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PSO/ACO Algorithm-based Risk Assessment of Human Neural Tube Defects in Heshun County,China

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Biomedical and Environmental Sciences 2012年第5期25卷 569-576页

作者： LIAO Yi Lan WANG jin Feng WU ji lei WANG jiao jiao ZHENG XiaoYing The State Key Laboratory of Resources and Environmental Information System Institute of Geographical Sciences and Nature Resources Research Chinese academy of Sciences Beijing 100101 China Institute of Population Research Peking University Beo'ing 100871 China College of Geoscience and Surveying Engineering China University of Mining & Technology Beo'ing 100083 China

Abstract Objective To develop a new technique for assessing the risk of birth defects, which are a major cause of infant mortality and disability in many parts of the world. Methods The region of interest in this study was Heshun County, the county in China with the highest rate of neural tube defects （NTDs）. A hybrid particle swarm optimization/ant colony optimization （PSO/ACO） algorithm was used to quantify the probability of NTDs occurring at villages with no births. The hybrid PSO/ACO algorithm is a form of artificial intelligence adapted for hierarchical classification. It is a powerful technique for modeling complex problems involving impacts of causes. Results The algorithm was easy to apply, with the accuracy of the results being 69.5%＋7.02% at the 95% confidence level. Conclusion The proposed method is simple to apply, has acceptable fault tolerance, and greatly enhances the accuracy of calculations.

关键词： Neural tube birth defects GIS PSO/ACO algorithm Hierarchical classification Risk map

糖基化对虹鳟鱼鱼松品质和挥发性风味特征的影响

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中国农业科技导报 2024年第9期26卷 159-172页

作者：纪蕾刘天红王颖李晓李红艳姜晓东孙元芹张帅中山东省海洋科学研究院山东青岛266104 山东省海洋科学研究院青岛市水产生物品质评价与利用工程研究中心山东青岛266104

为促进虹鳟鱼高值化产品开发,对添加不同糖的虹鳟鱼鱼松品质(理化特性、色泽和感官等)进行研究,同时采用气相色谱-质谱联用仪(gas chromatography-mass spectrometer,GC-MS)对鱼松进行脂肪酸和挥发性成分分析。结果表明,糖的添加对虹鳟... 详细信息

为促进虹鳟鱼高值化产品开发,对添加不同糖的虹鳟鱼鱼松品质(理化特性、色泽和感官等)进行研究,同时采用气相色谱-质谱联用仪(gas chromatography-mass spectrometer,GC-MS)对鱼松进行脂肪酸和挥发性成分分析。结果表明,糖的添加对虹鳟鱼鱼松品质具有重要影响,可促进美拉德反应进程,改善鱼松产品的口感、色泽等感官品质,其中阿拉伯糖作为戊糖,美拉德反应进程更快,颜色变化更明显,而添加低聚果糖的鱼松甜味更好。在脂肪酸方面,低聚果糖鱼松的饱和脂肪酸、二十碳五烯酸(eicosapntemacnioc acid,EPA)和二十碳六烯酸(docosahexaenoic acid,DHA)含量最高,而阿拉伯糖鱼松的多不饱和脂肪酸含量最高。综上,添加糖后的鱼松样品由于美拉德反应,产生了阈值较低、对风味影响更大的醛类、酮类、醇类等物质。以上研究结果为改善虹鳟鱼鱼松的品质和提高产品附加值提供了参考。

关键词：虹鳟鱼鱼松糖基化品质挥发性成分脂肪酸

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铸造混合型旧砂的复合再生工艺研究

铸造 2024年第6期73卷 799-803页

作者：韩海涛韩继磊王大威刘宁李宝娥师春生李海鹏承德北雁新材料科技有限公司河北承德068451 河北省硅砂材料技术创新中心河北承德068451 河北工业大学材料科学与工程学院天津300130 天津大学材料科学与工程学院天津300350

