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Quantitative assessment of the relevance of organic-aniontransporting-polypeptide 1B1 and 2B1 polymorphisms in fexofenadine pharmacokinetic variants via pharmacometrics

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Journal of Pharmaceutical Analysis 2023年第6期13卷 660-672页

作者： ji-Hun jang Seung-hyun Jeong Yong-Bok Lee Department of Pharmacy College of PharmacyChonnam National UniversityGwangju61186Republic of Korea Department of Pharmacy College of PharmacySunchon National UniversitySuncheon-si57922Republic of Korea

Fexofenadine is useful in various allergic disease ***,the pharmacokinetic variability information and quantitative factor identification of fexofenadine are very *** study aimed to verify the validity of previously proposed genetic factors through fexofenadine population pharmacokinetic modeling and to explore the quantitative correlations affecting the pharmacokinetic *** of the organic-anion-transporting-polypeptide(OATP)1B1 and 2B1 have been proposed to be closely related to fexofenadine pharmacokinetic ***,modeling was performed using fexofenadine oral exposure data according to the OATP1B1-and ***1B1 and 2B1 were identified as effective covariates of clearance(CL/F)and distribution volume(V/F)-CL/F,respectively,in fexofenadine pharmacokinetic ***/F and average steady-state plasma concentration of fexofenadine differed by up to 2.17-and 2.20-folds,respectively,depending on the OATP1B1 *** the individuals with different OATP2B1 polymorphisms,the CL/F and V/F differed by up to 1.73-and 2.00-folds,*** of the areas under the curves following single-and multiple-administrations,and the cumulative ratio were significantly different between OATP1B1-and 2B1-polymorphism *** on quantitative prediction comparison through a model-based approach,OATP1B1 was confirmed to be relatively more important than 2B1 regarding the degree of effect on fexofenadine pharmacokinetic *** on the established pharmacokineticpharmacodynamic relationship,the difference in fexofenadine efficacy according to genetic polymorphisms of OATP1B1 and 2B1 was 1.25-and 0.87-times,respectively,and genetic consideration of OATP1B1 was expected to be important in the pharmacodynamics area as *** population pharmacometrics study will be a very useful starting point for fexofenadine precision medicine.

关键词： OATP1B1 OATP2B1 Fexofenadine Population pharmacometrics Genetic polymorphism

Saccharomyces boulardii as a single trigger of food protein-induced enterocolitis syndrome: Seven case reports

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World Journal of Clinical Cases 2025年第6期13卷 35-40页

作者： jin-Bok Hwang Hyo-Jeong jang Department of Pediatrics Keimyung University School of MedicineDongsan Medical CenterDaegu 42601South Korea

BACKGROUND Food protein-induced enterocolitis syndrome(FPIES)is the most serious type of non-immunoglobulin E(IgE)-mediated food allergic reaction manifesting as sepsis-like symptom,which can lead to *** boulardii(***),a probiotic prescribed frequently in clinical settings,has been reported to trigger FPIES in an infant with soy-triggered *** this report,we describe a new clinical FPIES in which *** was the sole triggering factor of acute FPIES adverse reaction in seven healthy *** SUMMARY Seven FPIES cases triggered by only *** were gathered from 2011 to the *** of the patients had previously experienced any allergic reaction to cow’s milk,soy,or complementary *** age of the patients was 4-10-months old,and the symptoms of FPIES developed after ingestion of ***,which is mostly prescribed for the treatment of gastroenteritis or antibiotic-associated *** patients experienced severe repetitive vomiting 1-3 hours after *** *** lethargy,marked pallor,and cyanosis were also *** IgE-mediated hypersensitivity developed in any *** was followed by initial intense vomiting in approximately 5-10 hours after *** ingestion,and only one case showed bloody,purulent,and foul-smelling *** patients stabilized quickly,mostly within 6 *** got all improved within 24 hours after discontinuation of *** *** can be the sole trigger of acute FPIES and be prescribed cautiously even in healthy children without FPIES.

关键词： Food protein-induced enterocolitis syndrome Food hypersensitivity Saccharomyces boulardii Probiotics Child Case report

Memristive Devices Based on Two-Dimensional Transition Metal Chalcogenides for Neuromorphic Computing

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Nano-Micro Letters 2022年第4期14卷 29-58页

作者： Ki Chang Kwon ji hyun Baek Kootak Hong Soo Young Kim Ho Won jang Department of Materials Science and Engineering Research Institute of Advanced MaterialsSeoul National UniversitySeoul 08826Republic of Korea Interdisciplinary Materials Measurement Institute Korea Research Institute of Standards and Science(KRISS)Daejeon 34133Republic of Korea Department of Materials Science and Engineering Institute of Green Manufacturing TechnologyKorea UniversitySeoul 02841Republic of Korea Advanced Institute of Convergence Technology Seoul National UniversitySuwon 16229Korea

