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Journal of Environmental Sciences 1998年第1期10卷 112-114页

作者： ji yuan tang department of preventive medicine, anhui medical university,{2., wei xiao fei, li yi, liao hong mei department of biology, anhui university, hefei 2.0039, china

Practicability of method for the Hydra regeneration assay on the prescreening teratogenic potential of chlorinated drinking water disinfection by products was studied through both the assays of toxicity of adult Hydra (T) and inhibition of the growth of regeneration Hydra (I) by using chloroform, dichloromethane and chloroacetic acid. The results showed that T 50 / I 50 ratios of chloroform and chloroacetic acid were 2. 77 and 6 16 respectively, with teratogenic potential. T 50 / I 50 ratio of dichloromethane was 1.69, with weaker teratogenic potential. These experimental results indicated preliminarily that the Hydra regeneration assay has certainly applied value as a prescreening assay for developmental toxicity.

关键词： Hydra regeneration assay chlorinated disinfection chloroform dichloromethane chloroacetic acid.

Characterization of acute-on-chronic liver diseases: A multicenter prospective cohort study

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World Journal of Hepatology 2024年第5期16卷 809-821页

作者： yuan-yao Zhang Sen Luo Hai li Shu-Ning Sun Xian-Bo Wang Xin Zheng Yan Huang Bei-ling li Yan-Hang Gao Zhi-Ping Qian Feng liu xiao-Bo Lu Jun-Ping liu Hao-tang Ren Yu-Bao Zheng Hua-Dong Yan Guo-hong Deng liang Qiao Yan Zhang Wen-yi Gu xiao-mei Xiang yi Zhou yi-Xin Hou Qun Zhang Yan Xiong Cong-Cong Zou Jun chen Ze-Bing Huang Xiu-Hua jiang Ting-Ting Qi yuan-yuan chen Na Gao Chun-Yan liu wei yuan Xue mei jing li Tao li Rong-jiong Zheng Xin-yi Zhou Jun Zhao Zhong-ji Meng department of Infectious Disease Institute of Biomedical ResearchRegulatory Mechanism and Targeted Therapy for Liver Cancer Shiyan Key LaboratoryHubei provincial Clinical Research Center for Precise Diagnosis and Treatment of Liver CancerTaihe HospitalHubei University of MedicineShiyan 442000Hubei ProvinceChina department of Gastroenterology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200120China department of Infectious Diseases Southwest HospitalThe Third Military Medical University(Army Medical University)Chongqing 400000China Center of Integrative medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100020China department of Infectious Diseases Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430020Hubei ProvinceChina department of Infectious Diseases Hunan Key Laboratory of Viral HepatitisXiangya HospitalCentral South UniversityChangsha 110051Hunan ProvinceChina Hepatology Unit Department of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina department of Hepatology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina department of liver Intensive Care Unit Shanghai Public Health Clinical CentreFudan UniversityShanghai 200093China Tianjin Institute of Hepatology Nankai University Second People's HospitalTianjin 300192China Infectious Disease Center The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina department of Infectious Diseases and Hepatology The Second Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina State Key Laboratory for Diagnosis and Treatment of Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseaseThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina department of Infectious Diseases The Thir

BACKGROUND Acute-on-chronic liver disease(AoCLD)accounts for the majority of patients hospitalized in the {2. of Hepatology or Infectious *** To explore the characterization of AoCLD to provide theoretical guidance for the accurate diagnosis and prognosis of *** Patients with AoCLD from the Chinese Acute-on-Chronic liver Failure(ACLF)study cohort were included in this *** clinical characteristics and outcomes,and the 90-d survival rate associated with each clinical type of AoCLD were analyzed,using the Kaplan-meier method and the log-rank *** A total of 3375 patients with AoCLD were enrolled,including 1679(49.7%)patients with liver cirrhosis acute decompensation(LC-AD),850(2..2.)patients with ACLF,577(17.1%)patients with chronic hepatitis acute exacer-bation(CHAE),and 2.9(8.0%)patients with liver cirrhosis active phase(LC-A).The most common cause of chronic liver disease(CLD)was HBV infection(71.4%).The most common precipitants of AoCLD was bacterial infection(2..8%).The 90-d mortality rates of each clinical subtype of AoCLD were 43.4%(2.2.535)for type-C ACLF,36.0%(36/100)for type-B ACLF,2..0%(58/2.5)for type-A ACLF,9.0%(151/1679)for LC-AD,3.0%(8/2.9)for LC-A,and 1.2.(7/577)for *** HBV infection is the main cause of CLD,and bacterial infection is the main precipitant of *** most common clinical type of AoCLD is *** diagnosis and timely intervention are needed to reduce the mortality of patients with LC-AD or ACLF.

