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认知空间映射及其神经机制

心理科学进展 2025年第1期33卷 62-76页

作者：吴际李会杰南宁师范大学教育科学学院南宁530001 中国科学院行为科学重点实验室(中国科学院心理研究所) 北京100101 中国科学院大学心理学系北京100049

认知地图不仅可以映射物理空间,还可以支持认知空间映射,形成包括感知空间、情景记忆空间、概念空间和社会空间等在内的跨不同信息领域的地图式表征。认知空间映射的神经机制包括海马体对潜在结构的抽象和概括、支持分布式位置地图的生... 详细信息

认知地图不仅可以映射物理空间,还可以支持认知空间映射,形成包括感知空间、情景记忆空间、概念空间和社会空间等在内的跨不同信息领域的地图式表征。认知空间映射的神经机制包括海马体对潜在结构的抽象和概括、支持分布式位置地图的生成、将信息与背景结构捆绑,以及海马体与其它脑区的协同。未来研究应关注预测性的认知空间地图、海马体对不同精度和层级信息的表征、认知空间映射微观和介观层面的研究空缺以及物理空间和认知空间映射的共同机制和特异性机制等问题。

关键词：认知地图网格细胞位置细胞海马体

High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi Yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian Ge Hao li Yu Deng Hongbin Wu Xiaojian Xu Fei Niu Xinlong Dong bin Zhang Baiyun liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,RU486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

Effects of contaminant metal ions on precipitation recovery of rare earth elements using oxalic acid

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Journal of Rare Earths 2022年第3期40卷 482-490,I0005页

作者： Wencai Zhang Aaron Noble bin ji Qi li Department of Mining and Minerals Engineering Virginia Polytechnic Institute and State UniversityBlacksburgVA24061USA

Solution equilibrium calculations were performed in this study to understand the impact of contaminant metal ions on the precipitation efficiency of selected rare earth elements(Ce^(3+),Nd^(3+),and Y^(3+))using oxalic acid as a *** metal ions,Al^(3+) and Fe^(3+),are found to considerably affect the precipitation efficiency of *** Al^(3+) and Fe^(3+)concentrations are increased by 1×10^(−4) mol/L,in order to achieve an acceptable cerium recovery of 93%from solutions containing 1×10^(−4) mol/L Ce^(3+),oxalate dosage needs to increase by 1.2×10^(−4) and 1.68×10^(−4) mol/L,*** great impacts on the required oxalate dosage are also observed for Nd^(3+) and Y^(3+),which indicates that oxalic acid consumption and cost will be largely increased when the trivalent metal ions exist in REE-concentrated *** of the divalent metal ions on the oxalate dosage are ***,solution equilibrium calculation results show that the precipitation of Fe^(3+) and Ca^(2+)(e.g.,hematite and Ca(C_(2)O_(4))∙H_(2)O(s))likely occurs during the oxalate precipitation of REEs at relatively high pH(e.g.,pH 2.5),which will reduce rare earth oxalate product *** addition to the metal ions,anionic species,especially SO_(4)^(2-),are also found to negatively affect the precipitation recovery of *** example,when 0.1 mol/L SO_(4)^(2-) occurs in a solution containing 1×10^(−4) mol/L Ce^(3+) and 4×10^(−4) mol/L oxalate,the pH needs to be elevated from 2.0 to 3.3 to achieve the acceptable ***,findings from this study provide guidance for the obtainment of high-purity rare earth products from solutions containing a considerable amount of contaminant metal ions by means of oxalic acid precipitation.

关键词： Rare earth elements Oxalic acid Precipitation Contaminant metal ions

Failure modes of lattice sandwich plate by additive-manufacturing and its imperfection sensitivity

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Acta Mechanica Sinica 2020年第2期36卷 430-447页

作者： bin ji Han Han Renbang lin Hao li Shanghai Key Laboratory of Spacecraft Mechanism Shanghai 201109China Aerospace System Engineering Shanghai Shanghai 201109China

