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Effect of metronome rates on the quality of bag-mask ventilation during metronome-guided 30:2 cardiopulmonary resuscitation:A randomized simulation study

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World Journal of Emergency Medicine 2017年第2期8卷 136-140页

作者： ji Ung Na Sang Kuk Han Pil Cho Choi Dong Hyuk shin Department of Emergency Medicine Kangbuk Samsung HospitalSungkyunkwan University School of MedicineSeoulKorea

BACKGROUND: Metronome guidance is a feasible and effective feedback technique to improve the quality of cardiopulmonary resuscitation(CPR). The rate of the metronome should be set between 100 to 120 ticks/minute and the speed of ventilation may have crucial effect on the quality of ventilation. We compared three different metronome rates(100, 110, 120 ticks/minute) to investigate its effect on the quality of ventilation during metronome-guided 30:2 ***: This is a prospective, randomized, crossover observational study using a Respi Trainer r. To simulate 30 chest compressions, one investigator counted from 1 to 30 in cadence with the metronome rate(1 count for every 1 tick), and the participant performed 2 consecutive ventilations immediately following the counting of 30. Thirty physicians performed 5 sets of 2 consecutive(total 10) bag-mask ventilations for each metronome rate. Participants were instructed to squeeze the bag over 2 ticks(1.0 to 1.2 seconds depending on the rate of metronome) and defl ate the bag over 2 ticks. The sequence of three different metronome rates was ***: Mean tidal volume significantly decreased as the metronome rate was increased from 110 ticks/minute to 120 ticks/minute(343±84 m L vs. 294±90 m L, P=0.004). Peak airway pressure significantly increased as metronome rate increased from 100 ticks/minute to 110 ticks/minute(18.7 vs. 21.6 mm Hg, P=0.006).CONCLUSION: In metronome-guided 30:2 CPR, a higher metronome rate may adversely affect the quality of bag-mask ventilations. In cases of cardiac arrest where adequate ventilation support is necessary, 100 ticks/minute may be better than 110 or 120 ticks/minute to deliver adequate tidal volume during audio tone guided 30:2 CPR.

关键词： Non-invasive ventilation Resuscitation Cardiac arrest Cardiopulmonary resuscitation

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IL-1β activates p44/42 and p38 mitogen-activated protein kinases via different pathways in cat esophageal smooth muscle cells

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World Journal of Gastroenterology 2006年第5期12卷 716-722页

作者： Tai Sang Lee Hyun Ju Song ji Hoon Jeong Young Sil Min Chang Yell shin Uy Dong Sohn Department of Pharmacology College of PharmacyChung-Ang UniversitySeoul 156-756Republic of Korea Research Laboratory Dong-A Pharmaceuticals Co.LtdKyunggidoRepublic of Korea

AIM： To examine the pathway related to the IL-1β induced activation of mitogen-activated protein （MAP） kinases in cat esophageal smooth muscle cells. METHODS： Culture of the esophageal smooth muscle cells from cat was prepared. Specific inhibitors were treated before applying the IL-β3. Western blot analysis was performed to detect the expressions of COX, iNOS and MAP kinases. RESULTS： In the primary cultured cells, although IL-β3 failed to upregulate the COX and iNOS levels, the levels of the phosphorylated forms of 1344142 HAP kinase and p38 MAP kinase increased in both concentration- and time-dependent manner, of which the level of activation reached a maximum within 3 and 18 h, respectively. The pertussis toxin reduced the level of p44/42 MAP kinase phosphorylation. Tyrphostin 51 and genistein also inhibited this activation. Neomycin decreased the density of the p44/42 HAP kinase band to the basal level. Phosphokinase C （PKC） was found to play a mediating role in the IL-1β-induced p44/42 MAP kinase activity. In contrast, the activation of p38 MAP kinase was inhibited only by a pretreatment with forskolin, and was unaffected by the other compounds. CONCLUSION： Based on these results, IL-1β-induced p44/42 MAP kinase activation is mediated by the Gi protein, tyrosine kinase, phospholipase C （PLC） and PKC. The pathway for p38 MAP kinase phosphorylation is different from that of p44/42 MAP kinase, suggesting that it plays a different role in the cellular response to IL- 1β.

