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软科学 2014年第3期28卷 114-118页

作者：纪淑娴浙江科技学院经济管理学院浙江大学电子服务研究中心杭州310023

从感知成本和收益的角度,探索了用户参与在线信誉反馈系统的驱动力。实证研究发现,感知成本负向影响用户的参与度,且是影响系数最大的因素;乐于助人、个人分享动机以及感知收益对参与意愿具有正向显著影响;感知收益的影响系数最小。

关键词：在线信誉反馈系统成本收益

人类白细胞抗原半相合骨髓移植治疗白血病的进展

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中国实用内科杂志 2007年第1期27卷 47-48页

作者：纪树荃解放军空军总医院血液病中心北京100036

异基因造血干细胞移植（Allo-PBSCT）是恶性血液病及遗传性疾病有效的治疗手段，若人类主要组织相容性抗原（HLA）匹配，无论是血缘或非血缘相合供者，都是Allo-PBSCT最佳选择。在完善的骨髓库中，应获得30％HIA相合非血缘的供者，国内... 详细信息

异基因造血干细胞移植（Allo-PBSCT）是恶性血液病及遗传性疾病有效的治疗手段，若人类主要组织相容性抗原（HLA）匹配，无论是血缘或非血缘相合供者，都是Allo-PBSCT最佳选择。在完善的骨髓库中，应获得30％HIA相合非血缘的供者，国内单生子女在新一代中。亲缘供者不足10％，如果进行半相合移植，无疑它将解决由于没有供者带来的困惑。

关键词：白血病骨髓移植人类白细胞抗原半相合移植

一种基于小波系数综合能量特征的多算子图像融合算法

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光学技术 2008年第1期34卷 85-88,91页

作者：吉书鹏中国空空导弹研究院河南洛阳471009

提出了一种新的多算子小波分解图像融合算法,算法对输入图像进行多尺度小波分解,综合考虑同层各子带及相邻层子带小波系数图像特征描述的相关一致性,基于局部空间复合能量和局部相对能量差特征测度,采用多算子自适应融合规则构造融合图... 详细信息

提出了一种新的多算子小波分解图像融合算法,算法对输入图像进行多尺度小波分解,综合考虑同层各子带及相邻层子带小波系数图像特征描述的相关一致性,基于局部空间复合能量和局部相对能量差特征测度,采用多算子自适应融合规则构造融合图像,得到含有丰富细节特征的融合图像。

关键词：小波分解特征提取图像融合

INTRAMEDULLARY PRESSURE IN THE PROXIMAL FEMUR BEFORE AND AFTER TREATMENT OF CONGENITAL DISLOCATION OF THE HIP IN CHILDREN

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中华医学杂志(英文版) 1989年第7期102卷 552-552页

作者： Ma Rui-xue ji Shi-jun Zhou Yong-de Liu Wei-dong ji shu-rong Department of Pediatric Orthopedics 3rd Affiliated Hospital China Medical University Shenyang

Intramedullary pressure in the proximal femur was measured before and after treatment of congenital dialocation of the hip. The intramedullay pressure before treatment was higher than that of the control group , and after treatment it was lower as a whole; in the close reduction group the pressure decreased as compared with the operation group. In 8 hips, stress test yielded negative results. These findings suggested the characteristics of arteriai blockage may be that the potential cause of avascular necrosis of the femoral head after treatment of congenital dislocation of the hip.

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Mechanisms of myeloid-derived suppressor cell-mediated immunosuppression in colorectal cancer and related therapies

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1690-1704页

作者： shu-Chang Nie Yan-Hua jing Lu Lu Si-Si Ren Guang ji Han-Chen Xu Institute of Digestive Diseases Longhua HospitalChina-Canada Center of Research for Digestive DiseasesShanghai University of Traditional Chinese MedicineShanghai 200032China Shanghai Frontiers Science Center of Disease and Syndrome Biology of Inflammatory Cancer Transformation Shanghai 200032China State Key Laboratory of Integration and Innovation of Classic Formula and Modern Chinese Medicine(Shanghai University of Traditional Chinese Medicine) Shanghai 200032China

