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Ecotoxicity evaluation of Cu-and Fe-CNT complexes based on the activity of bacterial bioluminescence and seed germination

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Journal of Environmental Sciences 2018年第5期30卷 198-205页

作者： In Chul Kong Kyung Seok Ko Mun Hui lee ji Hwoan lee Young-Hwan Han Department of Environmental Engineering Yeungnam UniversityGyungsan 38541Republic of Korea Geologic Environment Division Korea Institute of Geoscience and Mineral Resources(KIGAM)Daejeon 34132Republic of Korea School of Materials Science and Engineering Yeungnam University Gyungsan 38541Republic of Korea International School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430079China

The toxic effects of the composites of Fe^0 and Cu^0 with different percentages of CNTs were examined based on the activity of bacterial bioluminescence and seed germination. In terms of the EC50 values, the toxic effects of Cu^0 on bacterial bioluminescence and seed germination were approximately 2 and 180 times greater than that of Fe^0, respectively. The toxicity increased with increasing CNT content in the Cu-CNT mixtures for both organisms,whereas opposite results were observed with Fe-CNT mixtures. The mean toxic effects of Cu-CNT（6%） were approximately 1.3–1.4 times greater than that of Cu-CNT（0%）, whereas the toxic effects of Fe-CNT（6%） were approximately 2.1–2.5 times lower than that of Fe-CNT（0%） for both the bioluminescence activity and seed germination. The causes of this phenomenon are unclear at this point. More research will be needed to elucidate the mechanism of the toxicity of nano-mixture materials and the causes of the different patterns of toxicity with Cu-and Fe-CNT mixtures.

关键词： Metal-CNT complex Bioluminescence Seed germination Toxic effect

Cholecystectomy increases the risk of metabolic syndrome in the Korean population:a longitudinal cohort study

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Hepatobiliary Surgery and Nutrition 2023年第4期12卷 523-533,I0023页

作者： ji hye Huh Kyong Joo lee Yun Kyung Cho Shinje Moon Yoon Jung Kim Kyung-Do Han Jun Goo Kang Seong jin lee Sung-Hee Ihm Department of Internal Medicine Hallym University College of MedicineChuncheonRepublic of Korea Department of Internal Medicine Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea Department of Statistics and Actuarial Science Soongsil UniversitySeoulRepublic of Korea

Background:Cholecystectomy is a common surgical procedure to treat symptomatic gallstones;however,the long-term outcomes after cholecystectomy are ***,we aimed to investigate whether incident metabolic syndrome(MetS)is associated with cholecystectomy through a large,population-based,longitudinal ***:Subjects aged≥20 years who underwent cholecystectomy from 2010 to 2014(n=76,485)and controls(n=76,485),matched for age and sex,were identified from the Korean National Health Insurance *** proportional hazards analyses were performed to evaluate the association between cases and incident MetS,and hazard ratios and 95% confidence intervals(CIs)were ***:A total of 152,970 patients were *** age was 52.47±12.76 years,and 50.65% of participants were *** the follow-up period,there were 38,979(25.48%)newly diagnosed MetS cases in the study *** risk of MetS in the cholecystectomy group was approximately 20% higher than that in the control group[adjusted odds ratio(OR),1.20;95%CI:1.17-1.23].In the fully adjusted models,the corresponding ORs for new-onset high waist circumference(WC),low high-density lipoprotein cholesterol(HDL-C)levels,high triglycerides(TG)levels,high blood pressure(BP),and high blood glucose levels were 1.16(1.13-1.19),1.19(1.16-1.22),1.25(1.22-1.28),1.27(1.23-1.31),and 1.21(1.18-1.24),*** was an independent risk factor of incident MetS,after adjusting for potential confounding *** the subgroup analyses,the cholecystectomy group had a higher risk of MetS than the control group in subjects without hypertension or dyslipidemia,***:In this large,population-based study,cholecystectomy was associated with an increased risk of developing MetS,independent of other confounding ***,careful monitoring of metabolic variables and long-term follow-up are required to evaluate MetS risk after cholecystectomy.

关键词： Cholecystectomy metabolic syndrome(MetS) obesity diabetes cardiovascular risk

Quantitative assessment of the relevance of organic-aniontransporting-polypeptide 1B1 and 2B1 polymorphisms in fexofenadine pharmacokinetic variants via pharmacometrics

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Journal of Pharmaceutical Analysis 2023年第6期13卷 660-672页

作者： ji-Hun Jang Seung-Hyun Jeong Yong-Bok lee Department of Pharmacy College of PharmacyChonnam National UniversityGwangju61186Republic of Korea Department of Pharmacy College of PharmacySunchon National UniversitySuncheon-si57922Republic of Korea

