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Diagnostic and prognostic value of secreted protein acidic and rich in cysteine in the diffuse large B-cell lymphoma

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World Journal of Clinical Cases 2021年第22期9卷 6287-6299页

作者： Peng-ji Pan Jun-xia Liu Department of Hematology Yongchuan Hospital of Chongqing Medical UniversityChongqing 402160China Department of Oncology Yongchuan Hospital of Chongqing Medical UniversityChongqing 402160China

BACKGROUND Secreted protein acidic and rich in cysteine(SPARC)is an extracellular matrixassociated *** have revealed that SPARC is involved in the cell interaction and function including proliferation,differentiation,and ***,the role of SPARC in cancer is controversial,as it was reported as the promoter or suppressor in different ***,the role of SPARC in lymphoma is *** To identify the expression and significance of SPARC in lymphoma,especially in diffuse large B-cell lymphoma(DLBCL).METHODS The expression analysis of SPARC in different cancers was evaluated with *** Brune,Eckerle,Piccaluga,Basso,Compagno,Alizadeh,and Rosenwald datasets were included to evaluate the mRNA expression of SPARC in *** Cancer Genome Atlas(TCGA)-DLBCL was used to analyze the diagnostic value of SPARC in *** Compagno and Brune DLBCL datasets were used for ***,the diagnostic value was evaluated with the receiver operating characteristic(ROC)*** Kaplan-Meier plot was conducted with TCGA-DLBCL,and the ROC analysis was performed based on the survival ***,the overall survival analysis based on the level of SPARC expression was performed with the GSE4475 and *** Gene Set Enrichment Analyses(GSEA)was performed to make the underlying mechanism-regulatory *** The pan-cancer analysis of SPARC showed that SPARC was highly expressed in the brain and central nervous system,breast,colon,esophagus,stomach,head and neck,pancreas,and sarcoma,especially in *** overexpression of SPARC in lymphoma,especially DLBCL,was confirmed in several *** ROC analysis revealed that SPARC was a valuable diagnostic *** importantly,compared with DLBCL patients with low SPARC expression,those with higher SPARC expression represented a higher overall survival *** ROC analysis showed that SPARC was a favorable prognostic biomarker for *** of the GSEA confirmed that

关键词： Secreted protein acidic and rich in cysteine Diffuse large B-cell lymphoma Inducible expression Diagnosis Prognosis Clinical application

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Nonconforming Finite Element Method for the Transmission Eigenvalue Problem

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Advances in Applied Mathematics and Mechanics 2017年第1期9卷 92-103页

作者： xia ji Yingxia Xi Hehu Xie LSEC NCMISInstitute of Computational MathematicsAcademy of Mathematics and Systems ScienceChinese Academy of SciencesBeijing 100190China

In this paper,we analyze a nonconforming finite element method for the computation of transmission eigenvalues and the corresponding *** error estimates of the eigenvalue and eigenfunction approximation are given,***,... 详细信息

关键词： Transmission eigenvalue Morley element nonconforming finite element method

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Biomimetic mineralization and cytocompatibility of nanorod hydroxyapatite/graphene oxide composites

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Frontiers of Chemical Science and Engineering 2018年第4期12卷 798-805页

作者： Peizhen Duan juan Shen Guohong Zou Xu xia Bo jin School of Materials Science and Engineering Southwest University of Science and TechnologyMianyang 621010China State Key Laboratory Cultivation Base for Nonmetal Composites and Functional Materials Southwest University of Science and Technology Mianyang 621010China

Nanorod hydroxyapatite (NRHA)/graphene oxide (GO) composites with weight ratios of 0.4, 1.5, and 5 have been fabricated by a facile ultrasonic-assisted method at room temperature and atmospheric pressure. The chemical structure properties and morphology of the composites were characterized by field emission source scanning electron microscope, X-ray diffraction, transmission electron microscopy, and high-resolution transmission electron microscopy. The results indicate that the NRHA/ GO composites have an irregular surface with different degree wrinkles and are stable, and NRHA are well combined with GO. In addition, the biomimetic mineralization mechanism of hydroxyapatite on the NRHA/GO composites in simulated body fluid (SBF) is presented. The presence of a bone-like apatite layer on the composite surface indicate that the NRHA/GO composites facilitate the nucleation and growth of hydroxyapatite crystals in SBF for biomimetic mineralization. Moreover, the NRHA- 1.5/GO composite and pure GO were cultured with MC3T3-E1 cells to investigate the proliferation and adhesion of cells. In vitro cytocompatibility evaluation demonstrated that the NRHA/GO composite can act as a good template for the growth and adhesion of cells. Therefore, the NRHA/GO composite could be applied as a GO-based, free-template, non-toxic, and bioactive composite to substitute for a damaged or defect bone.

