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Fusobacterium nucleatum-induced imbalance in microbiome-derived butyric acid levels promotes the occurrence and development of colorectal cancer

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World Journal of Gastroenterology 2024年第14期30卷 2018-2037页

作者： Qi-Long Wu Xiao-Ting Fang Xin-Xin Wan qing-yong Ding Yan-Jun Zhang Ling ji yong-Liang Lou Xiang Li School of Laboratory Medicine and Life Sciences Wenzhou Medical UniversityKey Laboratory of Laboratory MedicineMinistry of EducationWenzhou 325035Zhejiang ProvinceChina Department of Health Inspection and Quarantine School of Laboratory Medicine and Life SciencesWenzhou 325035Zhejiang ProvinceChina School of Laboratory Medicine and Life Sciences Wenzhou Medical UniversityZhejiang Provincial Key Laboratory of Medical GeneticsMinistry of EducationWenzhou 325035Zhejiang ProvinceChina Department of General Surgery The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou 325035Zhejiang ProvinceChina School of Laboratory Medicine and Life Sciences Institute of One HealthWenzhou Medical UniversityZhejiang Provincial Key Laboratory of Medical GeneticsMinistry of EducationWenzhou 325035Zhejiang ProvinceChina Department of Health Inspection and Quarantine School of Laboratory Medicine and Life SciencesInstitute of One HealthWenzhou Medical UniversityZhejiang Provincial Key Laboratory of Medical GeneticsMinistry of EducationWenzhou 325035Zhejiang ProvinceChina

BACKGROUND Colorectal cancer(CRC)ranks among the most prevalent malignant tumors *** reports suggest that Fusobacterium nucleatum(***)contributes to the initiation,progression,and prognosis of ***,a short-chain fatty acid derived from the bacterial fermentation of soluble dietary fiber,is known to inhibit various *** study is designed to explore whether *** influences the onset and progression of CRC by impacting the intestinal metabolite butyric *** To investigate the mechanism by which *** affects CRC occurrence and *** Alterations in the gut microbiota of BALB/c mice were observed following the oral administration of ***,DLD-1 and HCT116 cell lines were exposed to sodium butyrate(NaB)and *** in vitro to examine the effects on proliferative proteins and mitochondrial *** Our research indicates that the prevalence of *** in fecal samples from CRC patients is significantly greater than in healthy counterparts,while the prevalence of butyrate-producing bacteria is notably *** mice colonized with ***,the population of butyrate-producing bacteria decreased,resulting in altered levels of butyric acid,a key intestinal metabolite of *** to NaB can impair mitochondrial morphology and diminish mitochondrial membrane potential in DLD-1 and HCT116 CRC ***,this leads to modulated production of adenosine triphosphate and reactive oxygen species,thereby inhibiting cancer cell ***,NaB triggers the adenosine monophosphate-activated protein kinase(AMPK)signaling pathway,blocks the cell cycle in HCT116 and DLD-1 cells,and curtails the proliferation of CRC *** combined presence of *** and NaB attenuated the effects of the *** employing small interfering RNA to suppress AMPK,it was demonstrated that AMPK is essential for NaB’s inhibition of CRC cell *** F.n

关键词： Colorectal cancer Fusobacterium nucleatum Butyric acid Gut microbiota Adenosine monophosphate-activated protein kinase signal pathway

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Experimental study of the influencing factors and mechanisms of the pressure-reduction and augmented injection effect by nanoparticles in ultra-low permeability reservoirs

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Petroleum Science 2024年第3期21卷 1915-1927页

作者： Pan Wang Yu-Hang Hu Liao-Yuan Zhang yong Meng Zhen-Fu Ma Tian-Ru Wang Zi-Lin Zhang ji-Chao Fang Xiao-Qiang Liu qing You Yan Zhang Beijing Key Laboratory of Unconventional Natural Gas Geological Evaluation and Development Engineering China University of Geosciences(Beijing)Beijing100083China School of Energy Resources China University of Geosciences(Beijing)Beijing100083China Petroleum Engineering Technology Research Institute Sinopec Shengli Oilfield CompanyDongying257000ShandongChina Hekou Oil Production Plant Sinopec Shengli Oilfield CompanyDongying257200ShandongChina Petroleum Exploration and Production Research Institute SINOPECBeijing102206China CNPC Engineering Technology R&D Company Limited Beijing102206China

