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Journal of Environmental Sciences 2016年第4期28卷 187-195页

作者： Bo-Mi Kim Min Chul lee hye-Min Kang Jae-Sung Rhee Jae-Seong lee Department of Biological Science College of ScienceSungkyunkwan University Department of Marine Science College of Natural SciencesIncheon National University

Vitellogenin（Vtg）is the precursor of egg yolk proteins,and its expression has been used as a reliable biomarker for estrogenic contamination in the aquatic *** examine the biomarker potential of the self-fertilizing killifish Kryptolebias marmoratus Vtgs（Km-Vtgs）,full genomic DNAs of Km-Vtgs-Aa,Km-Vtgs-Ab,and Km-Vtgs-C were cloned,sequenced,and *** Vtg genes in *** are tandemly placed in a550 kb section of the same *** silico analysis of promoter regions revealed that both the Km-Vtgs-Aa and Km-Vtgs-Ab genes had an estrogen response element（ERE）,but the Km-Vtgs-C gene did ***,all three Km-Vtgs genes had several ERE-half sites in their promoter *** analysis demonstrated that the three deduced amino acid residues were highly conserved with conventional Vtgs protein,forming distinctive clades within teleost *** tissue showed the highest expression of Km-Vtg transcripts in all tested tissues（brain/pituitary,eye,gonad,intestine,skin,and muscle）in response to endocrine disrupting chemical（EDC）-exposed ***-Vtg transcripts were significantly increased in response to 17β-estradiol（E2）,tamoxifen（TMX）,4-n-nonylphenol（NP）,bisphenol A（BPA）,and octylphenol（OP）over 24 hr *** Km-Vtg-A gene was highly expressed compared to the control in response to NP and ***-induced modulatory patterns of Km-Vtg gene expression were different depending on tissue,gender,and isoforms.

关键词： Kryptolebias marmoratus Vitellogenin Endocrine disrupting chemical

Performance and genetic diversity of 23 provenances of northern red oak(Quercus rubra L.)after 25 years of growth in South Korea

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Journal of Forestry Research 2021年第5期32卷 2181-2188页

作者： Ki-Won Kim Kyoung-Mi lee Soon-Ho Kwon ji-Min Park Yang-Gil Kim hye-In Kang Da-Bin Yum Kyu-Suk Kang Department of Agriculture Forestry and BioresourcesSeoul National UniversitySeoul 08826Republic of Korea Department of Forest Bioresources National Institute of Forest ScienceSuwon 16631Republic of Korea Department of Plant Resource Research Korea National ArboretumPocheon 11186Republic of Korea Research Institute of Agriculture and Life Sciences CALS_SNUSeoul 08826Republic of Korea

Growth traits and genetic diversity of 23 provenances of Quercus rubra introduced from North America were analyzed in a provenance trial established with a randomized block design in Hwaseong,Gyeonggi,South Korea in *** variables and survival at age 25 were compared with results from early ***,DBH,volume and stem straightness of *** was better than those of the domestic oak(Quercus accutissima).Growth of the Dunham Island provenance from New York was the best among the 23 provenances that of the Eagle River provenance from Wisconsin was *** rate at age25 was on average 52%.The longitude of seed origin and growth of provenance were consistently significantly negatively correlated at all *** of coastal provenances was superior to that of the inland provenances,which were separated by the Appalachian *** diversity and genetic distance among the provenances were evaluated using micro satellite *** allelic frequencies showed high polymorphism in 10 microsatellite loci,and 292 alleles were *** 10 loci,two were commonly found in the 23 *** mean allelic diversity and heterozygosity observed among the provenances were similar to those from the native populations of *** in North ***’s genetic distance among the 23 was estimated and showed that a clear trend between geographic and genetic distances,indicating that some provenances have high genetic diversity with superior growth performance.

