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Enhanced subacute ischemic stroke treatment via multistage drug delivery system design for combination therapy

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Science China Chemistry 2025年

作者： Xihan Xu Juan-Juan Li jiamin Li Hui-Yan Zhang Yilin Qi Bing-Sen Shi Tianqi Li Shan-Shan Su Weitao Zhao Chang Chen Zhongying Gong Huiyu Liu Ke-Rang Wang dong-Sheng guo Xue Xue State Key Laboratory of Medicinal Chemical Biology College of Pharmacy Nankai University College of Chemistry State Key Laboratory of Elemento-Organic Chemistry Key Laboratory of Functional Polymer Materials (Ministry of Education) Frontiers Science Center for New Organic Matter Collaborative Innovation Center of Chemical Science and EngineeringNankai University College of Chemistry and Materials Science State Key Laboratory of New Pharmaceutical Preparations and Excipients Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education) Key Laboratory of Chemical Biology of Hebei Province Hebei Research Center of the Basic Discipline of Synthetic Chemistry Hebei University Department of Neurology Tianjin First Central Hospital School of Medicine Nankai University Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of BioprocessBeijing University of Chemical Technology

The management of acute ischemic stroke remains challenging due to its abrupt onset and the narrow treatment window,resulting in high rates of disability and *** therapy for neuroprotection and neurorepair strategies provided new hopes for subacute stroke *** we designed a multistage nanodelivery system that matches the unique microenvironment of the subacute phase of stroke,which utilizes calixarene as a building block to effectively load the neuroprotective drug *** calixarene is designed with glycosidic linkages targeting the glucose transporter 1 (GLUT1)on the blood-brain barrier (BBB) and azo bonds that are responsive to hypoxic ***,the decomposed calixarene molecules themselves possess intrinsic bio-activation to modulate inflammatory responses,achieving a multistage therapeutic approach that transitions from targeting to release and finally to *** approach combines anti-inflammation and neuroprotection,providing a multi-level treatment *** system was validated in a rat model of permanent middle cerebral artery occlusion (pMCAO),demonstrating that intravenous administration of the nanodelivery system repairs brain damage and improves motor function 24 h post-pMCAO *** work offers a precise and integrative strategy for stroke patients missing the acute therapy window to improve functional recovery and enhance the effect of comprehensive treatment.

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Effects of Grain Size and Cryogenic Temperature on the Strain Hardening Behavior of VCoNi Medium‑Entropy Alloys

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Acta Metallurgica Sinica(English Letters) 2023年第6期36卷 973-986页

作者： guo‑dong Liu Xue‑Mei Luo ji‑Peng Zou Bin Zhang Guang‑Ping Zhang Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Key Laboratory for Anisotropy and Texture of Materials Ministry of EducationSchool of Materials Science and EngineeringNortheastern UniversityShenyang 110819China

The mechanical behavior of VCoNi medium-entropy alloys with five different grain sizes at three different temperatures was *** VCoNi alloys with different grain sizes exhibit a traditional strength–ductility trade-off at 77 K,194 K and 293 *** the yield strength and the uniform elongation of the VCoNi alloys with similar grain size increase with decreasing the deformation temperature from 293 to 77 *** strain hardening rate recovery characterized by an evident up-turn behavior at stage II is observed in VCoNi alloys with the grain size above 11.1μ*** is found that the extent of the strain hardening rate recovery increases with increasing grain size or decreasing deformation *** may mainly result from the faster increase in the dislocation multiplication rate caused by the decrease in the dislocation mean free path,the decrease in the absorption of dislocations by grain boundaries and the dynamic recovery from the cross-slip with increasing grain size,as well as the suppressed dynamic recovery at cryogenic *** critical grain sizes for the occurrence of the recovery of strain hardening rate are determined to be around 9.5μm,8.3μm and 3μm for alloys deformed at 293 K,194 K and 77 K,*** basic mechanism for the strain hardening behavior of the VCoNi alloys associated with grain size and deformation temperature is analyzed.

关键词： Medium-entropy alloy Strain hardening rate Cryogenic temperature Grain size Slip band refinement

Enhanced performance of core-shell structured sodium manganese hexacyanoferrate achieved by self-limiting Na^(+)-Cs^(+)ion exchange for sodium-ion batteries

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Rare Metals 2022年第11期41卷 3740-3751页

作者： Yan-dong guo ji-Cheng jiang jian Xie Xin Wang jing-Ze Li dong-Huang Wang Ai-Jun Zhou School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu611731China Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou313001China State Key Laboratory of Silicon Materials School of Materials Science and EngineeringZhejiang UniversityHangzhou310027China