Nanoparticles(NPs)have gained significant attention as a functional material due to their ability to effectively enhance pressure reduction in injection processes in ultra-low permeability *** are typically studied in controlled laboratory conditions,and their behavior in real-world,complex environments such as ultra-low permeability reservoirs,is not well understood due to the limited scope of their *** study investigates the efficacy and underlying mechanisms of NPs in decreasing injection pressure under various injection conditions(25—85℃,10—25 MPa).The results reveal that under optimal injection conditions,NPs effectively reduce injection pressure by a maximum of 22.77%in core *** pressure reduction rate is found to be positively correlated with oil saturation and permeability,and negatively correlated with temperature and ***,particle image velocimetry(PIV)experiments(25℃,atmospheric pressure)indicate that the pressure reduction is achieved by NPs through the reduction of wall shear resistance and wettability *** work has important implications for the design of water injection strategies in ultra-low permeability reservoirs.

关键词： Nanoparticle Pressure reduction Augmented injection Ultra-low permeability reservoir

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Utilization of human excrement in pre-modern China,its theoretical interpretations and ecological significance

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Soil Ecology Letters 2024年第1期6卷 1-5页

作者： Xin-Hao Du Yuan-Ming Song ji-An Cai yong-Guan Zhu Institute for the History of Natural Sciences Chinese Academy of SciencesBeijing 100190China Institute for Cultural Heritage and History of Science&Technology University of Science and Technology BeijingBeijing 100083China Faculty of History Nankai UniversityTianjin 300350China Research Center for Eco Environmental Sciences Chinese Academy of SciencesBeijing 100085China

The use of human excrement as fertilizer is a characteristic of traditional Chinese agriculture..The application of excrement from urban residents in agriculture since the Song Dynasty has ensured the cleanliness and hygiene of *** early as the Ming Dynasty,the Chinese people defined the principle of fertilizing fields with human excrement from the perspective of *** concept Peri-URban ecosystems(PURE)provides inspiration forurban-rural symbiosis regarding *** use of human excrement in fertilization is a major attribute differentiating the Chinese traditional agriculture from the agriculture in other regions around the *** the fact that the exact record showing that human excrement was used as fertilizer in China emerged in the Western Han Dynasty(B.C.202-A.D.8),such records did not become prevalent until the Southern Song Dynasty(A.D.1127-1279).In the Ming and qing eras(A.D.1368-1912),human excrement was even considered"top-class fertilizerand servedas themost essential fertilizerin farmland *** importance of human excrement in the Ming and qing was mainly reflected by farmers'purchase of human excrement from urban *** fertilization practices became increasingly popular during the period,men of letters built a localized theoretical system centering on human *** the use of human excrement had both positive and negative impacts on public health and the ecological environment,the positive overshadowed the negativeas a ***,it is worth pondering on how the utilization of human excrement as an agricultural resource can be improved so that a material cycle system can be rebuilt to re-connect the urban and rural areas.

关键词： excrement fertilizer theorization urban and rural ecology public health

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Development of 400-μW cryogen-free dilution refrigerators for quantum experiments

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Chinese Physics B 2024年第7期33卷 28-35页

作者：关翔樊洁边勇波程智刚姬忠庆 Institute of Physics Chinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100190China

We have successfully developed cryogen-free dilution refrigerators with medium cooling power that can be applied to quantum experiments. Breakthroughs have been made in some key technologies and components of heat switches and dilution units. Our prototype has been running continuously and stably for more than 100 hours below 10 m K, with a minimum temperature of 7.6 m K and a cooling power of 450 μW at 100 m K. At the same time, we have also made progress in the application of dilution refrigerators, such as quantum computing, low-temperature detector, and magnet integration. These indicators and test results indicate good prospects for application in physics, astronomy, and quantum information.

