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度普利尤单抗治疗炎症性皮肤病临床应用研究进展

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中国药业 2025年第1期34卷 124-128页

作者：费来仪焦晴晴季江苏州大学附属第二人民医院江苏苏州215500 苏州大学附属第一人民医院江苏苏州215000

目的了解临床应用度普利尤单抗治疗慢性炎症性皮肤病的研究进展。方法采用计算机检索PubMed,Web of Science等数据库中2017年1月至2023年12月度普利尤单抗治疗慢性炎症性皮肤病的相关文献,总结度普利尤单抗治疗慢性炎症性皮肤病的有效... 详细信息

目的了解临床应用度普利尤单抗治疗慢性炎症性皮肤病的研究进展。方法采用计算机检索PubMed,Web of Science等数据库中2017年1月至2023年12月度普利尤单抗治疗慢性炎症性皮肤病的相关文献,总结度普利尤单抗治疗慢性炎症性皮肤病的有效性和安全性。结果度普利尤单抗治疗湿疹、慢性瘙痒症、大疱性皮肤病、斑秃、慢性荨麻疹、内瑟顿综合征、嗜酸性皮肤病等炎症性皮肤病的临床疗效良好;药品不良反应(ADR)发生率均较低,最常见的ADR为结膜炎、感染和嗜酸性粒细胞增多、眼部不适等,但多轻微,停药后可缓解。结论度普利尤单抗治疗慢性炎症性皮肤病的有效性及安全性良好,应用前景较好。

关键词：度普利尤单抗炎症性皮肤病慢性瘙痒症大疱性皮肤病斑秃慢性荨麻疹内瑟顿综合征嗜酸性皮肤病有效性安全性

Mass transfer model,preparation and applications of zeolite membranes for pervaporation dehydration:A review

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Chinese Journal of Chemical Engineering 2017年第11期25卷 1627-1638页

作者： Chun Zhang Li Peng ji jiang Xuehong Gu State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemical EngineeringSynergetic Innovation Center for Advanced MaterialsNanjing Tech UniversityNanjing 210009China

Pervaporation(including vapor permeation) is a kind of new membrane separation technology, possessing the advantages of high efficiency, energy saving and convenient operation. It has promising application in the separation and purification of organic solvents. Dehydration is an important step in the production and recovery of organic solvents. Zeolite membranes have attracted wide attention for pervaporation dehydration due to their high separation performance and good thermal/chemical stability. So far, zeolite membranes have been preliminarily industrialized for dehydration of organic solvents. This paper reviews the recent development of zeolite membranes for pervaporation dehydration, including mass transfer models, preparation and applications of zeolite membranes. The review also discusses the current industrial applications of zeolite membranes and their future development in pervaporation.

关键词： Zeolite membrane Pervaporation Organic solvent dehydration Mass transfer

Fabrication and properties of Al matrix composites strengthened by in situ alumina particulates

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Journal of University of Science and Technology Beijing 2006年第3期13卷 263-266页

作者： Gaofeng Fu Lan jiang ji Liu Yue Wang School of Materials and Metallurgy Northeastern University Shenyang 110004 China

New aluminum matrix composites strengthened by Al2O3 particulates through stirring cast by adding NH4Al（SO4）2 to the molten aluminum have been fabricated. TEM observation shows that in-situ Al2O3 particulates are generally spherical and they are uniformly distributed in the Al matrix. Dry sliding wear test results show that the volume loss of the unreinforced Al matrix is about three times that of the Al2O3 reinforced metal matrix composite （MMC） and the volume loss of the MMC fabricated by adding Al2O3 is larger than that of the MMC by adding NH4Al（SO4）2. Lubricating sliding wear test results show that the volume loss of the MMCs increases more slowly than that of the matrix with the increasing of the load.

关键词： aluminum matrix composite alumina microstructure wear

The influence of water level changes on sand bodies at river-dominated delta fronts:The Gubei Sag,Bohai Bay Basin

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Petroleum Science 2022年第1期19卷 58-73页

作者： Yang Zhang Zheng Shi ji Li Jun-Wei Wang Bao-Liang Yang ji-Guo jiang Faculty of Petroleum China University of Petroleum(Beijing)Karamay CampusKaramayXinjiang834000China College of Resources and Environmental Engineering Guizhou Institute of TechnologyGuiyangGuizhou550003China Experiment Testing Institute PetroChina Xinjiang Oilfield CompanyKaramayXinjiang834000China Research Institute of Exploration and Development PetroChina Xinjiang Oilfield CompanyKaramayXinjiang834000China School of Geosciences China University of PetroleumQingdaoShandong266580China Zhuangxi Oil Production Plant Sinopec Shengli Oilfield CompanyDongyingShandong257000China