关键词： Introduction breeding Provenance test Adaptation Microsatellite marker Genetic distance

Unusual case of emphysematous cystitis mimicking intestinal perforation:A case report

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World Journal of Clinical Cases 2023年第28期11卷 6943-6948页

作者： hye Yoon Kang Dae-Sup lee Donghyoun lee Department of Surgery Samsung Medical CenterSeoul 06338South Korea Department of Emergency Medicine Pusan National University Yangsan HospitalYangsan 50612South Korea Department of Surgery Jeju National University HospitalJeju National University College of MedicineJeju 63241South Korea

BACKGROUND Emphysematous cystitis(EC)is a bladder condition commonly caused by gasgenerating bacterial *** that increase the risk for developing this condition include female gender,age≥60 years,and diabetes mellitus,glycosuria,and urinary *** symptoms of EC often lack specificity,making diagnostic imaging techniques crucial for accurate identification of the *** SUMMARY This report presents an unusual case of EC that mimicked intestinal *** it was initially challenging to differentiate between intestinal perforation and EC on admission,the patient managed to avoid unnecessary surgery and made a good recovery solely through antibiotic *** Successful treatment of the patient described herein highlights the importance of accurately diagnosing EC,which can be difficult to differentiate from intestinal perforation.

关键词： Emphysematous cystitis Intestinal Bowel Perforation Bladder Case report

Corrugated surface microparticles with chitosan and levofloxacin for improved aerodynamic performance

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Asian Journal of Pharmaceutical Sciences 2023年第3期18卷 146-158页

作者： Chang-Soo Han ji-Hyun Kang Eun hye Park Hyo-Jung lee So-Jeong Jeong Dong-Wook Kim Chun-Woong Park College of Pharmacy Chungbuk National UniversityCheongju 28160Republic of Korea School of Pharmacy Jeonbuk National UniversityJeonju 54896Republic of Korea College of Pharmacy Wonkwang UniversityIksan 54538Republic of Korea

Corrugated surface microparticles comprising levofloxacin(LEV),chitosan and organic acid were prepared using the 3-combo spray drying *** amount and the boiling point of the organic acid affected the degree of *** this study,we tried to improve the aerodynamic performance and increase aerosolization by corrugated surface microparticle for lung drug delivery efficiency as dry powder ***175 L20 prepared with 175 mmol propionic acid solution was corrugated more than HMF175 L20 prepared with 175 mmol formic acid *** ACI and PIV results showed a significant increase in aerodynamic performance of corrugated *** FPF value of HMP175 L20 was 41.3%±3.9%compared with 25.6%±7.7%of HMF175 *** microparticles also showed better aerosolization,decreased x-axial velocity,and variable *** dissolution of drug formulationswas observed in *** administered to the lungs achieved higher LEV concentrations in the lung fluid than high doses administered *** modification in the polymer-based formulation was achieved by controlling the evaporation rate and improving the inhalation efficiency of DPIs.

关键词： Chitosan Organic acid Levofloxacin Corrugated surface Aerodynamic performance

Feasibility Study of R134a/R404a Cascade Heat Pump Cycle in Heat Pump Dryers with Electrical Heaters at Low Temperatures

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Journal of Thermal Science 2015年第5期24卷 463-467页

作者： ji Woo Jeong Young Lim lee Dept. of Mechanical Engineering Kongju National University Dept. of Mechanical and Automotive Engineering Kongju National University

Heat pump cycles have been widely applied to dryers for their high efficiency. However, low–efficiency electrical heaters are often used during early drying stage for frozen foods or winter since a standard heat pump cycle cannot operate at low temperature. This study introduced cascade heat pumps replacing electrical heaters to improve dryer performance at low temperatures. Experiments were performed to examine changes in performance of the cascade heat pump dryers in relation to ambient temperature, low-stage cycle mass flow rate, and high-stage cycle mass flow rate. The results showed a significant improvement in low-temperature dryer performance with the introduction of cascade heat pump cycles.

关键词： Cascade cycle R134a/R404a Heat pump dryer COP Energy efficiency

Effect of Length Scale Tuning of Background Error in WRF-3DVAR System on Assimilation of High-Resolution Surface Data for Heavy Rainfall Simulation

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Advances in Atmospheric Sciences 2012年第6期29卷 1142-1158页

作者： ji-Hyun HA Dong-Kyou lee Atmospheric Sciences Program School of Earth and Environmental SciencesSeoul National UniversitySeoul 151-747Korea