关键词： Acute-on-chronic liver disease Acute-on-chronic liver failure liver cirrhosis Clinical features Prognosis

Echocardiographic Measurements in Normal Chinese Adults(EMINCA)II focusing on left ventricular and left atrial size and function by three-dimensional echocardiography

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Frontiers of medicine 2024年第4期18卷 649-663页

作者： yingbin Wang Yu Zhang Guihua yao hong tang lixin chen lixue yin Tiangang Zhu jianjun yuan wei Han Jun Yang Xianhong Shu Ya Yang Yulin wei Yanli Guo weidong Ren Dongmei Gao Guilin Lu ji Wu hongning yin Yuming Mu jiawei Tian lijun yuan xiaojing Ma hongyan Dai Yunchuan Ding Mingyan Ding qing Zhou Hao Wang Di Xu mei Zhang Yun Zhang State Key Laboratory for Innovation and Transformation of Luobing Theory Key Laboratory of Cardiovascular Remodeling and Function ResearchChinese Ministry of EducationChinese National Health Commission and Chinese Academy of Medical SciencesDepartment of CardiologyQilu Hospital of Shandong UniversityJinan250012China department of Cardiology Qilu Hospital of Shandong University(Qingdao)Qingdao266000China department of Ultrasonography West China HospitalSichuan UniversityChengdu610041China department of Ultrasonography Shenzhen People’s Hospital/The Second Clinical Medical College of Jinan UniversityShenzhen518020China department of Ultrasonography Electronic Science and Technology University of ChinaThe Affiliated Sichuan Provincial People’s HospitalChengdu610072China department of Cardiology Peking University People’s HospitalBeijing100044China department of Ultrasonography Henan Provincial People’s HospitalZhengzhou463599China department of Cardiology The First Affiliated Hospital of Harbin Medical UniversityHarbin150007China department of Echocardiology The First Affiliated Hospital of China Medical UniversityShenyang110001China department of Echocardiology Zhongshan HospitalFudan UniversityShanghai200032China department of Echocardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing100029China department of Cardiology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou510120China department of Ultrasonography The Southwest Hospital of AMUChongqing400038China department of Ultrasonography Shengjing Hospital of China Medical UniversityShenyang110136China department of Ultrasonography China-Japan Union hospital of Jilin UniversityChangchun130033China department of Ultrasonography First Affiliated HospitalSchool of MedicineShihezi UniversityShihezi832000China department of Ultrasonography The First Affiliated Hospital of Guangxi Medical UniversityNanning537406China department of Echocardiology The Second Hospital of Hebei Medical Uni

Current guidelines encourage large studies in a diverse population to establish normal reference ranges for three-dimensional(3D)echocardiography for different ethnic *** study was designed to establish the normal values of 3D-left ventricular(LV)and left atrial(LA)volume and function in a nationwide,population-based cohort of healthy Han Chinese adults.A total of 1117 healthy volunteers aged 18–89 years were enrolled from 2. collaborating laboratories in *** sets of 3D echocardiographic instruments were used,and full-volume echocardiographic images were recorded and transmitted to a core laboratory for image analysis with a vendor-independent off-line ***,866 volunteers(mean age of 48.4 years,402.men)were qualified for final *** parameters exhibited substantial differences between different sex and age groups,even after indexation by body surface *** normal ranges of 3D-LV and 3D-LA volume and function differed from those recommended by the American Society of Echocardiography and the European Association of Cardiovascular Imaging guidelines,presented by the World Alliance Societies of Echocardiography(WASE)study,and from the 2. values in the EMINCA *** normal reference values of 3D echocardiography-derived LV and LA volume and function were established for the first time in healthy Han Chinese *** ranges of 3D-LV and 3D-LA echocardiographic measurements stratified with sex,age,and race should be recommended for clinical applications.

