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Changes of the Flowering Time of Trees in Spring by Climate Change in Seoul, South Korea

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Phyton-International Journal of Experimental Botany 2020年第4期89卷 1019-1033页

作者： hyewon kim Chanwoo Park Jong Hwan Lim hye Woo Shin Interdisciplinary Program of EcoCreative The Graduate SchoolEwha Womans UniversitySeoul03760Korea Forest Ecology and Climate Change Division National Institute of Forest ScienceSeoul02455Korea Research Institute of Ecoscience Ewha Womans UniversitySeoul03760Korea

Flowering onset has attracted much attention in ecological research as an important indicator of climate ***,warmer temperatures advance flowering *** effect of climate warming on flowering onset is more pronounced in spring because the difference between atmospheric and water temperatures creates more rapid convection than in other *** analyzed the correlation between 73 species of spring woody plants in Hongneung Arboretum in Seoul,South Korea and the spring minimum temperature and average precipitation over the past 50 years(1968–2018).The spring minimum temperature and average precipitation have increased over the past 50 years,resulting in the advance of the first flowing date(FFD)in all 73 species by 8.5 days on average.A comparison of FFD changes over time by dividing the survey period into three time periods confirmed the advance of the FFD in 50 species(68%of investigated species)by 11.1 days on average in both Period 2(1999–2008)and Period 3(2009–2018)relative to Period 1(1968–1975).Additionally,a delay of the FFD by 3.2 days on average was observed in 8 *** FFD of Lonicera chrysantha(Caprifoliaceae)advanced by over 40 days and was highly correlated with the increased spring minimum *** of the sensitivity of plant responses to climate change revealed that a temperature rise of 1℃ was associated with an FFD advance of 1.2 days in all *** species that was most sensitive to temperature change was Spiraea pubescens ***(Rosaceae),whose FFD advanced by 4.7 days per 1℃ temperature *** increase in precipitation by 1 mm was found to result in a 0.1-day advance of the FFD of all *** tomentosa(Rosa-ceae)was the most sensitive species,that advanced by 2.6 days for each 1 mm increase in ***,for all species,the FFD was more sensitive to the change in temperature than in *** that the current greenhouse gas(GHGs)emission levels or atmospheric CO_(2) conc

关键词： Phenology first flowering date climate change

Novel endogenous endoplasmic reticulum transmembrane protein SURF4 suppresses cell death by negatively regulating the STING-STAT6 axis inmyeloid leukemia

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Cancer Communications 2023年第3期43卷 395-399页

作者： Jayoung kim Hansong Lee Chae Mi Hong ji Ho Nam hye Ju Yeo Woo Hyun Cho Hyung-Sik kim Changwan Hong Yun Hak kim Dongjun Lee Department of Convergence Medicine School of MedicinePusan National UniversityYangsanGyeongsangnam-do 50612Republic of Korea Department of Biomedical Informatics School of MedicinePusan National UniversityYangsanGyeongsangnam-do 50612Republic of Korea Department of Radiation Oncology School of MedicinePusan National UniversityYangsanGyeongsangnam-do 50612Republic of Korea Division of Allergy Pulmonaryand Critical Care MedicineDepartment of Internal MedicinePusan National University Yangsan HospitalYangsanGyeongsangnam-do 50612Republic of Korea Department of Oral Pathology Dental and Life Science InstituteSchool of DentistryPusan National UniversityYangsanGyeongsangnam-do 50612Republic of Korea Department of Anatomy School of MedicinePusan National UniversityYangsanGyeongsangnam-do 50612Republic of Korea

Dear Editor,Myeloid differentiation was shown to be associated with reduced leukemic cell burden and leukemia-initiating cells and improved survival[1].Reactive oxygen species(ROS)are associated with leukemia and can induce endoplasmic reticulum(ER)*** stress induces several mechanisms,including cell death[2].The stimulator of interferon genes(STING)is also an ER transmembrane protein and promotes anti-tumor immunity by linking innate and adaptive immunity[3].Signal transducer and activator of transcription 6(STAT6)plays a prominent role in adaptive immunity by transducing signals fromextracellular cytokines and inducing apoptosis in cancer cells[4].

