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Research development of the relationship between thymidine phosphorylase expression and colorectal carcinoma

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Cancer Biology & Medicine 2013年第1期10卷 10-15页

作者： Dian-Jun Ye ji-min zhang Department of Gastrointestinal Surgery The Second Affiliated Hospital of Guangzhou Medical University

Thymidine phosphorylase (TP) is a key enzyme that contributes to the composition and decomposition of pyrimidine nucleotides. TP seems homologous to platelet-derived endothelial cell growth factor, and its effects on inducing vascularization and anti-apoptosis are closely related to growth and metastasis of colorectal carcinoma. In addition, TP is a key enzyme that catalyzes the transformation from 5-fluorouracil (FU) prodrugs of 5′-deoxy-5-fluorouridine (5′- DFUR) to 5-FU. The activity of TP is closely related to the sensitivity of colorectal carcinoma cells to fluorouracil drugs and targeted therapy. Given the important functions of TP in growth, metastasis, tumor treatment, and prognosis, determining its expression mechanism is significant. This article summarizes the research development of TP expression in colorectal carcinoma, tumor neovascularization, cytotoxicity activation of 5′-DFUR, and colorectal carcinoma therapy.

关键词： 1-hymidine phosphorylase colorectal carcinoma angiogenesis 5'deoxy-5-fluorouridine

Detection of H_2O_2 at a composite film modified electrode with highly dispersed Ag nanoparticles in Nafion

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Chinese Chemical Letters 2011年第4期22卷 458-460页

作者： Mei Xiu Kan Xue ji Wang Hui min zhang School of Science Beijing Institute of TechnologyBeijing 100081China

Ag nanoparticles were prepared by using the ion-exchange of Nafion combined with electrochemical reduction on the electrode. Ag nanoparticles are highly dispersed in Nafion film with an average size of 4.0±0.2 *** amount of Ag nanoparticles can be readily controlled by the amount of Nafion coated on the *** obtained Ag nanoparticles exhibit good catalytic activity for the reduction of H2O2 with a linear response to H2O2 in the concentration range of 0.04-8.0 mmol/L with a sensitivity of 0.34μA/mmol/L and a detection limit of 1.0×10^（-8） mol/L.

关键词： Ag nanoparticles Nafion Electrodeposition Electrocatalytic activity Hydrogen peroxide

A Novel Algorithm for Microcirculation Image Enhancement

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Chinese Journal of Biomedical Engineering(English Edition) 2010年第3期19卷 114-120页

作者： LI Hong-jun ZHAO Zhi-min ji Lei zhang Lin Nanjing University of Aeronautics and Astronautics Nanjing 210016 China

Microcirculation images often have low quality in acquisition process, which affect the following steps of process. This paper introduces enhancement algorithm based on nonsubsampled Contourlet transform (NSCT). It analyzes the characteristics of the microcirculation images generated, and separates microcirculation images to light weight and the reflection weight. It also analyzes the construction method on NSCT and proves that this method can be applied on microcirculation image enhancement algorithm. To correct light weight of microcirculation image and obtain enhancement image the enhancement microcirculation image was not only superior to the original image visually, but also improved objective data obviously. The algorithms provide a new method to microcirculation image pre-processing and guide the latter steps of the image processing.

关键词： image enhancement microcirculation image nonsubsampled Contourlet transform

Synthesis of Conformationally LockedIsonucleosides: 2'-Deoxy-2'-nucleobase-5'-deoxy-1', 4' : 3' , 6'-dianhydro-D-mannitol

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Chemical Research in Chinese Universities 2001年第2期17卷 178-185页

作者： TIAN Xiao-bing, zhang Ling, min ji-mei and zhang Li-he (School of Pharmaceutical Sciences, Beijing Medical University, Beijing 100083, P. R. China) LU Yang, jiANG Reng-wang and ZHENG Qi-tai (Institute of Materia Medica, Peking Union Medical College &. Ch 北京大学北京 100083 中国医学科学院药物所北京 100050

Novel bicyclic isonucleosides, 2′-deoxy-2′ -nucleobase-5′-deoxy-1′ , 4′ : 3′ , 6′ -dianhydro- D-mannitol 10a-10c, were synthesized from D-glucose. The computer-assisted molecular simu- lation indicated that the... 详细信息

关键词： Bicyclic isonucleoside Locked conformation Synthesis

空间曲面纤维网格制作及加固水下混凝土柱试验研究

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土木工程学报 2017年第10期50卷 45-53,90页

作者：魏洋张希吴刚纪军张敏南京林业大学江苏南京210037 东南大学混凝土及预应力混凝土结构教育部重点实验室江苏南京210096 北京特希达技术研发有限公司北京100011

平面纤维(FRP)网格以其卓越的性能在特定结构加固方面具有较好的应用优势,但其对小尺寸曲面、异形混凝土结构构件的约束加固并不适用。提出了空间曲面纤维网格制作工艺,制作了曲面纤维网格制品,测试了纤维网格拉伸的力学性能;提出了空... 详细信息

