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Mechanical strength and corrosion resistance of Al-additive friction stir welded AZ31B joints

Journal of Magnesium and Alloys 2023年第5期11卷 1519-1535页

作者： Jae-Yeon Kim eun-Woo Kim Dong-O Kim eun-Kyo Ju ji-eun lee Jaeheon lee Jai-Won Byeon Mining Engineering Department Colorado School of MinesGoldenCO 80401USA Department of Materials Science and Engineering Seoul National University of Science and TechnologySeoul 01811Republic of Korea

Compared to other structural alloys,magnesium alloys have a relatively poor corrosion resistance and low mechanical strength,which can be further deteriorated when these alloys are subjected to joining processes using the existing joining ***,we propose for the first time an additive friction stir-welding(AFSW)using fine Al powder as an additive to improve the mechanical strength as well as corrosion resistance of AZ31B weld *** is a solid-state welding method of forming a high-Al AZ31B joint via an in-situ reaction between pure Al powders filled in a machined groove and the AZ31B *** optimize the process parameters,AFSW was performed under different rotational and transverse speeds,and number of passes,using tools with a square or screw *** particular,to fabricate a weld zone,where the Al was homogenously dispersed,the effects of the groove shape were investigated using three types of grooves:surface one-line groove,surface-symmetric grooves,and inserted symmetric *** homogenous and defect-less AFS-welded AZ31B joint was successfully fabricated with the following optimal parameters:1400 rpm,25 mm/min,four passes,inserted symmetric grooves,and the tool with a square *** AFSW fully dissolved the additive Al intoα-Mg and in-situ precipitated Mg_(17)Al_(12)particles,which was confirmed via scanning electron microscopy,transmission electron microscope,and X-ray diffraction *** microhardness,joint efficiency,and elongation at the fracture point of the AFS-welded AZ31B joint were 80 HV,101%,and 8.9%,*** values are higher than those obtained for the FS-welded AZ31 joint in previous *** corrosion resistance of the AFS-welded AZ31B joint,evaluated via hydrogen evolution measurements and potentiodynamic polarization tests,was enhanced to 55%relative to the FS-welded AZ31B joint.

关键词： AZ31B magnesium alloy Additive friction stir-welding In-situ reaction Mg_(17)Al_(12)particles Joint efficiency Corrosion resistance

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Exosome-guided direct reprogramming of tumor-associated macrophages from protumorigenic to antitumorigenic to fight cancer

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Bioactive Materials 2023年第7期25卷 527-540页

作者： Hyosuk Kim Hyun-Ju Park Hyo Won Chang ji Hyun Back Su jin lee Yae eun Park eun Hye Kim Yeonsun Hong Gijung Kwak Ick Chan Kwon ji eun lee Yoon Se lee Sang Yoon Kim Yoosoo Yang Sun Hwa Kim Medicinal Materials Research Center Biomedical Research InstituteKorea Institute of Science and TechnologySeoul02792Republic of Korea Department of Functional Genomics KRIBB School of BioscienceKorea University of Science and Technology(UST)Daejeon34141Republic of Korea Department of Otolaryngology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul05505Republic of Korea Chemical&Biological Integrative Research Center Biomedical Research InstituteKorea Institute of Science and TechnologySeoul02792Republic of Korea Department of Biotechnology College of Life Sciences and BiotechnologyKorea UniversitySeoul02841Republic of Korea Department of Life Sciences Korea UniversitySeoul02841Republic of Korea

Highly immunosuppressive tumor microenvironment containing various protumoral immune cells accelerates malignant transformation and treatment *** particular,tumor-associated macrophages(TAMs),as the predominant infiltrated immune cells in a tumor,play a pivotal role in regulating the immunosuppressive tumor *** a potential therapeutic strategy to counteract TAMs,here we explore an exosome-guided in situ direct reprogramming of tumor-supportive M2-polarized TAMs into tumor-attacking M1-type *** derived from M1-type macrophages(M1-Exo)promote a phenotypic switch from anti-inflammatory M2-like TAMs toward pro-inflammatory M1-type macrophages with high conversion *** M1 macrophages possessing protein-expression profiles similar to those of classically activated M1 macrophages display significantly increased phagocytic function and robust cross-presentation ability,potentiating antitumor immunity surrounding the ***,these M1-Exo also lead to the conversion of human patient-derived TAMs into M1-like macrophages that highly express MHC class II,offering the clinical potential of autologous and allogeneic exosome-guided direct TAM reprogramming for arming macrophages to join the fight against cancer.

