检索结果-南通市图书馆

Journal of Iron and Steel Research International 2022年第11期29卷 1864-1872页

作者： Wei Ding Kai Yang Yu Gong Li Wang ji-yao hong Wei Li Xue-jun jin Shanghai Key Laboratory of Materials Laser Processing and Modification Shanghai Jiao Tong UniversityShanghai 200240China Institute of Advanced Steels and Materials School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Development and Application Technology of Automotive Steels BaoSteel Research InstituteShanghai 201900China

The effect of retained austenite(RA)with higher mechanical stability on hydrogen embrittlement resistance of a modified 22MnB5(C 0.22,Si 0.8,Mn 1.5,B 0.002,Fe balance,in wt.%)press hardening steel(PHS)has been ***-step quenching and partitioning(Q&P)treatment was applied to PHS,and around 6 vol.%ultra-fine RA was *** ultra-fine RA was found to act as stronger hydrogen trap than dislocations and grain boundaries in martensitic matrix and can decrease the apparent diffusion coefficient of hydrogen from 5.97×10^(-7) to 3.83×10^(-7) cm^(2) s^(-1),which was verified by the combination of thermal desorption spectroscopy analysis and hydrogen permeation *** higher mechanical stability of the ultrafine RA assures enough stability of the hydrogen trap,which results in better hydrogen embrittlement resistance in Q&P-treated PHS than the conventional directly quenched PHS.

关键词： Hydrogen embrittlement Press hardening steel Quenching and partitioning Retained austenite Thermal desorption spectroscopy Hydrogen permeation

Ubiquitin-specific protease 22 enhances intestinal cell proliferation and tissue regeneration after intestinal ischemia reperfusion injury

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2019年第7期25卷 824-836页

作者： An-Long ji Tong Li Guo Zu Dong-Cheng Feng Yang Li Guang-Zhi Wang ji-hong yao Xiao-Feng Tian Department of General Surgery Second Affiliated Hospital of Dalian Medical University Department of Pharmacology Dalian Medical University

BACKGROUND Intestinal ischemia reperfusion(I/R) injury is a serious but common pathophysiological process of many diseases, resulting in a high mortality rate in clinical practice. Ubiquitin-specific protease 22(USP22) acts as regulator of cell cycle progression, proliferation, and tumor invasion. Depleted USP22 expression has been reported to contribute to arrested cell cycle and disrupted generation of differentiated cell types in crypts and villi. However, the role of USP22 in intestinal damage recovery has not been investigated. Therefore, elucidation of the underlying mechanism of USP22 in intestinal I/R injury may help to improve the tissue repair and patient prognosis in clinical *** To investigate the role of USP22 in intestinal cell proliferation and regeneration after intestinal I/R *** An animal model of intestinal I/R injury was generated in male Sprague-Dawley rats by occlusion of the superior mesenteric artery followed by ***'s scoring system was used to grade the damage to the intestinal mucosa. An in vitro model was developed by incubating rat intestinal epithelial IEC-6 cells in hypoxia/reoxygenation conditions in order to simulate I/R in vivo. siRNA and overexpression plasmid were used to regulate the expression of USP22. USP22,Cyclin D1, and proliferating cell nuclear antigen(PCNA) expression levels were measured by Western blot analysis and immunohistochemistry staining. Cell survival(viability) and cell cycle were evaluated using the Cell Counting Kit-8and flow cytometry, *** USP22 expression was positively correlated with the expression levels of PCNA and Cyclin D1 both in vivo and in vitro, which confirmed that USP22 was involved in cell proliferation and intestinal regeneration after intestinal I/R injury. Decreased levels of Cyclin D1 and cell cycle arrest were observed in the USP22 knockdown group(P < 0.05), while opposite results were observed in the USP22 overexpression group(P < 0.05). In

关键词： Ubiquitin-specific protease 22 Proliferation Regeneration Repair Intestinal ischemia-reperfusion

A new ent-labdane diterpenoid lactone from Andrographis paniculata

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2010年第5期21卷 587-589页

作者： Xiao Chi Ma Zhan Ping Gou Chang Yuan Wang ji hong yao Xiu Lan Xin Yuan Lin Ke Xin Liu School of Pharmacy Dalian Medical UniversityDalian 116044China School of Pharmacology Guangdong Medical CollegeDongguan 523808China Biotechnology Application Center Beijing Vocational College of Electronic Science and TechnologyBeijing 100029China

A new ent-labdane diterpenoid lactone was isolated from Andrographis *** structure was identified on the basis of spectral data including 2D NMR.

