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Parthenolide inhibits proliferation of vascular smooth muscle cells through induction of G_0/G_1 phase cell cycle arrest

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第7期10卷 528-535页

作者： Shao-xiang WENG Mei-hua SUI Shan CHEN jian-an WANG Geng XU ji ma jiang SHAN Lu FANG Department of Cardiology the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China Department of Chemical and Biochemical Engineering Zhejiang University Hangzhou 310027 China Department of Pathology and Laboratory Medicine Medical University of South Carolina Charleston SC 29425 USA

Objective： This study is to determine the effect of the natural product parthenolide, a sesquiterpene lactone isolated from extracts of the herb Tanacetum parthenium, on the proliferation of vascular smooth muscle cells （VSMCs）. Methods： Rat aortic VSMCs were isolated and cultured in vitro, and treated with different concentrations ofparthenolide （l 0, 20 and 30 μmol/L）. [^3H]thymidine incorporation was used as an index of cell proliferation. Cell cycle progression and distribution were determined by flow cytometric analysis. Furthermore, the expression of several regulatory proteins relevant to VSMC proliferation including IκBα, cyclooxygenase-2 （Cox-2）, p21, and p27 was examined to investigate the potential molecular mechanism. Results： Treatment with parthenolide significantly decreased the [^3H]thymidine incorporation into DNA by 30%-56% relative to control values in a dose-dependent manner （P〈0.05）. Addition of parthenolide also increased cell population at G0/G1 phase by 19.2%-65.7% （P〈0.05） and decreased cell population at S phase by 50.7%-84.8% （P〈0.05）, which is consistent with its stimulatory effects on p21 and p27. In addition, parthenolide also increased IκBα expression and reduced Cox-2 expression in a time-dependent manner. Conclusion： Our results show that parthenolide significantly inhibits the VSMC proliferation by inducing G0/G1 cell cycle arrest. IκBα and Cox-2 are likely involved in such inhibitory effect ofparthenolide on VSMC proliferation. These findings warrant further investigation on potential therapeutic implications ofparthenolide on VSMC proliferation in vivo.

关键词： Parthenolide Vascular smooth muscle cell (VSMC) Cell proliferation IκBα Cyclooxygenase-2 (Cox-2) p21

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世界三代压水堆主要机型技术分析（英文）

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2016年第11期17卷 911-922页

作者： Yong WANG ji-en ma You-tong FANG Shanghai Nuclear Engineering Research and Design Institute Shanghai 200233China College of Electrical Engineering Zhejiang UniversityHangzhou 310027China

本文针对目前主要的第三代压水堆机型EPR、AES2006以及CAP1400,从核电厂设计理念,综合性能、安全性和经济性等方面进行对比分析。在此基础上,结合福岛核事故,探讨中国商用核电未来的技术发展方向。通过对EPR、AES2006以及CAP1400的对比... 详细信息

本文针对目前主要的第三代压水堆机型EPR、AES2006以及CAP1400,从核电厂设计理念,综合性能、安全性和经济性等方面进行对比分析。在此基础上,结合福岛核事故,探讨中国商用核电未来的技术发展方向。通过对EPR、AES2006以及CAP1400的对比分析发现,尽管它们采用了不同的设计理念和技术方式,但作为目前第三代商用压水堆的代表机型,其目标都在于提高核电厂的整体性能、安全性能和经济性,从而在提高安全性的前提下,强化其相比于其他发电方式的竞争力,获得政府、公众和业主的支持。第三代压水堆技术的主要努力方向在于:在安全方面,进一步强化纵深防御体系,将设计加强工况(包括全厂断电、商用飞机撞击和预期未能停堆的瞬态等)纳入设计考虑的范畴;设置预防和缓解严重事故的措施;考虑极端外部事件设防(包括地震和洪水等)。再者,对非能动安全与能动安全两者之间的关系定位、相互衔接进行优化设置,从而更好的保障核安全。此外,严重事故下设备和仪表的可用性成为福岛核事故后需要特别关注的问题。从经济性的角度讲,加强设计简化和标准化,及时将EPR、AES2006以及CAP1400的首台组的建造经验反馈到后续机组,改进可建造性和模块化从而确保经济性和缩短建造周期。从运行的角度讲,考虑国内核电装机容量的增加、较长的设计寿命以及其他可再生能源的并网,核电设计需强化负荷跟踪的能力。长期来看,需要考虑可能的气候变化,从而确保核电站(沿海和内陆)具有较强的应对极端气候以及较高环境温度和冷却水升温的能力。

关键词：第三代压水堆技术性能安全性经济性核电

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A novel biomarker based on five tsDElncRNAs SLC25A5-AS1,RP11-336A10.4,FLJ42969,RP11-21L19.1 and RP11-406H23.2 can predict the prognostic risk of papillary renal cell carcinoma

A novel biomarker based on five tsDElncRNAs SLC25A5-AS1,RP11...