关键词： Exosome Cancer therapy Tumor microenvironment Tumor-associated macrophage Direct conversion

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Elucidating Ion Transport Phenomena in Sulfide/Polymer Composite Electrolytes for Practical Solid-State Batteries

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Nano-Micro Letters 2023年第10期15卷 416-432页

作者： Kyeong‑Seok Oh ji eun lee Yong‑Hyeok lee Yi‑Su Jeong Imanuel Kristanto Hong‑Seok Min Sang‑Mo Kim Young Jun Hong Sang Kyu Kwak Sang‑Young lee Department of Chemical and Biomolecular Engineering Yonsei University50 Yonsei‑roSeodaemun‑guSeoul 03722Republic of Korea Department of Chemical and Biological Engineering Korea University145 Anam‑roSeongbuk‑guSeoul 02841Republic of Korea School of Energy and Chemical Engineering Ulsan National Institute of Science and Technology(UNIST)50 UNIST‑gilEonyang‑eupUlju‑gunUlsan 44919Republic of Korea Hyundai Motor Company 150Hyundaiyeonguso‑roNamyang‑eupHwaseong‑siGyeonggi‑do 18280Republic of Korea

Despite the enormous interest in inorganic/polymer composite solid-state electrolytes(CSEs)for solid-state batteries(SSBs),the underlying ion transport phenomena in CSEs have not yet been ***,we address this issue by formulating a mechanistic understanding of bi-percolating ion channels formation and ion conduction across inorganic-polymer electrolyte interfaces in CSEs.A model CSE is composed of argyrodite-type Li_6PS_5Cl(LPSCl)and gel polymer electrolyte(GPE,including Li~+-glyme complex as an ion-conducting medium).The percolation threshold of the LPSCl phase in the CSE strongly depends on the elasticity of the GPE ***,manipulating the solvation/desolvation behavior of the Li~+-glyme complex in the GPE facilitates ion conduction across the LPSCl-GPE *** resulting scalable CSE(area=8×6(cm×cm),thickness~40μm)can be assembled with a high-mass-loading LiNi_(0.7)Co_(0.15)Mn_(0.15)O_(2)cathode(areal-mass-loading=39 mg cm~(-2))and a graphite anode(negative(N)/positive(P)capacity ratio=1.1)in order to fabricate an SSB full cell with bi-cell *** this constrained cell condition,the SSB full cell exhibits high volumetric energy density(480 Wh L_(cell)~(-1))and stable cyclability at 25℃,far exceeding the values reported by previous CSE-based SSBs.

关键词： Solid-state batteries Composite solid-state electrolytes Ion transport phenomena Bi-percolating ion channels Interfacial resistance

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Suboptimal Feature Selection Techniques for Effective Malicious Traffic Detection on Lightweight Devices

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1669-1687页

作者： So-eun Jeon Ye-Sol Oh Yeon-ji lee Il-Gu lee Department of Future Convergence Technology Engineering Sungshin Women’s UniversitySeoul02844Korea Department of Convergence Security Engineering SungshinWomen’s UniversitySeoul02844Korea

With the advancement of wireless network technology,vast amounts of traffic have been generated,and malicious traffic attacks that threaten the network environment are becoming increasingly *** signature-based detection methods,static analysis,and dynamic analysis techniques have been previously explored for malicious traffic detection,they have limitations in identifying diversified malware traffic *** research has been focused on the application of machine learning to detect these ***,applying machine learning to lightweight devices like IoT devices is challenging because of the high computational demands and complexity involved in the learning *** this study,we examined methods for effectively utilizing machine learning-based malicious traffic detection approaches for lightweight *** introduced the suboptimal feature selection model(SFSM),a feature selection technique designed to reduce complexity while maintaining the effectiveness of malicious traffic *** performance was evaluated on various malicious traffic,benign,exploits,and generic,using the UNSW-NB15 dataset and SFSM sub-optimized hyperparameters for feature selection and narrowed the search scope to encompass all *** improved learning performance while minimizing complexity by considering feature selection and exhaustive search as two steps,a problem not considered in conventional *** experimental results showed that the detection accuracy was improved by approximately 20%compared to the random model,and the reduction in accuracy compared to the greedy model,which performs an exhaustive search on all features,was kept within 6%.Additionally,latency and complexity were reduced by approximately 96%and 99.78%,respectively,compared to the greedy *** study demonstrates that malicious traffic can be effectively detected even in lightweight device *** verified the possibility of detecting various attack

关键词： Feature selection lightweight device machine learning Internet of Things malicious traffic

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Ascaris-mimicking common bile duct stone: A case report

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World Journal of Clinical Cases 2020年第19期8卷 4499-4504页

作者： Seo-Youn Choi Ha eun Jo Yun Nah lee ji eun lee Min Hee lee San ghyeok Lim Boem Ha Yi Radiology Soonchunhyang University HospitalBucheonBucheon 14584South Korea Digestive disease center and research institute Soonchunhyang University HospitalBucheonBucheon 14584South Korea