关键词： cryogen-free dilution refrigerator quantum computing low-temperature detector superconducting magnet

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Dcalycinumines A-E,Alkaloids with Cytotoxic Activities of Nasopharyngeal Carcinoma Cells from Daphniphyllum calycinum

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Chinese Journal of Chemistry 2024年第1期42卷 35-42页

作者： qing Tang Xiao-yong Dai Qiang Lin Zhi-Peng Ling Yi-Kun Hao Tian-Xi Zhu ji-Hui Zhang Yi-Bo Hou Yao-Lan Li Lai-Qiang Huang jing-Hao Wang Guo-Cai Wang Yu-Bo Zhang Guangdong Clinical Translational Centerfor Targeted Drug Department of PharmacologySchoolof MedicineJinan University GuangzhouGuangdong 510632China Institute of Traditional Chinese Medicine&Natural Products Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs ResearchCollegeof PharmacyJinan UniversityGuangzhouGuangdong511443China Institute of Biopharmaceutical and Health Engineering Shenzhen Key Laboratory of Gene and Antibody TherapyState Key Laboratory of Chemical OncogenomicsShenzhen International Graduate SchoolTsinghua UniversityShenzhenGuangdong 518055China The Guangzhou Key Laboratoryof Basic and Translational Research on Chronic Disease Department of PharmacyThe First Affiliated HospitalJinan UniversityGuangzhouGuangdong 510630China

Fivenovel Daphniphyllum alkaloids,named dcalycinumines A-E(1-4,6),andeight previously described Daphniphyllum alkaloids(5,7-13)were isolated from Daphniphyllum *** 1 is the first Daphniphyllum alkaloid possessing a highly rearranged 6/6/6/7/5/6 hexacyclic architecture with a unique 3-methyl-1-azabicyclo[4,4,0]decane ring *** 2 represents a rare diamino Daphniphyllum alkaloid with an unprecedented 6/5/5/6/6/5 carbon skeleton featuring a unique 1-aza-6-azaspiro[4,5]decane unit,whereas 3 also represents a rare diamino Daphniphyllum alkaloid as a possible precursor of *** 4 is the second example of c-22-nor yuzurimine-type *** structures and absolute configurations were elucidated by HRESIMS,NMR spectroscopic analyses,EcD calculations,and single-crystal X-ray ***,compound 1 showed remarkable antitumor activities,which could inhibit the proliferation,migration and invasion of nasopharyngeal carcinoma cells,and promoted nasopharyngeal carcinoma cells apoptosis.

关键词： Daphniphyllum calycinum Natural products Daphniphyllum alkaloid Structural elucidation Biological activity Apoptosis Nasopharyngealcarcinoma

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Machine learning identifies the risk of complications after laparoscopic radical gastrectomy for gastric cancer

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World Journal of Gastroenterology 2024年第1期30卷 79-90页

作者： qing-Qi Hong Su Yan yong-Liang Zhao Lin Fan Li Yang Wen-Bin Zhang Hao Liu He-Xin Lin jian Zhang Zhi-jian Ye Xian Shen Li-Sheng Cai Guo-Wei Zhang jia-Ming Zhu Gang ji jin-Ping Chen Wei Wang Zheng-Rong Li jing-Tao Zhu Guo-Xin Li Jun You Department of Gastrointestinal Oncology Surgery The First Affiliated Hospital of Xiamen UniversitySchool of MedicineXiamen 361001Fujian ProvinceChina Department of Gastrointestinal Surgery Qinghai University Affiliated HospitalXining 810000Qinghai ProvinceChina Department of General Surgery and Center of Minimal Invasive Gastrointestinal Surgery The First Hospital Affiliated to Army Medical UniversityChongqing 400038China Department of General Surgery The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Department of General Surgery The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Xinjiang Medical UniversityUrmuqi 830054Xinjiang Uygur Autonomous RegionChina Department of General Surgery Nanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Gastrointestinal Surgery Affiliated Hangzhou First People's HospitalZhejiang University School of MedicineHangzhou 310006Zhejiang ProvinceChina Department of Gastrointestinal Surgery Zhongshan Hospital of Xiamen UniversityXiamen 361004Fujian ProvinceChina Department of Surgery The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Department of General Surgery Unit 4 Zhangzhou Affiliated Hospital of Fujian Medical UniversityZhangzhou 363000Fujian ProvinceChina Department of Gastrointestinal Surgery The Second Affiliated Hospital of Xiamen Medical CollegeXiamen 361021Fujian ProvinceChina Department of Gastrointestinal Nutrition and Hernia Surgery The Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina Department of Digestive Diseases Xijing HospitalAir Force Military Medical UniversityXi'an 710032Shaanxi ProvinceChina Department of Gastrointestinal Surgery Quanzhou First Hospital Affiliated to Fujian Medical UniversityQuanzhou 362002Fujian Provin

