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Preparation of polymer-supported phosphine from ferrocene for palladium-catalyzed Suzuki-Miyaura cross-coupling reactions

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Chinese Chemical Letters 2007年第1期18卷 37-40页

作者： Hong Wei Yu Qing Song Tong Yi Ru Peng Li jia ji cheng shi Zi Lin jin State Key Laboratory of Fine Chemicals Dalian University of Technology Dalian 116012 China Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China College of Chemistry and Materials Science Fujian Provincial Key Laboratory of Polymer Materials Fujian Normal University Fuzhou 350007 China

Polymer-supported phosphine ligand 3b derived from ferrocene was prepared, and applied in palladium-catalyzed Suzuki- Miyaura reactions. A range of aryl bromides can couple with phenylboronic acid to obtain correspond... 详细信息

关键词： Immobilization Palladium Suzulki-Miyaura reaction Biaryl Catalysis

Quantitative Trait Loci for Yield Traits Located Between Hd3a and Hd1 on Short Arm of Chromosome 6 in Rice

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Rice science 2011年第4期18卷 257-264页

作者： Ye-yang FAN Chen CHEN ji-rong WU shi-hua cheng jie-yun ZHUANG Chinese National Center for Rice Improvement / State Key Laboratory of Rice Biology China National Rice Research Institute Hangzhou 310006 China

QTLs for heading date located in the regions of Hd3a and Hd1 were detected using an F2:3 population developed from a residual heterozygous line(RHL) identified from the recombinant inbred lines of the indica rice cross Zhenshan 97B /Milyang *** in coupling phase between the QTLs for heading date and yield traits detected in a previous study was *** more F2:3 populations were each developed from an RHL that was homozygous at Hd3a and Hd1 but heterozygous in a portion of the intervals flanked by Hd3a and *** for grain yield per plant,number of panicles per plant,number of grains per panicle and 1000-grain weight were detected in the heterozygous *** sets of near-isogenic lines(NILs) with overlapping heterogenous segments covering the interval RM6119-RM6779 were developed and used to validate and delimitate the QTLs.A QTL conferring a consistent effect for the number of grains per panicle was located within the interval RM19615-RM19652 that corresponded to a 514.4-kb region on chromosome *** same region might have pleiotropic effects on the other three yield-related traits analyzed,but the effects varied greatly among different populations and across different *** study suggests that it is possible to develop a population with little variation on heading date and to identify QTLs for yield traits that might not be associated with heading date by using the information of physical positions of DNA markers and cloned genes.

关键词： rice yield trait heading date quantitative trait locus residual heterozygous line

Regulating effect of Chinese herbal medicine on the peritoneal lymphatic stomata in enhancing ascites absorption of experimental hepatofibrotic mice

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World Journal of Gastroenterology 2002年第2期8卷 333-337页

作者： ji-cheng Li shi-Ping Ding,Department of Lymphology,Department of Histology and Embryology, Medical College of Zhejiang University,Hangzhou 310031,Zhejiang Province,China jian Xu,Hangzhou First People’ s Hospital,Hangzhou 310006,Zhejiang Province,China Department of Lymphology Department of Histology and Embryology Medical College of Zhejiang University Hangzhou 310031 Zhejiang Province China. lijc@***