关键词： three-dimensional echocardiography left ventricle left atrium normal reference values Chinese adults

Consensus for criteria of running a pediatric inflammatory bowel disease center using a modified Delphi approach

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World Journal of Pediatrics 2023年第10期19卷 939-948页

作者： You-You Luo Kai-Chun Wu Si-tang Gong ying Huang hong Yang qing-Ya tang ying-kit Leung jie Wu Lan-Lan Geng wei Zhou mei Sun Chao-Min Wan Zai-ling li ying Fang xiao-qin li mei li Zhao-Xia Wang yuan xiao Xue-mei Zhong xiao-fei chen jie chen department of Gastroenterology Children’s HospitalZhejiang University School of MedicineHangzhou 310052China National Clinical Research Center for Child Health Hangzhou 310051China department of Gastroenterology Xijing HospitalFourth Military Medical UniversityXi’an 710032China department of Gastroenterology Guangzhou Women and Children’s Medical Center of Guangzhou Medical UniversityGuangzhou 510623China department of Gastroenterology Children’s Hospital of Fudan UniversityShanghai 201102China department of Gastroenterology Peking Union Medical College HospitalPeking Union Medical College&Chinese Academy of Medical ScienceBeijing 100730China department of Clinical Nutrition Xinhua Hospital School of MedicineShanghai Jiao Tong UniversityShanghai 200092China department of Pediatric Gastroenterology The First Hospital of Jilin UniversityJilin 130061China department of Gastroenterology Beijing Children’s HospitalCapital Medical UniversityBeijing 100045China department of General Surgery Sir Run Run Shaw HospitalCollege of MedicineZhejiang UniversityHangzhou 310016China department of Gastroenterology Shengjing Hospital of China Medical UniversityShenyang 110004China department of Pediatrics West China Second HospitalWest China Women’s and Children’s HospitalChengdu 610041China department of Pediatrics Peking University Third HospitalBeijing 100191China department of Gastroenterology Xi’an Children’s HospitalXi’an 710003China department of Gastroenterology Children’s Hospital of Zhengzhou UniversityZhengzhou 450053China department of Gastroenterology Children’s Hospital of Nanjing Medical UniversityNanjing 210008China department of Gastroenterology Shenzhen Children’s HospitalShenzhen 518034China department of Pediatrics Ruijing HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 350025China department of Gastroenterology Children’s HospitalCapital Institute of PediatricsBeijing 100020China

Background Good quality of care for inflammatory bowel disease(IBD)depends on high-standard management and facility in the IBD ***,there are no clear measures or criteria for evaluating pediatric IBD(PIBD)center in *** aim of this study was to develop a comprehensive set of quality indicators(QIs)for evaluating PIBD center in *** A modified Delphi consensus-based approach was used to identify a set of QIs of structure,process,and outcomes for defining the *** process included an exhaustive search using complementary approaches to identify potential QIs,and two web-based voting rounds to select the QIs defining the criteria for PIBD *** A total of 101 QIs(35 structures,48 processes and 18 outcomes)were included in this *** QIs focused on the composition of multidisciplinary team,facilities and services that PIBD center should *** QIs highlight core requirements in diagnosing,evaluating,treating PIBD,and disease *** QIs mainly included criteria evaluating effectiveness of various interventions in PIBD *** The present Delphi consensus developed a set of main QIs that may be useful for managing a PIBD center.