BACKGROUND In most cases,it is not difficult to differentiate common bile duct(CBD)stone from Ascaris infection because they are different disease entities and have different imaging *** two diseases usually demonstrate unique characteristic findings on computed tomography or magnetic resonance ***,we report a rare case from our experience in which a CBD stone mimicked and was misdiagnosed as *** SUMMARY A 72-year-old male presented with elevated serum liver *** tomography showed a hyper-attenuated,elongated lesion in the CBD lumen and associated biliary *** resonance cholangiopancreatography and endoscopic retrograde cholangiopancreatography revealed a linear filling defect in the bile ***,elongated echogenic material with a central hypoechogenic area was seen on endoscopic *** the imaging findings caused us to suspect infection with the nematode Ascaris,the lesion was revealed to be a dark-brown-colored CBD stone through endoscopic *** We report a rare case of a CBD stone that mimicked *** also review the literature for side-by-side comparisons of the imaging features of CBD stones and ascariasis.

关键词： Case report Common bile duct Gallstones Ascaris Ascariasis Multidetector computed tomography Magnetic resonance cholangiopancreatography

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Effect of Asiasari radix on osteoblastic differentiation of stem cells derived from gingiva

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Journal of Traditional Chinese Medicine 2016年第6期36卷 756-759页

作者： Su-Hyeon Jeong ji-eun lee Seong-Ho jin Youngkyung Ko Jun-Beom Park Department of Rehabilitation Medicine of Korean Medicine Chungju Hospital of Korean MedicineCollege of Korean Medicine Semyung University Development of Periodontics College of MedicineThe Catholic University of Korea

OBJECTIVE: To examine the dose-dependent impact of Asiasari Radix(A. radix) on the cell viability,differentiation and mineralization of stem cells derived from ***: Stem cells that were derived from gingiva were grown in the presence of A. radix at final concentrations that ranged from 0.001 to 10 μg/m L. The morphology of the cells was viewed under an inverted microscope and the analysis of cell proliferation was performed by using Cell Counting Kit-8(CCK-8) on day 1. The alkaline phosphatase activity test was used to assess differentiation and Alizarin red S staining was used to assess mineralization of treated ***: The control group showed spindleshaped, fibroblast-like morphology and the shapesof the cells in 0.001, 0.01, 0.1, 1 and 10 μg/mL of *** were similar to that of the control group at day 1. The cultures growing in the presence of0.001 μg/m L of A. radix at day 1 showed an increase in the CCK-8 value(P 0.05). Mineralized extracellular deposits were observed after Alizarin Red S staining and the cultures grown in the presence of 0.001 μg/m L of A. radix showed the highest value for quantitative results for bound dye(P < 0.05).CONCLUSION: Within the limits of this study, A. radix influenced the proliferation of stem cells derived from the gingiva and low concentrations of *** might enhance osteogenic differentiation of the stem cells.

关键词：成骨细胞分化胚胎干细胞牙龈细辛碱性磷酸酶活性 CCK-8 细胞增殖细胞形态

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Retinal injury following intravitreal injection of a dexamethasone implant in a vitrectomized eye

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INTERNATIONAL JOURNAL OF OPHTHALMOLOGY 2017年第6期10卷 1019-1020页

作者： lee, Seung Min Jung, Jae Woo Park, Sung Who lee, ji eun Byon, Ik Soo Pusan Natl Univ Yangsan Hosp Res Inst Convergence Biomed Sci & Technol Yangsan 50612 South Korea Pusan Natl Univ Coll Med Dept Ophthalmol Yangsan 50612 South Korea Pusan Natl Univ Biomed Res Inst Busan 49241 South Korea

lee SM, Jung JW, Park SW, lee JE, Byon IS. Retinal injury following intravitreal injection of a dexamethasone implant in a vitrectomized eye. Int J Ophthalmo12017; 10（6）： 1019-1020

关键词： BODY LENS

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Clinical efficacy of combined topical 0.05%cyclosporine A and 0.1%sodium hyaluronate in the dry eyes with meibomian gland dysfunction

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International Journal of Ophthalmology(English edition) 2018年第4期11卷 593-600页

作者： Ho-Yun Kim ji-eun lee Ha-Na Oh Ju-Whan Song Sang-Youp Han Jong-Soo lee Department of Ophthalmology Maryknoll Medical CenterBusan 48972South Korea Department of Ophthalmology Pusan National University Yangsan HospitalYangsan 50612South Korea Department of Ophthalmology Inje University Baek HospitalBusan 47392South Korea Department of Ophthalmology Kosin University hospitalBusan 49267South Korea Sungrno Eye Clinic Busan 48064South Korea Department of Ophthalmology Pusan National University HospitalBusan 49241South Korea Medical Research Institute Pusan National University HospitalBusan 49241South Korea

