检索结果-南通市图书馆

Genetic variants in TP53 and MDM2 associated with male infertility in Chinese population

Asian Journal of Andrology 2012年第5期14卷 691-694页

作者： Cong huang Wei Liu Gui-Xiang ji Ai-hua Gu jian-hua Qu Ling Song Xin-Ru Wang State Key Laboratory of Reproductive Medicine Institute of ToxicologyNanjing Medical UniversityNanjing 210029China Key Laboratory of Modern Toxicology of Ministry of Education School of Public HealthNanjing Medical UniversityNanjing 210029China Nanjing Institute of Environmental Sciences/Key Laboratory of Pesticide Environmental Assessment and Pollution Control Ministry of Environmental ProtectionNanjing 210042China School of Public Health Nantong UniversityNantong 226019China

The TP53, a transcriptional regulator and tumor suppressor, is functionally important in spermatogenesis. MDM2 is a key regulator of the p53 pathway and modulates p53 activity. Both proteins have been functionally linked to germ cell apoptosis, which may affect human infertility, but very little is known on how common polymorphisms in these genes may influence germ cell apoptosis and the risk of male infertility. Thus, this study was designed to test whether three previously described polymorphisms 72Arg〉Pro （rs1042522） and the Ex2＋ 19C〉T （rs2287498） in TP53, and the 5＇ untranslated region （5＇ UTR） 309T〉G （rs937283） in MDM2, are associated with idiopathic male infertility in a Chinese population. The three polymorphisms were genotyped using OpenArray assay in a hospital-based case-control study, including 580 infertile patients and 580 fertile controls. Our analyses revealed that TP53 Ex2-1-19C〉T and MDM2 309T〉G polymorphisms are associated with male infertility. Furthermore, we detected a nearly statistically significant additive interaction between TP53 rs2287498 and MDM2 rs937283 for the development of male infertility （Pinteraction--O-055）- In summary, this study found preliminary evidence, demonstrating that genetic variants in genes of the TP53 pathway are risk factors for male infertility.

关键词： apoptosis male infertility MDM2 polymorphisms TP53

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

In-situ TEM investigation on the evolution of He bubbles and dislocation loops in Ni-based alloy irradiated by H_(2)^(+)&He^(+)dual-beam ions

引用

Journal of Materials Science & Technology 2023年第7期138卷 36-49页

作者： Zhenbo Zhu Weichi ji Hefei huang Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China

The synergistic evolution mechanisms of He bubbles and dislocation loops under 30 keV H_(2)^(+)&He^(+)dual-beam ions irradiation at 650℃ in the Ni-based alloy GH3535,which is the most promising candidate structure material for molten salt reactors(MSRs),were revealed via in-situ *** nucleation,merg-ing,and change in the size of the dislocation loops and He bubbles were characterized in detail to study the influences of irradiation fluence and pre-existing dislocation loops on their *** number density of both the He bubbles and dislocation loops increases rapidly and subsequently saturates,whereas their size continuously increases with the increasing ion ***-existing dislocation loops with strong absorption characteristics grow preferentially and suppress the nucleation of dislocation loops during the dual-beam ions ***,the bubbles tend to nucleate within the dislocation loops to form bubble-loop complexes,and then decrease in their number *** details of the un-faulting processes of the Frank loops were discussed,where the energy difference between the two types of loops as well as the evolution of the inside Shockley dislocation loops dominates the unfaulting *** several evolution stages of the loop-punching mechanism are revealed,and the emitted loops can directly form perfect loops as well as unfault the neighboring Frank *** He bubbles inside the loops provide corresponding stress for the formation of rhombic loops,which can achieve rapid growth and sweep ability by merging with the neighboring ***,its dissociation to Shockley dis-location can unfault the Frank loops along their slip *** the four Frank loop variations,the edge-on Frank loop variations have the highest growth rate,followed by the perfect *** related mechanisms based on in-situ experimental observation are discussed in depth.

关键词： In-situ TEM observation Ni-based alloy Dislocation loop Punching loop Bubble-loop complex

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

P-Laplace Equation for the Grushin Type Operator

引用

Acta Mathematica Sinica,English Series 2023年第5期39卷 923-938页

作者： ji Zheng huang Xin Xin YANG School of Science Beijing University of Posts and TelecommunicationsBeijing 100876P.R.China

Let Gλ,λ>0,be a Grushin type operator on Rn×*** this paper,we will first establish existence and uniqueness for the p-Laplace equation for Gλ,then we prove the regularity of *** order to prove our results,we will ... 详细信息

关键词： solutions. inequality uniqueness

来源：

维普期刊数据库

同方期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Periodic Folded Wave Patterns for(2+1)-Dimensional Higher-Order Broer-Kaup Equation

引用

Communications in Theoretical Physics 2008年第10期50卷 827-831页

作者： huang Wen-hua College of Science Huzhou University Huzhou 313000 China Shanghai Institute of Mathematics and Mechanics Shanghai University Shanghai 200072 China

A general solution including three arbitrary functions is obtained for the (2+1)-dimensional higher-orderBroer-Kaup equation by means of WTC truncation *** proper multiple valued functions and Jacobielliptic functions in the seed solution,special types of periodic folded waves are *** long wave limit theseperiodic folded wave patterns may degenerate into single localized folded solitary wave *** interactions ofthe periodic folded waves and their degenerated single folded solitary waves are investigated graphically and are foundto be completely elastic.