Fexofenadine is useful in various allergic disease ***,the pharmacokinetic variability information and quantitative factor identification of fexofenadine are very *** study aimed to verify the validity of previously proposed genetic factors through fexofenadine population pharmacokinetic modeling and to explore the quantitative correlations affecting the pharmacokinetic *** of the organic-anion-transporting-polypeptide(OATP)1B1 and 2B1 have been proposed to be closely related to fexofenadine pharmacokinetic ***,modeling was performed using fexofenadine oral exposure data according to the OATP1B1-and ***1B1 and 2B1 were identified as effective covariates of clearance(CL/F)and distribution volume(V/F)-CL/F,respectively,in fexofenadine pharmacokinetic ***/F and average steady-state plasma concentration of fexofenadine differed by up to 2.17-and 2.20-folds,respectively,depending on the OATP1B1 *** the individuals with different OATP2B1 polymorphisms,the CL/F and V/F differed by up to 1.73-and 2.00-folds,*** of the areas under the curves following single-and multiple-administrations,and the cumulative ratio were significantly different between OATP1B1-and 2B1-polymorphism *** on quantitative prediction comparison through a model-based approach,OATP1B1 was confirmed to be relatively more important than 2B1 regarding the degree of effect on fexofenadine pharmacokinetic *** on the established pharmacokineticpharmacodynamic relationship,the difference in fexofenadine efficacy according to genetic polymorphisms of OATP1B1 and 2B1 was 1.25-and 0.87-times,respectively,and genetic consideration of OATP1B1 was expected to be important in the pharmacodynamics area as *** population pharmacometrics study will be a very useful starting point for fexofenadine precision medicine.

关键词： OATP1B1 OATP2B1 Fexofenadine Population pharmacometrics Genetic polymorphism

Effect of PAIP1 on the metastatic potential and prognostic significance in oral squamous cell carcinoma

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International Journal of Oral Science 2022年第1期14卷 113-122页

作者： Neeti Swarup Kyoung-Ok Hong Kunal Chawla Su-Jung Choi ji-Ae Shin Kyu-Young Oh hye-Jung Yoon Jae-Il lee Sung-Dae Cho Seong-Doo Hong Department of Oral Pathology School of Dentistry and Dental Research InstituteSeoul National UniversitySeoulRepublic of Korea Department of Computer Science School of Interactive ComputingGeorgia Institute of TechnologyAtlantaGAUSA

Poly Adenylate Binding Protein Interacting protein 1(PAIP1) plays a critical role in translation initiation and is associated with the several cancer types. However, its function and clinical significance have not yet been described in oral squamous cell carcinoma(OSCC) and its associated features like lymph node metastasis(LNM). Here, we used the data available from Gene Expression Omnibus(GEO), The Cancer Genome Atlas(TCGA), and Clinical Proteomic Tumor Analysis Consortium(CPTAC) to analyze PAIP1 expression in oral cancer. The publicly available data suggests that PAIP1 mRNA and protein levels were increased in OSCC. The high PAIP1 expression was more evident in samples with advanced stage, LNM, and worse pattern of invasion. Moreover, the in vitro experiments revealed that PAIP1 knockdown attenuated colony forming, the aggressiveness of OSCC cell lines, decreasing MMP9 activity and SRC phosphorylation. Importantly, we found a correlation between PAIP1 and pSRC through the analysis of the IHC scores and CPTAC data in patient samples. Our findings suggest that PAIP1 could be an independent prognostic factor in OSCC with LNM and a suitable therapeutic target to improve OSCC patient outcomes.

关键词： squamous invasion metastasis

Submergence promotes auxin-induced callus formation through ethylene-mediated post-transcriptional control of auxin receptors

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Molecular Plant 2022年第12期15卷 1947-1961页

作者： Seung Yong Shin Yuri Choi Sang-Gyu Kim Su-jin Park ji-Sun Park Ki-Beom Moon Hyun-Soon Kim Jae Heung Jeon hye Sun Cho Hyo-Jun lee Plant Systems Engineering Research Center Korea Research Institute of Bioscience and BiotechnologyDaejeon 34141Korea Department of Functional Genomics KRIBB School of BioscienceUniversity of Science and TechnologyDaejeon 34113Korea Department of Biological Sciences Korea Advanced Institute of Science and TechnologyDaejeon 34141Korea Department of Biosystems and Bioengineering KRIBB School of BiotechnologyUniversity of Science and TechnologyDaejeon 34113Korea Department of Biological Sciences Sungkyunkwan UniversitySuwon 16419Korea