关键词： STAT6 immunity reticulum

Polyarteritis nodosa presenting as leg pain with resolution of positron emission tomography-images:A case report

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World Journal of Clinical Cases 2023年第4期11卷 918-921页

作者： ji-Hyoun Kang Jahae kim Division of Rheumatology Department of Internal MedicineChonnam National University Medical School&HospitalGwangju 61469South Korea Department of Nuclear Medicine Chonnam National University Hospital&Medical SchoolGwangju 61469South Korea

BACKGROUND Although fluorodeoxyglucose-positron emission tomography/computed tomography(FDG-PET/CT)is widely used for diagnosis and follow-up of large sized vessel vasculitis,it is still not widely used for small to medium sized vessel *** SUMMARY This is the case of a 68-year-old male who presented at the emergency department complaining of fever,myalgia,and bilateral leg pain of over two weeks duration,with elevated levels of C-reactive *** was subsequently admitted and despite the absence of clinically significant findings,the patient continued to exhibit recurrent fever.A fever of unknown origin workup,which included imaging studies using FDG-PET/CT,revealed vasculitis involving small to medium-sized vessels of both lower extremities,demonstrated by linear hypermetabolism throughout the leg *** patient was treated with methylprednisolone and methotrexate after diagnosis leading to the gradual resolution of the patient’s *** weeks later,a follow-up FDGPET/CT was *** hypermetabolic vessels were markedly *** Our case report demonstrated that FDG-PET/CT has tremendous potential to detect medium-sized vessel inflammation;it can also play a crucial role in prognosticating outcomes and monitoring therapeutic efficacy.

关键词： Positron emission tomography-computed tomography Polyarteritis nodosa Case report

Comparison of postoperative optical quality according to the degree of decentering of V4c implantable collamer lens

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International Journal of Ophthalmology(English edition) 2017年第4期10卷 619-623页

作者： Min ji Park hye Min Jeon Kyoung Heon Lee Sang Youp Han Department of Cornea and Refractive Surgery Sungmo Eye Hospital Busan 48064 Korea

AIM：To evaluate the clinical outcomes of V4 c implantable collamer lens（Hole ICL） implantation with regard to the optical quality assessed according to different degrees of ***：This included 49 eyes that received conventional ICL and 94 eyes that received Hole *** eyes that received Hole ICL were divided into three groups according to the degree of decentering：group 1,central hole within 1 hole diameter（HD） from the pupil center;group 2,central hole within 1 HD to 2 HD;and group 3,central hole within 2 HD to 3 *** acuity（VA）,intraocular pressure（IOP）,and spherical equivalent（SE） values were assessed at 1wk,1 and 3mo after *** ocular modulation transfer function,Strehl ratio,objective scattering index,and higher order aberrations（HOAs） were measured for 4-mm pupils at 3mo after ***：There were no significant differences in VA,IOP,and SE among the conventional and Hole ICL *** regard to HOAs,values for coma and spherical aberrations showed no *** total HOA and trefoil values were significantly higher in group 2 than in group 1（P=0.02,0.03,respectively）.There were no significant differences among groups with regard to other optical quality parameter at 3mo after ***：Our results suggest that Hole ICL implantation provides satisfactory visual quality that is equivalent to that provided by conventional ICL,regardless of the presence of central hole and degree of decentering.

关键词： implantable collamer lens optical quality phakic IOL refractive surgery

Effect of citrulline on post-exercise rating of perceived exertion,muscle soreness,and blood lactate levels:A systematic review and meta-analysis

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Journal of Sport and Health Science 2020年第6期9卷 553-561页

作者： hye Chang Rhim Sung Jong kim Jewel Park Ki-Mo Jang College of Medicine Korea UniversitySeoul 02842Republic of Korea Department of Orthopaedic Surgery Anam HospitalKorea University College of MedicineSeoul 02841Republic of Korea