关键词： IL-1β MAP kinase Esophageal smoothmuscle cells

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PD-1 blockade-unresponsive human tumor-infiltrating CD8^(+)T cells are marked by loss of CD28 expression and rescued by IL-15

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Cellular & Molecular Immunology 2021年第2期18卷 385-397页

作者： Kyung Hwan Kim Hong Kwan Kim Hyung-Don Kim Chang Gon Kim Hoyoung Lee ji Won Han Seong jin Choi Seongju Jeong Minwoo Jeon Hyunglae Kim jiae Koh Bo Mi Ku Su-Hyung Park Myung-Ju Ahn Eui-cheol shin Graduate School of Medical Science and Engineering Korea Advanced Institute of Science and TechnologyDaejeonRepublic of Korea Department of Thoracic and Cardiovascular Surgery Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea Biomedical Science and Engineering Interdisciplinary Program Korea Advanced Institute of Science and TechnologyDaejeonRepublic of Korea Research Institute for Future Medicine Samsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea Department of Radiation Oncology Yonsei Cancer CenterYonsei University College of MedicineSeoulRepublic of Korea Division of Hematology-Oncology Department of MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoulRepublic of Korea

Blockade of programmed death-1(PD-1)reinvigorates exhausted CD8^(+)T cells,resulting in tumor regression in cancer ***,reinvigoration of exhausted CD8^(+)T cells following PD-1 blockade was shown to be CD28-dependent in mouse ***,we examined the role of CD28 in anti-PD-1 antibody-induced human T cell reinvigoration using tumor-infiltrating CD8^(+)T cells(CD8^(+)TILs)obtained from non-small-cell lung cancer ***-cell analysis demonstrated a distinct expression pattern of CD28 between mouse and human CD8^(+)***,we found that human CD28^(+)CD8^(+)but not CD28^(–)CD8^(+)TILs responded to PD-1 blockade irrespective of B7/CD28 blockade,indicating that CD28 costimulation in human CD8^(+)TILs is dispensable for PD-1 blockade-induced reinvigoration and that loss of CD28 expression serves as a marker of anti-PD-1 antibody-unresponsive CD8^(+)*** and phenotypically,PD-1 blockade-unresponsive human CD28^(–)PD-1^(+)CD8^(+)TILs exhibited characteristics of terminally exhausted CD8^(+)T cells with low TCF1 ***,CD28^(–)PD-1^(+)CD8^(+)TILs had preserved machinery to respond to IL-15,and IL-15 treatment enhanced the proliferation of CD28^(–)PD-1^(+)CD8^(+)TILs as well as CD28^(+)PD-1^(+)CD8^(+)*** together,these results show that loss of CD28 expression is a marker of PD-1 blockade-unresponsive human CD8^(+)TILs with a TCF1–signature and provide mechanistic insights into combining IL-15 with anti-PD-1 antibodies.

关键词： anti-PD-1 T cells TCF1 CD28 IL-15

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Effects of edible insect extracts on the antioxidant, physiochemical, and microbial properties of Tteokgalbi during refrigerated storage

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Food Bioscience 2023年第2期52卷 326-333页

作者： Hae In Yong Tae-Kyung Kim ji Yoon Cha Jae Hoon Lee Min-cheol Kang Samooel Jung Yun-Sang Choi Research Group of Food Processing Korea Food Research InstituteWanju55365Republic of Korea Division of Animal and Dairy Science Chungnam National UniversityDaejeon34134Republic of Korea

In this study,Tteokgalbi,a meat product,was prepared with edible insect larvae extracts and its antioxidant,physiochemical,and microbial properties were evaluated during refrigerated *** prepared with 2%*** and 2%*** showed the highest radical-scavenging activity and metal-chelating activity,but the lowest thiobarbituric acid reactive substance(TBARS)value,among the treatments(P<0.05).In addition,those antioxidant activities were the lowest and the TBARS value was the highest in control Tteokgalbi(P<0.05)during all storage *** prepared with 2%*** showed the highest brownness index,pH,and cooking yield,but the lowest shear force value(P<0.05).During all storage days,the total aerobic bacteria level did not differ significantly among the *** conclusion,*** extracts(2%)were effective as antioxidants,inhibiting lipid oxidation,and improving the quality properties of Tteokgalbi,without negatively affecting microbial *** results confirmed that the edible insect extracts have industrial value as a food additive.