AIM: To observe the regulatory effect of Chinese herbal medicine on peritoneal lymphatic stomata and its significance in treating ascites in liver fibrosis model mice. METHODS: Two Chinese herbal composite prescriptions were used separately to treat the carbon tetrachloride-induced mouse model of liver fibrosis. The histo-pathologic changes of the liver sections (HE and VG stainings) were observed. The peritoneal lymphatic stomata was detected by scanning electron microscopy and computer image processing. The changes of urinary volume and sodium ion concentration were measured. RESULTS: In the model group, lots of fibrous tissue formed in liver and extended into the hepatic lobules to separate them incompletely. In the treated and prevention groups, the histo-pathologic changes of liver was rather milder, only showed much less fibrous tissue proliferation in the hepatic lobules. The peritoneal lymphatic stomata enlarged with increased density in the experimental groups (diameter: PA, 3.07 +/- 0.69 microm; PB, 2.82 +/- 0.37 microm; TA, 3.25 +/- 0.82 microm and TB, 2.82 +/- 0.56 microm; density: PA, 7.11 +/- 1.90 stomata.1000 microm(-2); PB, 8.76 +/- 1.45 stomata.1000 microm(-2); TA, 6.55 +/- 1.44 stomata.1000 microm(-2)and TB, 8.76+/-1.79 stomata.1000 microm(-2)), as compared with the model group (diameter: 2.00+/-0.52 microm density: 4.45+/-1.05 stomata.1000 microm(-2)). After treatment, the urinary volume and sodium ion excretion increased in the experimental groups (PA, 231.28+/-41.09 mmol.L(-1); PB, 171.69 +/- 27.48 mmol.L(-1) and TA, 231.44 +/- 34.12 mmol.L(-1)), which were significantly different with those in the model group (129.33 +/- 36.75 mmol.L(-1)). CONCLUSION: Chinese herbal medicine has marked effects in alleviating liver fibrosis, regulating peritoneal lymphatic stomata, improving the drainage of ascites from peritoneal cavity and causing increase of urinary volume and sodium ion excretion to reduce the water and sodium retention, and thus have favora

关键词： Phytotherapy Animals Ascites Carbon Tetrachloride Chlorides Drugs, Chinese Herbal Liver Liver Cirrhosis, Experimental Lymph Nodes Male Medicine, Chinese Traditional Mice Peritoneum Potassium Random Allocation Research Support, Non-U.S. Gov't Sodium

Association between age at diagnosis of diabetes and ocular disease:Insights from a recent article

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World Journal of Diabetes 2025年第1期16卷 211-216页

作者： shi-Qi Liu Dong Wang cheng-Chun Tang Department of Cardiology Zhongda HospitalSoutheast UniversityNanjing 210009Jiangsu ProvinceChina School of Medicine Southeast UniversityNanjing 210009Jiangsu ProvinceChina

In this article,we discuss Ye et al's recent article on the association between age at diabetes diagnosis and subsequent risk of age-related ocular *** study,which utilized United Kingdom Biobank data,highlighted a strong link between early diabetes onset and major eye conditions,such as cataracts,glaucoma,agerelated macular degeneration,and vision loss,independent of glycemic control and disease *** finding challenges the previous belief that diabetic eye disease primarily correlates with *** lifestyles evolve and the age of diabetes diagnosis decreases,understanding this relationship may reveal the complex pathogenesis underlying diabetes-related *** editorial summarizes potential mechanisms connecting the age of diabetes onset with four types of ocular diseases,emphasizing the significance of early diagnosis.

关键词： Diabetes Age at diagnosis Cataract Glaucoma Age-related macular disease Vision acuity

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao De-En Xu Ming-Lei Wu ji-Chuan Liu Zi-Ling shi Quan-Hong Ma Department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

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基于托肯数不均匀性的安检流程标准化研究

中国标准化 2017年第10期 77-82页

作者：曹诚季士诚晏雷云南大学西南大学重庆大学

随着交通流量的不断增大,安检流程的标准化变得越加重要。为了保障旅客出行顺利提高安检效率,本文通过采用佩特里网和马尔可夫链相结合的方法,针对非标准化一般安检流程进行瓶颈判断及仿真优化分析研究。

关键词：安检瓶颈佩特里网马尔科夫链

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温度场下LNG储罐外罐地震响应研究进展

当代化工 2023年第5期52卷 1159-1162页

作者：李文季成石葛楠东北石油大学黑龙江大庆163318

储罐是储存低温液化天然气(LNG)的重要装置,研究它的安全性、稳定性和耐久性一直以来都是人们关注的重点对象。在地震作用下往往会导致LNG储罐罐体破裂,产生温度场变化,导致低温液体发生泄漏。因此对LNG储罐进行地震响应分析是很有价值... 详细信息