Background:Citrulline is one of the non-essential amino acids that is thought to improve exercise performance and reduce post-exercise muscle *** conducted a systematic review and meta-analysis to determine the effect of citrulline supplements on the post-exercise rating of perceived exertion(RPE),muscle soreness,and blood lactate ***:A random effects model was used to calculate the effect sizes due to the high variability in the study design and study populations of the articles included.A systematic search of PubMed,Web of Science,and *** was *** for study inclusion was limited to studies that were randomized controlled trials involving healthy individuals and that investigated the acute effect of citrulline supplements on RPE,muscle soreness,and blood lactate *** supplementation time frame was limited to 2 h before *** types and number of participants,types of exercise tests performed,supplementation protocols for L-citrulline or citrulline malate,and primary(RPE and muscle soreness)and secondary(blood lactate level)study outcomes were extracted from the identified ***:The analysis included 13 eligible articles including a total of 206 *** most frequent dosage used in the studies was 8 g of citrulline *** supplementation significantly reduced RPE(n=7,p=0.03)and muscle soreness 24-h and 48-h after post-exercise(n=7,p=0.04;n=6,p=0.25,respectively).However,citrulline supplementation did not significantly reduce muscle soreness 72-h post-exercise(n=4,p=0.62)or lower blood lactate levels(n=8,p=0.17).Conclusion:Citrulline supplements significantly reduced post-exercise RPE and muscle soreness without affecting blood lactate levels.

关键词： Amino acids Dietary supplements Ergogenic aid Nitric oxide Watermelon juice

Effects of PWHT on Microstructure and Mechanical Properties of Weld Metals of Ni-Based Superalloy 617 and 263 for Hyper-Supercritical Power Plants

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Acta Metallurgica Sinica(English Letters) 2016年第12期29卷 1107-1118页

作者： Jeong Kil kim Hae ji Park Deog Nam Shim Doosan Heavy Industries and Construction ChangwonGeongnam Korea

It is well known that solid solution-strengthened alloy 617 and γ′ precipitation-strengthened alloy 263 have excellent mechanical properties and corrosion resistance at high temperatures. Hyper-supercritical power plants work at temperatures above 700 ℃, and these superalloys are considered candidate materials for steam turbines components of these power plants. In this study, gas tungsten arc weldability of these superalloys was evaluated, and the effects of post- weld heat treatment （PWHT） on the microstructural characteristics and the mechanical properties of their weld metals were investigated. Scanning transmission electron microscopy, energy-dispersive spectroscopy and electron probe microanalysis were utilized for the investigation. The experimental results confirmed that these weld metals had different characteristics in microstructure and mechanical properties. PWHT resulted in the precipitation of intergranular carbides, γ′ particles and an increase in tensile strength of these superalloy weld metals. Furthermore, fine γ′ particles, which were not detected in the as-welded metal of alloy 263, were precipitated after PWHT and those particles were the reason for the drastic increase in tensile strength.

关键词： Superalloy Welding Precipitation Segregation

Effects of Flower Buds Extract of Tussilago farfara on Focal Cerebral Ischemia in Rats and Inflammatory Response in BV2 Microglia

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Chinese Journal of Integrative Medicine 2018年第11期24卷 844-852页

作者： ji hye Hwang Vinoth Kumar R Seok Yong Kang Hyo Won Jung Yong-Ki Park Department of Acupuncture and Moxibustion Medicine College of Korean Medicine Gachon University Department of Herbology College of Korean Medicine Dongguk University

Objective： To investigate the effects of the flower buds extract of Tussilago farfara Linné（Farfarae Flos; FF） on focal cerebral ischemia through regulation of inflammatory responses in activated microglia. Methods： Brain ischemia was induced in Sprague-Dawley rats by a transient middle cerebral artery occlusion（t MCAO） for 90 min and reperfusion for 24 h. Twenty rats were randomly divided into 4 groups（n=5 per group）： normal, t MCAO-induced ischemic control, t MCAO plus FF extract 300 mg/kg-treated, and t MCAO plus MK-801 1 mg/kg-treated as reference drug. FF extract（300 mg/kg, p.o.） or MK-801（1 mg/kg, i.p.） was administered after reperfusion. Brain infarction was measured by 2,3,5,-triphenyltetrazolium chloride staining. Neuronal damage was observed by haematoxylin eosin, Nissl staining and immunohistochemistry using anti-neuronal nuclei（Neu N）, anti-glial fibril ary acidic protein（GFAP）, and antiCD11 b/c（OX42） antibodies in ischemic brain. The expressions of inducible nitric oxide synthase（i NOS）, tumor necrosis factor（TNF-α）, and hypoxia-inducible factor-1 a（HIF-1α） were determined by Western blot. BV2 microglial cel s were treated with FF extract or its main bioactive compound, tussilagone with or without lipopolysaccharide（LPS）. Nitric oxide（NO） production was measured in culture medium by Griess assay. The expressions of i NOS, COX-2 and pro-inflammatory cytokines mRNA were analyzed by reverse transcription-polymerase chain reaction. The expression of i NOS, and COX-2 proteins, the phosphorylation of ERK1/2, JNK, and p38 MAPK and the nuclear expression of NF-κB p65 in BV2 cells were determined by Western blot. Results： FF extract significantly decreased brain infarctions in ischemic rats（P〈0.01）. The neuronal death and the microglia/astrocytes activation in ischemic brains were inhibited by FF extract. FF extract also suppressed i NOS, TNF-α, and HIF-1α expression in ischemic brains. FF extract（0.2 and 0.5 mg/m L, P〈0.01） and tussilagone 20 and 50 μmol/L, P〈0