Severe immunosuppression is a hallmark of colorectal cancer(CRC).Myeloid-derived suppressor cells(MDSCs),one of the most abundant components of the tumor stroma,play an important role in the invasion,metastasis,and immune escape of *** create an immunosuppressive microenvironment by inhibiting the proliferation and activation of immunoreactive cells,including T and natural killer cells,as well as by inducing the proliferation of immunosuppressive cells,such as regulatory T cells and tumor-associated macrophages,which,in turn,promote the growth of cancer ***,MDSCs are key contributors to the emergence of an immunosup-pressive microenvironment in CRC and play an important role in the breakdown of antitumor *** this narrative review,we explore the mechanisms through which MDSCs contribute to the immunosuppressive microenvironment,the current therapeutic approaches and technologies targeting MDSCs,and the therapeutic potential of modulating MDSCs in CRC *** study provides ideas and methods to enhance survival rates in patients with CRC.

关键词： Myeloid-derived suppressor cells Tumor microenvironment Colorectal cancer Therapy Immunosuppression

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一种新的自适应图像增强融合算法

激光与红外 2007年第6期37卷 571-574页

作者：吉书鹏中国空空导弹研究院河南洛阳471009

提出了一种新的自适应图像增强融合算法,算法将输入图像分解为反映图像平均照度特征的低频分量和反映图像对比度特征的高频分量图像,基于局部灰度方差增强因子和非线性投影变换因子进行自适应图像增强处理,基于局部能量、局部归一化互... 详细信息

提出了一种新的自适应图像增强融合算法,算法将输入图像分解为反映图像平均照度特征的低频分量和反映图像对比度特征的高频分量图像,基于局部灰度方差增强因子和非线性投影变换因子进行自适应图像增强处理,基于局部能量、局部归一化互相关融合测度和加权融合算子对增强后的图像进行特征提取和重构,得到融合图像。有效地将输入图像细节特征传递组合到融合图像中。

关键词：图像增强图像融合特征提取

PRIMARY MACROGLOBULINEMIA WITH MYELOFIBROSIS: REPORT OF A CASE

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中华医学杂志(英文版) 1987年第1期100卷 86-86页

作者： ji shu-quan Zhu Min Wang Yu-zhi General Hospital Ministry of Astronautics Beijing Academy of Military Medical Sciences Beijing

There are reports on cases in which macroglo-bulinemia developed into myeloma and leukemia, but no report on cases with myelofibrosis. Such a case is described in this paper.

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内蒙古鄂托克旗早白垩世龟类化石一新种

地质学报 2018年第4期92卷 629-637页

作者：姬书安陈晓云中国地质科学院地质研究所北京100037 中国地质博物馆北京100034

内蒙古鄂尔多斯地区早白垩世地层中产有丰富的龟类化石,本文记述了鄂托克旗查布一带泾川组的一件龟类背甲,其近六边形的第3椎盾宽为长的2倍且其前侧缘长约为后侧缘长的1.7倍、第8对肋板在中线处相接、第1上臀板宽大、侧棘发达等组合特征... 详细信息

内蒙古鄂尔多斯地区早白垩世地层中产有丰富的龟类化石,本文记述了鄂托克旗查布一带泾川组的一件龟类背甲,其近六边形的第3椎盾宽为长的2倍且其前侧缘长约为后侧缘长的1.7倍、第8对肋板在中线处相接、第1上臀板宽大、侧棘发达等组合特征,表明其不同于中国龟属Sinemys的已知种,被命名为查布中国龟(新种)Sinemys chabuensis ***.。龟类在鄂尔多斯地区早白垩世恐龙动物群中具有较高的分异度,志丹群泾川组和罗汉洞组中各发现至少2个种的龟类,它们既有继承性又有差异性,为研究中国龟类(sinemydids)的演化提供重要依据。

关键词：中国龟属早白垩世泾川组鄂托克旗鄂尔多斯盆地

Epigallocatechin-3-gallate Alleviates Cognitive Deficits in APP/PS1 Mice

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Current Medical Science 2020年第1期40卷 18-27页

作者： jian BAO Wei LIU Hong-yan ZHOU Yu-ran GUI You-hua YANG Meng-juan WU Yi-fan XIAO jin-ting SHANG Gui-feng LONG Xi-ji shu Department of Pathology and Pathophysiology School of MedicineJianghan UniversityWuhan 430056China Department of Traditional Chinese Medicine School of MedicineJianghan UniversityWuhan 430056China Department of Physiology School of MedicineJianghan UniversityWuhan 430056China Institutes of Biomedical Sciences School of Medicinet Jianghan UniversityWuhan 430056China School of Life Science Jianghan UniversityWuhan 430056China