关键词： Andrographis paniculata Ent-labdane diterpenoid Lactone

维普期刊数据库

Effect of nuclear factor kappa B on intercellular adhesion molecule-1 expression and neutrophil infiltration in lung injury induced by intestinal ischemia/reperfusion in rats

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第3期12卷 388-392页

作者： Xiao-Feng Tian ji-hong yao Ying-Hua Li Xue-Song Zhang Bing-An Fen Chun-Ming Yang Shu-Sen Zheng Department of General Surgery Second Affiliated Hospital of Dalian Medical University Dalian 116027 Liaoning Province China Department of Pharmacology Dalian Medical University Dalian 116027 Liaoning Province China Department of Hepatobiliary and Pancreatic Surgery First Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310003 Zhejiang Province China

AIM： To investigate the role of nuclear factor kappa B （NF-κB） in the pathogenesis of lung injury induced by intestinal ischemia/reperfusion （I/R）, and its effect on intercellular adhesion molecule-1 （ICAM-1） expression and neutrophil infiltration. METHODS： Twenty-four Wistar rats were divided randomly into control, I/R and pyrrolidine dithiocarbamate （PDTC） treatment groups, n = 8 in each. I/R group and PDTC treatment group received superior mysenteric artery （SMA） occluding for 1 h and reperfusion for 2 h. PDTC group was administrated with intraperitoneal injection of 2% 100 mg/kg PDTC 1 h before surgery. Lung histology and bronchia alveolus lung fluid （BALF） protein were assayed. Serum IL-6, lung malondialdehyde （MDA） and myeloperoxidase （MPO） as well as the expression level of NF-κB and ICAM-1 were measured.RESULTS： Lung injury induced by intestinal I/R, was characterized by edema, hemorrhage and neutrophil infiltration as well as by the significant rising of BALF protein. Compared to control group, the levels of serum IL-6 and lung MDA and MPO increased significantly in I/R group （P=0.001）. Strong positive expression of NF-κB p65 and ICAM-1 was observed. After the administration of PDTC, the level of serum IL-6, lung MDA and MPO as well as NF-κB and ICAM-1 decreased significantly （P〈 0.05） when compared to I/R group.CONCLUSION： The activation of NF-κB plays an important role in the pathogenesis of lung injury induced by intestinal I/R through upregulating the neutrophil infiltration and lung ICAM-1 expression. PDTC as an inhibitor of NF-κB can prevent lung injury induced by intestinal I/R through inhibiting the activity of NF-κB.

关键词： Lung injury Intestinal ischemia/reperfusion NF-κB ICAM-1 Neutrophil infiltration

PTEN-induced kinase 1-induced dynamin-related protein 1 Ser637 phosphorylation reduces mitochondrial fission and protects against intestinal ischemia reperfusion injury

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2020年第15期26卷 1758-1774页

作者： Wasim Qasim Yang Li Rui-Min Sun Dong-Cheng Feng Zhan-Yu Wang De-Shun Liu ji-hong yao Xiao-Feng Tian Department of General Surgery The Second Affiliated Hospital of Dalian Medical UniversityDalian 116023Liaoning ProvinceChina Department of Gastrointestinal Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina Department of Pharmacology Dalian Medical UniversityDalian 116044Liaoning ProvinceChina