AIM： To investigate the efficacy of combined topical 0.05% cyclosporine A（CsA; Restasis~？, Allergan pharmaceuticals, USA） and 0.1% sodium hyaluronate treatment in dry eyes with meibomian gland dysfunction（MGD）.METHODS： In a retrospective analysis, 53 patients（106 eyes） with MGD were enrolled and performed lid warm massage for 10 min daily and be instilled preservative free sodium hyaluronate 0.1% eye drops 4 times daily. Patients were divided into subjects treated with topical 0.05% CsA and preservative free sodium hyaluronate vehicle（experimental group, n=74 eyes） and subjects treated with the preservative free sodium hyaluronate vehicle（control group, n=32 eyes）. They were evaluated at baseline and 1, 2, and 3 mo for subjective symptoms and objective signs including tear film break-up time（t BUT）, Schirmer test, corneal staining（CS） score, lid margin telangiectasia（LMT）, meibomian gland secretion（MGS）, and conjunctival injection（CI）.RESULTS： In the short-term treatment, the experimental group showed a statistically significant improvement in the ocular surface disease index（OSDI; P〈0.001）, tBUT（P=0.004）, Schirmer test score（P=0.008） and LMT（P=0.021） by repeated measure ANOVA. Additionally, mean changes from baseline in OSDI（P〈0.001）, tBUT（P=0.001）, Schirmer test score（P=0.029）, CS score（P=0.047）, LMT（P=0.002）, CI（P=0.030） were improved better in the experimental group than in the control group at 3 mo. However, there was no significant difference between the two groups in MGS（P=0.67）.CONCLUSION： In dry eyes with MGD, 0.05% CsA improves the tear film stability as well as subjective ocular discomfort, and is effective in controlling lid margin inflammation.

关键词： 0.05% cyclosporine 0.1% hyauronate meibomian gland dysfunction dry eye

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Comparison of clinical outcomes after femtosecond laser in situ keratomileusis in eyes with low or high myopia

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International Journal of Ophthalmology(English edition) 2020年第11期13卷 1780-1787页

作者： Su Hwan Park Cheng-Ye Che Sung Il Kim Choul Yong Park Jong Heon lee Young Hee Kim ji Won Jung Jong Soo lee ji eun lee Department of Ophthalmology School of MedicinePusan National UniversityYangsan 50612Gyeongnam ProvinceRepublic of Korea Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan HospitalYangsan 50612Gyeongnam ProvinceRepublic of Korea Department of Ophthalmology the Affiliated Hospital of Medical CollegeQingdao UniversityQingdao 266003Shandong ProvinceChina Department of Ophthalmology Dongguk University Ilsan HospitalDongguk University College of MedicineGoyang 10326Gyeonggi ProvinceRepublic of Korea Busan Medical Center Busan 47527Republic of Korea BalGunNun Eye Hospital Busan 47195Republic of Korea

AIM:To compare the clinical results of femtosecond(FS)laser in situ keratomileusis(LASIK)in high myopic patients and low myopic ***:This study included 212 myopic eyes undergoing LASIK using a VisuMax 500kHz FS *** treated eyes were assigned to one of two groups according to preoperative manifest spherical refraction:low myopia group(A,>-4.0 D)and high myopia group(B,0.50 D in spherical equivalent from Iwk to 6mo postoperatively(P=0.005).In terms of postoperative astigmatism,each group had 89.1%and 76.6%within±0.50 D,respectively and there was significant difference(P=0.006).Group A tends to induce smaller HOAs than group ***:FS LASIK is effective and safe for correcting high myopia as well as low ***,high myopic eyes showed more postoperative astigmatism and HOAs which affect visual acuity.

关键词： femtosecond laser LASIK myopia

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Mobile lens- induced angle closure glaucoma and rubeosis iridis in Sturge Weber syndrome

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International Journal of Ophthalmology(English edition) 2015年第5期8卷 1080-1082页

作者： Dong Hyun lee Jonghoon Shin Jae Hyun Seo Ik Soo Byon Jae Ho Jung ji eun lee Department of Ophthalmology Pusan National University Yangsan Hospital Department of Ophthalmology Pusan National University Hospital Research Institute for Convergence of Biomedical Science and Technology Yangsan Pusan National University Hospital Medical Institute School of MedicinePusan National University

Dear Sir,I am Dong Hyun lee from the Department of Ophthalmology at the Pusan National University Yangsan Hospital,Yangsan,***,I present the development of a lens-induced angle closed glaucoma and iris neovascularization in the patient with Sturge Weber syndrome(SWS)with open angle *** consent was obtained from a patient before each procedure The study was conducted in accordance with the tenets of the Declaration of Helsinki.

关键词： induced angle closure glaucoma and rubeosis iridis in Sturge Weber syndrome SWS open IOP Mobile lens Figure

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