对含不同类型树脂芯砂的粘土混合旧砂进行再生试验研究,对比了湿法再生、化学再生和复合再生等对再生砂表面形貌和性能的影响。结果表明:单一再生方法无法同时满足对含泥量、灼减量、酸耗值等要求。“水洗+碱/酸处理+高温焙烧”工艺能... 详细信息

对含不同类型树脂芯砂的粘土混合旧砂进行再生试验研究,对比了湿法再生、化学再生和复合再生等对再生砂表面形貌和性能的影响。结果表明:单一再生方法无法同时满足对含泥量、灼减量、酸耗值等要求。“水洗+碱/酸处理+高温焙烧”工艺能充分发挥不同工艺优势,获得理想结果,适宜的工艺参数为在400 r/min的转速下水洗6次,每次5 min,砂水比约为1.7∶1,并在水洗初期和水洗后每100 g旧砂依次加入0.1 mol/L的氢氧化钠溶液4 mL和草酸溶液6 mL,最后将水洗后的砂子在700℃焙烧15 min。再生砂含泥量、酸耗值、灼减量分别达到0.18%,2.61 mL和0.08%,均超过行业标准和企业生产要求。

关键词：粘土混合旧砂复合再生微观形貌工艺性能

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新工科视域下省属高校一流本科专业新能源科学与工程的建设内涵

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中国现代教育装备 2024年第11期 79-81,85页

作者：蔡伟通舒日洋张刘挺吴其兴姬磊广东工业大学材料与能源学院大思政课建设协同创新中心广东广州510006 江苏科技大学能源动力学院江苏镇江212100 深圳大学化学与环境工程学院广东深圳518052 广东工业大学先进制造学院广东揭阳515200

在新工科背景下,广东工业大学新能源科学与工程加快推进一流本科专业建设进程,提出“五点五‘+’”的建设内涵,以明德励行为方向点构筑“德+”的内涵,以生师共长为关键点发展“人+”的内涵,以高校课堂为突破点打造“课堂+”的内涵,以课... 详细信息

在新工科背景下,广东工业大学新能源科学与工程加快推进一流本科专业建设进程,提出“五点五‘+’”的建设内涵,以明德励行为方向点构筑“德+”的内涵,以生师共长为关键点发展“人+”的内涵,以高校课堂为突破点打造“课堂+”的内涵,以课程建设为切入点拓展“课程+”的内涵,以技术平台为支撑点优化“平台+”的内涵。

关键词：新工科一流本科专业建设人才培养

Effect of Pathoanatomic Diagnosis on the Quality of Birth Defects Surveillance in China

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Biomedical and Environmental Sciences 2009年第6期22卷 464-471页

作者： LI-JUN PEI GONG CHEN XIN-MING SONG ji-lei WU CHENG-FU LI ji-ZHEN ZOU jiU-ZHI LIN TING ZHANG XIAO-YING ZHENG Institute of Population Research/WHO Collaborating Center on Reproductive Health and Population Science Peking University Beijing 100871 China Capital Institute of Pediatrics Beijing 100020 China

Objective To provide evidence for more accurate diagnosis of birth defects based on the pathoauatomy of congenital malformations. Methods Data used in this study were obtained fi＇om Luliang City Hospital and three county hospitals of Shanxi province between February 2004 and March 2006. Autopsy and pathological examination of 160 dead fetuses and stillbirths were performed. Photos of dead fetuses and stillbirths were taken, tissues were cut into sections for pathological examination under microscope, all pathological information was recorded, and percentage of birth defects was calculated. Results The proportion of dead fetuses and stillbirths with or without congenital malformations was 84.4% （135/160） and 15.6% （25/160）, respectively. There were 16 categories of major external and internal birth defects in 135 cases of such defects. Congenital heart defects, anencephaly and spina bifida had a higher prevalence rate in the study period. The prevalence rate of non-malformation death and birth defects 〈 28 gestational weeks and internal anomalies ≥ 28 gestational weeks was 14.61% （61/4175） and 17.25% （72/4175）, respectively. A total of 413 in situ anomalies were found in 135 cases of autopsy. Spina bifida, anencephaly, congenital heart defects, aplasia or accessory lobe of lung, renal agenesis and dysplasis and congenital hydrocephaly were more closely associated with severe malformations than with mitis malformations. The cases of dead fetuses and stillbirths with multiple malformations （/〉 2 in situ anomalies） had a higher proportion （74.1%）, whereas those with isolated malformations had a lower proportion （25.93%）. Conclusion The occurrence of congenital malformations in different embryonic developmental stages affects multiple organs. Postmortem examination of internal and multiple malformations of fetal deaths and stillbirths can provide more accurate diagnostic information for birth defects.