关键词： Crohn’s disease Pediatric inflammatory bowel disease Quality indicators Ulcerative colitis

Onset of Coronary Heart Disease is Associated with HCMV Infection and Increased CD14^+CD16^+Monocytes in a Population of weifang,china

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Biomedical and Environmental Sciences 2020年第8期33卷 573-582页

作者： li hong Zheng WANG {2. ZHANG yi yuan WANG jin Dong WU hong Juan ZHANG Mo Gen li ji chen liU Zhi Jun department of medical Micro{2. Weifang Medical UniversityWeifang 261053ShandongChina National Institute for Viral Diseases Control and Prevention China Center for Disease Control and PreventionBeijing 102206China School of Clinical medicine Weifang Medical UniversityWeifang 261053ShandongChina Morphological Laboratory Weifang Medical UniversityWeifang 261053ShandongChina

Objective To investigate the relationship between human cytomegalovirus(HCMV)infection and peripheral blood CD14+CD16+monocytes in the pathogenesis of coronary heart disease(CHD),and to elucidate the mechanism of pathogenesis in CHD by analyzing the correlation between infection,inflammation,and CHD,to provide a basis for the prevention,evaluation,and treatment of the *** In total,192.patients with CHD were divided into three groups:latent CHD,angina pectoris,and myocardial ***-IgM and-IgG antibodies were assessed using EliSA;CD14+CD16+monocytes were counted using a five-type automated hematology analyzer;mononuclear cells were assessed using fluorescence-activated cell sorting;and an automatic biochemical analyzer was used to measure the levels of triglyceride,cholesterol,high-and low-density lipoprotein cholesterols,lipoprotein,hs-CRp and *** The positive rates of HCMV-IgM and-IgG were significantly higher in the CHD groups than in the control *** infection affects lipid metabolism to promote immune and inflammatory *** HCMV infection has a specific correlation with the occurrence and development of *** expression of CD14+CD16+mononuclear cells in the CHD group was increased accordingly and correlated with acute HCMV ***,HCMV antibody as well as peripheral blood CD14+CD16+mononuclear cells can be used to monitor the occurrence and development of CHD.

关键词： Human cytomegalovirus Coronary heart disease Antibody CD14+CD16+monocytes weifang

双胎早产儿支气管肺发育不良危险因素分析:一项多中心研究

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中国当代儿科杂志 2024年第6期26卷 611-618页

作者：樊雨薇张伊佳温和梅晏红沈蔚丁月琴龙运峰张志钢李桂芳姜泓饶红萍邱建武魏贤张亚昱曾纪斌赵常亮许伟鹏王凡员丽杨秀芳李薇林霓阳陈倩夏昌顺钟鑫琪崔其亮广州医科大学附属第三医院新生儿科/广东省产科重大疾病重点实验室/广东省妇产疾病临床医学研究中心/粤港澳母胎医学高校联合实验室广东广州510150 北京大学第三医院儿科北京100191 四川锦欣妇女儿童医院新生儿科四川成都610011 贵州医科大学附属医院新生儿科贵州贵阳550001 厦门大学附属妇女儿童医院新生儿科福建厦门361003 南方医科大学附属东莞医院新生儿科广东东莞523000 邵阳学院附属第一医院新生儿科湖南邵阳422000 广东省第二人民医院新生儿科广东广州511000 沧州市人民医院新生儿科河北沧州061000 延安大学附属医院新生儿科陕西延安716000 惠州市中心人民医院新生儿科广东惠州516001 汕头大学医学院附属粤北人民医院新生儿科广东韶关512026 武汉科技大学附属孝感医院新生儿科湖北孝感432000 内蒙古医科大学附属医院新生儿科内蒙古呼和浩特010050 汕头大学医学院第二附属医院新生儿科广东汕头515041 包钢集团第三职工医院新生儿科内蒙古包头014010 暨南大学附属第一医院新生儿科广东广州510630 兰州大学第二医院甘肃兰州730000 新乡市中心医院新生儿科河南新乡453000 中山市人民医院新生儿科广东中山528400 东莞市滨海湾中心医院新生儿科广东东莞523808 汕头大学医学院第一附属医院新生儿科广东汕头515041

目的分析胎龄2.%是双胎中仅一胎患BPD的危险因素(OR=3.370,95%CI:1.500~7.568,P<0.05),胎龄大是双胎均患BPD的保护因素(P<0.05)。对双胎中仅一胎为BPD组进行组内条件logistic回归分析,提示小于胎龄儿是双胎内个体发生BPD的危险因素(OR=... 详细信息

