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Thyroid storm in a pregnant woman with COVID-19 infection: A case report and review of literatures

World Journal of Clinical Cases 2023年第4期11卷 888-895页

作者： Hyo-eun Kim Juseok Yang ji-eun park Jong-Chul Baek Hyen-Chul Jo Department of Obstetrics and Gynecology Gyeongsang National University Changwon HospitalChangwon 51472South Korea

BACKGROUND The severe acute respiratory syndrome coronavirus-2(SARS-CoV-2) has been found to be responsible for the recent global pandemic known as coronavirus disease 2019(COVID-19). SARS-CoV-2 infections not only result in significant respiratory symptoms but also cause several extrapulmonary manifestations, such as thrombotic complications, myocardial dysfunction and arrhythmia, thyroid dysfunction, acute kidney injury, gastrointestinal symptoms, neurological symptoms, ocular symptoms, and dermatological complications. We present the first documented case of thyroid storm in a pregnant woman precipitated by *** SUMMARY A 42-year-old multiparous woman at 35 + 2 wk of gestation visited the emergency room(ER) with altered mentation, seizures, tachycardia, and high fever. The patient showed no remarkable events in the prenatal examination, and the nasopharyngeal COVID-19 polymerase chain reaction(PCR) test was positive two days before the ER visit. The results of laboratory tests, such as liver function test,serum electrolytes, blood glucose, blood urea nitrogen, and creatinine, were all within the normal ranges. However, the thyroid function test showed hyperthyroidism, and the nasopharyngeal COVID-19 PCR test was positive, as expected. No specific findings were observed on the brain computed tomography,and there were no signs of lateralization on neurological examination. Fetal heartbeat and movement were good, and there were no significant uterine contractions. The initial impression was atypical eclampsia. However, the patient’s condition worsened, and a cesarean section was performed under general anesthesia;a healthy boy was delivered, and 12 h after delivery, the patient’s seizures disappeared and consciousness was restored. The patient was referred to an endocrinologist for hyperthyroidism, and a thyroid storm with Graves’ disease was diagnosed. Here, SARS-CoV-2 was believed to be the trigger for the thyroid storm, considering that the patient tes

关键词： COVID-19 Hyperthyroidism Pregnancy Thyroid storm Thyrotoxicosis Case report

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Morphology Control of Bi2S3 Nanostructures and the Formation Mechanism

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Chinese Journal of Chemistry 2013年第6期31卷 752-756页

作者： Heejin Kim ji-eun park Kyung Kim Mi-Kyung Han Sung-jin Kim Wooyoung Lee Department of Materials Science and Engineering Yonsei University Seou1120- 749 Korea Department of Chemistry and Nano Science Ewha Womans University Seoul 120-750 Korea

Bismuthinite （Bi2S3）nanostructures were prepared by a hydrothermal method with sodium ethylenediamine- tetraacetate （EDTA-Na2）. The morphology of Bi2S3 nanostructures was changed from a nanorod to a nanoplate by presence of the EDTA-Na2. The altered morphology was caused by the capping effect of EDTA-Na2 with Bi3＋ ions, which induces the suboptimal growth direction due to partially blocking the preferential orientation direction. When the EDTA-Na2/Bi3＋ molar ratio= 1, the growth of Bi2S3 nanostructures was not allowed due to the chelating effect of EDTA-Na2. The obtained Bi2S3 nanorods, stacked nanorods, nanoplates and nanoparticles were characterized using X-ray diffraction （XRD）, transmission electron microscopy （TEM）, high-resolution transmission electron mi- croscopy （HRTEM） and selected area electron diffraction （SAED） pattern. A possible formation mechanism of these morphologies was proposed. The successful synthesis of various morphologies of nanostructured Bi2S3 may open up new possibilities for thermoelectric, electronic and optoelectronic uses of nanodevices based on Bi2S3 nanostructure.