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2022CCTB中国肿瘤标志物学术大会暨中国整合肿瘤学大会暨第十六届肿瘤标志物青年科学家论坛暨中国肿瘤标志物产业创新大会

作者： ji ma Zhejiang Sci-Tech University

Background:Long non-coding RNA(lncRNA) has attracted attention of researchers in recent years because of its potential role in ***-specific differentially expressed lncRNAs(tsDElncRNAs) play an important role in the occurrence and development of papillary renal cell carcinoma(pRCC).The prognosis of pRCC remains poor and the research of developing prognostic lncRNA biomarkers of pRCC has been ***,tsDElncRNAs of pRCC have not been screened and whether they can be used as prognostic biomarkers has not been ***:RNA-seq data obtained from the pRCC project of TCGA database(TCGA-KIRP) were analyzed by using bioinformatics tools,including the screening of prognostic tsDElncRNAs,the establishment of a prognostic risk prediction model,and the correlation analysis between risk score and clinical characteristics(***,gender,pathological stage,tumor stage,etc.).Results:441 pRCC tsDElncRNAs were *** Cox regression analysis showed that 53 tsDElncRNAs were significantly associated with the prognosis of pRCC(p 0.05),but related to vital status,race,height,tumor recurrence,primary lymph node(PLN) presentation and TNM stage(pmarker based on th

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Long-term follow-up of HCV patients with sustained virological response after treatment with pegylated interferon plus ribavirin

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Hepatobiliary & Pancreatic Diseases International 2021年第2期20卷 137-141页

作者： Yuan-ji ma Ling-Yao Du Li-Bo Yan Juan Liao Xing Cheng Wu-Wei Xie Hong Tang Center of Infectious Diseases West China Hospital of Sichuan UniversityChengdu 610041China

Background:The progress of liver diseases may not stop after viral *** study aimed to provide data on long-term prognosis of patients with hepatitis C virus(HCV)infection who underwent pegylated interferon plus ribavirin(PR)regimen and achieved a sustained virological response 24 weeks post-treatment(SVR24).Methods:Responders to the PR regimen in our hospital from January 2011 to June 2014 were enrolled and prospectively followed *** characteristics were *** incidence of hepatocellular carcinoma(HCC),progression of liver disease(increase in liver stiffness or occurrence of decompensated complication),and HCV recurrence was all *** accumulative and annualized incidence rates(AIRs)of these adverse events were analyzed,and the risk factors were also ***:In total,151 patients reached a median follow-up time of 103 *** them,two had an incidence of HCC during the surveillance with AIR of 0.68%(95%CI:0.00-1.63%).Six patients showed progression of liver disease with AIR of 2.05%(95%CI:0.42%-3.68%).Three patients who had risky behaviors encountered HCV *** cirrhotic patients faced higher risk of poor prognosis than non-cirrhotic patients,including HCC and progression of liver disease(AIR:6.17%vs.1.42%,P=0.039).Conclusions:The incidence of HCC and progression of liver disease was evident in PR responders during the long-term follow-up period,but the risk level was *** responders were more vulnerable to develop HCC post SVR24 compared with non-cirrhotic *** recurrence was rare in responders with SVR24 who had corrected their risky behaviors.