Alzheimer's disease(AD)shows cognitive impairments in clinic,which is multifactorial with different etiopathogenic mechanisms such as A|3 deposition,neuroinflammation and neuronal dystrophy ***,multi-targets drugs with neuroprotective,anti-amyloidogenic and anti-inflammatory properties will be effective in AD ***-3-gallate(EGCG)possesses a broad spectrum of pharmacological activities in the prevention and treatment of multiple neurodegenerative *** the present study,we showed that oral administration of EGCG(50 mg/kg)for 4 months significantly attenuated the cognitive deficits in APP/PS1 transgenic mice,which served as AD ***,EGCG induced an improvement in dendritic integrity and expression levels of synaptic proteins in the brain of APP/PS 1 *** EGCG exerted obvious anti-inflammatory effects,which was manifested by alleviating microglia activation,decreasing pro-inflammatory cytokine(IL-β)and increasing anti-inflammatory cytokines(IL-10,IL-β).Furthermore,p-amyloid(AP)plaques were markedly reduced in the hippocampus of 6-month old APP/PS 1 mice after EGCG *** conclusion,these findings indicate that EGCG improves AD-like cognitive impairments through neuroprotective,anti-amyloidogenic and anti-inflammatory effects,thus is a promising therapeutic can didate for AD.

关键词： Alzheimer's disease cognitive impairments epigallocatechin-3-gallate anti・inflammation p-amyloid

Mesenchymal stem cell-derived extracellular vesicles in skin wound healing:roles,opportunities and challenges

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Military Medical Research 2024年第3期11卷 400-429页

作者： jia-Yi Ding Min-jiang Chen Ling-Feng Wu Gao-Feng shu Shi-ji Fang Zhao-Yu Li Xu-Ran Chu Xiao-Kun Li Zhou-Guang Wang jian-Song ji Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research Institute of Imaging Diagnosis and Minimally Invasive Intervention Researchthe Fifth Affiliated Hospital of Wenzhou Medical UniversityZhejiangLishui 323000China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)School of Pharmaceutical ScienceWenzhou Medical UniversityWenzhou 325035ZhejiangChina Clinical College of the Affiliated Central Hospital School of MedicineLishui UniversityLishui 323000ZhejiangChina Department of Overseas Education College Jimei UniversityXiamen 361021FujianChina Department of Medicine Ⅱ Internal MedicineCardio-Pulmonary Institute(CPI)Universities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Justus-Liebig University Giessen35392 GiessenGermany Pulmonary and Critical Care Department of Medicine VInternal MedicineInfectious Diseases and Infection ControlUniversities of Giessen and Marburg Lung Center(UGMLC)Member of the German Center for Lung Research(DZL)Justus-Liebig University Giessen35392 GiessenGermany

Skin wounds are characterized by injury to the skin due to trauma,tearing,cuts,or *** such injuries are common to all human groups,they may at times represent a serious socioeconomic ***,increasing numbers of studies have focused on the role of mesenchymal stem cell(MSC)-derived extracellular vesicles(EVs)in skin wound *** a cell-free therapy,MSC-derived EVs have shown significant application potential in the field of wound repair as a more stable and safer option than conventional cell *** based on MSC-derived EVs can significantly promote the repair of damaged substructures,including the regeneration of vessels,nerves,and hair *** addition,MSC-derived EVs can inhibit scar formation by affecting angiogenesis-related and antifibrotic pathways in promoting macrophage polarization,wound angiogenesis,cell proliferation,and cell migration,and by inhibiting excessive extracellular matrix ***,these structures can serve as a scaffold for components used in wound repair,and they can be developed into bioengineered EVs to support trauma *** the formulation of standardized culture,isolation,purification,and drug delivery strategies,exploration of the detailed mechanism of EVs will allow them to be used as clinical treatments for wound *** conclusion,MSCderived EV-based therapies have important application prospects in wound *** we provide a comprehensive overview of their current status,application potential,and associated drawbacks.

关键词： Mesenchymal stem cell(MSC) Extracellular vesicles(EVs) Wound repair Engineered nanoparticles