关键词： bismuth sulfide (Bi2S3) hydrothermal nanorod nanoplate thermoelectric material

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The association of stromal antigen 3(STAG3) sequence variations with spermatogenic impairment in the male Korean population

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Asian Journal of Andrology 2020年第1期22卷 106-111页

作者： Yeojung Nam Kyung Min Kang Se Ra Sung ji eun park Yun-Jeong Shin Seung Hun Song Ju Tae Seo Tae Ki Yoon Sung Han Shim Department of Biomedical Science College of Life ScienceCHA UniversitySeongnam 13488Korea Genetics Laboratory Fertility Center of CHA Gangnam Medical CenterCHA UniversitySeoul 06135Korea Department of Urology CHA Gangnam Medical CenterCHA UniversitySeoul 06135Korea Department of Urology Cheil General HospitalSeoul 04619Korea Department of Obstetrics and Gynecology CHA Gangnam Medical CenterSeoul 04637Korea

The stromal antigen 3(STAG3)gene,encoding a meiosis-specific cohesin component,is a strong candidate for causing male infertility,but little is known about this gene so *** identified STAG3 in patients with nonobstructive azoospermia(NOA)and normozoospermia in the Korean *** coding regions and their intron boundaries of STAG3 were identified in 120 Korean men with spermatogenic impairments and 245 normal controls by using direct sequencing and haplotype analysis.A total of 30 sequence variations were identified in this *** the total,seven were exonic variants,18 were intronic variants,one was in the 5’-UTR,and four were in the 3'-*** variations that directly caused NOA were not ***,two variants,c.3669+35C>G(rs1727130)and+198A>T(rs1052482),showed significant differences in the frequency between the patient and control groups(P=0.021,odds ratio[OR]:1.79,95%confidence interval[Cl]:1.098-2.918)and were tightly linked in the linkage disequilibrium(LD)*** pmir-rs1052482A was cotransfected with miR-3162-5p,there was a substantial decrease in luciferase activity,compared with *** result suggests that rsl052482 was located within a binding site of miR-3162-5p in the STAG33'-UTR,and the minor allele,the rs1052482T polymorphism,might offset inhibition by *** are the first to identify a total of 30 single-nucleotide variations(SNVs)of STAG3 gene in the Korean *** found that two SNVs(rs1727130 and rsl052482)located in the 3'-UTR region may be associated with the NOA *** findings contribute to understanding male infertility with spermatogenic impairment.

关键词： linkage disequilibrium meiotic-specific gene single-nucleotide variations spermatogenic impairment stromal antigen 3 gene

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Ssu72 is a T-cell receptor-responsive modifier that is indispensable for regulatory T cells

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Cellular & Molecular Immunology 2021年第6期18卷 1395-1411页

作者： jin-Kwan Lee Seo-Young Koo Hye-Mi Nam Jee-Boong Lee jiwon Ko Kyung-Mo Kim eun-ji park Tae jin Kim Ho Lee Heounjeong Go Chang-Woo Lee Research Institute Curogen TechnologySuwonSouth Korea Department of Molecular Cell Biology Samsung Medical CenterSungkyunkwan University School of MedicineSuwonSouth Korea MOGAM Institute for Biomedical Research GyeonggiSouth Korea Department of Pathology Asan Medical CenterUniversity of Ulsan College of MedicineSeoulSouth Korea Asan Institute for Life Sciences Asan Medical CenterUniversity of Ulsan College of MedicineSeoulSouth Korea Department of Immunology Sungkyunkwan University School of MedicineSeoulSouth Korea Department of Cancer Biomedical Science Graduate School of Cancer Science and PolicyResearch InstituteNational Cancer CenterGyeonggiSouth Korea