Plant cells in damaged tissue can be reprogrammed to acquire pluripotency and induce callus ***,in the aboveground organs of many species,somatic cells that are distal to the wound site become less sensitive to auxin-induced callus formation,suggesting the existence of repressive regulatory mechanisms that are largely *** we reveal that submergence-induced ethylene signals promote callus formation by releasing post-transcriptional silencing of auxin receptor transcripts in non-wounded *** determined that short-term submergence of intact seedlings induces auxin-mediated cell dedifferentiation across the entirety of Arabidopsis thaliana *** constitutive triple response 1-1(ctr1-1)mutation induced callus formation in explants without submergence,suggesting that ethylene facilitates cell *** show that ETHYLENE-INSENSITIVE 2(EIN2)post-transcriptionally regulates the abundance of transcripts for auxin receptor genes by facilitating microRNA393 ***-induced calli in non-wounded regions were suitable for shoot regeneration,similar to those near the wound *** also observed submergence-promoted callus formation in Chinese cabbage(Brassica rapa),indicating that this may be a conserved mechanism in other *** study identifies previously unknown regulatory mechanisms by which ethylene promotes cell dedifferentiation and provides a new approach for boosting callus induction efficiency in shoot explants.

关键词： cell dedifferentiation auxin signaling ethylene callus formation EIN2

Suboptimal Feature Selection Techniques for Effective Malicious Traffic Detection on Lightweight Devices

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1669-1687页

作者： So-Eun Jeon Ye-Sol Oh Yeon-ji lee Il-Gu lee Department of Future Convergence Technology Engineering Sungshin Women’s UniversitySeoul02844Korea Department of Convergence Security Engineering SungshinWomen’s UniversitySeoul02844Korea

With the advancement of wireless network technology,vast amounts of traffic have been generated,and malicious traffic attacks that threaten the network environment are becoming increasingly *** signature-based detection methods,static analysis,and dynamic analysis techniques have been previously explored for malicious traffic detection,they have limitations in identifying diversified malware traffic *** research has been focused on the application of machine learning to detect these ***,applying machine learning to lightweight devices like IoT devices is challenging because of the high computational demands and complexity involved in the learning *** this study,we examined methods for effectively utilizing machine learning-based malicious traffic detection approaches for lightweight *** introduced the suboptimal feature selection model(SFSM),a feature selection technique designed to reduce complexity while maintaining the effectiveness of malicious traffic *** performance was evaluated on various malicious traffic,benign,exploits,and generic,using the UNSW-NB15 dataset and SFSM sub-optimized hyperparameters for feature selection and narrowed the search scope to encompass all *** improved learning performance while minimizing complexity by considering feature selection and exhaustive search as two steps,a problem not considered in conventional *** experimental results showed that the detection accuracy was improved by approximately 20%compared to the random model,and the reduction in accuracy compared to the greedy model,which performs an exhaustive search on all features,was kept within 6%.Additionally,latency and complexity were reduced by approximately 96%and 99.78%,respectively,compared to the greedy *** study demonstrates that malicious traffic can be effectively detected even in lightweight device *** verified the possibility of detecting various attack

关键词： Feature selection lightweight device machine learning Internet of Things malicious traffic

Aluminum doping for optimization of ultrathin and high-k dielectric layer based on SrTiO3

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Journal of Materials Science & Technology 2020年第7期42卷 28-37页

作者： ji-Ye Baek Le Thai Duy Sang Yeon lee Hyungtak Seo Department of Energy Systems Research Ajou UniversitySuwon 443-749South Kore Department of Materials Science and Engineering Ajou UniversitySuwon 443-749South Korea

An ultrathin SrTiO3 dielectric layer is optimized through Al doping to solve the problems existing in development of ultra-high-k oxide MOS *** post-deposition annealing,Al doping induces changes in the electronic structure of SrTiO3,thereby effectively reducing leakage current to 80) of ultrathin SrTMO3 MOS *** titanate(SrTiO3) is a high-k material but its bandgap is smaller than that of other oxide dielectrics(e.g.,SiO2,Al2 O3).Consequently,an ultrathin SrTiO3 film may have a high tunneling leakage current,which is not suitable for capacitor-based *** improve the performance of metal-oxide-semiconductor(MOS) capacitors using SrTiO3,an approach based on homogenous and uniform aluminum doping to SrTiO3 through co-sputtering is *** bandgap of a pristine SrTiO3 film showed an increase of 0.5 eV after Al ***,Al doping decreased the leakage current of SrTiO3/Si-based MOS capacitors by more than five orders of magnitude(at the level of nanoampere per square centimeter).Importantly,a dielectric constant of 81.3 and equivalent oxide thickness less than 5 A were achieved in an 8-nm-thick Al-doped SrTiO3 film owing to changes in its crystal structure and conduction band edge electronic ***,the obtained data show the effectiveness of the proposed approach for solving the problems existing in the development of ultra-high-k oxide MOS capacitors.