Sodium manganese hexacyanoferrate(NaMnHCF)is a promising cathode material for sodiumion batteries(SIBs)due to its low cost and high energy *** Jahn-Teller effect of Mn,however,leads to the poor structural stability of NaMnHCF,resulting in undesired electrochemical ***,we developed a novel coating strategy and obtained a coreshell structured NaMnHCF through facile Na^(+)-Cs^(+)ion exchange,which naturally produced a robust and insoluble Cs-rich surface layer(CsMnHCF)with several nanometers in thickness on pristine *** is shown that the Csrich surface plays a positive role in the stability of the NaMnHCF structure by prohibiting the leakage of crystal water,stabilizing the solid-liquid interfaces,and solidifying crystal *** electrochemical performance of the core-shell NaMnHCF is dramatically improved with a discharge capacity of 76.3 mAh·g^(-1)after 1000 cycles at 1.0 C and a reversible capacity of 87.0 mAh·g^(-1)at 10.0 C,which is much superior to that of the pristine NaMnHCF with only 26.6 mAh·g^(-1)after 400 cycles and 31 mAh·g^(-1)at 10.0 *** work reports a new method for the synthesis of core-shell NaMnHCF and provides a novel perspective for the development of advanced NaMnHCF cathode for SIBs.

关键词： Sodium manganese hexacyanoferrate Ion-exchange Core-shell structure Surface modification Sodium-ion batteries

A comparison study of hydrogen storage performances of SmMg_(11)Ni alloys prepared by melt spinning and ball milling

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Journal of Rare Earths 2018年第4期36卷 409-417页

作者： Yanghuan Zhang Meng ji Zeming Yuan jingliang Gao Yan Qi Xiaoping dong Shihai guo Key Laboratory of Integrated Exploitation of Baiyun Obo Multi-Metal Resources Inner Mongolia University of Science and Technology Department of Functional Material Research Central Iron and Steel Research Institute Weishan Cisri-Eare Earth Materials Co. Ltd. Department of Mechanical Engineering Hebei University

The melt spinning（MS） and ball milling（BM） technologies are thought to be efficient to prepare nanostructured Mg and Mg-based alloys for improving their hydrogen storage performances. In this paper, two technologies, viz. melt spinning and ball milling, were employed to fabricate the SmMg_（11）Ni alloy. The structure and hydrogen storage performance of these two kinds of alloys were researched in detail. The results reveal that the as-spun and milled alloys both contain nanocrystalline and amorphous structures. By means of the measurement of PCT curves, the thermodynamic parameters of the alloys prepared by MS and BM are ΔN_（Ms）（des） = 82.51 kJ/mol and ΔH_（BM）（des） = 81.68 kJ/mol, respectively, viz.ΔH_（MS）（des）〉 ΔH_（BM）（des）. The as-milled alloy shows a larger hydrogen absorption capacity as compared with the as-spun one. The as-milled alloy exhibits lower onset hydrogen desorption temperature than the as-spun one. As to the as-milled and spun alloys, the onset hydrogen desorption temperatures are557.6 and 565.3 K, respectively. Additionally, the as-milled alloy shows a superior hydrogen desorption property than the as-spun one. On the basis of time that required by desorbing hydrogen of 3 wt% H_2, the as-milled alloy needs 1488.574,390 and 192 s corresponding to hydrogen desorption temperatures 593,613,633 and 653 K, while the as-spun alloy needs 3600,1020,778 and 306 s corresponding to the same temperatures. The dehydrogenation activation energies of the as-milled and spun alloys are 100.31 and105.56 kJ/mol, respectively, the difference of which is responsible for the much faster dehydriding rate of the as-milled alloy.

关键词： Mg-based alloy Melt spinning Ball milling Hydrogen storage kinetics Comparison Rare earths

A review on liquid metals as cathodes for molten salt/oxide electrolysis

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International Journal of Minerals,Metallurgy and Materials 2020年第12期27卷 1588-1598页

作者： Shu-qiang jiao Han-dong jiao Wei-li Song Ming-yong Wang ji-guo TU State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China Institute of Advanced Structure Technology Beijing Institute of TechnologyBeijing 100081China

Compared with solid metals,liquid metals are considered more promising cathodes for molten slat/oxide electrolysis due to their fascinating advantages,which include strong depolarization effect,strong alloying effect,excellent selective separation,and low operating *** this review,we briefly introduce the properties of the liquid metal cathodes and their selection rules,and then summarize development in liquid metal cathodes for molten salt electrolysis,specifically the extraction of Ti and separation of actinides and rare-earth metals in halide *** also review recent attractive progress in the preparation of liquid Ti alloys via molten oxide electrolysis by using liquid metal *** related to high-quality alloy production and large-scale applications are cited,and several research directions to further improve the quality of alloys are also discussed to realize the industrial applications of liquid metal cathodes.