目的分析胎龄2.家医院2.18年1月—2.2.年12.收治的胎龄2.%是双胎中仅一胎患BPD的危险因素(OR=3.370,95%CI:1.500~7.568,P2..190,P<0.05)。结论双胎早产儿BPD的发生不仅与胎龄相关,也与双胎出生体重差异、小于胎龄儿密切相关。

关键词：支气管肺发育不良危险因素多中心研究双胎儿早产儿

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四川省骨质疏松症诊疗质量及考核标准调查

中华骨质疏松和骨矿盐疾病杂志 2024年第1期17卷 17-24页

作者：许钟月王覃卢春燕李大江曹洪义钟莉何清华许慎李静陈雯张琪黄媛媛袁艳玲杨帆刘玉溥周虹王楠唐晨鲜海英陈德才四川大学华西医院内分泌代谢科成都610041 四川大学华西医院医务部成都610041 成都市第五人民医院内分泌代谢科成都611130 成都市龙泉驿区第一人民医院内分泌代谢科成都610100 四川电力医院内科成都610100 成都市龙泉驿区第一人民医院康复科成都610100

目的调查四川省各级医院相关科室基线时和医院行为干预后骨质疏松症诊疗质量,了解骨质疏松症诊疗现状及医院行为干预作用,制定各级医院和各类科室质量控制建议标准。方法本研究以四川大学华西医院和成都市第五人民医院、成都市龙泉驿区... 详细信息

目的调查四川省各级医院相关科室基线时和医院行为干预后骨质疏松症诊疗质量,了解骨质疏松症诊疗现状及医院行为干预作用,制定各级医院和各类科室质量控制建议标准。方法本研究以四川大学华西医院和成都市第五人民医院、成都市龙泉驿区第一人民医院、四川电力医院作为四川省三级甲等医院、二级甲等医院和社区医院各层次医院代表,采用自行设计的骨质疏松症调查问卷和病历查阅方式,在2.15—2.18年间以预调查-医院干预-调查-医院干预-再调查的模式在各级医院各科室展开调查,对收集到的数据进行汇总分析。结果调查共完成了5773份问卷和病历查询,基线时各级医院骨密度筛查率多在10%左右,骨质疏松症诊断率明显高于治疗率,二级医院和社区医院的骨质疏松症患者转诊率和随访率远高于三级医院。医院行为干预后,各级医院的骨密度筛查率、骨质疏松症诊断率和治疗率均较前提升,显示出更好的骨质疏松症诊疗质量,但仍存在较为明显的诊治差距。基于此次调查结果制定各级医院和相关科室骨质疏松症诊疗质量相关指标的考核标准。结论目前骨质疏松症诊疗现状仍不理想,呈现低筛查率、低诊断率、低治疗率的现状。但骨质疏松症医疗质量可控,通过实施和贯彻骨质疏松症诊疗质控量化考核指标,可一定程度上提升骨质疏松症诊疗质量。

关键词：骨质疏松症诊疗质量质量控制

A Simple and Quick Screening Method for Intrapulmonary Vascular Dilation in Cirrhotic Patients Based on Machine Learning

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Journal of Clinical and Translational Hepatology 2021年第5期9卷 682-689页

作者： Yu-jie li Kun-Hua Z{2. Xue-{2. Bai Xi tang Peng li Zhi-Yong Yang {2.-Yu Zhi xiao-Jun li Yang chen Peng Deng xiao-lin {12. jian-Teng Gu jiao-lin Ning Kai-Zhi Lu Ju Zhang Zheng-yuan Xia Yu-Wen chen Bin yi department of Anaesthesiology Southwest HospitalThird Military Medical University(First Affiliated Hospital of Army Medical University)ChongqingChina chengdu Institute of Computer Applications Chinese Academy of SciencesChengduSichuanChina university of Chinese Academy of Sciences BeijingChina Chongqing Institute of Green and Intel{2.gent Technology Chinese Academy of ScienceChongqingChina department of Anaesthesiology Li Ka Shing Faculty of MedicineThe University of Hong KongHong KongChina