BACKGROUND Intestinal ischemia reperfusion(I/R)occurs in various diseases,such as trauma and intestinal *** reactive oxygen species(ROS)accumulation and subsequent apoptotic cell death in intestinal epithelia are important causes of I/R ***-induced putative kinase 1(PINK1)and phosphorylation of dynamin-related protein 1(DRP1)are critical regulators of ROS and ***,the correlation of PINK1 and DRP1 and their function in intestinal I/R injury have not been ***,examining the PINK1/DRP1 pathway may help to identify a protective strategy and improve the patient *** To clarify the mechanism of the PINK1/DRP1 pathway in intestinal I/R *** Male C57BL/6 mice were used to generate an intestinal I/R model via superior mesenteric artery occlusion followed by ***’s score was used to evaluate intestinal mucosa *** mitochondrial fission inhibitor mdivi-1 was administered by intraperitoneal ***-2 cells were incubated in vitro in hypoxia/reoxygenation *** interfering RNAs and overexpression plasmids were transfected to regulate PINK1 *** protein expression levels of PINK1,DRP1,p-DRP1 and cleaved caspase 3 were measured by Western *** viability was evaluated using a Cell Counting Kit-8 assay and cell apoptosis was analyzed by TUNEL *** fission and ROS were tested by MitoTracker and MitoSOX *** Intestinal I/R and Caco-2 cell hypoxia/reoxygenation decreased the expression of PINK1 and p-DRP1 *** with mdivi-1 inhibited mitochondrial fission,ROS generation,and apoptosis and ameliorated cell injury in intestinal I/*** PINK1 knockdown or overexpression in vitro,we found that p-DRP1 Ser637 expression and DRP1 recruitment to the mitochondria were associated with ***,we verified the physical combination of PINK1 and p-DRP1 *** PINK1 is correlated with mitochondrial fissi

关键词： Intestinal ischemia reperfusion injury Mitochondrial fission PTEN-induced putative kinase 1 Dynamin-related protein 1 ser637 Phosphorylation Apoptosis

Protection of Veratrum nigrum *** Nakai alkaloids against ischemia-reperfusion injury of the rat liver

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2007年第4期13卷 564-571页

作者： Zhen-Zhen Wang Wei-jie Zhao Xue-Song Zhang Xiao-Feng Tian Yu-Zhu Wang Feng Zhang jin-Chan Yuan Guo-Zhu Han Ke-Xin Liu ji-hong yao Department of Pharmacology Dalian Medical University Dalian 116027 Liaoning Province China Department of Chemical Pharmaceutics Dalian University of Science and Technology Dalian 116027 Liaoning Province China Department of General Surgery Second Affiliated Hospital of Dalian Medical University Dalian 116023 Liaoning Province China

AIM： TO investigate the protective effects and possible mechanisms of Veratrum nigrum L. var. ussuriense Nakai alkaloids （VnA） on hepatic ischemia/reperfusion （I/R） injury in rats. METHODS： Forty male Wistar rats were randomly divided into four experimental groups （n = 10 in each）：（A） Control group （the sham operation group）; （8） I/R group （pretreated with normal saline）; （C） Small-dose （10 μg/kg） VnA pretreatment group; （D） Large-dose （20 μg/kg） VnA pretreatment group. Hepatic ischemia/ reperfusion （Hepatic I/R） was induced by occlusion of the portal vein and the hepatic artery for 90 min, followed by reperfusion for 240 min. The pretreatment groups were administered with VnA intraperitoneally, 30 min before surgery, while the control group and I/R group were given equal volumes of normal saline. Superoxide dismutase （SOD） activity, myeloperoxidase （MPO） activity and nitric oxide （NO） content in the liver tissue at the end of reperfusion were determined and liver function was measured. The expression of intercellular adhesion molecule-1 （ICAM-1） and E-selectin （ES） were detected by immunohistochemical examinations and Western blot analyses. RESULTS： The results showed that hepatic I/R elicited a significant increase in the plasma levels of alanine aminotransferase （ALT： 74.53 ± 2.58 IU/L vs 1512.54 ± 200.76 IU/L, P 〈 0.01） and lactic dehydrogenase （LDH： 473.48 ± 52.17 IU/L vs 5821.53 ± 163.69 IU/L, P 〈 0.01）, as well as the levels of MPO （1.97 ± 0.11 U/g vs 2.57 ± 0.13 U/g, P 〈 0.01） and NO （69.37 ± 1.52 μmol/g protein vs 78.39 ± 2.28 μmol/g protein, P 〈 0.01） in the liver tissue, all of which were reduced by pretreatment with VnA, respectively （ALT： 1512.54 ± 200.76 IU/L vs 977.93 ± 89.62 IU/L, 909.81 ± 132.76 IU/L, P 〈 0.01, P 〈 0.01; LDH： 5821.53 ± 163.69 IU/L vs 3015.44 ± 253.01 IU/L, 2448.75 ± 169.4 IU/L, P 〈 0.01, P 〈 0.01; MPO： 2.57 ± 0.13 U/g vs 2.13 ± 0.13 U/g, 2.07 ± 0.05 U/g, P 〈 0.01, P 〈 0.01; NO： 78.39 ± 2.28 μmol/g protein vs 71.11 ± 1.73 μmol/g