关键词： hydroxyapatite graphene oxide biomimetic mineralization cytocompatibility

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Synthesis of TiO_2 films on glass slides by the sol-gel method and their photocatalytic activity

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Rare Metals 2009年第4期28卷 378-384页

作者： ZHANG Cuixuan CHEN Rufen ZHOU juan CHENG jianhui xia Qing College of Chemistry and Material Science Hebei Normal University Shijiazhuang 050016 China

Titanium dioxide （TiO2） films with rod-like and sphere-like TiO2 particles were prepared on glass slides employing the sol-gel method. The shape and size of TiO2 particles were controlled using different concentrations of sodium dodecylbenzensulfonate （SDBS）. By increasing the mole ratio of SDBS, the shape of TiO2 particles transformed from rod-like to sphere-like. Also, the size of TiO2 particles became gradually smaller. Then, the size became bigger when an excess amount of SDBS was added. The films were mainly composed of anatase titania and the relative content of anatase increased with the increasing amount of SDBS. The photocatalytic activity of the TiO2 films that were added with SDBS was higher than that without SDBS. When the concentration of SDBS was 8.0 at%, the sample exhibited the best photocatalytic activity.

关键词： titanium dioxide film synthesis photocatalytic activity particle shape

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TRAF proteins as key regulators of plant development and stress responses

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Journal of Integrative Plant Biology 2022年第2期64卷 431-448页

作者： Hua Qi Fan-Nv xia Shi xiao juan Li State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources College of Plant ProtectionSouth China Agricultural UniversityGuangzhou510642 China Guangdong Laboratory for Lingnan Modern Agriculture Guangzhou510642 China State Key Laboratory of Biocontrol Guangdong Provincial Key Laboratory of Plant ResourcesSchool of Life SciencesSun Yat-sen UniversityGuangzhou510275 China College of Agronomy Hunan Agricultural UniversityChangsha410128 China

Tumor necrosis factor receptor-associated factor(TRAF)proteins are conserved in higher eukaryotes and play key roles in transducing cellular signals across different *** are characterized by their C-terminal region(TRAF-C domain)containing seven to eight antiparallelβ-sheets,also known as the meprin and TRAF-C homology(MATH)*** the past few decades,significant progress has been made toward understanding the diverse roles of TRAF proteins in mammals and *** to other eukaryotic species,the Arabidopsis thaliana and rice(Oryza sativa)genomes encode many more TRAF/MATH domaincontaining proteins;these plant proteins cluster into five classes:TRAF/MATH-only,MATH-BPM,MATH-UBP(ubiquitin protease),Seven in absentia(SINA),and MATH-Filament and MATHPEARLI-4 proteins,suggesting parallel evolution of TRAF proteins in *** evidence now indicates that plant TRAF proteins form central signaling networks essential for multiple biological processes,such as vegetative and reproductive development,autophagosome formation,plant immunity,symbiosis,phytohormone signaling,and abiotic stress ***,we summarize recent advances and highlight future prospects for understanding on the molecular mechanisms by which TRAF proteins act in plant development and stress responses.

关键词： autophagy E3 ubiquitin ligase hormone signaling plant development plant stress responses protein adaptor TRAF family proteins

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Overview of Impacts of Climate Change and Adaptation in China's Agriculture

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Journal of Integrative Agriculture 2014年第1期13卷 1-17页

作者： WANG jin-xia HUANG ji-kun YANG Jun Center for Chinese Agricultural Policy Institute of Geographical Sciences and Natural Resources ResearchChinese Academy of Sciences

The purpose of this paper is to document the likely impacts of climate change on China＇s agriculture and the current adaptation efforts made by government and farmers. The review of literature shows that climate change will have a significant impact on agriculture, primarily through its effect on crop yields. The extent of predicted impacts highly depends on the crop, the CO2 fertilization effect assumption and adaptation abilities. Market response to the production shocks resulting from climate change will lessen the impacts on agricultural production predicted by natural scientists. On adaptation, the government＇s major efforts have been in the developing new technologies, reforming extension system and enhancing institutional capacity. Farmers do adapt to climate change, but their adaptation measures cannot fully offset the negative impacts of climate change. The paper concludes and makes implications for future studies.

关键词： climate change agriculture adaptation China

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All-solid-state carbon-nanotube-fiber-based finger-muscle and robotic gripper

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International Journal of Smart and Nano Materials 2022年第1期13卷 64-78,I0004页

作者： xia Liu Hua ji Boyan Liu Qingsheng Yang Institute of Modern Engineering Mechanics Department of Materials and ManufacturingBeijing University of TechnologyBeijingChina

Carbon nanotube fibers(CNTFs)have many desirable properties such as lightweight,high strength,high conductivity,and long *** CNTF is an ideal material for preparing electrochemically driven artificial *** previous studies focused mainly on the actuation performance of artificial muscles made of CNTF,this study focuses on an actuator that mimics human finger movements(flexion).More specifically,the preparation of CNTF muscles were optimized by twisting with ***,actuators are designed and assembled by combining all-solid-state CNTF muscles with polypropylene(PP)***,a dualelectrode system,which is infiltrated by a gel electrolyte,is built into the muscle *** addition,a robotic gripper is fabricated,which uses these *** study can help improve the design of CNTF-based muscle-actuators and future applications in robotics.