Changes in water level are one of the important factors controlling the constructive characteristics of *** paper studies the influence of water level changes on sand bodies in the third member of the Shahejie Formation(Es3)on the gentle southern slope of the Gubei Sag,Bohai Bay Basin and draw some conclusions that,for complex sand bodies,with the increase in water level the distributary channels bifurcate frequently,from a simple branching shape to a network shape along with the increase in the development of crevasse splays,mouth bars and sheet *** single sand bodies,with an increase in water level in the slope zone of the lake basin close to the source area,the superimposition style transitioned from vertical cutting-stacking and lateral isolation to vertical stitching,isolation and lateral ***,in the central zone of the lake basin far from the source area,the superimposition style transitioned from vertical stitching and lateral stitching to vertical isolation and lateral *** water level stays stable,the greater the distance from the source area the greater the disaggregation ratio of a single sand *** the same distance from the source area,higher water level tends to result in greater disaggregation ratio of a single sand body.

关键词： Water level changes River-dominated delta Delta front sandbodies Paleogene Shahejie Formation Gubei Sag of Bohai Bay Basin

Self-healing elastomer modified proppants for proppant flowback control in hydraulic fracturing

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Petroleum Science 2022年第1期19卷 245-253页

作者： jian-Da Li Gui-Cai Zhang ji-jiang Ge Wen-Li Qiao Ping jiang Hai-Hua Pei School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongPR China

To address proppant flowback issues during post-fracturing treatments and production,self-healing elastomer modified proppants(SMPs)are *** to their inherent self-aggregation behavior,the SMPs can aggregate together spontaneously to prevent proppant flowback and increase the pack *** is noteworthy that the SMPs have a firm and dry self-healing elastomer(SE)coating,making their storage,transport and use as conventional proppants *** SE synthesized through polymerization is rich in amidogens and carbonyl groups as characterized by Fourier transform infrared spectroscopy and the proton nuclear magnetic *** and thermomechanical properties of the SE coating are revealed by the thermogravimetric analysis,the differential scanning calorimetry and the rheological *** self-aggregation behavior of the SMPs is demonstrated by the adhesion force *** reversible hydrogen bonding interactions in SE coating contribute to the self-aggregation behavior of the SMPs,which is revealed by the thixotropy test and the FTIR analysis at different *** the self-aggregation behavior,the crushed proppants can aggregate in situ to form a stable structure again and therefore reduce the threat of narrowing down the fracture and proppant flowback,which has an important practical significance during oil and gas production.

关键词： Proppant flowback Self-healing elastomer Self-aggregation Adhesion force

Unlocking the potentials of gel conformance for water shutoff in fractured reservoirs: Favorable attributes of the double network gel for enhancing oil recovery

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Petroleum Science 2023年第2期20卷 1005-1017页

作者： Qian-Hui Wu ji-jiang Ge Lei Ding Gui-Cai Zhang School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongPR China Laboratoire Sciences et Ingénierie de la Matière Molle ESPCI ParisPSL University75005ParisFrance Total Energies SE. E&PPôle d’Etudes et Recherche de LacqBP 47LACQ64170France

The double-network prepared with an in-situ monomer gel and a fast-crosslinked Cr(III) gel is introduced to develop a thixotropic and high-strength gel (THSG), which is found to have many advantages over the traditional gels. The THSG gel demonstrates remarkable thermal stability, and no syneresis is observed after 12 months with high salinity brine (95,500 mg/L). Moreover, the SEM and XRD results indicate that the gel is intercalated into the lamellar structures of Na-MMT, where the gel can form a uniform and compact structure. In addition, the THSG gel has an excellent swelling behavior, even in the high salinity brine. In the slim tube experiments, the THSG gel exhibits high rupture pressure and improves blocking capacity after being ruptured. The core flooding results show that a layer of gel filter cake is formed on the face of the fracture, which may be promoted by a high matrix permeability, a small aperture fracture, and a high injection rate. After the gel treatment, the fracture can be completely blocked by the THSG gel. It is found that a high incremental oil recovery (65.3%) can be achieved when the fracture was completely blocked, compared to 40.2% if the gel is ruptured. Although the swelling of ruptured gel can improve oil recovery, part of the injected brine may be channeled through the gel-filled fractures, resulting in a decrease in the sweep efficiency. Therefore, the improved blocking ability by gel swelling (e.g., in fresh water) may be less efficient to contribute to an enhancement of oil recovery. It is also found that the pressure gradient and residual resistance factor to water (Frrw) are higher if the matrix is less permeable, indicating that the fractured reservoir with lower matrix permeability may require a higher gel strength for treatment. The findings of this study may provide novel insights on designing robust double network gels for water shutoff in fractured reservoirs.