Additive-manufacturing process has substantially promoted the development of lattice structure and makes it possible to fabricate complex lattice sandwich ***-plane compression load always appears in engineering,such as in the primary structure of *** order to reveal potential engineering application in future,this paper focuses on the lattice sandwich plate that is fabricated by additive-manufacturing and subjected to in-plane ***,five failure modes are proposed for lattice sandwich plate under in-plane compression,including Euler buckling,shear buckling,face sheet dimpling,face sheet wrinkling and face sheet ***,an optimization method is proposed to obtain the optimum sizes,including the panel thickness,the length of rod,the size of rod cross-section,the inclined angle of rod and the wideness ratio of ***,the in-plane compression experiment is operated after measuring the geometrical imperfection of the specimen by the optical *** method is adopted to illustrate the effect on failure behaviors caused by the imperfections of struts,face sheets and global *** introducing these imperfection,numerical result can be well agreed with experimental result and explain the failure mechanisms mostly derived from the radius imperfection for the struts.

关键词： Additive-manufacturing Lattice structure In-plane compression Failure mode Imperfection sensitivity

Highly Stretchable,Compressible,Adhesive,Conductive Self-healing Composite Hydrogels with Sensor Capacity

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Chinese Journal of Polymer Science 2020年第11期38卷 1221-1229,I0007页

作者： ji-Jun Wang Qiang Zhang Xing-Xiang ji li-bin liu State Key Laboratory of Biobased Material and Green Papermaking School of Chemistry and Pharmaceutical EngineeringQilu University of Technology(Shandong Academy of Sciences)Jinan 250353China

The design and fabrication of conductive hydrogels with high stretchability,compressibility,self-healing properties and good adhesion remains a significant *** have fabricated composite hydrogels by random polymerization of acrylic acid(AA)and dopamine(DA)in the presence of multi-walled carbon nanotubes(MWCNTs).The π-π interaction between DA and MWCNTs makes MWCNTs stably and homogenously dispersed in *** fabricated PAA-PDA/CNT composite hydrogels possess relatively high mechanical strength(maximum Youngzs modulus:800 kPa)and can be stretched to 1280%strain and compressed to 80%*** multiple hydrogen bonding formed between functional groups of PAA-PDA and MWCNTs can effectively dissipate energy and quickly achieve *** composite hydrogels also show good adhesion and can easily adhere to various inorganic or organic *** addition,the hydrogel reveals stable strain sensitivity and can be used as skin sensors.

关键词： Hydrogels Self-healing Conductivity Sensor

Solar trough receiver with V-grooved light traps for efficiency improvement

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Science China Technological Sciences 2025年第1期 146-156页

作者： bin liU Qing li Yu QIU School of Energy Science and Engineering Central South University

Parabolic trough collector is a promising technology for both domestic and industrial heat supplies. To enhance the collector efficiency, a modified trough receiver with dozens of V-grooved light traps incorporated into its lower-half absorber was introduced. For assessing the performance of this receiver, a solar-thermal-stress coupled model was established. Using this model, firstly, the effects of the V-grooved light traps were investigated. The results reveal that, compared to the conventional trough receiver, the modified trough receivers equipped with different traps can reduce their optical losses by 81.9–138.0 Wm-1（i.e., 15.0%–25.2%）, improving their optical efficiencies by 1.60%–2.69%. However, these traps also result in increased thermal loss from the receiver. Therefore, there is no single optimal modified trough receiver that consistently outperforms all other receivers across all possible conditions. Nonetheless, the MTR30-3 and MTR60-3 receivers emerge as the optimized choices due to their better solar-thermal performance. Subsequently, performance evaluation reveals that the two optimized receivers can enhance the receiver efficiencies within the typical solar irradiance range by 0.02%–2.65% and 0.05%–1.70% when the inlet fluid temperatures are below 488 and 523 K, respectively. Consequently, the collector efficiencies can be improved by 0.02%–2.49% and 0.05%–1.60%, respectively. Additionally, thermal stress analysis verifies that the two optimized receivers remain within safe limits under all typical conditions. Given that the heating temperature of a typical solar collector for domestic or industrial heat supply is typically below 523 K, the integration of the two optimized receivers has the capability to effectively enhance the overall collector efficiency.