平面纤维(FRP)网格以其卓越的性能在特定结构加固方面具有较好的应用优势,但其对小尺寸曲面、异形混凝土结构构件的约束加固并不适用。提出了空间曲面纤维网格制作工艺,制作了曲面纤维网格制品,测试了纤维网格拉伸的力学性能;提出了空间曲面纤维网格加固水下混凝土柱的施工工艺,并进行了轴压试验研究,试验结果表明:空间曲面纤维网格加固水下混凝土试件的轴压性能明显优于未加固混凝土圆柱试件,随着纤维网格纤维用量的增加,加固试件的承载能力和变形能力能有效提高,并取得和陆上试件相近的加固效果,根据纤维网格约束量的不同,水下加固试件的应力-应变曲线表现为软化、强化与临界行为,采用现有FRP约束混凝土模型能够较好地预测空间曲面纤维网格加固水下混凝土的极限应力与极限应变。

关键词：混凝土结构空间曲面水下加固技术纤维网格力学性能

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Splenogonadal fusion

Chinese Medical Journal 2008年第4期121卷 383-384页

作者： SHEN Xiao-cao DU Chuan-jun CHEN ji-min zhang Zhe-wei QIU Yi-qing Department of Urology Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou Zhejiang 310009 China

Splenogonadal fusion is a rare congenital anomaly, which is described as abnormal fusion between thespleen and gonad or derivatives of the mesonephros. Surgical exploration is generally performed to rule out malignanc... 详细信息

关键词： testis spleen splenogonadal fusion

Structural Analysis and Physicochemical Properties of the Collagen Sponge

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Chinese Journal of Biomedical Engineering(English Edition) 2003年第3期12卷 126-132页

作者： WU ji-min, GUAN jing, zhang Xi-zheng, LI Rui-xin, GUO Yong

This paper summed up experimental data for the structural analyses and properties of collagen sponge to be used as wound dressing or scaffolds of cell growth in tissue engineering. The structural analyses included UV spectrum, amino acid and electrophoresis, while the physicochemical properties were bulk density, water-binding capacity, digestibility and residue on ignition. The structural analysis showed that the collagen sponge made from bovine tendon was purely composed of type Ⅰ collagen, and contained many aggregated compositions with high molecular mass owing to the storage under ambient condition. The bulk density of the collagen sponge was between 18 and 21 mg/cm 3, water-binding capacity from 44 to 53 mg/mg, digestive time about half an hour and residue on ignition between 0.42% and 0.45%.

关键词： TypeⅠcollagen Physicochemical properties Structural analysis

Magneto‑Dielectric Synergy and Multiscale Hierarchical Structure Design Enable Flexible Multipurpose Microwave Absorption and Infrared Stealth Compatibility

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Nano-Micro Letters 2025年第2期17卷 401-416页

作者： Chen Li Leilei Liang Baoshan zhang Yi Yang Guangbin ji School of Electronic Science and Engineering Nanjing UniversityNanjing 210093People’s Republic of China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

Developing advanced stealth devices to cope with radar-infrared(IR)fusion detection and diverse application scenarios is increasingly demanded,which faces significant challenges due to conflicting microwave and IR cloaking mechanisms and functional integration ***,we propose a multiscale hierarchical structure design,integrating wrinkled MXene IR shielding layer and flexible Fe_(3)O_(4)@C/PDMS microwave absorption *** top wrinkled MXene layer induces the intensive diffuse reflection effect,shielding IR radiation signals while allowing microwave to pass ***,the permeable microwaves are assimilated into the bottom Fe_(3)O_(4)@C/PDMS layer via strong magneto-electric *** theoretical and experimental optimization,the assembled stealth devices realize a near-perfect stealth capability in both X-band(8–12 GHz)and long-wave infrared(8–14μm)wavelength ***,it delivers a radar cross-section reduction of−20 dB m^(2),a large apparent temperature modulation range(ΔT=70℃),and a low average IR emissivity of ***,the optimal device demonstrates exceptional curved surface conformability,self-cleaning capability(contact angle≈129°),and abrasion resistance(recovery time≈5 s).This design strategy promotes the development of multispectral stealth technology and reinforces its applicability and durability in complex and hostile environments.

关键词： Microwave absorption Radar-infrared compatible stealth Wrinkled MXene Magneto-dielectric synergy Multifunction

Erratum to research development of the relationship between thymidine phosphorylase expression and colorectal carcinoma

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Cancer Biology & Medicine 2013年第2期10卷 121-121页

作者： Dian-Jun Ye ji-min zhang Department of Gastrointestinal Surgery The Second Affiliated Hospital of Guangzhou Medical University

Erratum to: Cancer Biol Med 2013;10:10-15. doi:10.7497/***.2095-3941.2013.01.002 In the published article 1 , an error appeared on page 10. The footnote about corresponding author should have read as follows: Correspondence to: ji-min zhang Email: jimin0820@*** The authors and the journal apologize for the error and for any confusion it may have ***

关键词： zhang Erratum to research development of the relationship between thymidine phosphorylase expression and colorectal carcinoma