Background and Aims:Screening for hepatopulmonary syndrome in cirrhotic patients is limited due to the need to perform contrast enhanced echocardiography(CEE)and arterial blood gas(ABG)*** aimed to develop a simple and quick method to screen for the presence of intrapulmonary vascular dilation(IPVD)using noninvasive and easily available variables with machine learning(ML)***:Cirrhotic patients were enrolled from our *** eligible patients underwent CEE,ABG analysis and physical *** developed a twostep model based on three ML algorithms,namely,adaptive boosting(termed AdaBoost),gradient boosting decision tree(termed GBDT)and eXtreme gradient boosting(termed Xgboost).Noninvasive variables were input in the first step(the NI model),and for the second step(the NIBG model),a combination of noninvasive variables and ABG results were *** performance was determined by the area under the curve of receiver operating characteristics(AUCROCs),precision,recall,F1-score and ***:A total of 193 cirrhotic patients were ultimately *** AUCROCs of the NI and NIBG models were 0.850(0.738–0.962.and 0.867(0.760–0.973),respectively,and both had an accuracy of 87.2..For both negative and positive cases,the recall values of the NI and NIBG models were both 0.867(0.760–0.973)and 0.875(0.771–0.979),respectively,and the precisions were 0.813(0.690–0.935)and 0.913(0.82.–1.000),***:We developed a two-step model based on ML using noninvasive variables and ABG results to screen for the presence of IPVD in cirrhotic *** model may partly solve the problem of limited access to CEE and ABG by a large numbers of cirrhotic patients.

关键词： Hepatopulmonary syndrome Intrapulmonary vascular dilation Cirrhosis Screening Machine learning

The Chinese Society of Clinical Oncology(CSCO)clinical guidelines for the diagnosis and treatment of nasopharyngeal carcinoma

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Cancer Communications 2021年第11期41卷 1195-1227页

作者： ling-Long tang Yu-Pei chen Chuan-Ben chen Ming-yuan chen Nian-Yong chen xiao-Zhong chen xiao-jing Du Wen-Feng Fang mei Feng jin Gao fei Han Xia He Chao-Su Hu De-sheng Hu Guang-yuan Hu Hao jiang wei jiang Feng jin jin-yi Lang jin-Gao li Shao-Jun lin Xu liu Qiu-Fang liu lin Ma Hai-Qiang Mai ji-Yong qin liang-Fang Shen ying Sun Pei-Guo Wang Ren-Sheng Wang Ruo-Zheng Wang xiao-Shen Wang ying Wang Hui Wu Yun-fei Xia Shao-Wen xiao Kun-Yu Yang Jun-lin yi xiao-Dong Zhu Jun Ma department of Radiation Oncology State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center of Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer Center651 Dongfeng Road EastGuangzhouGuangdong 510060P.R.China department of Radiation Oncology Fujian Provincial Cancer HospitalFujian Medical University Department of Radiation OncologyTeaching Hospital of Fujian Medical University Provincial Clinical CollegeCancer Hospital of Fujian Medical UniversityFuzhouFujian 350014P.R.China department of Nasopharyngeal Carcinoma State Key Laboratory of Oncology in South ChinaCollaborative Innovation Centre for Cancer MedicineGuangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and TherapySun Yat-sen University Cancer CenterGuangzhouGuangdong 510060P.R.China department of Radiation Oncology Cancer CenterWest China HospitalSichuan UniversityChengduSichuan 610041P.R.China Cancer Hospital of the university of Chinese Academy of Sciences(Zhejiang Cancer Hospital)Institute of Cancer and Basic {2.(IBMC)Chinese Academy of Sciences HangzhouZhejiang 310000P.R.China State Key Laboratory of Oncology in South china Collaborative Innovation Center for Cancer MedicineMedical Oncology DepartmentSun Yat-Sen University Cancer CenterGuangzhouGuangdong 510060P.R.China department of Radiation Oncology Sichuan Cancer Hospital and InstituteSichuan Cancer CenterSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan 610041P.R.China department of Radiation Oncology Anhui Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui 230001P.R.China department of Clinical Laboratory Affiliated Cancer Hospital of Nanjing Medical UniversityJiangsu Cancer HospitalJiangsu Institute of Cancer ResearchNanjingJiangsu 210000P.R.China department of Radiation Oncology Fudan University Shanghai Cancer CenterShanghai 200032P.R.China department of Radiotherapy Hubei Cancer HospitalTong