关键词： Tussilago farfara focal cerebral ischemia inflammation microglia tussilagone

Effect of tellurium on the microstructure and mechanical properties of Fe-14Cr oxide-dispersion-strengthened steels produced by additive manufacturing

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Journal of Materials Science & Technology 2021年第36期95卷 114-126页

作者： Barton Mensah Arkhurst Jee Hwan Bae Min Young Na hye Jung Chang Hyun Gil kim Il Hyun kim Ho jin Ryu Jeoung Han kim School of Materials Science and Engineering University of New South Wales SydneyNSW 2052Australia Advanced Analysis Center Korea Institute of Science and Technology SeoulSeongbuk-guRepublic of Korea LWR Fuel Technology Division Korea Atomic Energy Research InstituteDaejeonYuseong-guRepublic of Korea Department of Nuclear and Quantum Engineering KAISTDaejeonYuseong-guRepublic of Korea Department of Materials Science&Engineering Hanbat National UniversityRepublic of Korea

Conventionally,Te has primarily been used to improve the machinability of steel and its *** this work,Te was used to refine the grains of an oxide-dispersion-strengthened(ODS)steel produced by additive manufacturing(AM)with fixed processing *** of Te to the raw powder produced an ODS steel with a fine-grained microstructure,in contrast to the ODS steel manufactured without ***,the addition of Te resulted in superior yield strength and ultimate tensile strength,which was attributed to the combined effects of grain refinement and the finer nanoparticles(NPs)composed of Terich composite NPs and Cr-rich *** the first time,the AM technique was used to obtain grain and nanoparticle sizes of~3.4μm and 6 nm,respectively,from the Te-added ODS steel.

关键词： Additive manufacturing Directed energy deposition Oxide-dispersion-strengthened steel Nanoparticle Tellurium

Median arcuate ligamentum syndrome:Four case reports

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World Journal of Clinical Cases 2022年第6期10卷 1991-1997页

作者： ji Eun kim Poong Lyul Rhee Division of Gastroenterology Samsung Medical CenterSeoul 06351South Korea

BACKGROUND Median arcuate ligamentum syndrome(MALS)is a disease entity with unclear *** it is not considered in advance,the clinical diagnosis of the disease is very difficult because patients complain of digestive discomfort including ***,this characteristic is not specific to *** have been no studies to assist in making a quick *** aim of this case series was to recognize that MALS must be considered as a differential factor in the cause of abdominal *** SUMMARY We described cases in which four patients complained of abdominal pain over a long period but in whom a diagnosis of MALS could not be *** the gastroenterologist does not take into account abdominal pain in advance,the patient is considered an asymptomatic gallstone patient and has their gallbladder removed despite imaging *** patient may also be considered a psychiatric patient and may be administered psychiatric drugs over a long *** all four cases in this report,the patients experienced abdominal *** three cases,the diagnosis was possible by the clinician’s judgment considering both clinical symptoms and imaging techniques shortly after the onset of ***,in one case that lasted over 20 years,a clear diagnosis was not *** after complaining of colicky pain and performing a cholecystectomy,the diagnosis was made only after the symptoms *** all four cases,the symptoms were relieved by *** MALS is a rare disease and it is easy to miss because it is not malignant,but patients can suffer from pain over a long *** the accurate diagnosis of a patient complaining of abdominal pain,the diagnosis must be *** addition,as there are asymptomatic patients,patients who need treatment should be carefully selected,and improvement with medical treatment can be ***-scale studies are also needed.

关键词： Median arcuate ligamentum syndrome Abdominal pain Missed diagnosis Neuromodulator Celiac artery compression Case report