关键词： Hepatitis C virus Sustained virological response Hepatocellular carcinoma

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Predictive scores for mortality in full-term infants with necrotizing enterocolitis: experience of a tertiary hospital in Southwest China

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World Journal of Pediatrics 2016年第2期12卷 202-208页

作者： Yu Zhang ji-Kun ma Hong Wei Xiao-Wen Li Lu-Quan Li jia-Lin Yu Department of Neonatology Children's Hospital of Chongqing Medical UniversityMinistry of Education Key Laboratory of Child Development and DisordersKey Laboratory of Pediatrics in Chongqing and Chongqing International Science and Technology Cooperation Center for Child Development and DisordersChongqingChina

Background: Although many risk factors for mortalityof necrotizing enterocolitis (NEC) were investigated,most of them were obtained from preterm infants, andfew works focused on the prognostic risk factors in fullterminfants. This study aimed to identify risk factors anddevelop a prediction score model for mortality in fulltermneonates with ***: The risk factors were analyzed retrospectivelyby bivariate and multivariate logistic regression analysis in153 full-term neonates with NEC, who were hospitalizedin Children's Hospital of Chongqing Medical Universityfrom 2000 to 2013. A prediction score model was developedaccording to the regression coeffi cients of risk ***: The mortality of the infants was 19.6%(30/153). The non-survivors had a younger age of diagnosisand advanced stage of NEC (Pmal laboratoryindicators than survivors (P<0.05). Age at diagnosis [oddsratio (OR)=0.91, 95% confidence interval (CI)=0.836-0.99], respiratory failure (OR=2.76, 95% CI=1.10-6.92),and peritonitis (OR=26.36, 95% CI=7.52-173.92) hadsignificant independent contributions to death. A scoremodel predicting death was developed, and the area underthe receiver operating characteristic curve was 0.869 (95%CI=0.803-0.935). All infants with scores ≥8 ***: Younger age at diagnosis, peritonitis,and respiratory failure might be risk factors for themortality of full-term infants with NEC. Infants with apredictive score of 8 were at high risk for death.

关键词： necrotizing enterocolitis neonate predictive score model prognosis

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Three classes of smooth Banach submanifolds in B(E,F)

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Science China mathematics 2007年第9期50卷 1233-1239页

作者： ji-pu ma Tseng Yaun Rong Functional Analysis Research Center,Harbin Normal University,Harbin 150025,China 1. Tseng Yaun Rong Functional Analysis Research Center Harbin Normal University Harbin 150025 China

Let E,F be two Banach spaces, and B(E,F), Ф(E,F), SФ(E,F) and R(E,F) be the bounded linear, Fredholm, semi-Frdholm and finite rank operators from E into F, respectively. In this paper, using the continuity characteristics of generalized inverses of operators under small perturbations, we prove the following result: Let Σ be any one of the following sets: {T ∈ Ф(E,F) : IndexT = const. and dim N(T) = const.}, {T ∈ SФ(E,F) : either dim N(T) = const. manifold of B(E,F) with the tangent space T AΣ = {B ∈ B(E,F) : BN(A) ? R(A)} for any A ∈ Σ. The result is available for the further application to Thom’s famous results on the transversility and the study of the infinite dimensional geometry.

关键词： semi-Fredholm operators smooth submanifold transversility generalized inverse 47B38 15A29 58A05

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ent-Kaurane diterpenoids from the plant Wedelia trilobata

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Natural Products and Bioprospecting 2013年第3期3卷 107-111页

作者： Bing-ji ma Chun-Nan Wen Yuan Gao Fu-Cai Ren Fei Wang ji-Kai Liu Agronomy College of Henan Agricultural University Zhengzhou 450002China BioBioPha Co. Ltd.Kunming 650201China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China

Four new ent-kaurane diterpenoids,namely,3α-tigloyloxypterokaurene L_(3)(1),ent-17-hydroxy-kaura-9(11),15-dien-19-oic acid(2),and wedelobatins A(3)and B(4),together with 11 known ent-kaurane diterpenoids(5-15),were isolated from the ethanol extract of Wedelia *** the structures of 1-15 were elucidated on the basis of spectroscopic studies.

关键词： ent-kaurane diterpenoids Wedelia trilobata phytochemical investigation

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GPR160 regulates the self-renewal and pluripotency of mouse embryonic stem cells via JAK1/STAT3 signaling pathway

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Journal of Genetics and Genomics 2024年第10期51卷 1055-1065页

作者： Shasha Fan Chuanliang Guo Guanheng Yang Lei Hong Hongyu Li ji ma Yiye Zhou Shuyue Fan Yan Xue Fanyi Zeng Department of Histo-Embryology Genetics and Developmental BiologyShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Institute of Medical Genetics Shanghai Children's HospitalShanghai Jiao Tong UniversityShanghai 200040China NHC Key Laboratory of Medical Embryogenesis and Developmental Molecular Biology&Shanghai Key Laboratory of Embryo and Reproduction Engineering Shanghai200040China School of Pharmacy Macao University of Science and TechnologyMacao 99078China