Nasopharyngeal carcinoma(NPC)is a malignant epithelial tumor originating in the nasopharynx and has a high incidence in Southeast Asia and North *** develop these comprehensive guidelines for the diagnosis and management of NPC,the Chinese Society of Clinical Oncology(CSCO)arranged a multi-disciplinary team comprising of experts from all sub-specialties of NPC to write,discuss,and revise the *** on the findings of evidencebased medicine in china and abroad,domestic experts have iteratively developed these guidelines to provide proper management of ***,the guidelines describe the screening,clinical and pathological diagnosis,staging and risk assessment,therapies,and follow-up of NPC,which aim to improve the management of NPC.

关键词： Chinese Society of Clinical Oncology CSCO Nasopharyngeal carcinoma Diagnosis Staging Risk Radiotherapy Chemotherapy Surgery Immunotherapy

Efficacy and Safety Investigation of Kuntai Capsule for the Add-back Therapy of Gonadotropin Releasing Hormone Agonist Administration to Endometriosis Patients： A Randomized,Double-blind, Blank-and Tibolone-controlled Study

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Chinese medical Journal 2015年第4期128卷 427-432页

作者： ji-Ming chen {2.-Yan Gao yi Ding Xia yuan qing Wang qin li Guo-Hua jiang department of Gynecology Third Affiliated Hospital of Soochow University Changzhou Jiangsu 213003 China department of Gynecology Jintan Hospital Affiliated to Jiangsu University Jintan Jiangsu 213200 China

Background：As a Chinese Traditional medicine product,Kuntai capsule could improve the peri-menopausal symptoms in postmenopausal *** it is still not clear whether Kuntai capsule has a good effect on alleviating peri-menopausal symptoms induced by gonadotropin releasing hormone agonist （GnRH-a） *** purpose of this study was to investigate the clinical effectiveness and safety of Kuntai capsule,on peri-menopausal symptoms in endometriosis （EMS） patients,with postoperative GnRH-a ***：Ninety EMS ovarian cyst women with postoperative GnRH-a administration were enrolled in the study,and were randomly divided into Kuntai group,Tibolone group,or blank Control *** therapeutic strategy in Kuntai group was 4 Kuntai capsules tid,po for 12.weeks after the first GnRH-a injection,while Tibolone 2.5 mg qd,po for 12.weeks in Tibolone *** was no drug addition in Control *** complaints were evaluated by Kupperman menopausal index （KMI） and hot flash/sweating *** and renal functions,lipid profile,serum sex hormone levels and endometrial thickness were measured,and the frequency of adverse events in Kuntai and Tibolone groups was ***：（l） Before GnRH-a therapy,the baseline parameter results were comparable in the three groups （P ＞ 0.05）.（2. After GnRH-a therapy,KMI and hot flash/sweating scores in all the three groups increased significantly （P ＜ 0.05）.At the 4th week after GnRH-a therapy,KMI and hot flash/sweating score results were as follows：Control group ＞ Kuntai group ＞ Tibolone group （P ＜ 0.05）; at the 8th and 12.h week after GnRH-a therapy,KMI and hot flash/sweating score in Control group were significantly higher than the other two groups （P ＜ 0.05）,and no significant difference was identified between Kuntai and Tibolone group （P ＞ 0.05）.（3） No statistical change took place in the liver and renal functions and lipid profile in all the three groups after the treatment （P ＞ 0.05）.（4） The posttherapeutic

关键词： Endometriosis Kuntai Capsule Kupperman Menopausal Index Peri-menopausal Symptoms Tibolone