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Repetitive transcranial magnetic stimulation in Alzheimer’s disease:effects on neural and synaptic rehabilitation

Neural Regeneration Research 2025年第2期20卷 326-342页

作者： yi ji Chaoyi Yang Xuerui Pang yibing Yan Yue Wu Zhi Geng Wenjie Hu Panpan Hu Xingqi Wu Kai Wang Department of Neurology The First Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders HefeiAnhui ProvinceChina Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health HefeiAnhui ProvinceChina Institute of Artificial Intelligence Hefei Comprehensive National Science CenterHefeiAnhui ProvinceChina Department of Psychology and Sleep Medicine The Second Affiliated Hospital of Anhui Medical UniversityHefeiAnhui ProvinceChina

Alzheimer’s disease is a neurodegenerative disease resulting from deficits in synaptic transmission and *** Alzheimer’s disease brain tends to be hyperexcitable and hypersynchronized,thereby causing neurodegeneration and ultimately disrupting the operational abilities in daily life,leaving patients *** transcranial magnetic stimulation is a cost-effective,neuro-modulatory technique used for multiple neurological *** the past two decades,it has been widely used to predict cognitive decline;identify pathophysiological markers;promote neuroplasticity;and assess brain excitability,plasticity,and *** has also been applied to patients with dementia,because it can yield facilitatory effects on cognition and promote brain recovery after a neurological ***,its therapeutic effectiveness at the molecular and synaptic levels has not been elucidated because of a limited number of *** study aimed to characterize the neurobiological changes following repetitive transcranial magnetic stimulation treatment,evaluate its effects on synaptic plasticity,and identify the associated *** review essentially focuses on changes in the pathology,amyloidogenesis,and clearance pathways,given that amyloid deposition is a major hypothesis in the pathogenesis of Alzheimer’s *** mechanisms associated with repetitive transcranial magnetic stimulation procedures and different pathways mediating gene transcription,which are closely related to the neural regeneration process,are also ***,we discuss the outcomes of animal studies in which neuroplasticity is modulated and assessed at the structural and functional levels by using repetitive transcranial magnetic stimulation,with the aim to highlight future directions for better clinical translations.

关键词： Alzheimer’s disease amyloid deposition apoptotic mechanisms biomarker neural regeneration neurodegeneration repetitive transcranial magnetic stimulation synaptic plasticity

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An Improved Higher-Order Time Integration Algorithm for Structural Dynamics

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Computer Modeling in Engineering & Sciences 2021年第2期126卷 549-575页

作者： yi ji Yufeng Xing Institute of Solid Mechanics Beihang UniversityBeijing100083China Shen Yuan Honors College Beihang UniversityBeijing100083China

Based on the weighted residual method,a single-step time integration algorithm with higher-order accuracy and unconditional stability has been proposed,which is superior to the second-order accurate algorithms in tracking long-term *** improving such a higher-order accurate algorithm,this paper proposes a two sub-step higher-order algorithm with unconditional stability and controllable *** the proposed algorithm,a time step interval[t_(k),t_(k)+h]where h stands for the size of a time step is divided into two sub-steps[t_(k),t_(k)+γh]and[t_(k)+γh,t_(k)+h].A non-dissipative fourth-order algorithm is used in the rst sub-step to ensure low-frequency accuracy and a dissipative third-order algorithm is employed in the second sub-step to lter out the contribution of high-frequency ***,two approaches are used to design the algorithm parameterγ.The rst approach determinesγby maximizing low-frequency accuracy and the other determinesγfor quickly damping out highfrequency *** present algorithm usesρ_(∞)to exactly control the degree of numerical dissipation,and it is third-order accurate when 0≤ρ_(∞)<1 and fourth-order accurate whenρ_(∞)=***,the proposed algorithm is self-starting and easy to *** illustrative linear and nonlinear examples are solved to check the performances of the proposed two sub-step higher-order algorithm.

关键词： Time integration algorithm two-sub-step higher-order accuracy controllable dissipation unconditional stability

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On Extension of Isometries Between the Unit Spheres of Normed Space E and l^p(p>1)

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Acta Mathematica Sinica,English Series 2009年第7期25卷 1139-1144页

作者： ji jin yi Rui Dong WANG School of Mathematics Liaocheng University Liaocheng 252059 P. R. China School of Mathematics Nankai University Tianjing 300071 P. R. China Department of Mathematics Tianjin University of Technology Tianjin 300191 P. R. China

In this paper, we study the extension of isometries between the unit spheres of normed space E and lP（p 〉 1）. We arrive at a conclusion that any surjective isometry between the unit sphere of normed space lP（p 〉 ... 详细信息

关键词： isometric mapping isometric extension strictly convex

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Deep spectral learning for label-free optical imaging oximetry with uncertainty quantification