The homeostatic balance between effector T cells and regulatory T cells(Tregs)is crucial for adaptive immunity;however,epigenetic programs that inhibit phosphorylation to regulate Treg development,peripheral expression,and suppressive activity are ***,we found that the Ssu72 phosphatase is activated by various T-cell receptor signaling pathways,including the T-cell receptor and IL-2R pathways,and localizes at the cell *** of Ssu72 in T cells disrupts CD4+T-cell differentiation into Tregs in the periphery via the production of high levels of the effector cytokines IL-2 and IFNγ,which induce CD4+T-cell activation and differentiation into effector cell *** also found a close correlation between downregulation of Ssu72 and severe defects in mucosal tolerance in ***,Ssu72 forms a complex with PLCγ1,which is an essential effector molecule for T-cell receptor signaling as well as Treg development and ***72 deficiency impairs PLCγ1 downstream signaling and results in failure of Foxp3 ***,our studies show that the Ssu72-mediated cytokine response coordinates the differentiation and function of Treg cells in the periphery.

关键词： Ssu72 Regulatory T cells FoxP3 T cell receptor Autoimmunity

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马来西亚传统与补充医学监管二十年及其影响

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亚太传统医药 2022年第4期18卷 1-4页

作者： ji-eun park Junhyeok Yi Ohmin Kwon 韩国东方医学研究所全球合作中心韩国大田韩国东方医学研究所韩国传统医学政策小组韩国大田韩国韩医学研究所韩医学数据部韩国大田

目的:从马来西亚传统与补充医学(T&CM)纳入国家医疗保健系统(NHS)的案例中汲取政策成果和经验教训。方法:通过在数据库和网站搜索文献,并使用滚雪球抽样技术保护数据信息,根据世界卫生组织卫生系统框架对数据进行分类和整理。结果:马来... 详细信息

目的:从马来西亚传统与补充医学(T&CM)纳入国家医疗保健系统(NHS)的案例中汲取政策成果和经验教训。方法:通过在数据库和网站搜索文献,并使用滚雪球抽样技术保护数据信息,根据世界卫生组织卫生系统框架对数据进行分类和整理。结果:马来西亚一直致力于传统医学安全和质量的管理,通过制定法律以及循序渐进推进政策和措施的方法将T&CM制度化。结论:马来西亚在实施T&CM政策的经验将对那些正在努力将传统医学纳入NHS的国家产生深远的影响。

关键词：传统与补充医学东盟马来西亚整合制度化世界卫生组织卫生系统框架

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Gastric metastasis from primary lung adenocarcinoma mimicking primary gastric cancer

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World Journal of Gastrointestinal Oncology 2015年第3期7卷 12-16页

作者： Min ji Kim ji Hyung Hong eun Su park Jae Ho Byun Department of Internal Medicine Incheon St.Mary’s HospitalCollege of MedicineThe Catholic University of Korea Division of Medical Oncology Department of Internal MedicineIncheon St.Mary’s HospitalCollege of MedicineThe Catholic University of Korea Department of Hospital Pathology Incheon St.Mary’s HospitalCollege of MedicineThe Catholic University of Korea

Gastric metastases from lung adenocarcinoma are rare. Because gastric metastasis grossly resembles advanced gastric cancer, it is difficult to diagnose gastric metastasis especially when the histology of the primary lung cancer is adenocarcinoma. We describe a case of gastric metastasis from primary lung adenocarcinoma mimicking Borrmann type Ⅳ primary gastric cancer. A 68-year-old man with known lung adenocarcinoma with multiple bone metastases had been experiencing progressive epigastric pain and dyspepsia over one year. Esophagogastroduodenoscopy revealed linitis plasticalike lesions in the fundus of the stomach. Pathologic examination revealed a moderately differentiated adenocarcinoma with submucosal infiltration. Positive immunohistochemical staining for thyroid transcription factor-1(TTF-1) and napsin A(Nap-A) confirmed that the metastasis was pulmonary in origin. The patient had been treated with palliative chemotherapy for the lung cancer and had lived for over fifteen months after the diagnosis of gastric metastasis. Clinicians should be aware of the possibility of gastric metastasis in patients with primary lung adenocarcinoma, and additional immunohistochemical staining for Nap-A as well as TTF-1 may help in differentiating its origin.