关键词： Aluminum doping SrTiO3 ultrathin High dielectric constant MOS capacitors

Comparison of cytotoxicity and wound healing effect of carboxymethylcellulose and hyaluronic acid on human corneal epithelial cells

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International Journal of Ophthalmology(English edition) 2015年第2期8卷 215-221页

作者： Jong Soo lee Seung Uk lee Cheng-Ye Che ji-Eun lee Department of Ophthalmology School of MedicinePusan National University Biomedical Research Institute Pusan National University Hospital Department of Ophthalmology School of Medicine Kosin University Department of Ophthalmology the Affiliated Hospital of Medical College Qingdao University Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital

AIM: To investigate the cytotoxic effect on human corneal epithelial cells(HCECs) and the ability to faciliate corneal epithelial wound healing of carboxymethylcellulose(CMC) and hyaluronic acid(HA).METHODS: HCECs were exposed to 0.5% CMC(Refresh plus, Allergan, Irvine, California, USA) and 0.1% and 0.3%HA(Kynex , Alcon, Seoul, Korea, and Hyalein mini,Santen, Osaka, Japan) for the period of 30 min, and 4, 12,and 24 h. Methyl thiazolyl tetrazoiun(MTT)-based calorimetric assay was performed to assess the metabolic activity of cellular proliferation and lactate dehydrogenase(LDH) leakage assay to assess the cytotoxicity. apoptotic response was evaluated with flow cytometric analysis and fluorescence staining with Annexin V and propiodium iodide. Cellular morphology was evaluated by inverted phase-contrast light microscopy and electron microscopy. The wound widths were measured 24 h after confluent HCECs were scratch ***: The inhibitory effect of human corneal epithelial proliferation and cytotoxicity showed the time-dependent response but no significant effect. Apoptosis developed in flow cytometry and apoptotic cells weredemonstrated in fluorescent micrograph. The damaged HCECs were detached from the bottom of the dish and showed the well-developed vacuole formations. Both CMC and HA stimulated reepithehlialization of HCECs scratched, which were more observed in ***: CMC and HA, used in artificial tear formulation, could be utilized without any significant toxic effect on HCECs. Both significantly stimulated HCEC reepithelialization of corneal wounds.

关键词： carboxymethylcellulose corneal wound healing human corneal epithelial cells hyaluronic acid cytotoxicity

Magnifying endoscopy for the diagnosis of specialized intestinal metaplasia in short-segment Barrett's esophagus

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World Journal of Gastroenterology 2013年第41期19卷 7089-7096页

作者： Nam Seok Ham Jae Young Jang Sung Woo Ryu ji hye Kim Eui Ju Park Woong Cheul lee Kwang Yeun Shim Soung Won Jeong Hyun Gun Kim Tae Hee lee Sung Ran Jeon Jun Hyung Cho Joo Young Cho So Young jin ji Sung lee Institution for Digestive Research Digestive Disease CenterDepartment of Internal MedicineSoonchunhyang University HospitalSeoul 140-743South Korea Department of Pathology Soonchunhyang University HospitalSeoul 140-743South Korea Biostatistical Consulting Unit Soonchunhyang University HospitalSeoul 140-743South Korea

AIM:To determine whether magnified observation of short-segment Barrett’s esophagus(BE)is useful for the detection of specialized intestinal metaplasia(SIM).METHODS:Thirty patients with suspected short-segment BE underwent magnifying endoscopy up to×*** magnified images were analyzed with respect to their pit-patterns,which were simultaneously classified into five epithelial types[Ⅰ(small round),Ⅱ(straight),Ⅲ(long oval),Ⅳ(tubular),Ⅴ(villous)]by Endo’s ***,a 0.5%solution of methylene blue(MB)was sprayed over columnar *** patterns of the magnified image and MB staining were *** were obtained from the regions previously observed by magnifying endoscopy and MB ***:Three of five patients with a typeⅤ(villous)epithelial pattern had SIM,whereas 21 patients with a non-typeⅤepithelial patterns did not have *** sensitivity,specificity,accuracy,positive predictive value,and negative predictive value of pit-patterns in detecting SIM were 100%,91.3%,92.3%,60%and100%,respectively(P=0.004).Three of the 12 patients with positive MB staining had SIM,whereas 14patients with negative MB staining did not have *** sensitivity,specificity,accuracy,positive predictive value,and negative predictive value of MB staining in detecting SIM were 100%,60.9%,65.4%,25%and100%,respectively(P=0.085).The specificity and accuracy of pit-pattern evaluation were significantly superior compared with MB staining for detecting SIM by comparison with the exact McNemar’s test(P=0.0391).CONCLUSION:The magnified observation of a shortsegment BE according to the mucosal pattern and its classification can be predictive of SIM.

关键词： Short-segment Barrett’s esophagus Magnifying endoscopy Methylene blue chromoendoscopy Specialized intestinal metaplasia Dysplasia Esophageal adenocarcinoma Diagnosis