关键词： Birth defects Pathoanatomy Congenital internal anomaly Congenital external anomaly ICD-10 codes

Activation of bone morphogenetic protein-6 gene transcription in MCF-7 cells by estrogen

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Chinese Medical Journal 2005年第19期118卷 1629-1636页

作者： ZHANG Ming YAN ji-dong ZHANG lei WANG Qing Lü Shu-jun ZHANG jie ZHU Tian-hui Laboratory of Molecular Medicines Medical College Nankai University Tianjin 300071 China

Background Bone morphogenetic protein-6 （BMP-6） is closely correlated with tumor differentiation and skeletal metastasis. Estrogen is considered as a stimulant for the initiation and promotion of breast cancer. Previous studies demonstrated that 17β-estadiol （E2） can selectively increase the expression of BMP-6. This experiment is designed to detect the molecular mechanism of estrogen activating BMP-6 gene transcription in human estrogen receptor positive （ER ^＋） breast cancer cell line MCF-7. Methods After the treatment of MCF-7 cells with E2 at different concentrations （ 10^-11 mol/L, 10.9 mol/L, 10.7 mol/L）, the BMP-6 expression level was examined through real-time polymerase chain reaction. Through restriction enzyme digestion, human BMP-6 1.2 kb long promoter, BMP-6 0. 7 kb long promoter was cloned into pGL-3 basic vector; after the treatment with 10^-7 mol/L E2, luciferase activities of the two promoters were detected. Site-directed mutagenesis was performed to obtain the mutant forms of estrogen response element half- site （ 1/2 ERE） element and Spl sites in the BMP-6 promoter, the activities of these mutant form promoters were detected following the methods mentioned above. Chromatin immunoprecipitation （CHIP） assay was also used to confirm the binding of estrogen receptor a （ERα） on BMP-6 promoter in the presence of E2. Results E2 dose dependently increased BMP-6 mRNA expression in human ER ^＋ breast cancer cell line MCF-7. At a dose of 10^-7 mol/L E2, human BMP-6 1.2 kb promoter activity was increased by 90% compared with the control group treated with ethanol （P 〈 0. 05 ）. Both the 1/2 ERE response element mutant form and the Spl site mutant form of the BMP-6 promoter abolished the activation of the BMP-6 promoter＇ s response to E2. Through ChIP assay, the binding of ERot on 1/2 ERE response element in BMP-6 promoter was further validated. Conclusion Estrogen induces BMP-6 expression in human ER^＋ breast cancer cell line MCF-7 receptor ERα binding on 1/2

关键词： bone morphogenetic protein-6 estrogen chromatin immunoprecipitation site-directed mutagenesis

Soot particle distributions inside a diesel particulate filter during soot loading in plateau environment

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Journal of Central South University 2022年第7期29卷 2201-2212页

作者： WANG Peng BI Yu-hua SHEN Li-zhong lei ji-lin YU Feng-rong Yunnan Province Key Laboratory of Internal Combustion Engines Kunming University of Science and TechnologyKunming 650500China Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming 650500China

A three-dimensional diesel particulate filter(DPF)simulation model was developed by using AVL software FIRE to study the effects of four factors on soot particle distributions along the axial and radial directions in the DPF after the model accuracy was *** orthogonal test method was used to determine the importance and weights of the design of experiments(DoE)factors such as the expanding angle,the number of channels per square inch,and the exhaust mass flow *** effects of these factors on the uniformity of the soot particle distributions were also *** results show that when the soot loading time was 400 s,the soot particles inside the DPF along the axial direction exhibited a bowl shape,which was high on the both ends and low in the *** uniformity of the axial distribution of soot particles reduces significantly with an increase in the number of channels per square *** uniformity of the radial distribution reduced with an increase in the expanding angle of the divergent *** on the impacts on the axial uniformity,the three most influencing factors in a descending order are the number of channels per square inch,the exhaust mass flow rate,and the expanding angle of the divergent tube.