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Light(Science & Applications) 2019年第1期8卷 223-235页

作者： Rongrong Liu Shiyi Cheng Lei Tian ji yi Department of Biomedical Engineering Northwestern UniversityEvanstonIL 60208USA Department of Electrical and Computer Engineering Boston UniversityBostonMA 02215USA Department of Biomedical Engineering Boston UniversityBostonMA 02215USA Department of Medicine Boston University School of MedicineBoston Medical CenterBostonMA 02118USA

Measurement of blood oxygen saturation(sO_(2))by optical imaging oximetry provides invaluable insight into local tissue functions and *** different embodiments and modalities,all label-free optical-imaging oximetry techniques utilize the same principle of sO_(2)-dependent spectral contrast from *** approaches for quantifying sO_(2) often rely on analytical models that are fitted by the spectral *** approaches in practice suffer from uncertainties due to biological variability,tissue geometry,light scattering,systemic spectral bias,and variations in the experimental ***,we propose a new data-driven approach,termed deep spectral learning(DSL),to achieve oximetry that is highly robust to experimental variations and,more importantly,able to provide uncertainty quantification for each sO_(2) *** demonstrate the robustness and generalizability of DSL,we analyse data from two visible light optical coherence tomography(vis-OCT)setups across two separate in vivo experiments on rat *** made by DSL are highly adaptive to experimental variabilities as well as the depth-dependent backscattering *** neural-network-based models are tested and compared with the traditional least-squares fitting(LSF)*** DSL-predicted sO_(2) shows significantly lower mean-square errors than those of the *** the first time,we have demonstrated en face maps of retinal oximetry along with a pixel-wise confidence *** DSL overcomes several limitations of traditional approaches and provides a more flexible,robust,and reliable deep learning approach for in vivo non-invasive label-free optical oximetry.

关键词： DSL optical scattering

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A Solution of Grid Computing Flow Using MDA Methodology

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The Journal of China Universities of Posts and Telecommunications 2006年第1期13卷 29-33页

作者： ji yi-mu WANG Ru-chuan Department of Computer Science Nanjing University of Posts and Telecommunications Nanjing 210003 P.R. China State Key Laboratory for Novel Software Technology Nanjing University Nanjing 210093 P.R. China

This paper presents an approach to build a flow of grid services named GFlow. This approach converts all of the services＇ interfaces in globus toolkit 3 into platform independent model format. The conversion uses eclipse modeling framework plug-ins and graphical editing framework plug-ins to parse the models into platform specific models, which are responsible for implementation of grid services＇ clients and servers and their automatic deployment. This paper emphasizes on design method, which uses model drive architecture, and design process, which uses model-view-control.

关键词： grid computing platform MDA open grid service infrastructure MVC architecture

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Query routing mismatch alleviation architecture for P2P file lookup in MANETs

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The Journal of China Universities of Posts and Telecommunications 2011年第4期18卷 111-117页

作者： MEI jing-qing ji Hong LI yi Key Laboratory of Universal Wireless Communications Ministry of Education Beijing University of Posts and Telecommunications Beijing 100876 China

A cross-layer optimized query routing mismatch alleviation （QRMA） architecture is proposed to mitigate the problem of query routing mismatch （QRM） phenomenon between the structured peer to peer （P2P） overlay and the routing layer in mobile Ad-hoc networks （MANETs）, which is an important issue that results in the inefficiency of lookup process in the system. Explicated with the representative Chord protocol, the proposal exploits the information of topologic neighbors in the routing layer of MANETs to find if there is any optimized alternative next hop in P2P overlay during conventional lookup progress. Once an alternative next hop is detected, it will take the shortcut to accelerate the query procedure and therefore alleviate the QRM problem in scalable MANETs without any assistance of affiliation equipments such as GPS device. The probability of finding out such an alternative node is formulated and the factors that could increase the chance are discussed. The simulation results show that the proposed architecture can effectively alleviate the QRM problem and significantly improve the system performance compared with the conventional mechanism.

关键词： query routing mismatch P2P overlay Chord MANETs

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Curcumin Inhibits Viability of Clear Cell Renal Cell Carcinoma by Down-Regulating ADAMTS18 Gene Methylation through NF-κB and AKT Signaling Pathway

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Chinese Journal of Integrative Medicine 2022年第5期28卷 419-424页

作者： XU Ben PENG yi-ji ZHU Wei-jie Department of Urology Peking University First Hospital and Institute of UrologyPeking UniversityNational Urological Cancer CenterBeijing(100034)China