关键词： higher-order Broer Kaup equation WTC truncation method periodic folded wave

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Scanning tunneling spectroscopic study of monolayer 1T-TaS2 and 1T-TaSe2

引用

Nano Research 2020年第1期13卷 133-137页

作者： Haicheng Lin Wantong huang Kun Zhao Shuang Qiao Zheng Liu jian Wu Xi Chen Shuai-hua ji State Key Laboratory of Low Dimensional Quantum Physics and Department of Physics Tsinghua UniversityBeijing100084China Institute for Advanced Studies Tsinghua UniversityBeijing100084China

The isostructural and isoelectronic transition-metal-dichalcogenides 1T-TaS2 and 1T-TaSe2 are layered materials with intricate electronic *** the molecular beam epitaxy growth,scanning tunneling microscopy measurements and first-principles calculations,we prepare monolayer 1T-TaS2 and TaSe2 and explore their electronic structures at the atomic *** two-dimensional(2D)compounds exhibit commensurate charge density wave phase at low *** conductance mapping identifies the contributions from different Ta atoms to the local density of states with spatial and energy *** 1T-TaS2 and 1T-TaSe2 monolayer are shown to be insulators,while the former has a Mott gap and the latter is a regular band insulator.

关键词： monolayer 1T-TaS2 1T-TaSe2 commensurate charge density wave(CCDW) Mott gap band insulator

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A preliminary study of polymer inclusion membrane for lutetium(Ⅲ)separation and membrane regeneration

引用

Journal of Rare Earths 2021年第10期39卷 1256-1263,I0004页

作者： Siyan huang ji Chen Dan Zou State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China University of Science and Technology of China Hefei 230026China

This paper reports on the selective transport of Lu(Ⅲ)from La(III)and Sm(III)through a polymer inclusion membrane(PIM)composed of 40 wt%di(2-ethylhexyl)phosphinic acid(P227)and 60 wt%poly(vinylidene fluoride)(PVDF).Basically,the changes in surface morphology,thickness and water contact angle of this PVDF-based PIM containing P227(P227@PVDF PIM)with different polymer concentrations were *** solvent extraction experiments,it is found that Lu(Ⅲ)can be selectively extracted from La(Ⅲ)and Sm(Ⅲ)at pH 1.5 in hydrochloric acid *** to this result,P227@PVDF PIM was used to selectively transport Lu(Ⅲ)from hydrochloric acid feed solution containing similar concentration of La(Ⅲ)and Sm(Ⅲ).The recovery factor of Lu(III)is 91% after 36 h,and about 5%of Sm(Ⅲ)was also transported through the *** concentration of La(III)in the feed solution and the stripping solution does not ***,to overcome the ubiquitous decline of transport efficiency caused by the loss of carrier or the damage of membrane structure after long-term use of PIMs,a process for regenerating PIMs was first proposed and *** comparison of the regenerated PIM with the normal PIM,there is almost no difference in the SEM image,ATR-FTIR spectrum and Lu(III)transport *** is expected that P227@PVDF PIMs have the potential to be applied to the grouped separation of rare earth elements(REEs),and this study also can be as an inspiration for the further study on the PIMs regeneration process.

关键词： Polymer inclusion membrane(PIM) Di(2-ethylhexyl)phosphinic acid(P227) Lutetium Rare earths Separation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A New Sufficient Degree Condition for a Graphic Sequence to Be Forcibly k-Edge-Connected

引用

Acta Mathematicae Applicatae Sinica 2022年第1期38卷 223-228页

作者： jian-hua YIN ji-yun GUO School of Science Hainan UniversityHaikou 570228China

A graphic sequence π =(d1, d2,..., dn) is said to be forcibly k-edge-connected if every realization of π is k-edge-connected. In this paper, we obtain a new sufficient degree condition for π to be forcibly k-edgeconnected. We also show that this new sufficient degree condition implies a strongest monotone degree condition for π to be forcibly 2-edge-connected and a conjecture about a strongest monotone degree condition for π to be forcibly 3-edge-connected due to Bauer et al.(Networks, 54(2)(2009) 95-98), and also implies a strongest monotone degree condition for π to be forcibly 4-edge-connected.