关键词： Adenocarcinoma of lung Napsin-A Thyroidtranscription factor-1 Gastric metastasis

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Seismic hazard level reduction for existing buildings considering remaining building lifespans

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Earthquake Engineering and Engineering Vibration 2019年第3期18卷 649-661页

作者： ji-Hun park Division of Architecture and Urban Design Incheon National University

Seismic hazard levels lower than those for design of new buildings have been permitted for seismic evaluation and retrofi t of existing buildings due to the relatively short remaining lifespans. The seismic hazard reduction enables costeff ective seismic evaluation and retrofi t of existing buildings with limited structural capacity. The current study proposes seismic hazard reduction factors for Korea, one of low to moderate seismicity regions. The seismic hazard reduction factors are based on equal probabilities of non-exceedance within diff erent remaining building lifespans. A validation procedure is proposed to investigate equality of seismic risk in terms of ductility-based limit states using seismic fragility assessment of nonlinear SDOF systems, of which retrofi t demands are determined by the displacement coeffi cient method of ASCE 41-13 for diff erent target remaining building lifespans and corresponding reduced design earthquakes. Validation result shows that the use of seismic hazard reduction factors can be permitted in conjunction with appropriate lower bounds of the remaining building lifespans.

关键词： seismic hazard level existing building remaining building lifespan probability of limit state

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Experience of primary intestinal lymphangiectasia in adults: Twelve case series from a tertiary referral hospital

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World Journal of Clinical Cases 2024年第4期12卷 746-757页

作者： ji eun Na ji eun Kim Sujin park eun Ran Kim Sung Noh Hong Young-Ho Kim Dong Kyung Chang Department of Internal Medicine Inje University Haeundae Paik HospitalBusan 48108South Korea Department of Medicine Samsung Medical CenterSeoul 06351South Korea Department of Pathology Samsung Medical CenterSeoul 06351South Korea

BACKGROUND While primary intestinal lymphangiectasia(PIL)is considered a rare condition,there have been several reported cases in ***,the absence of clear guidance from diagnosis to treatment and prognosis poses challenges for both physicians and *** To enhance understanding by investigating clinical presentation,diagnosis,treatment,complications,and prognoses in adult PIL *** We enrolled adult patients diagnosed with PIL between March 2016 and September *** primary outcome involved examining the diagnosis and treatment process of these *** secondary outcomes included identifying complications(infections,thromboembolism)and assessing prognoses(frequency of hospitalization and mortality)during the follow-up *** Among the 12 included patients,peripheral edema(100%)and diarrhea(75%)were the main presenting *** tests showed that all the pati-ents exhibited symptoms of hypoalbuminemia and ***,the predominant findings were edema of the small intestine(67%)and ascites(58%).The typical endoscopic finding with a snowflake appearance was observed in 75%of *** the 12 patients,two responded positive-ly to octreotide and sirolimus,and eight who could undergo maintenance therapy discontinued *** due to PIL led to infection in half of the patients,thromboembolism in three patients,and one *** PIL can be diagnosed in adults across various age groups,with different severity and treatment responses among patients,leading to diverse complications and ***,tailored treatments will be *** anticipate that our findings will contribute to the management of PIL,an etiology of protein-losing enteropathy.

关键词： Primary intestinal lymphangiectasia in adults Protein-losing enteropathy Diagnosis Treatment Prognosis

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Sphingosine-1-phosphate hinders the osteogenic differentiation of dental pulp stem cells in association with AKT signaling pathways

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International Journal of Oral Science 2022年第2期14卷 192-200页

作者： Bongkun Choi ji-eun Kim Si-On park eun-Young Kim Soyoon Oh Hyuksu Choi Dohee Yoon Hyo-jin Min Hyung-Ryong Kim eun-Ju Chang Department of Biomedical Sciences Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Stem Cell Immunomodulation Research Center Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea Department of Pharmacology College of DentistryJeonbuk National UniversityJeonjuKorea Department of Biochemistry and Molecular Biology Asan Medical CenterUniversity of Ulsan College of MedicineSeoulKorea