关键词： Edible insect Lipid oxidation Natural antioxidant Refrigerated storage Tteokgalbi

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Interventional management of tracheobronchial strictures

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World Journal of Radiology 2010年第8期2卷 323-328页

作者： ji Hoon shin Department of Radiology and Research Institute of Radiology University of Ulsan College of MedicineAsan Medical Center 388-1Pungnap-2dongSongpa-guSeoul 138-736South Korea

Tracheobronchial balloon dilation and stent placement have been well used in the treatment of patients with benign and/or malignant *** dilation is the first option in the treatment of benign airway *** balloon dilation is simple and fast,recurrence rate is *** placement promptly relieves acute airway distress from malignant extraluminal and intraluminal airway *** stent placement may be an alternative for benign airway strictures refractory to balloon *** article reviews the indications,pre-procedure evaluation,technique,outcomes and complications of balloon dilation and stent placement with regard to benign and malignant tracheobronchial stenoses.

关键词： Stent placement Tracheobronchial balloon dilation Tracheobronchial strictures

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Corrosion Behavior of MgZnCa Bulk Amorphous Alloys Fabricated by Spark Plasma Sintering

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Acta Metallurgica Sinica(English Letters) 2016年第9期29卷 793-799页

作者： Feng-Xiang Qin Chuan ji Zhen-Hua Dan Guo-Qiang Xie Hao Wang shin-Ichi Yamaura Mitsuo Niinomi Yang-De Li School of Materials Science and Engineering Nanjing University of Science and Technology Institute for Materials Research Tohoku University College of Materials Science and Engineering Nanjing TECH University WPI-AIMR Tohoku University Dongguan Eontech Co. Ltd

Centimeter-sized Mg65Zn30Ca5 bulk amorphous alloys were fabricated by the spark plasma sintering process from the amorphous powders with a size smaller than 5 la m prepared by ball-milling. The sintered Mg65Zn30Ca5 samples were in an amorphous state when the spark plasma sintering was performed at a temperature of 383 K under a pressure of 600 MPa. The data of polarization curves presented that the sintered Mg65Zn30Ca5 bulk amorphous alloys exhibited higher corrosion resistance than pure Mg and AZ31B alloy owing to high content of Zn and homogeneous structure. A calcium phosphate compound layer was formed on the sintered Mg65Zn30Ca5 bulk amorphous sample after immersion in Hanks＇ solution, which is effective in improving corrosion resistance and bioactivity. The sintered MgZnCa bulk amorphous alloys with large dimensions broaden the potential application of bulk amorphous alloys in the biomedical fields.

关键词： Mg Bulk amorphous alloys Spark plasma sintering Corrosion behavior Biomedical applications

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Malicious Node Detection Using Confidence Level Evaluation in a Grid-Based Wireless Sensor Network

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Wireless Sensor Network 2013年第3期5卷 52-60页

作者： Min-cheol shin Yoon-Hwa Choi Department of Computer Engineering Hongik University Seoul Korea

In this paper, we present a malicious node detection scheme using confidence-level evaluation in a grid-based wireless sensor network. The sensor field is divided into square grids, where sensor nodes in each grid form a cluster with a cluster head. Each cluster head maintains the confidence levels of its member nodes based on their readings and reflects them in decision-making. Two thresholds are used to distinguish between false alarms due to malicious nodes and events. In addition, the center of an event region is estimated, if necessary, to enhance the event and malicious node detection accuracy. Experimental results show that the scheme can achieve high malicious node detection accuracy without sacrificing normal sensor nodes.

关键词： Sensor Networks Malicious Node Detection Grid-Based WSN Faults Confidence Levels

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Induction of vascular endothelial growth factor receptor expression in human umbilical vein endothelial cells after repeated bevacizumab treatment in vitro

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International Journal of Ophthalmology(English edition) 2017年第7期10卷 1064-1068页

作者： ji Eun Lee jin Young Kim Jae Ho Jung Dong Hoon shin Sung Who Park Department of Ophthalmology School of MedicinePusan National University Medical Research Institute Pusan National University Hospital Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan Hospital Department of Pathology School of MedicinePusan National University