Objective:To investigate the effect of curcumin on viability of clear cell renal cell carcinoma(cc RCC)and analyze its possible ***:In cell lines of A498 and 786-O,the effects of curcumin(1.25,2.5,5 and 10μmol/L)on the viability of cc RCC were analyzed at 24,48 and 72 h by MTT *** protein expression levels of ADAMTS18 gene,p65,phosphorylation p65(pp65),AKT,phosphorylation AKT(p AKT)and matrix metallopeptidase 2(MMP-2)before and after curcumin(10μmol/L)treatment were examined by Western ***-time PCR and methylation specific PCR(MSP)were applied to analyze the expression and methylation level of ADAMTS18 gene before and after curcumin treatment(10μmol/L).Results:Curcumin significantly inhibited the viability of A498 and 786-O cell lines in a dose-and time-dependent manner(P<0.01).Up-regulation of ADAMTS18 gene expression with down-regulation of ADAMTS18 gene methylation was reflected after curcumin treatment,accompanied by down-regulation of nuclear factorκB(NF-κk B)related protein(p65 and pp65),AKT related protein(AKT and p AKT),and NF-κB/AKT common related protein *** ADAMTS18 gene overexpressed,the expression levels of p65,AKT and MMP2 were downregulated,of which were conversely up-regulated in silenced ADAMTS18(sh-ADAMTS18).The expression of pp65,p AKT and MMP2 in sh-ADAMTS18 was down-regulated after being treated with PDTC(NF-κB inhibitor)and LY294002(AKT inhibitor).Conclusion:Curcumin could inhibit the viability of cc RCC by down-regulating ADAMTS18 gene methylation though NF-κB and AKT signaling pathway.

关键词： curcumin clear cell renal cell carcinoma ADAMTS18 gene methylation signaling pathway

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Multi-path routing based on load-balance for cognitive packet networks

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The Journal of China Universities of Posts and Telecommunications 2011年第5期18卷 71-75页

作者： CHEN Liang ji Hong LI yi LI Xi College of Information and Commumieation Engineering Beijing University of Posts and Telecommunications Beijing 100876 China

Quality of service （QoS） routing algorithms have been hardly discussed in the scientific community, most previous work on QoS routing concentrates on the performance of the single route. Cognitive packet network （CPN） has been designed for providing QoS routing. In this paper, to balance the loads among networks, we present a multi-path routing algorithm based on load-balance （MPRLB）, which is carried out in two steps. The algorithm with low computational complexity is firstly applied to establish multi path routing for each source and destination node pairs （SD-pair） nodes in the network. Then, we propose the hopfield neural network algorithm, which is applied to improve the efficiency of the flow deviation method for fast flow allocation among the links of the network based on load balance. Extensive simulation results demonstrate that the proposed scheme significantly improves the performance compared with the existing scheme that ignores load balancing.

关键词： hopfield neural network CPN multi-path routing

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Copper-Catalyzed Oxidative Dearomatization of 2-Naphthols via Etherification

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Chinese Journal of Chemistry 2019年第9期37卷 903-908页

作者： ji-Cheng yi Zhi-jie Wu Shu-Li You State Key Laboratory of Organometallic Chemistry Center for Excellence in Molecular SynthesisShanghai Institute of Organic ChemistryChinese Academy of Sciences345 Lingling LuShanghai 200032China School of Physical Science and Technology ShanghaiTech University100 Haike RoadShanghai 201210China

Copper-catalyzed intermolecular oxidative-etherification type dearomatization reaction of 2-naphthols was *** air as the terminal oxidant,the reaction proceeded in excellent yields under mild *** addition,the reaction between two different naphthol substrates occurred smoothly.A series of multifunctionalized β-naphthalenones,important scaffold existed widely in natural products and biologically active molecules,were synthesized efficiently.

关键词： Copper-Catalyzed Oxidative Dearomatization 2-Naphthols via Etherification multifunctionalized β-naphthalenones

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Sites of Protonation and Unimolecular Fragmentation of Protonated N-Hydroxyphthalimide in the Gas Phase

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Chemical Research in Chinese Universities 1998年第2期14卷 63-67页

作者： SHE yi-min SUN Yu-quan ji yi-ping LIU Shu-ying Changchun Institute of Applied Chemistry Chinese Academy of SciencesChangchun130022

The low energy collisioninduced dissociation, linked scan techniques and isotopic labeling experiment were used to investigate the unimolecular fragmentation of protonated N-hydroxyphthalimide under electron impact and chemical ionization conditions. It was found that this compound shows an unusual reactivity towards protonation. Two possible sites of protonation have been proposed to explain the corresponding fragmentation processes, one is that the protonation takes place on the oxygen atom of hydroxyl group, resulting in the loss of water and the other is the formation of an intermediary protonbound complex in the fragmentation process, giving rise to the fragment ions of m/z 133 and m/z 135. The results show both cases are coexistence in the fragmentations of protonated N-hydroxyphthalimide, and the unimolecular fragmentation pathways are available.

关键词： Sites of protonation Unimolecular fragmentation Collisioninduced dissociation Nhydroxyphthalimide

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