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Effectiveness of antidepressant repetitive transcranial magnetic stimulation in a patient with refractory psychogenic dysphagia:A case report and review of literature

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世界临床病例杂志 2023年第28期11卷 6850-6856页

作者： Chang Gok woo ji Hyoun Kim jeong Hwan Lee Hyo Jong Kim Department of Pathology Chungbuk National University HospitalChungbuk National University College of MedicineCheongju 28644South Korea Department of Internal Medicine Chungbuk National University HospitalChungbuk National University College of MedicineCheongju 28644South Korea Department of Psychiatry Chungbuk National University HospitalChungbuk National University College of MedicineCheongju 28644South Korea Department of Rehabilitation Medicine Chungbuk National University HospitalChungbuk National University College of MedicineCheongju 28644South Korea

BACKGROUND Dysphagia is a common condition in older as well as young patients,and a variety of treatments have been reported depending on the ***,clinicians are challenged when the cause is *** is the case with psychogenic dysphagia,which has typically been treated with supportive psychotherapy,medi-cation,swallowing exercise,and dysphagia rehabilitation ***,we aimed to relieve the symptoms of a patient with refractory psychogenic dysphagia,who was unresponsive to conventional swallowing therapy,with repetitive transcranial magnetic stimulation(rTMS).CASE SUMMARY A relatively calm-looking 35-year-old female patient presented with a 2-year history of *** showed little improvement with conventional swallowing treatments over the past 2 *** was relatively compliant with inhospital dysphagia therapy,but uncooperative with home exercise and *** particular,since she was resistant to drug treatment,we had to take a different approach than the treatment she had been receiving for the past 2 *** much deliberation,we decided to initiate antidepressant rTMS treatment with her consent(IRB No.2023-05-021).Antidepressant rTMS treatment was performed twice weekly for a total of 20 sessions over 10 *** results showed improvement in subjective symptoms and video fluoroscopic swallowing study *** the best of our knowledge,this is the first report of symptomatic improvement using antidepressant rTMS protocol for refractory psychogenic *** This case demonstrates that rTMS with antidepressant protocol can be used to improve swallowing in patients with refractory psychogenic dysphagia.

关键词： Deglutition disorder Depression Health Rehabilitation Transcranial magnetic stimulation Case report

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Multi-View Multi-Modal Head-Gaze Estimation for Advanced Indoor User Interaction

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Computers, Materials & Continua 2022年第3期70卷 5107-5132页

作者： Jung-Hwa Kim jin-woo jeong Department of Computer Engineering Kumoh National Institute of TechnologyGumi39177Korea Department of Data Science Seoul National University of Science and TechnologySeoul01811Kore

Gaze estimation is one of the most promising technologies for supporting indoor monitoring and interaction ***,previous gaze estimation techniques generally work only in a controlled laboratory environment because they require a number of high-resolution eye *** makes them unsuitable for welfare and healthcare facilities with the following challenging characteristics:1)users’continuous movements,2)various lighting conditions,and 3)a limited amount of available *** address these issues,we introduce a multi-view multi-modal head-gaze estimation system that translates the user’s head orientation into the gaze *** proposed system captures the user using multiple cameras with depth and infrared modalities to train more robust gaze estimators under the aforementioned *** this end,we implemented a deep learning pipeline that can handle different types and combinations of *** proposed system was evaluated using the data collected from 10 volunteer participants to analyze how the use of single/multiple cameras and modalities affect the performance of head-gaze *** various experiments,we found that 1)an infrared-modality provides more useful features than a depth-modality,2)multi-view multi-modal approaches provide better accuracy than singleview single-modal approaches,and 3)the proposed estimators achieve a high inference efficiency that can be used in real-time applications.