关键词： graphic sequence forcibly k-edge-connected graphic sequence a strongest monotone degree condition

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Using ecosystem service supply and ecosystem sensitivity to identify landscape ecology security patterns in the Lanzhou-Xining urban agglomeration, China

引用

Journal of Mountain Science 2020年第11期17卷 2758-2773页

作者： TONG hua-li SHI Pei-ji College of Geography and Environmental Science Northwest Normal UniversityLanzhou 730070China Gansu Province Land Use and Comprehensive Improvement Engineering Research Center Lanzhou 730070China

The construction of an ecological security pattern(ESP)is an important way to ensure regional ecological security and to achieve sustainable regional *** is also one of the hotspot topics of landscape ecology *** paper identifies the ecological source through the evaluation of the ecosystem service and ecosystem sensitivity of the Lanzhou-Xining(Lan-Xi)urban *** minimum cumulative resistance(MCR)model modified by night light data NPP/VIIRS(National Polar-orbiting Operational Environmental Satellite System Preparatory Project/Visible Infrared Imaging Radiometer Suite)was used to measure the relative resistance of the materials and energy circulation between the source areas,and to establish the resistance surface of the ecological source area *** ecological corridors were identified based on ecological sources and resistance *** ecological strategic node is the ecological fragile point in the ecological *** ecological strategic node is identified with hydrological module by superimposing the"ridge line"of cumulative ecological resistance with the ecological *** with ecological sources,corridors and strategic nodes,the ESP of the Lan-Xi urban agglomeration can be *** ecological source of the Lan-Xi urban agglomeration accounts for 28.42%of the total area,most of which is distributed within Qinghai *** nature reserves in the area are all located within the ecological source area.A total of 41 potential ecological corridors have been identified in the study *** total length of the potential corridors is 1201.03 km,comprising 23 source corridors and 18 radiation *** are 30 strategic nodes identified in the Lan-Xi urban *** locations are the most vulnerable areas of the ecological *** engineering should be applied in the construction of *** by the ecological source,the potential ecological corridor extends from

关键词： Ecological security pattern Ecosystem service Ecosystem sensitivity Ecological source Ecological corridor Urban agglomeration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Oxygen transfer phenomenon between slag and molten steel for production of IF steel

引用

Journal of Iron and Steel Research International 2020年第4期27卷 402-408页

作者： Yun-qing ji Chun-yang Liu Hui-xiang Yu Xiao-xuan Deng Fu-xiang huang Xin-hua Wang School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Steelmaking Plant Beijing Shougang Co.Ltd.Qian’an 100041HebeiChina Research Institute of Technology Shougang Group Co.Ltd.Beijing 100043China

FeO-containing slag originated from the basic oxygen furnace to the ladle is a major reoxidation source during the following secondary *** slag reduction treatment(slag treatment)is one of the common countermeasures adopted to eliminate the steel contamination by FeO *** oxygen transfer phenomenon between molten steel and slag was studied during the industrial production of interstitial-free(IF)steel,the measured and calculated oxygen activities in steel were compared,and the Fe–O equilibrium at the slag–molten steel interface was investigated by thermodynamic *** slag treatment,the oxygen potential is higher in the molten steel than in the pre-deoxidation slag;this causes oxygen transfer from the molten steel to the slag,decreasing the efficiency of slag *** on this,a two-step slag deoxidation process was *** second step further reduced the FeO *** the other hand,the CaO/Al2O3(C/A)ratio in the refining slag must be controlled,because it affects the FeO activity and inclusion absorption capacity of the *** results suggest that the C/A ratio of 1.2–1.5 and the FeO content of\6%are beneficial to refine IF steel.

关键词： Oxygen transfer IF steel Deoxidation Slag treatment Refining slag

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of Nutrient Limitation on Pigments in Thalassiosira weissflogii and Prorocentrum donghaiense

引用

Journal of Integrative Plant Biology 2007年第5期49卷 686-697页

作者： jian-Jun Hou Bang-Qin huang Zhen-Rui Cao ji-Xin Chen hua-Sheng Hong State Key Laboratory of Marine Environmental Science Xiamen University Xiamen 361005 China College of Fisheries Huazhong Agricultural University Wuhan 430070 China Hubei Institute for Nationalities Enshi 445000 China

The response of Prorocentrum donghaiense and Thalassiosira weissfiogii pigments under nitrate （N） and phosphate （P） limitation were studied using HPLC and in vivo fluorescence protocols in batch cultures. For P. donghaiense, the pigment ratio was kept stable under different nutrient conditions from the results of HPLC. For T. weissflogii, there was a lower ratio of chlorophyllide to Chl a during the exponential phase, but the reverse during the stationary phase. Different members of the phytoplankton had different pigments response mechanisms under nutrient limitation. From the results of in vivo fluorescence, the ratio of peridinin to Chl a for P. donghaiense increased in nutrient-free culture, while it was kept stable for nutrient-limited cultures during the exponential phase. For T. weissflogii, the ratio of fucoxanthin to Chl a for each culture increased during the exponential phase, but the ratio under N limitation was apparently lower than that for P limitation during the stationary phase. The results indicate that both pigment ratios from HPLC and in vivo fluorescence of To weissflogii were changed greatly under different nutrient conditions, which suggests that both ratios could be used as indicators of algal physiological status in different nutrient conditions.

关键词： HPLC in vivo fluorescence nutrient limitation pigments Prorocentrum donghaiense Thalassiosira weissflogii.

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：