关键词： diesel particulate filter(DPF) soot particle distribution plateau environment pressure loss

Oxygen and nitrogen tailoring carbon fiber aerogel with platinum electrocatalysis interfaced lithium/sulfur(Li/S)batteries

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Chinese Chemical Letters 2023年第1期34卷 145-151页

作者： lei ji Xia Wang Yongfeng jia Xiaoxi Qin Yi Sui Huizhong Yan Zhiqiang Niu jinghai Liu Yuegang Zhang State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization Baotou Research Institute of Rare EarthsBaotou 014030China Inner Mongolia Key Laboratory of Carbon Nanomaterials Nano Innovation Institute(NII)College of Chemistry and Materials ScienceInner Mongolia MinZu UniversityTongliao 028000China Department of Physics Tsinghua UniversityBeijing 100084China Key Laboratory of Advanced Energy Materials Chemistry(Ministry of Education) Renewable Energy Conversion and Storage CenterCollege of ChemistryNankai UniversityTianjin 300071China

Sluggish kinetics of lithium/sulfur(Li/S)conversion chemistry and the ion channels formation in the cathode is still a bottleneck for developing future Li/S batteries with high-rate,long-cycling and ***,a rational cathode structure design of an oxygen(O)and nitrogen(N)tailoring carbon fiber aerogel(OCNF)as a host material integrated with platinum(Pt)electrocatalysis interface is employed to regulate Li/S conversion chemistry and ion *** Pt nanoparticles were uniformly sprayed onto the S surface to construct the electrocatalysis interface(Pt/S/OCNF)for generating ion channels to promote the effective penetration of electrolyte into the *** Pt/S/OCNF gives the cathode a high sulfur utilization of 77.5%,an excellent rate capacity of 813.2 m Ah/g(2 C),and an outstanding long-cycling performance with a capacitance retention of 82.6%and a decay of 0.086%per cycle after 200 cycles at 0.5 *** functional theory(DFT)calculations reveal that the Pt electrocatalysis interface makes the cathode a high density of state(DOS)at Fermi level to facilitate the electrical conductivity,charge transfer kinetics and electrocatalysis to accelerate the lithium polysulfides(LiPSs)electrochemical ***,the unique chemisorption structure and adsorption ability of Li2Sn(n=1,2,4,6,8)and S8on OCNF are attributed to the bridging effects of interfacial Pt and the bonding of *** Pt electrocatalysis interface combined with the unique 3D hierarchical porous structure and abundant functional active sites at OCNF guarantee strong adsorption confinement,fast Li/S electrocatalytic conversion and unblocked ion channels for electrolyte permeation in cathode.

关键词： Li/S conversion chemistry Ion channels Pt electrocatalysis interface 3D aerogel host(OCNF) Adsorption confinement

Synthesis of substituted polyaryls via sterically hindered double Suzuki cross-couplings

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Chinese Chemical Letters 2009年第8期20卷 927-930页

作者： Zhan Zhang Hai Ying ji Xian lei Fu Yu Yang Yun Rong Xue Guo Hua Gao Shanghai Key Laboratory of Green Chemistry and Chemical Process Department of ChemistryEast China Normal University Shanghai 200062 China

Substituted polyaryls were synthesized successfully via sterically hindered double Suzuki cross-couplings of arylboronic acids with aryl dibromides in the presence of Pd（PPh3）4 and KOtBu within a very short time. ？... 详细信息

关键词： Double Suzuki coupling Sterically Polyaryls