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学龄儿童数字计算的fMRI研究

实用放射学杂志 2007年第2期23卷 171-174页

作者：孙积宁王滨李丽新张保隆龙金凤潍坊医学院附属医院影像中心潍坊市妇幼保健院潍坊医学院附属医院影像中心山东潍坊261031

目的应用功能磁共振成像(fMRI)技术,研究学龄儿童在执行计算任务时的脑功能状态及激活模式。方法对12名儿童进行加、减、乘、除计算和数物对照判断实验。采用组块设计模式,静息组块与刺激组块交替出现,循环3次。设备为Siemens公司Trio3... 详细信息

目的应用功能磁共振成像(fMRI)技术,研究学龄儿童在执行计算任务时的脑功能状态及激活模式。方法对12名儿童进行加、减、乘、除计算和数物对照判断实验。采用组块设计模式,静息组块与刺激组块交替出现,循环3次。设备为Siemens公司Trio3.0T磁共振扫描仪及头部正交线圈,采用EPI序列进行BOLD脑功能磁共振成像。应用SPM2软件进行数据处理和脑功能区定位。结果4种计算实验均可见双侧额中回、右侧顶下小叶、右侧舌回和双侧小脑半球激活。加、减、除法计算中还引起右侧顶上小叶激活。右侧梭状回激活见于加、乘和除法计算。结论fMRI可以对儿童计算方面的脑功能区进行定位。儿童计算过程的优势半球有别于成人,大脑的右侧半球在儿童的计算中可能发挥着主要作用。

关键词：功能磁共振成像儿童计算脑

Tracklet-to-object Matching for Climbing Starlink Satellites through Recursive Orbit Determination and Prediction

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Research in Astronomy and Astrophysics 2022年第11期22卷 107-119页

作者： bin li Lei liu ji-Zhang Sang School of Geodesy and Geomatics Wuhan UniversityWuhan 430079China Collaborative Innovation Center for Geospatial Technology Wuhan 430079China

Concerns for the collision risk involving Starlink satellites have motivated the interest in obtaining their accurate orbit ***,accurate orbit determination(OD)and prediction(OP)of Starlink satellites confront two main challenges:mismatching or missed matching of sparse tracklets to maneuvering satellites,and unknown or unmodeled orbit *** to exactly associate a tracklet to the right satellite is the primary issue,since a maneuvering satellite does not follow the naturally evolving orbit during the maneuvering,while more tracklets are needed for developing an accurate orbit maneuver *** these two challenges are not well addressed,it may lead to catalog maintenance failure or even loss of *** paper proposes a method to correctly match tracklets to the climbing Starlink *** is based on the recursive OD and OP,in which the orbit maneuver is modeled and the thrust is estimated,such that the subsequent OP accuracy guarantees the correct match of tracklets shortly after the OD *** with climbing Starlink satellites demonstrate that the tracklets within three days of the last TLE(two-line element)are all correctly matched to the right *** the matched tracklets,the thrust accelerations of climbing Starlink satellites can be precisely estimated through an orbit control approach,and the position prediction accuracy over 48 hours is at the level of a few kilometers,providing accurate orbit knowledge for reliable collision warning involving Starlink satellites.

关键词： celestial mechanics methods:analytical miscellaneous

Deep learning-based LPI radar signals analysis and identification using a Nyquist Folding Receiver architecture

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Defence Technology（防务技术） 2023年第1期19卷 196-209页

作者： Tao Wan Kai-li jiang Hao ji bin Tang School of Information and Communication Engineering University of Electronic Science and Technology of ChinaChengdu611731China

Nyquist Folding Receiver(NYFR)is a perceptron structure that realizes a low probability of intercept(LPI)signal analog to *** at the problem of LPI radar signal receiving,the time domain,frequency domain,and time-frequency domain problems of signals intercepted by NYFR structure are *** with the time-frequency analysis(TFA)method,a radar recognition scheme based on deep learning(DL)is introduced,which can reliably classify common LPI radar ***,the structure of NYFR and its characteristics in the time domain,frequency domain,and time and frequency domain are ***,the received signal is then converted into a time-frequency image(TFI).Finally,four kinds of DL algorithms are used to classify LPI radar *** results demonstrate the correctness of the NYFR structure,and the effectiveness of the proposed recognition method is verified by comparison experiments.

关键词： Nyquist folding receiver Ultra-wideband Deep learning Time-frequency analysis Identification Classification