We investigated the impact of tuning the length scale of the background error covariance in the Weather Research and Forecasting （WRF） three-dimensional variational assimilation （3DVAR） system. In particular, we studied the effect of this parameter on the assimilation of high-resolution surface data for heavy rainfall forecasts associated with mesoscale convective systems over the Korean Peninsula. In the assimilation of high-resolution surface data, the National Meteorological Center method tended to exaggerate the length scale that determined the shape and extent to which observed information spreads out. In this study, we used the difference between observation and background data to tune the length scale in the assimilation of high-resolution surface data. The resulting assimilation clearly showed that the analysis with the tuned length scale was able to reproduce the small-scale features of the ideal field effectively. We also investigated the effect of a double-iteration method with two different length scales, representing large and small-length scales in the WRF-3DVAR. This method reflected the large and small-scale features of observed information in the model fields. The quantitative accuracy of the precipitation forecast using this double iteration with two different length scales for heavy rainfall was high; results were in good agreement with observations in terms of the maximum rainfall amount and equitable threat scores. The improved forecast in the experiment resulted from the development of well-identified mesoscale convective systems by intensified low-level winds and their consequent convergence near the rainfall area.

关键词： WRF 3DVAR tuning surface data heavy rainfall

Mechanisms linking gut microbial metabolites to insulin resistance

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World Journal of Diabetes 2021年第6期12卷 730-744页

作者： hye Rim Jang Hui-Young lee Laboratory of Mitochondrial and Metabolic Diseases Department of Health Sciences and TechnologyGAIHSTGachon UniversityIncheon 21999South Korea Korea Mouse Metabolic Phenotyping Center Lee Gil Ya Cancer and Diabetes InstituteGachon UniversityIncheon 21999South Korea Division of Molecular Medicine Department of MedicineGachon University College of MedicineIncheon 21936South Korea

Insulin resistance is the rate-limiting step in the development of metabolic diseases,including type 2 *** gut microbiota has been implicated in host energy metabolism and metabolic diseases and is recognized as a quantitatively important organelle in host metabolism,as the human gut harbors 10 trillion bacterial *** microbiota break down various nutrients and produce metabolites that play fundamental roles in host metabolism and aid in the identification of possible therapeutic targets for metabolic ***,understanding the various effects of bacterial metabolites in the development of insulin resistance is ***,we review the mechanisms linking gut microbial metabolites to insulin resistance in various insulin-responsive tissues.

关键词： Insulin resistance Skeletal muscle Liver Adipose tissue Intestine Gut bacterial metabolites

Gyejibokryeong-Hwan improves recovery of injured muscles in mouse model of muscle contusion

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Journal of Traditional Chinese Medicine 2021年第3期41卷 406-413页

作者： Chi Ho lee Jeong June Choi Joo hye Sim Younmin Shin Seung-Joon Oh ji-Hyang Gu Hyun Ju Ha Dong Hwi Jeon Eun-Jung lee Min-Seok Oh Department of Korean Medicine Rehabilitation College of Korean MedicineDaejeon UniversityDaejeon 34520Republic of Korea Laboratory of Molecular Medicine College of Korean MedicineDaejeon UniversityDaejeon 34520Republic of Korea

OBJECTIVE: To investigate the effects of Gyejibokryeong-Hwan(Guizhifuling-wan, GBH) on muscle injury in a mouse model of muscle ***: C57/BL6 mouse biceps femoris muscles were injured using the drop-mass method and injured animals were treated orally with GBH(50,100, or 500 mg/kg) once a day for 7 d. Open field and treadmill running tests were performed to assess functional recovery from muscle injury. The production of pro-inflammatory cytokines was examined by enzyme-linked immunosorbent assay and Western blotting analysis. Expression of the muscle regeneration biomarkers, myoblast determination(Myo D), myogenic factor 5(Myf5), and smooth muscle actin(α-SMA), in the biceps femoris muscle was investigated at the protein and m RNA level by Western blotting and real time-PCR, respectively. Histological analysis was performed using hematoxylin and eosin staining. Finally, myosin heavy chain production was investigated in differentiated C2C12 myoblasts in the presence of ***: GBH treatment markedly improved locomotion and running behavior. GBH significantly inhibited the secretion of monocyte chemoattractant protein-1 into the bloodstream in muscle-contused animals. The levels of Myo D, Myf5, and α-SMA protein and m RNA were significantly up-regulated by GBH in injured muscle tissue. Histological studies suggested that GBH facilitated recovery from muscle damage. However, GBH did not induce the production of myosin heavy chain in ***: Overall, the present study suggested that GBH improves the recovery of the injured muscles in the mouse model of muscle contusion.