关键词： Human-computer interaction deep learning head-gaze estimation indoor monitoring

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Folfirinox chemotherapy prolongs stent patency in patients with malignant biliary obstruction due to unresectable pancreatic cancer

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Hepatobiliary & Pancreatic Diseases International 2020年第6期19卷 590-595页

作者： jinwoo Kang Sang Hyub Lee jin Ho Choi woo Hyun Paik Dong-Won Ahn ji Bong jeong ji Kon Ryu Yong-Tae Kim Department of Internal Medicine and Liver Research Institute Seoul National University HospitalSeoul National University College of MedicineSeoulKorea Department of Internal Medicine SMG-SNU Boramae Medical CenterSeoulKorea

Background:Stent insertion for biliary decompression to relieve jaundice and subsequent biliary infection is necessary for patients with biliary obstruction caused by pancreatic cancer,and it is important to keep the stent patent as long as ***,few studies have compared stent patency in terms of chemotherapy in patients with pancreatic *** study aimed to evaluate the differences in stent patency in terms of recently evolving ***:Between January 2015 and May 2017,161 patients with pancreatic cancer who had undergone biliary stent insertion with a metal stent were retrospectively *** relationship between chemotherapy and stent patency was ***,overall survival according to the treatment,risk factors for stent patency,and long-term adverse events were ***:Median stent patency was 42 days for patients with the best supportive care and 217 days for patients with chemotherapy(conventional gemcitabine-based chemotherapy and folfirinox)(P<0.001).Furthermore,the folfirinox group showed the longest median stent patency and overall survival,with 283 days and 466 days,respectively(P<0.001)despite higher adverse events *** who underwent folfirinox chemotherapy after stent insertion had better stent patency in multivariate analysis(HR=0.26;95%CI:0.12–0.60;P=0.001).Conclusions:Compared with patients who received best supportive care only,patients who underwent chemotherapy after stent insertion had better stent *** prolonged stent patency can be expected for patients with folfirinox than conventional gemcitabine-based chemotherapy.

关键词： Stent patency Malignant distal biliary obstruction Pancreatic cancer Folfirinox Chemotherapy

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Portable nano probe for micro/nano mechanical scratching and measuring

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Transactions of Nonferrous Metals Society of China 2011年第A01期21卷 205-209页

作者： woo-Park jeong Chang-Choi SOO Cho HYUN woo-Lee DEUG Department of Mechanical Design Engineering Chosun University Department of Nano Fusion Technology Pusan National University Department of Nano-mechatronics Engineering Pusan National University

A nano probe system which can measure precise contact force in mN scale was demonstrated. The nano probe micro parts or optical parts in nanometer range resolution and scratch was originally designed for on-machine measuring applications and one kind of contact type measuring probes was designed for miniaturized or microfactory system. It ideally should be of small size and able to measure surface topography in nanometer scale. A commercial capacitive displacement sensor was proposed. It was a new concept in nano probe systems which can measure the displacement of shaft driven by the variation of surface topography. The nano probe mainly consisted of three parts： a capacitive displacement sensor, a porous type air slide and a contact probe part with various tip radiuses. The porous type air slide assured the shaft slided smoothly with controllable normal force in mN scale and had high positioning accuracy. The probe part which was directly in contact with target surface, can be applied to micro/nanoscale scratching as well as the measurement of sample topography by a simple tip change.

关键词： nano probe displacement sensor air slide PCD tip

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Detection of early gastric cancer using hydro-stomach CT:Blinded vs unblinded analysis

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World Journal of Gastroenterology 2011年第8期17卷 1051-1057页

作者： Ki jeong Park Min woo Lee ji Hyun Koo Yulri Park Heejung Kim Dongil Choi Soon jin Lee Department of Radiol-ogy and Center for Imaging Science Samsung Medical Center Sungkyunkwan University School of Medicine