储罐是储存低温液化天然气(LNG)的重要装置,研究它的安全性、稳定性和耐久性一直以来都是人们关注的重点对象。在地震作用下往往会导致LNG储罐罐体破裂,产生温度场变化,导致低温液体发生泄漏。因此对LNG储罐进行地震响应分析是很有价值的研究方向。首先对LNG储罐温度场的研究现状以及其地震响应分析和流固耦合进行研究综述,指出了温度场变化及地震作用对LNG储罐造成的不利影响,并对未来地震响应下LNG储罐的研究提供了建议,为今后的研究工作奠定基础。

关键词：储罐泄漏温度场地震响应流固耦合

Antiviral therapy for hepatitis B virus infection is beneficial for the prognosis hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 1-9页

作者： Hui Wan Yu-Xin Zhang Guan-Yue Shan Jun-Ya cheng Duan-Rui Qiao Yi-Ying Liu Wen-Na shi Hai-Jun Li Institute of Translational Medicine The First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina Department of Bioengineering Pharmacy School of Jilin UniversityChangchun 130061Jilin ProvinceChina Institute of Liver Diseases Institute of Translational MedicineThe First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina

In this editorial,we comment on the article by Mu et al,published in the recent issue of the World Journal of Gastrointestinal *** pay special attention to the immune tolerance mechanism caused by hepatitis B virus(HBV)infection,the pathogenesis of hepatocellular carcinoma(HCC),and the role of antiviral therapy in treating HCC related to HBV *** infection leads to systemic innate immune tolerance by directly inhibiting pattern recognition receptor recognition and antiviral signaling pathways,as well as by inhibiting the immune functions of macrophages,natural killer cells and dendritic *** addition,HBV leads to an immunosuppressive cascade by expressing inhibitory molecules to induce exhaustion of HBV-specific cluster of differentiation 8+T cells,ultimately leading to long-term viral *** loss of immune cell function caused by HBV infection ultimately leads to ***-term antiviral therapy can improve the prognosis of patients with HCC and prevent tumor recurrence and metastasis.

关键词： Hepatitis B virus Hepatocellular carcinoma Hepatitis B virus-DNA Immune tolerance Antiviral therapy

T cell interactions with microglia in immune-inflammatory processes of ischemic stroke

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Neural Regeneration Research 2025年第5期20卷 1277-1292页

作者： Yuxiao Zheng Zilin Ren Ying Liu Juntang Yan Congai Chen Yanhui He Yuyu shi Fafeng cheng Qingguo Wang Changxiang Li Xueqian Wang School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina Library Beijing University of Chinese MedicineBeijingChina Dongzhimen Hospital Beijing University of Chinese MedicineBeijingChina

The primary mechanism of secondary injury after cerebral ischemia may be the brain inflammation that emerges after an ischemic stroke,which promotes neuronal death and inhibits nerve tissue *** the first immune cells to be activated after an ischemic stroke,microglia play an important immunomodulatory role in the progression of the *** an ischemic stroke,peripheral blood immune cells(mainly T cells)are recruited to the central nervous system by chemokines secreted by immune cells in the brain,where they interact with central nervous system cells(mainly microglia)to trigger a secondary neuroimmune *** review summarizes the interactions between T cells and microglia in the immune-inflammatory processes of ischemic *** found that,during ischemic stroke,T cells and microglia demonstrate a more pronounced synergistic ***1,Th17,and M1 microglia can co-secrete proinflammatory factors,such as interferon-γ,tumor necrosis factor-α,and interleukin-1β,to promote neuroinflammation and exacerbate brain ***2,Treg,and M2 microglia jointly secrete anti-inflammatory factors,such as interleukin-4,interleukin-10,and transforming growth factor-β,to inhibit the progression of neuroinflammation,as well as growth factors such as brain-derived neurotrophic factor to promote nerve regeneration and repair brain *** interactions between microglia and T cells influence the direction of the subsequent neuroinflammation,which in turn determines the prognosis of ischemic stroke *** trials have been conducted on the ways to modulate the interactions between T cells and microglia toward anti-inflammatory communication using the immunosuppressant fingolimod or overdosing with Treg cells to promote neural tissue repair and reduce the damage caused by ischemic ***,such studies have been relatively infrequent,and clinical experience is still *** summary,in ischemic stroke,T cell subsets and activated micro

关键词： brain immune inflammation interaction ischemic stroke mechanism microglia neuron secondary injury T cells