关键词： muscles wounds and injuries contusions regeneration muscle skeletal myogenic regulatory factor 5 Gyejibokryeong-Hwan

Increased end-stage renal disease risk in patients with inflammatory bowel disease:A nationwide populationbased study

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World Journal of Gastroenterology 2018年第42期24卷 4798-4808页

作者： Seona Park Jaeyoung Chun Kyung-Do Han Hosim Soh Kookhwan Choi ji hye Kim Jooyoung lee Changhyun lee Jong Pil Im Joo Sung Kim Department of Internal Medicine Liver Research InstituteSeoul National University College of Medicine Department of Biostatistics College of MedicineThe Catholic University of Korea Department of Internal Medicine CHA Gangnam Medical CenterCHA University Department of Internal Medicine and Healthcare Research Institute Healthcare System Gangnam CenterSeoul National University Hospital

AIM To estimate the risk of end-stage renal disease(ESRD)in patients with inflammatory bowel disease(IBD).METHODS From January 2010 to December 2013, patients with Crohn's disease(CD) and ulcerative colitis(UC) were identified, based on both the International Classification of Diseases, 10 th revision(ICD-10) and the rare,intractable disease registration program codes from the National Health Insurance(NHI) database in South Korea. We compared 38812 patients with IBD to ageand sex-matched non-IBD controls with a ratio of 1:*** newly diagnosed with ESRD were identified with the ICD-10 *** During a mean follow-up of 4.9 years, ESRD was detected in 79(0.2%) patients with IBD and 166(0.1%)controls. The incidence of ESRD in patients with IBD was0.42 per 1000 person-years. Patients with IBD had a significantly higher risk of ESRD than controls [adjusted hazard ratio(HR) = 3.03; 95% confidence interval(CI):1.77-5.20; P < 0.001]. The incidences(per 1000 personyears)of ESRD were 0.51 in patients with CD and 0.13 in controls, respectively(adjusted HR = 6.33; 95%CI:2.75-14.56; P < 0.001). In contrast, the incidence of ESRD was similar between the UC and control groups(0.37 vs 0.37 per 1000 person-years; adjusted HR = 2.01;95%CI: 0.90-4.51; P = 0.089).CONCLUSION The risk of ESRD was elevated in patients with CD, but not UC. Patients with CD should be monitored carefully for signs of renal insufficiency.

关键词： Claims data Inflammatory bowel disease Crohn’s disease End-stage renal disease Ulcerative colitis

ZnS Nano-Spheres Formed by the Aggregation of Small Crys- tallites and Their Photocatalytic Degradation of Eosin B

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Chinese Journal of Chemistry 2017年第2期35卷 159-164页

作者： Sovann Khan Joon Soo Han SeungYong lee So-hye Cho Materials Architecturing Research Center Korea Institute of Science and Technology 02792 Republic of Korea Department of Nanomaterial Science and Engineering Korea University of Science and Technology Daejeon 34113 Republic of Korea

Monodispersed ZnS nano-spheres were synthesized by a simple precipitation. By adjusting the concentration of Zn and S sources, the particle size and morphology were easily controlled. Careful examination of the obtained par- ticles suggested porous structures composed of building blocks of small crystallites, ca. 4-- 13.4 nm in diameter. A higher [S]/[Zn]-precursor ratio resulted in a bigger crystallite size but a smaller particle size, and vice versa, for the lower precursor ratio. However, an extreme [S]/[Zn] ratio of 20 provided no spherical aggregation, but a formation of amorphous aggregates. We consider the rate to nucleation and the diffusion-controlled aggregation of crystallites to be important parameters in determining particle sizes and size distributions. Size homogeneity of the obtained ZnS nano-spheres, especially with a [S]/[Zn]-precursor ratio of 5, afforded a photonic crystal array that can poten- tially benefit the photocatalytic activity. When the photocatalytic activities of the ZnS nano-spheres obtained via different conditions were compared, it was found that spherical aggregation and high surface areas have a positive effect on catalytic activity. Although using a [S]/[Zn] ratio of 20 provided the highest surface area, the amorphous aggregation and overly excessive use of S caused a detrimental influence on the catalytic activity.

关键词： ZnS nano-spheres photocatalysis aggregation eosin B