AIM： To investigate the mechanism underlying the loss of responsiveness to anti-vascular endothelial growth factor（VEGF） treatment after repeated injections for choroidal neovascularization, VEGF and VEGF receptor（VEGFR） expressions were evaluated following repeated bevacizumab treatments in hypoxic human umbilical vein endothelial cells（HUVECs） in ***： HUVECs were incubated under hypoxic conditions in two media of different bevacizumab concentrations（1.0 or 2.5 mg/m L） for 17 h, and then in a new medium without bevacizumab for 7h. This procedure was repeated twice more. A culture with an identical volume of excipients served as the control. Cytotoxicity and cell proliferation were assessed using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide and Ki-67 assays, respectively. Levels of VEGF and VEGFR were assessed using enzyme-linked immunosorbent assay and Western blot ***： Cytotoxic effects were not reported for either bevacizumab concentration. Cell proliferation was not reduced after anti-VEGF treatments. VEGF level after single treatment was significantly higher than that of the control and after repeated treatments. Phosphorylated VEGFR-2 expression increased significantly after singleand repeated bevacizumab treatments compared with the control. The 1.0 mg/m L bevacizumab induced significantly higher expressions of VEGFR-2 than the 2.5 mg/m L in single and repeated treatment ***： Bevacizumab treatment of HUVECs elevated VEGFR expression in both single and repeated treatments, indicating a mechanism for the reduced efficacy of anti-VEGF therapy in ocular neovascular disorders.

关键词： vascular endothelial growth factor vascular endothelial growth factor receptor choroidal neovascularization bevacizumab repeated treatments

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Enhanced third-harmonic generation by manipulating the twist angle of bilayer graphene

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Light(Science & Applications) 2021年第2期10卷 176-185页

作者： Seongju Ha Nam Hun Park Hyeonkyeong Kim jiseon shin Jungseok Choi Sungmin Park ji-Yun Moon Kwanbyung Chae Jeil Jung Jae-Hyun Lee Youngdong Yoo ji-Yong Park Kwang Jun Ahn Dong-Il Yeom Department of Energy Systems Research Ajou University206 Worldcup-roYeongtong-guSuwon 16499Republic of Korea Korea Research Institute of Standards and Science Daejeon 34113Republic of Korea Department of Physics University of Seoul163 SiripdaeroDongdaemun-guSeoul 02504Republic of Korea Department of Smart Cities University of Seoul163 SiripdaeroDongdaemun-guSeoul 02504Republic of Korea Department of Materials Science and Engineering Ajou University206 Worldcup-roYeongtong-guSuwon 16499Republic of Korea Department of Chemistry Ajou University206 Worldcup-roYeongtong-guSuwon 16499Republic of Korea Department of Physics Ajou University206 Worldcup-roYeongtong-guSuwon 16499Republic of Korea

Twisted bilayer graphene(tBLG)has received substantial attention in various research fields due to its unconventional physical properties originating from Moire *** electronic band structure in tBLG modified by interlayer interactions enables the emergence of low-energy van Hove singularities in the density of states,allowing the observation of intriguing features such as increased optical conductivity and photocurrent at visible or near-infrared ***,we show that the third-order optical nonlinearity can be considerably modified depending on the stacking angle in *** third-harmonic generation(THG)efficiency is found to significantly increase when the energy gap at the van Hove singularity matches the three-photon resonance of incident *** study on electrically tuneable optical nonlinearity reveals that the gate-controlled THG enhancement varies with the twist angle in tBLG,resulting in a THG enhanced up to 60 times compared to neutral monolayer *** results prove that the twist angle opens up a new way to control and increase the optical *** tBLG,,suggesting rotation-induced tuneable nonlinear optics in stacked two-dimensional material systems.

关键词： twist angle harmonic

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Helicobacter pylori eradication with moxifloxacin-containing therapy following failed first-line therapies in South korea

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World Journal of Gastroenterology 2014年第22期20卷 6932-6938页

作者： Kyu Keun Kang Dong Ho Lee Dong Hyun Oh Hyuk Yoon cheol Min shin Young Soo Park Nayoung Kim Hyun Chae Jung Department of Internal Medicine Seoul National University Bundang HospitalSeongnamGyeongi-do 463-707South Korea Department of Internal Medicine Seoul National University College of MedicineSeoul 100-744South Korea

AIM: To investigate moxifloxacin-containing triple therapy as second-line treatment for Helicobacter pylori (H. pylori) infection following failed first-line treatment.

关键词： Fluoroquinolones Helicobacter pylori Disease eradication Drug resistance Second-line

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