility of the ESD treatment which depends on a lesion's location,size or fibrosis level,or operator's *** the case of a lesion with a high level of difficulty,a more experienced operator is ***,the treatment for a lesion with a high level of difficulty should be performed according to the degree of the operator's *** this paper,the authors describe the ESD procedure for lesions with a high level of difficulty.

关键词： Endoscopic submucosal dissection Anatomical location Technical feasibility

Rapid assessment checklist for green roof ecosystem services in Bangkok,Thailand

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Ecological Processes 2020年第1期9卷 205-221页

作者： Rattanapan Phoomirat Nipada Ruankaew Disyatat tae Yoon park Dong Kun Lee Pongchai Dumrongrojwatthana Biological Sciences Program Faculty of ScienceChulalongkorn UniversityBangkok 10330Thailand Department of Biology Faculty of ScienceChulalongkorn UniversityBangkok 10330Thailand Graduate School of Education Yonsei UniversitySeoul 03722Republic of Korea Department of Landscape Architecture and Rural System Engineering Seoul National UniversitySeoul 08826Republic of Korea

Background:A green roof is a man-made ecosystem created when a rooftop is covered with substrate and *** green roof ecosystems(GREs)are able to provide ecosystem services,there is currently no assessment tool available to specifically evaluate ***,the aim of this study was to develop a rapid assessment checklist(RAC)to assess GRE services(GRES),which was developed and tested on 10 green roofs in Bangkok,***:The RAC consisted of 46 proxy indicators(33 qualitative and 13 quantitative indicators)encompassing various aspects of *** GRES values or scores varied according to structural differences in the green *** average score(from a maximum of 100)of total ecosystem services was 61±7,which could be inferred as a good performance in ecosystem service *** highest scores were obtained from the regulating services at 68±*** lowest average score was 53±11 from the provisioning ***:The RAC was able to evaluate the levels of GRES provided by the selected green roofs,enabling the meaningful comparison of their potential capability to provide ***,this RAC could be an innovative tool for evaluation of four categories of GRES.

关键词： Vegetated roof Evaluation Composite indicator Urban ecosystem Ecosystem management

Structural considerations in friction welding of hybrid Al_2O_3-reinforced aluminum composites

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 42-46页

作者： In-Duck park Choon-tae LEE Hyun-Soo KIM Woo-jin CHOI Myung-Chang KANG Busan Metropolitan City Hall Fundamental Industries Division 2001 Jungang-ro Yeonje-gu Busan 611-735 Korea Department of Automotive & Mechanical Engineering Silla University Research & Development Center Sam-Ho precision 1256-1 Daejeo2-dong Gangseo-gu Busan 618-807 Korea National Core Research Center for Hybrid Materials Solution Pusan National University

Comparative studies on the relationship between the welding parameters and joining efficiency in the friction welding of hybrid Al203-reinforced aluminum composites were conducted. Metal matrix composites （MMCs） with 37% （volume fraction） aluminum particle were joined by friction welding. The results show that the effects of the rotation speed on the reduction rate of particle size are greater than those of the upset pressure, and the area of the MMC weld zone decreases as the joining efficiency increases, while it is considered that the joining efficiency does not increase as the reduction rate of particle size decreases. During the macro-examination of the bonding interlace, a gray discolored region was observed on the bonding interface, and the center of the region was dark gray. After the micro-examination of the bonding interface, base metal made some second particulate formed by condensed alumina particulate but discoloration part distributed minute alumina particulate without second particulate. Consequently, it was also observed that rotational speed of 3 000 r/min and upset pressure of 63.6 MPa showed a very ***.

关键词： friction welding hybrid aluminum composite bonding interface joining efficiency metal matrix composite

Gastric metastasis from primary lung adenocarcinoma mimicking primary gastric cancer

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World Journal of Gastrointestinal Oncology 2015年第3期7卷 12-16页

作者： Min ji Kim ji Hyung Hong Eun Su park Jae Ho Byun Department of Internal Medicine Incheon St.Mary’s HospitalCollege of MedicineThe Catholic University of Korea Division of Medical Oncology Department of Internal MedicineIncheon St.Mary’s HospitalCollege of MedicineThe Catholic University of Korea Department of Hospital Pathology Incheon St.Mary’s HospitalCollege of MedicineThe Catholic University of Korea

Gastric metastases from lung adenocarcinoma are rare. Because gastric metastasis grossly resembles advanced gastric cancer, it is difficult to diagnose gastric metastasis especially when the histology of the primary lung cancer is adenocarcinoma. We describe a case of gastric metastasis from primary lung adenocarcinoma mimicking Borrmann type Ⅳ primary gastric cancer. A 68-year-old man with known lung adenocarcinoma with multiple bone metastases had been experiencing progressive epigastric pain and dyspepsia over one year. Esophagogastroduodenoscopy revealed linitis plasticalike lesions in the fundus of the stomach. Pathologic examination revealed a moderately differentiated adenocarcinoma with submucosal infiltration. Positive immunohistochemical staining for thyroid transcription factor-1(TTF-1) and napsin A(Nap-A) confirmed that the metastasis was pulmonary in origin. The patient had been treated with palliative chemotherapy for the lung cancer and had lived for over fifteen months after the diagnosis of gastric metastasis. Clinicians should be aware of the possibility of gastric metastasis in patients with primary lung adenocarcinoma, and additional immunohistochemical staining for Nap-A as well as TTF-1 may help in differentiating its origin.

关键词： Adenocarcinoma of lung Napsin-A Thyroidtranscription factor-1 Gastric metastasis