关键词： Double network structure Gel swelling Rupture pressure Fractured core Oil recovery factor

On the Mixed Propagator Approach to ρ-ω Mixing

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Communications in Theoretical Physics 2002年第8期38卷 195-199页

作者： YAN Mu-Lin jiang ji-Hao WANG Xiao-Jun CCAST World Laboratory P.O. Box 8730 Beijing 100080 China Center for Fundamental Physics University of Science and Technology of China Hefei 230026 China CCAST World Laboratory P.O. Box 8730 Beijing 100080 China Center for Fundamental Physics University of Science and Technology of China Hefei 230026 China Instite of Theoretical Physics Academia Sinica Beijing 100080 China

The mixed propagator (MP) approach to ρ-ω mixing is discussed. It is found that under the pole-approximation assumption the results of MP approach is not compatible both with the effective Lagrangian theory andwith the experiment measurement criterion. To overcome these inconsistent, we propose a new MP approach in whichthe physical states of ρ and ω are determined by the requirement of experimental measurement to meson resonance. Interms of this new MP approach, the EM pion form factor Fπ and form factors of ρo →π0γ and of ω→πo γ are *** results of Fπ are in good agreement with data. The form factor of ρo →π0γ exhibits a hidden charge-asymmetryenhancement effect which agrees with the prediction of the effective Lagrangian theory.

关键词： isospin breaking, VMD, ρ-ω mixing, decay of vector mesons

Evaluation of hollow fiber T-type zeolite membrane modules for ethanol dehydration

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Chinese Journal of Chemical Engineering 2017年第5期25卷 581-586页

作者： Xuerui Wang ji jiang Dezhong Liu Youquan Xue Chun Zhang Xuehong Gu State Key Laboratory of Materials-Oriented Chemical Engineering College of Chemistry and Chemical EngineeringThe Synergetic Innovation Center for Advanced MaterialsNanjing Tech University

This work presents the design of hollow fiber T-type zeolite membrane modules with different geometric configurations. The module performances were evaluated by pervaporation dehydration of ethanol/water mixtures. Strong concentration polarization was found for the modules with big membrane bundles. The concentration polarization was enhanced at high temperature due to the higher water permeation flux. The increase of feed flow could improve water permeation flux for the membrane modules with small membrane *** fluid dynamics was used to visualize the flow field distribution inside of the modules with different configurations. The membrane module with seven bundles exhibited highest separation efficiency due to the uniform distribution of flow rate. The packing density could be 10 times higher than that of the tubular membrane module. The hollow fiber membrane module exhibited good stability for ethanol dehydration.

关键词： Hollow fiber Module Pervaporation T-type zeolite membrane

The effect of betaine surfactants on the association behavior of associating polymer

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Petroleum Science 2021年第5期18卷 1441-1449页

作者： ji-jiang Ge Tian-Ci Zhang Yi-Ping Pan Xuan Zhang College of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina

The interfacial properties and rheological behavior of surfactant/polymer complex systems were measured to investigate the association behavior of the associating *** with the pure surfactant solution,there are two inflection points in the surface tension curve for the surfactant/polymer complex *** two inflection points are dependent on the surfactant type and polymer *** effect of surfactant on the rheological behavior of polymer can be divided into two ***,the addition of short-chain betaine surfactant is detrimental to the viscosity of polymer solution due to the electrostatic shielding ***,long-chain betaine surfactant also reduces the viscosity of polymer solutions at low ***,when the concentration of the long-chain betaine surfactant is relatively high,the long-chain betaine surfactant could form worm-like micelles that promote the intermolecular association and thus increase the number of associating junctions,thereby resulting in the augmentation of *** it is necessary to apply the long-chain betaine surfactant to build the polymer/surfactant flooding *** interaction model between surfactant and polymer is proposed,which is different from the traditional‘Three-Region Model’.

关键词： Betaine surfactant Associating polymer Surface tension Viscosity Intermolecular association