关键词： liquid metal cathodes molten salts molten oxides electrolysis

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CPS固载离子液体催化剂的制备及性能研究

现代化工 2025年第1期45卷 195-200页

作者：徐晨霞吕建华刘继东郭豹李文松河北工业大学化工学院过程工业安全研究中心天津300131

采用改性后的聚苯乙烯树脂CPS为载体,制备了CPS固载3种不同离子液体的催化剂;在无助剂条件下催化CO_(2)和环氧丙烷(PO)转化为碳酸丙烯酯(PC)。利用FT-IR、XPS、SEM、TG对不同催化剂进行表征分析,并比较了3种催化剂的催化性能。结果表明,... 详细信息

采用改性后的聚苯乙烯树脂CPS为载体,制备了CPS固载3种不同离子液体的催化剂;在无助剂条件下催化CO_(2)和环氧丙烷(PO)转化为碳酸丙烯酯(PC)。利用FT-IR、XPS、SEM、TG对不同催化剂进行表征分析,并比较了3种催化剂的催化性能。结果表明,CPS-Imi/COOH表现出最好的催化活性,这是由于—COOH通过形成氢键对PO的C—O键具有较强的极化能力;Br^(-)对PO的亲核攻击也是其容易开环的重要因素。考察了不同反应条件下CPS-Imi/COOH对PO转化率和PC选择性的影响,在110℃、2.5 MPa、3 h的反应条件下,PO转化率为95.8%,PC选择性为98.8%;催化剂循环使用6次后仍保持良好的催化性能。

关键词： CPS固载离子液体二氧化碳环氧丙烷碳酸丙烯酯

Approach to N-Alkoxy-2-oxoindole for Mimicing SERMs Structure

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Chinese Chemical Letters 2005年第12期16卷 1593-1596页

作者： ji Cheng CHU dong Zhi LIU Hong Sheng guo Kang ZHAO School of Chemical Engineering and Technology Tianjin University Tianjin 300072 Medical College Chinese People＇s Armed Police Force Tianjin 300071 College of Pharmaceutical and Biotechnology Tianjin UniversityTianjin 300072

Treatment of N-alkoxyamides with bis（trifluoroacetoxy）iodobenzene generated electron deficient nitrogen species, which readily cyclized onto aromatic ring to give N-alkoxy-2- oxoindoles. The effect of different subs... 详细信息

关键词： N-Alkoxyamides bis(trifluoroacetoxy)iodobenzene intramolecular cyclization

Structurally modulated Li-rich cathode materials through cooperative cation doping and anion hybridization

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Science China Chemistry 2017年第12期60卷 1554-1560页

作者： Xu-dong Zhang ji-Lei Shi jia-Yan Liang Ya-Xia Yin Yu-guo guo Li-Jun Wan CAS Key Laboratory of Molecular Nanostructure and Nanotechnology CAS Research/Education Center for Excellence in Molecular SciencesInstitute of Chemistry Chinese Academy of Sciences School of Chemistry and Chemical Engineering University of Chinese Academy of Sciences

High capacity Li-rich materials are mighty contenders for building rechargeable batteries that coincide with the demand in energy density. Fully realizing the extraordinary capacity involves oxygen evolution and related cation migration, resulting in phase transitions and deteriorations that would hinder their practical application. In an attempt to enhance the anodic redox participation and stabilize the structure at the same time, we proposed a structural modulation strategy with modification on anion hybridization intensifying and cation doping. Spectator ions with large ionic radius were introduced into the lattice during calcination with stannous chloride and the d-p hybridization between transition metal 3 d and oxygen 2 p orbitals was subsequently intensified along with expelling weakly bonded chloride species in the reheating process. Both of the reversible capacity and stability upon cycling were remarkably improved through the cooperation of bond alteration and dopant. This strategy might provide new insight into the modulation of the structure to truly fulfill the potential of Li-rich materials.

关键词： Li-ion batteries cathode materials structural modification doping anodic redox

Catalytic Oxidation of Hexanol to Hexanal with H_2O_2 Over P-W Heteropoly Compounds

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Chemical Research in Chinese Universities 2001年第3期17卷 293-298页

作者： ZHOU Guang-dong guo Xiao-hong LIU Yan BI Ying-li ZHEN Kai-ji Department of Chemistry Jilin UniversityChangchun 130023P.R.China

The syntheses of Keggin and Dawson-structural phospho-tungsto heteropoly compounds and their Peroxo-derivatives(PCWP), and the catalytic performance over this series of catalysts for the selective oxidation of hexanol to hexylaldehyde are reported. By means of IR, NMR and UV-DRS techniques the catalysts were characterized and a comparison of the structural properties of these catalysts before and after the reaction was made. The correlation between the catalytic performance and the structure of this series of catalysts was discussed as well.

关键词： P-W Heteropoly compound Hexanol Hexanal