BACKGROUND Laparoscopic radical gastrectomy is widely used,and perioperative complications have become a highly concerned *** To develop a predictive model for complications in laparoscopic radical gastrectomy for gastric cancer to better predict the likelihood of complications in gastric cancer patients within 30 days after surgery,guide perioperative treatment strategies for gastric cancer patients,and prevent serious *** In total,998 patients who underwent laparoscopic radical gastrectomy for gastric cancer at 16 Chinese medical centers were included in the training group for the complication model,and 398 patients were included in the validation *** clinicopathological data and 30-d postoperative complications of gastric cancer patients were *** machine learning methods,lasso regression,random forest,and artificial neural networks,were used to construct postoperative complication prediction models for laparoscopic distal gastrectomy and laparoscopic total gastrectomy,and their prediction efficacy and accuracy were *** The constructed complication model,particularly the random forest model,could better predict serious complications in gastric cancer patients undergoing laparoscopic radical *** exhibited stable performance in external validation and is worthy of further promotion in more *** Using the risk factors identified in multicenter datasets,highly sensitive risk prediction models for complications following laparoscopic radical gastrectomy were *** hope to facilitate the diagnosis and treatment of preoperative and postoperative decision-making by using these models.

关键词： Gastric cancer Laparoscopic radical gastrectomy Postoperative complications Laparoscopic total gastrectomy

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光伏电站建设对陆地生态环境的影响:研究进展与展望

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环境科学 2024年第1期45卷 239-247页

作者：田政卿张勇刘向陈生云柳本立吴纪华兰州大学生态学院草种创新与草地农业生态系统全国重点实验室兰州730000 中国科学院西北生态环境资源研究院冰冻圈科学国家重点实验室兰州730000 中国科学院西北生态环境资源研究院沙漠与沙漠化重点实验室兰州730000

随着全球能源消耗的快速增长,环境将进一步恶化,各国减排的竞争将更加激烈,而利用太阳能作为清洁能源的光伏发电对于实现地球碳中和具有重要战略意义.陆地生态系统中的集中式光伏电站大范围覆盖地球表面,导致土地利用发生变化,对地表能... 详细信息

随着全球能源消耗的快速增长,环境将进一步恶化,各国减排的竞争将更加激烈,而利用太阳能作为清洁能源的光伏发电对于实现地球碳中和具有重要战略意义.陆地生态系统中的集中式光伏电站大范围覆盖地球表面,导致土地利用发生变化,对地表能量平衡和降水的再分配产生显著影响,进而改变土壤养分循环和植物生产力,并最终带来明显的生态环境效应.通过回顾近20年来国内外光伏电站生态环境影响研究的相关文献,综述了光伏电站建设对微气候、土壤和动植物等的影响强度和方向,以及对陆地生态系统功能的潜在影响.光伏电站可以通过调节微气候因子中的太阳辐射强度、空气温湿度、风速和风向等,进一步影响植物生产力、土壤抗蚀性和土壤碳固存等多项生态系统功能.尽管已有文献报道中有关光伏电站建设对陆地生态系统的影响并不一致,但总体而言,可以提高植被盖度和植物生产力;特别在荒漠等生态系统中可在一定程度上改善生态环境.目前,尽管有大量研究报道了光伏电站对生态系统可能具有的效应,但实验性论据尚不充分,对生态系统功能影响机制的研究更为少见.在后续的工作中,可进一步关注光伏电站对生态环境影响的区域差异性,以及对生态系统功能潜在的影响途径,结合生态效应为光伏电站建设区域的生态保护与修复提供依据,并针对潜在的生态风险制定相应预案措施.