Sphingosine-1-phosphate(S1P)is an important lipid mediator that regulates a diverse range of intracellular cell signaling pathways that are relevant to tissue engineering and regenerative ***,the precise function of S1P in dental pulp stem cells(DPSCs)and its osteogenic differentiation remains *** here investigated the function of S1P/S1P receptor(S1PR)-mediated cellular signaling in the osteogenic differentiation of DPSCs and clarified the fundamental signaling *** results showed that S1P-treated DPSCs exhibited a low rate of differentiation toward the osteogenic phenotype in association with a marked reduction in osteogenesis-related gene expression and AKT *** note,both S1PR1/S1PR3 and S1PR2 agonists significantly downregulated the expression of osteogenic genes and suppressed AKT activation,resulting in an attenuated osteogenic capacity of *** importantly,an AKT activator completely abrogated the S1P-mediated downregulation of osteoblastic markers and partially prevented S1P-mediated attenuation effects during ***,the pro-inflammatory TNF-αcytokine promoted the infiltration of macrophages toward DPSCs and induced S1P production in both DPSCs and *** findings indicate that the elevation of S1P under inflammatory conditions suppresses the osteogenic capacity of the DPSCs responsible for regenerative endodontics.

关键词： pulp hinder precise

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Effect of angiotensin Ⅱ type 1 receptor blocker and angiotensin converting enzyme inhibitor on the intraocular growth factors and their receptors in streptozotocin-induced diabetic rats

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International Journal of Ophthalmology(English edition) 2017年第6期10卷 896-901页

作者： Ik Soo Byon Dong Hyun Lee eun Sook Jun Min Kyu Shin Sung Who park ji eun Lee Department of Ophthalmology Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital Yangsan 50612 Korea College of Medicine Pusan National University Yangsan 50612 Korea Department of Ophthalmology Biomedical Research Institute Pusan National University Hospital Busan 49241 Korea Balgeunsesang Eye Clinic Busan 47286 Korea

AIM： To investigate the effect of angiotensin II type 1 receptor blocker （ARB） and angiotensin converting enzyme inhibitor （ACEI） on intraocular growth factors and their receptors in streptozotocin-induced diabetic rats. METHODS： Forty Sprague-Dawley rats were divided into 4 groups： control, diabetes mellitus （DM）, candesartan- treated DM, and enalapril-treated DM （each group, n---10）. After the induction of DM by streptozotocin, candesartan [ARB, 5 mg/（kg · d）] and enalapril [ACEI, 10 mg/（kg · d）] were administered to rats orally for 4Wko Vascular endothelial growth factor （VEGF） and angiotensin II （Ang II） concentrations in the vitreous were measured using enzyme-linked immunosorbent assays, and VEGF receptor 2 and angiotensin II type 1 receptor （ATIR） levels were assessed at week 4 by Western blotting. RESULTS： Vitreous Ang II levels were significantly higher in the DM group and candesartan-treated DM group than in the control （P=0.04 and 0.005, respectively）. Vitreous ATIR increased significantly in DM compared to the other three groups （P〈0.007）. Candesartan-treated DM rats showed higher vitreal ATIR concentration than the enalapril-treated DM group and control （P〈0.001 and P=0.005, respectively）. No difference in vitreous Ang II and ATIR concentration was found between the enalapril- treated DM group and control. VEGF and its receptor were below the minimum detection limit in all 4 groups. CONCLUSION： Increased Ang II and ATIR in the hyperglycemic state indicate activated the intraocular renin-angiotensin system, which is inhibited more effectively by systemic ACEI than systemic ARB.

关键词： angiotensin converting enzyme inhibitor angiotensin II type 1 receptor blocker diabetic rat intraocularrenin-angiotensin system

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