关键词： Veratrum nigrum L.var. ussuriense Nakaialkaloids Hepatic Ischemia/Reperfusion Injury Intracellular adhesion molecule-i E-selectin

Prophylaxis with carnosol attenuates liver injury induced by intestinal ischemia/reperfusion

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2009年第26期15卷 3240-3245页

作者： ji-hong yao Xue-Song Zhang Shu-Sen Zheng Ying-Hua Li Li-Ming Wang Zhen-Zhen Wang Liang Chu Xiao-Wei Hu Ke-Xin Liu Xiao-Feng Tian Department of Pharmacology Dalian Medical University Dalian 116044 Liaoning Province China Department of Heneral Surgery Second Affiliated Hospital of Dalian Medical University Dalian 116023 LiaoningProvince China Department of Hepatobiliary and Pancreatic Surgery First Affiliated Hospital Zhejiang University Schoolof Medicine Hangzhou 310003 Zhejiang Province China

AIM： To investigate the possible protective effects of carnosol on liver injury induced by intestinal ischemia reperfusion （I/R）. METHODS： Rats were divided randomly into three experimental groups： sham, intestinal I/R and carnosol treatment （n = 18 each）. The intestinal I/R model was established by clamping the superior mesenteric artery for 1 h. In the carnosol treatment group, surgery was performed as in the intestinal I/R group, with intraperitoneal administration of 3 mg/kg carnosol 1 h before the operation. At 2, 4 and 6 h after reperfusion, rats were killed and blood, intestine and liver tissue samples were obtained. Intestine and liver histology was investigated. Serum levels of aspartate aminotransferase （AST）, alanine aminotransferase （ALT） and interleukin （IL）-6 were measured. Liver tissue superoxide dismutase （SOD） and myeloperoxidase （IvIPO） activity were assayed. The liver intercellular adhesion molecule-1 （ICAM-1） and nuclear factor κB （NF-κB） were determined by immunohistochemical analysis and western blot analysis. RESULTS： Intestinal I/R induced intestine and liver injury, characterized by histological changes, as well as a significant increase in serum AST and ALT levels. The activity of SOD in the liver tissue decreased after I/R, which was enhanced by carnosol pretreatment. In addition, compared with the control group, carnosol markedly reduced liver tissue MPO activity and serum IL-6 level, which was in parallel with the decreased level of liver ICAI-1 and NF-κB expression. CONCLUSION： Our results indicate that carnosol pretreatment attenuates liver injury induced by intestinal I/R, attributable to the antioxidant effect and inhibition of the NF-κB pathway.

关键词： Carnosol Liver injury Ischemia reperfusion Nuclear factor κB

新型超高强度热冲压用钢的热变形行为及本构关系

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

材料工程 2016年第5期44卷 15-21页

作者：张施琦冯定张跃洪继要非常规油气湖北省协同创新中心武汉430100 长江大学机械工程学院湖北荆州434023 北京科技大学材料科学与工程学院北京100083 汽车用钢开发与应用技术国家重点实验室(宝钢) 上海201900

利用Gleeble-1500D热模拟机对新型超高强度热冲压用钢22MnB5Nb进行等温单向拉伸实验,研究了其在变形温度为650~950℃,应变速率为0.1,1.0,10s^(-1)下的热变形行为,并采用3种本构分析方法,即基于传统拟合回归方法的Arrhenius型、考虑材料... 详细信息