关键词：光伏电站生态效应微气候因子植物多样性土壤生态系统

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基于异构系统的多级并行稀疏张量向量乘算法

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计算机学报 2024年第2期47卷 441-455页

作者：陈玥丹肖国庆阳王东金纪勇龙军李肯立中南大学大数据研究院湖南大学深圳研究院湖南大学信息科学与工程学院国家超级计算长沙中心之江实验室基础理论研究院—应用数学与机器智能研究中心

张量在许多实际应用中被用来表示大规模、多源、高维、多模态的数据.稀疏张量分解作为挖掘数据中隐藏信息的有效方法之一，已被广泛应用于机器学习、文本分析、生物医疗等研究领域中.稀疏张量向量乘(Sparse Tensor-VectorMultiplication... 详细信息

张量在许多实际应用中被用来表示大规模、多源、高维、多模态的数据.稀疏张量分解作为挖掘数据中隐藏信息的有效方法之一，已被广泛应用于机器学习、文本分析、生物医疗等研究领域中.稀疏张量向量乘(Sparse Tensor-VectorMultiplication,SpTV)是张量分解中最基础、耗时最多的运算之一.为加速大数据和人工智能相关应用的运行效率，本文提出了基于CPU-GPU异构结构的多级并行SpTV加速算法.首先，为了将SpTV运算映射到混合、多级并行的分布式CPU-GPU异构多/众核构架，本文设计了一种多维并行SpTV划分方法，采用面向节点级并行的N-1维张量划分和面向GPU线程级并行的矩阵划分，充分利用计算节点间和节点内的多级并行计算能力.其次，设计了一种基于稀疏张量纤维的压缩存储格式，压缩稀疏张量的内存占用，优化SpTV运算的计算和访存模式.最后，提出了基于多流并行的异构高效SpTV算法，进一步设计了稀疏张量的细粒度划分方法、多流并行运行机制和基于张量块排序的多流并行优化技术，实现了SpTV运算中通信开销和计算开销的相互重叠与隐藏.实验结果表明，与相关工作aeSpTV相比，所提出的SpTV算法在所有测试数据集上最高能够获得3.28倍的加速比.

关键词： CPU-GPU 异构并行计算多级并行稀疏张量张量运算

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Dosimetric risk factors for radiation esophagitis in patients with breast cancer following regional nodal radiation

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World Journal of Clinical Cases 2024年第17期12卷 2995-3003页

作者： Mei-Chen ji Zhi-jia Li Ke Li Yun-Xiao Wang Bo Yang Lin-Lin Lv Ying Su Zhi-Wei Zhang Zhong-Chao Huo qing Qi yong-Chang Lu Zhi-Qiang Cui Yan-Bao Liu Oncology Center The Affiliated Hospital of Hebei University of EngineeringHandan 056002Hebei ProvinceChina General Surgery Department Handan First HospitalHandan 056002Hebei ProvinceChina Department of Breast Surgery The Affiliated Hospital of Hebei University of EngineeringHandan 056002Hebei ProvinceChina School of Clinical Medicine Hebei University of EngineeringHandan 056002Hebei ProvinceChina