G-protein-coupled receptors(GPCRs)are the largest family of transmembrane receptors and regulate various physiological and pathological *** extensive studies,the roles of GPCRs in mouse embryonic stem cells(mESCs)remain poorly ***,we show that GPR160,a class A member of GPCRs,is dramatically downregulated concurrent with mESC differentiation into embryoid bodies in *** of Gpr160 leads to downregulation of the expression of pluripotency-associated transcription factors and upregulation of the expression of lineage markers,accompanying with the ar-rest of the mESC cell-cycle in the G0/G1 ***-seq analysis shows that GPR160 participates in the JAK/STAT signaling pathway crucial formaintaining ESC stemness,and the knockdown of Gpr160 results in the downregulation of STAT3 phosphorylation level,which in turn is partially rescued by colivelin,a STAT3 *** with these observations,GPR160 physically interacts with JAK1,and co-operates with leukemia inhibitory factor receptor(LIFR)and gp130 to activate the STAT3 *** summary,our results suggest that GPR160 regulates mESC self-renewal and pluripotency by interacting with the JAK1-LIFR-gp130 complex to mediate the JAK1/STAT3 signaling pathway.

关键词： Embryonic stem cell GPCR GPR160 JAK1/STAT3 signaling pathway

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中国高速铁路的可持续发展战略（英文）

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2016年第12期17卷 923-932页

作者： Ping TAN ji-en ma jing ZHOU You-tong FANG School of Automation and Electrical Engineering Zhejiang University of Science and Technology China Academy of West Region Development Zhejiang University College of Electrical Engineering Zhejiang University

2008年以来,通过引进和消化国外高速铁路先进技术,联合设计生产和在此基础上的再创新,中国高速铁路技术进入了世界前列,并建成了世界上规模最大,技术水平最高的高速铁路网,大幅改善了中国的交通状况,带动了区域经济和装备制造业的发展... 详细信息

2008年以来,通过引进和消化国外高速铁路先进技术,联合设计生产和在此基础上的再创新,中国高速铁路技术进入了世界前列,并建成了世界上规模最大,技术水平最高的高速铁路网,大幅改善了中国的交通状况,带动了区域经济和装备制造业的发展。新的中长期铁路网规划的发布和"一带一路"及中国铁路"走出去"战略的实施,给高速铁路技术提出了新的要求。未来需要将现代科学的最新进展与高速铁路建设、运营、维护和管理的工程进一步结合,通过创新支撑中国乃至世界高速铁路的可持续发展。

关键词：高速铁路技术创新可持续发展

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Microstructural Exploration of the High Capacitance in RuO_(2)-ZrO_(2) Coating

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Chinese Journal of Structural Chemistry 2021年第1期40卷 125-135,5页

作者： ma ji-Dong WU Yun-Miao jiANG Chun-Hai ZHANG Hou-An ZHU Jun-Qiu Fujian Key Laboratory of Functional materials and Applications Xiamen University of TechnologyXiamen 361024China School of Chemical Engineering and materials Science Quanzhou Normal UniversityQuanzhou 362000China

A high capacitance RuO_(2)-ZrO_(2) coating was prepared by thermal decomposition *** X-ray absorption fine structure(EXAFS),X-ray diffraction(XRD),high-resolution transmission electron microscope(HRTEM)and ab initio calculations were applied to understand the role of the microstructure in the acquisition of high specific capacitance of RuO_(2)-based *** results show that the RuO_(2)-ZrO_(2) oxide prepared at critical crystallization temperature can be considered to be quasi-amorphous or microcrystalline(A short-range ordered crystal structure can be seen from the TEM image,but no diffraction peaks can be seen from the XRD diffraction patterns).And this RuO_(2)-ZrO_(2) was identified as a solid solution with high solid *** referred to herein as a quasi-amorphous solid *** a special microstructure was conducive for"synergistic catalysis"owing to the cationic interaction and thus could gain high"active site density"and high"active surface",thus developing high specific capacitance.

关键词： supercapacitor quasi-amorphous RuO_(2) ZrO_(2) synergistic catalysis

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