关键词： Carbon nanotube fibers artificial finger muscle twisted and coiled actuator electrochemical actuation module

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Flame-retardant and Self-healing Biomass Aerogels Based on Electrostatic Assembly

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Chinese Journal of Polymer Science 2020年第12期38卷 1294-1304页

作者： ji-Yu Yang Yu xia jin Zhao Long-Fei Yi Yong-jiao Song Hong Wu Shao-Yun Guo Li-juan Zhao jin-Rong Wu College of Chemistry and Materials Science Sichuan Normal UniversityChengdu 610066China State Key Laboratory ofPolymer Materials Engineering Polymer Research InstituteSichuan UniversityChengdu 610065China State Key Laboratory ofPolymer Materials Engineering Collegeof Polymer Science and EngineeringSichuan UniversityChengdu 610065China

It remains a significant challenge to fabricate self-healing aerogels with excellent flame ***,we develop a class of biomass aerogels by electrostatically assembling chitosan(CS),phytic acid(PA),and itaconic acid(IA).The electrostatic interaction between CS and IA is weak and dynamic,so freeze-drying the solution of CS and IA enables the formation of continuous aerogel skeleton with self-healing ability and re-programmability;in comparison,the electrostatic interaction between CS and PA is strong and less dynamic,and thus mixing PA with CS in aqueous solution leads to fine precipitates of high flame retardancy due to the synergistic phosphorus-nitrogen *** the continuous skeleton and the fine precipitates results in self-healing aerogles with UL-4 V-0 rating of flame retardancy aerogels and autoextinguishable ***,the aerogels after burning in flame for 30 s form a skin-core structure,and the carbonized skin protects the integrity of the aerogels and the self-healing ability of the internal ***,this work provides a facile strategy to develop multifunctional aerogels which hold great promise for advanced applications.

关键词： Chitosan Flame retardancy Electrostatic interactions Biomass aerogel Self-healing

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Synthesis and Crystal Structure of Co(DMSO)_2(H_2O)_2(SCN)_2 with One-dimensional Hydrogen-bonded Structure (DMSO = Dimethylsulfoxide)

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Chinese Journal of Structural Chemistry 2006年第6期25卷 643-646页

作者： WEI Rong-Min CHE Yun-xia ZHENG ji-Min Departmentof Biology Chemistry Tianjin Normal University Tianjin 300071 China

The title complex Co（DMSO）2（H2O）2（SCN）2 has been prepared and structurally characterized. It crystallizes in monoclinic, space group P21/n with a= 5.1981（9）, b = 11.944（2）, c = 12.646（2） A,β = 98.686（2）°, V = 776.2（2） A^3, C6H16CoN2O4S4, Mr = 367.38, Z = 2, De = 1.572 g/cm^3, F（000） = 378 and μ（MoKa） = 1.646 mm^-1. The structure was refined to R= 0.0232 and wR = 0.0645 for 1241 observed reflections with I 〉 2σ（I）. In the title complex, each Co（II） atom is octahedrally coordinated by four O atoms from two DMSO ligands and two water molecules as well as two N atoms from SCN^- ions. The title molecules are connected to each other through intermolecular hydrogen bonds to form a 1-D structure extended by eight-membered Co2O4H2 rings.

关键词： dimethylsulfoxide thiocyanate group supramolecule,complex intermolecular hydrogen bond

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A biarc-based shape optimization approach to reduce stress concentration effects

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Acta Mechanica Sinica 2014年第3期30卷 370-382页

作者： Liang Meng Wei-Hong Zhang ji-Hong Zhu Liang xia Engineering Simulation and Aerospace Computing (ESAC) Northwestern Polytechnical University

In order to avoid stress concentration, the shape boundary must be properly designed via shape optimiza- tion. Traditional shape optimization approach eliminates the stress concentration effect by using free-form curve to present the design boundaries without taking the machin- ability into consideration. In most numerical control （NC） machines, linear as well as circular interpolations are used to generate the tool path. Non-circular curves, such as non- uniform rotational B-spline （NURBS）, need other more ad- vanced interpolation functions to formulate the tool path. Forming the circular tool path by approximating the opti- mal free curve boundary with arcs or biarcs is another op- tion. However, these two approaches are both at a cost of sharp expansion of program code and long machining time consequently. Motivated by the success of recent researches on biarcs, a reliable shape optimization approach is pro- posed in this work to directly optimize the shape boundaries with biarcs while the efficiency and precision of traditional method are preserved. Finally, the approach is validated by several illustrative examples.

关键词： Structural shape optimization Biarc Curvefitting NURBS Stress concentration

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