BACKGROUND Radiation esophagitis(RE)is one of the most common clinical symptoms of regional lymph node radiotherapy for breast ***,there are fewer studies focusing on RE caused by hypofractionated radiotherapy(HFRT).AIM To analyze the clinical and dosimetric factors that contribute to the development of RE in patients with breast cancer treated with HFRT of regional lymph *** Between January and December 2022,we retrospectively analysed 64 patients with breast cancer who met our inclusion criteria underwent regional nodal intensity-modulated radiotherapy at a radiotherapy dose of 43.5 Gy/*** Of the 64 patients in this study,24(37.5%)did not develop RE,29(45.3%)developed grade 1 RE(G1RE),11(17.2%)developed grade 2 RE(G2RE),and none developed grade 3 RE or *** univariable logistic regression analysis found G2RE to be significantly correlated with the maximum dose,mean dose,relative volume 20-40,and absolute volume(AV)*** stepwise linear regression analyses found AV30 and AV35 to be significantly associated with G2RE(P<0.001).The optimal threshold for AV30 was 2.39 mL[area under the curve(AUC):0.996;sensitivity:90.9%;specificity:91.1%].The optimal threshold for AV35 was 0.71 mL(AUC:0.932;sensitivity:90.9%;specificity:83.9%).CONCLUSION AV30 and AV35 were significantly associated with *** thresholds for AV30 and AV35 should be limited to 2.39 mL and 0.71 mL,respectively.

关键词： Breast cancer Dosimetric parameters Radiation esophagitis Esophagitis Hypofractionated radiotherapy

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Direct measurement of the break-out ^(19)F(p,γ)^(20)Ne reaction in the China jinping underground laboratory(CJPL)

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Nuclear Science and Techniques 2024年第8期35卷 142-152页

作者： Yin‑ji Chen Hao Zhang Li‑yong Zhang jian‑Jun He Richard James deBoer Michael Wiescher Alexander Heger David Kahl Jun Su Daniel Odell Xin‑Yue Li jian‑Guo Wang Long Zhang Fu‑Qiang Cao Zhi‑Cheng Zhang Xin‑Zhi jiang Luo‑Huan Wang Zi‑Ming Li Lu‑Yang Song Liang‑Ting Sun Qi Wu jia‑qing Li Bao‑Qun Cui Li‑Hua Chen Rui‑Gang Ma Er‑Tao Li Gang Lian Yao‑De Sheng Zhi‑Hong Li Bing Guo Wei‑Ping Liu Key Laboratory of Beam Technology of the Ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China Department of Physics and Astronomy The Joint Institute for Nuclear AstrophysicsUniversity of Notre DameNotre DameIN 46556USA School of Physics and Astronomy Monash UniversityClaytonVIC 3800Australia Facility for Rare Isotope Beams Michigan State UniversityEast LansingMI 48824USA Institute of Nuclear and Particle Physics and Department of Physics and Astronomy Ohio UniversityAthensOH 45701USA Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China China Institute of Atomic Energy Beijing 102413China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China College of Science Southern University of Science and TechnologyShenzhen 518055China Institute of Radiation Technology Beijing Academy of Science and TechnologyBeijing 100875China Key Laboratory of Nuclear Physics and Ion‑Beam Application(MOE) Institute of Modern PhysicsFudan UniversityShanghai 200433China School of Mathematics and Physics Handan UniversityHandan 056005China

Calcium production and the stellar evolution of first-generation stars remain fascinating mysteries in *** one possible nucleosynthesis scenario,break-out from the hot carbon–nitrogen–oxygen(HCNO)cycle was thought to be the source of the calcium observed in these oldest ***,according to the stellar modeling,a nearly tenfold increase in the thermonuclear rate ratio of the break-out ^(19)F(p,γ)^(20) Ne reaction with respect to the competing ^(19)F(p,α)^(16) O back-processing reaction is required to reproduce the observed calcium *** performed a direct measurement of this break-out reaction at the China jinping underground *** measurement was performed down to the low-energy limit of E_(c.m.)=186 keV in the center-of-mass *** key resonance was observed at 225.2 keV for the first *** a temperature of approximately 0.1 GK,this new resonance enhanced the thermonuclear ^(19)F(p,γ)^(20) Ne rate by up to a factor of≈7.4,compared with the previously recommended NACRE *** is of particular interest to the study of the evolution of the first stars and implies a stronger breakdown in their“warm”CNO cycle through the ^(19)F(p,γ)^(20) Ne reaction than previously *** break-out resulted in the production of the calcium observed in the oldest stars,enhancing our understanding of the evolution of the first stars.

关键词： Nuclear astrophysics First stars Abundance of calcium Reaction cross section Reaction rate China jinping underground laboratory(CJPL) JUNA

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