AIM:To evaluate the difference in diagnostic performance of hydro-stomach computed tomography(CT) to detect early gastric cancer(EGC) between blinded and unblinded analysis and to assess independent factors affecting visibility of cancer ***:Two radiologists initially blinded and then unblinded to gastroscopic and surgical-histological findings independently reviewed hydro-stomach CT images of 110 patients with single *** graded the visibility of cancer foci for each of three gastric segments(upper,middle and lower thirds) using a 4-point scale(1:definitely absent,2:probably absent,3:probably present,and 4:definitely present).The sensitivity and specificity for detecting an EGC were *** and interobserver agreements were *** visibility of an EGC was evaluated with regard to tumor size,invasion depth,gastric segments,histological type and gross morphology using univariate and multivariate ***:The respective sensitivities and specificities [reviewer 1:blinded,20%(22/110) and 98%(215/220);unblinded,27%(30/110) and 100%(219/220)/reviewer 2:blinded,19%(21/110) and 98%(216/220);unblinded,25%(27/110) and 98%(215/220)] were not significantly *** intraobserver agreements were good(weighted κ = 0.677 and 0.666),interobserver agreements were fair(blinded,0.371) or moderate(unblinded,0.558).For both univariate and multivariate analyses,the tumor size and invasion depth were statistically significant factors affecting ***:The diagnostic performance of hydrostomach CT to detect an EGC was not significantly different between blinded and unblinded *** tumor size and invasion depth were independent factors for visibility.

关键词： Stomach neoplasm Computed tomography Water Early detection of cancer Sensitivity

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Antioxidant and anti-inflammatory roles of tea polyphenols in inflammatory bowel diseases

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Food Science and Human Wellness 2022年第3期11卷 502-511页

作者： Van-Long Truong woo-Sik jeong Food and Bio-industry Research Institute School of Food Science&BiotechnologyCollege of Agriculture and Life SciencesKyungpook National UniversityDaegu 41566Korea

Polyphenols,including phenolic acids,flavonoids,and procyanidins,are abundant in food and beverage derived from ***(Camellia sinensis)is particularly rich in polyphenols(e.g.,catechins,theaflavins,thearubigins,gallic acid,and flavonols),which are thought to contribute to the health benefits of *** intake of tea polyphenols has been described to prevent and/or attenuate a variety of chronic pathological conditions like cardiovascular diseases,neurodegenerative diseases,diabetes,and *** review focuses on established antioxidant and anti-inflammatory properties of tea polyphenols and underlying mechanisms of their involvement in inflammatory bowel diseases(IBD).Tea polyphenols act as efficient antioxidants by inducing an endogenous antioxidant defense system and maintaining intracellular redox *** polyphenols also regulate signaling pathways such as nuclear factor-κB,activator protein 1,signal transducer and activator of transcriptions,and nuclear factor E2-related factor 2,which are associated with IBD *** pieces of evidence have indicated that tea polyphenols enhance epithelial barrier function and improve gut microbial dysbiosis,contributing to the management of inflammatory ***,this study suggests that supplementation of tea polyphenols could prevent inflammatory conditions and improve the outcome of patients with IBD.

关键词： Antioxidant Anti-inflammation Epithelial barrier function Inflammatory bowel diseases Gut microbiota Tea polyphenols

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Managing portal hypertension in patients with liver cirrhosis and hepatocellular carcinoma:non-invasive diagnosis and systemic treatment considerations

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Hepatobiliary Surgery and Nutrition 2023年第6期12卷 960-962页

作者： woo Kyoung jeong Department of Radiology and Center for Imaging Sciences Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea

Portal hypertension(PH)represents a crucial complication of liver cirrhosis that significantly impacts a patient’s *** portal venous pressure requires a combination of medical and interventional ***,it’s important to note that the presence of other conditions in patients,such as hepatocellular carcinoma(HCC),can influence the treatment approaches for PH and subsequently affect the overall *** should consider that condition when developing treatment strategies to enhance patient outcomes(1).