利用Gleeble-1500D热模拟机对新型超高强度热冲压用钢22MnB5Nb进行等温单向拉伸实验,研究了其在变形温度为650~950℃,应变速率为0.1,1.0,10s^(-1)下的热变形行为,并采用3种本构分析方法,即基于传统拟合回归方法的Arrhenius型、考虑材料常数应变补偿的Arrhenius型和本工作新提出的基于Quasi-Newton BFGS算法的Arrhenius型本构方程来描述22MnB5Nb钢的热变形行为。结果表明:22MnB5Nb钢表现出典型的加工硬化和动态回复软化行为,变形温度与应变速率均对其流变应力有较大影响;3种方程均可以准确预测实验钢的峰值流变应力,其中,Quasi-Newton BFGS算法具有可一次性求解所有材料参数、求解步骤简单和预测精度最高(R=0.99578,Re=11.03MPa,E=2.48%)的特点,考虑材料常数应变补偿的Arrhenius型本构方程预测精度相对较低,但能直接预测不同变形条件下的流变应力曲线且可以较好地预测变形过程中的加工硬化效应、动态回复软化效应和应变速率强化效应。

关键词：热冲压用钢热变形行为本构模型 Nb

维普期刊数据库

Evapotranspiration and its components partitioning based on an improved hydrological model: historical attributions and future projections

在线全文

学校读者我要写书评

暂无评论

Journal of Earth Science 2025年

作者： hong Du Sidong Zeng Yongyue ji Jun Xia College of Resources and Environmental Science， South-Central Minzu University Chongqing Institute of Green and Intelligent Technology， Chinese Academy of Sciences Chongqing School， University of Chinese Academy of Sciences State Key Laboratory of Water Resources and Hydropower Engineering Science， Wuhan University

Estimation and attribution of evapotranspiration （ET） and its components under changing environment is still a challenge but is essential for understanding the mechanisms of water and energy transfer subsequently regional water resources management. In this study， an improved hydrological model is developed to estimate evapotranspiration and its components i.e.， evaporation （E） and transpiration （T） by integrated the advantages of hydrological modeling constrained by water balance and the water-carbon close relationships. Results show that the improved hydrological model could captures ET and its components well in the study region. During the past years， annual ET and E increase obviously about 2.40mm/a and 1.42mm/a， particularly in spring and summer accounting for 90%. T shows less increasement and mainly increases in spring while it decreases in summer. Precipitation is the dominant factor and contributes 74.1% and 90.0% increases of annual ET and E， while the attribution of T changes is more complex by coupling of the positive effects of precipitation， rising temperature and interactive influences， the negative effects of solar diming and elevated CO2. In the future， ET and its components tend to increase under most of the Shared Socioeconomic Pathways （SSP） scenarios except for T decreases under the very high emissions scenario （SSP5-8.5） based on the projections. From seasonal perspective， the changes of ET and the components are mainly in spring and summer accounting for 75%， while more slightly changes are found in autumn and winter. This study highlights the effectiveness of estimating ET and its components by improving hydrological model within water-carbon coupling relationships， and more complex mechanisms of transpiration changes than evapotranspiration and evaporation changes under the interactive effects of climate variability and vegetation dynamics. Besides， decision makers should pay attention to the more increases in the undesirable E than desirab

关键词：

沙美特罗丙酸氟替卡松对慢性阻塞性肺疾病患者临床疗效及对免疫功能的影响

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

临床肺科杂志 2015年第4期20卷 646-648页

作者：季宏耀昆山市第二人民医院呼吸科江苏昆山215300

目的探讨沙美特罗丙酸氟替卡松治疗慢性阻塞性肺疾病(简称慢阻肺)患者的临床疗效及其对免疫功能的影响。方法将100例慢阻肺患者随机分为观察组和对照组各50例。对照组采用常规治疗,观察组在此基础上给予沙美特罗丙酸氟替卡松吸入治疗。... 详细信息

目的探讨沙美特罗丙酸氟替卡松治疗慢性阻塞性肺疾病(简称慢阻肺)患者的临床疗效及其对免疫功能的影响。方法将100例慢阻肺患者随机分为观察组和对照组各50例。对照组采用常规治疗,观察组在此基础上给予沙美特罗丙酸氟替卡松吸入治疗。观察两组治疗后21天的临床疗效及治疗前后免疫功能指标变化。结果治疗组的有效率为96.00%明显高于对照组的有效率84.00%,差异有明显的统计学意义(P0.05)。结论沙美特罗丙酸氟替卡松治疗慢阻肺疗效确切,可改善患者免疫功能,值的临床推广应用。

关键词：沙美特罗丙酸氟替卡松慢性阻塞性肺疾病免疫功能

维普期刊数据库