关键词： Portal hypertension(PH) hepatocellular carcinoma(HCC) elastography bevacizumab variceal bleeding

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Strategies to overcome resistance to epidermal growth factor receptor monoclonal antibody therapy in metastatic colorectal cancer

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World Journal of Gastroenterology 2014年第29期20卷 9862-9871页

作者： woo-jeong jeong Pu-Hyeon Cha Kang-Yell Choi Translational Research Center for Protein Function Control Department of BiotechnologyCollege of Life Science and BiotechnologyYonsei University

Administration of monoclonal antibodies(mAbs)against epidermal growth factor receptor(EGFR)such as cetuximab and panitumumab in combination with conventional chemotherapy substantially prolongs survival of patients with metastatic colorectal cancer(mCRC).However,the efficacy of these mAbs is limited due to genetic variation among patients,in particular K-ras *** discovery of K-ras mutation as a predictor of non-responsiveness to EGFR mAb therapy has caused a major change in the treatment of *** that inhibit transformation caused by oncogenic alterations of Ras and its downstream components such as BRAF,MEK and AKT seem to be promising cancer therapeutics as single agents or when given with EGFR *** multiple therapeutic strategies to overcome EGFR mAb-resistance are under investigation,our understanding of their mode of action is *** drug development based on stringent preclinical data,biomarker validation,and proper selection of patients is of paramount importance in the treatment of *** this review,we will discuss diverse approaches to overcome the problem of resistance to existing anti-EGFR therapies and potential future directions for cancer therapies related to the mutational status of genes associated with EGFRRas-ERK and PI3K signalings.

关键词： Colorectal cancer Epidermal growth factor receptor Resistance K-ras mutation Combinational therapy

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Simply Fine-Tuned Deep Learning-Based Classification for Breast Cancer with Mammograms

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Computers, Materials & Continua 2022年第12期73卷 4677-4693页

作者： Vicky Mudeng jin-woo jeong Se-woon Choe Department of Medical IT Convergence Engineering Kumoh National Institute of TechnologyGumi39253Korea Department of Electrical Engineering Institut Teknologi KalimantanBalikpapan76127Indonesia Department of Data Science Seoul National University of Science and TechnologySeoul01811Korea Department of IT Convergence Engineering Kumoh National Institute of TechnologyGumi39253Korea

A lump growing in the breast may be referred to as a breast mass related to the ***,not all tumors are cancerous or *** masses can cause discomfort and pain,depending on the size and texture of the *** an appropriate diagnosis,non-cancerous breast masses can be diagnosed earlier to prevent their cultivation from being *** the development of the artificial neural network,the deep discriminative model,such as a convolutional neural network,may evaluate the breast lesion to distinguish benign and malignant cancers frommammogram breast masses *** work accomplished breastmasses classification relative to benign and malignant cancers using a digital database for screening mammography image datasets.A residual neural network 50(ResNet50)model along with an adaptive gradient algorithm,adaptive moment estimation,and stochastic gradient descent optimizers,as well as data augmentations and fine-tuning methods,were *** addition,a learning rate scheduler and 5-fold cross-validation were applied with 60 training procedures to determine the best *** results of training accuracy,p-value,test accuracy,area under the curve,sensitivity,precision,F1-score,specificity,and kappa for adaptive gradient algorithm 25%,75%,100%,and stochastic gradient descent 100%fine-tunings indicate that the classifier is feasible for categorizing breast cancer into benign and malignant from the mammographic breast masses images.

关键词： Medical image analysis convolutional neural network mammogram breast masses breast cancer

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Attaching single carbon nanotube on tip's apex using dielectrophoresis of DC-pulse voltage

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中国有色金属学会会刊：英文版 2009年第B09期19卷 280-283页

作者： Hee-jin jeong Yoong-Ho JUNG Deug-woo LEE Gyeongbuk Hybrid Technology Institute School of Mechanical Engineering Pusan National University Department of Nanosystem and Nanoprocess Engineering Pusan National University

Single carbon nanotubes (CNTs) are candidates for a number of electronics and sensing applications, provided that single CNTs can be separated from a bundle of CNTs in suspension. Dielectrophoresis has recently been demonstrated as one route for the extraction of desired CNTs. However, previous methods using dielectrophoresis have found it difficult to extract single nanotubes from bundles of CNTs in solution. Here, we show that this restriction can be overcome by using pulsed DC voltage of an electric field, instead of regular AC and DC voltages.

关键词：碳纳米管直流脉冲脉冲电压介电顶点消息电子号码 CNTs

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