Two-dimensional(2D)transition metal chalcogenides(TMC)and their heterostructures are appealing as building blocks in a wide range of electronic and optoelectronic devices,particularly futuristic memristive and synaptic devices for brain-inspired neuromorphic computing *** distinct properties such as high durability,electrical and optical tunability,clean surface,flexibility,and LEGO-staking capability enable simple fabrication with high integration density,energy-efficient operation,and high *** review provides a thorough examination of high-performance memristors based on 2D TMCs for neuromorphic computing applications,including the promise of 2D TMC materials and heterostructures,as well as the state-of-the-art demonstration of memristive *** challenges and future prospects for the development of these emerging materials and devices are also *** purpose of this review is to provide an outlook on the fabrication and characterization of neuromorphic memristors based on 2D TMCs.

关键词： Two-dimensional materials Memristors Neuromorphic computing Artificial synapses Transition metal chalcogenides

Pharmacokinetic comparison with different assays for simultaneous determination of cis-,trans-cefprozil diastereomers in human plasma

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Journal of Pharmaceutical Analysis 2021年第3期11卷 351-363页

作者： Seung-hyun Jeong ji-Hun jang Hea-Young Cho Yong-Bok Lee College of Pharmacy Chonnam National University77 Yongbong-roBuk-guGwangju61186Republic of Korea College of Pharmacy CHA University335 Pangyo-roBundang-guSeongnam-siGyeonggi-Do13488Republic of Korea

The purpose of this study was to compare pharmacokinetic(PK)parameters obtained using two newly developed assays,HPLC-UV and UPLC-ESI-MS/*** of assay and results obtained therefrom are very important in PK studies and can have a major impact on the PK-based clinical dose and usage *** this study,we developed two new methods that are most commonly used in biosample analysis and focused on PK parameters obtained from *** HPLC-UV equipped with a Luna-C8 column using UV detector,cefprozil diastereomers were separated using water containing 2%(V/V)acetic acid and acetonitrile as a mobile *** UPLC-ESI-MS/MS equipped with a HALO-C18 column,cefprozil diastereomers were separated using 0.5%(V/V)aqueous formic acid containing 5 mM ammoniumformate buffer and methanol as a mobile *** showed high resolution,sensitivity,and selectivity without interference by plasma *** intra-and inter-day precisions(CV,%)were within 8.88%for HPLC-UV and UPLC-ESI-MS/*** of both methods was 95.67%-107.50%.These two analytical methods satisfied the criteria of international guidance and could be successfully applied to PK *** of PK parameters between two assays confirmed that there is a difference in the predicted minimum plasma concentrations at steady state,which may affect clinical dose and usage ***,we confirmed possible correlation between PK parameters and various biochemical parameters after oral administration of 1000 mg cefprozil to humans.

关键词： Cefprozil diastereomers Comparison HPLC-UV UPLC-ESI-MS/MS Pharmacokinetic parameter Biochemical parameters

Regulation of sleep by astrocytes in the hypothalamic ventrolateral preoptic nucleus

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Neural Regeneration Research 2025年第4期20卷 1098-1100页

作者： Jae-Hong Kim Ruqayya Afridi Il-Sung jang Maan Gee Lee Kyoungho Suk Brain Korea 21 four KNU Convergence Educational Program of Biomedical Sciences for Creative Future Talents School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of MedicineKyungpook National UniversityDaeguRepublic of Korea Department of Pharmacology School of DentistryKyungpook National UniversityDaeguRepublic of Korea Brain Science&Engineering Institute Kyungpook National UniversityDaeguRepublic of Korea

Astrocytes are functionally dynamic cells that support neurons in multiple ways throughout an organism’s *** astrocytic regulation of neuronal activity has been increasingly recognized in recent *** are now recognized as playing a more complex role than mere bystanders in the central nervous ***,their role in regulating the sleep neurocircuitry is not well *** this perspective,we highlight the role of astrocytes in sleep modulation,with a particular focus on regulatory mechanisms related to the ventrolateral preoptic nucleus(VLPO)of the *** briefly discuss recent literature reporting the role of VLPO astrocytes in regulating sleep-associated behaviors.

关键词： sleep ventrolateral astrocytes

A Note on the Universal Factorization Property of Groups

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Algebra Colloquium 2021年第4期28卷 635-644页

作者： Injo Hur jang hyun Jo Department of Mathematics Education Chonnam National University Gwangju 61186Korea Department of Mathematics Sogang UniversitySeoul 04107Korea

We give criteria when a full subcategory D of the category of groups has C-universal factorization property(C-UFP)or C-strong universal factorization property(C-SUFP)for a certain category of groups *** a byproduct,we give affirmative answers to three unsettled questions in[***,***,Universal factorization property of certain polycyclic groups,*** *** 204(2006)555-567].

关键词： hereditary productive universal factorization property

A Structural Topic Model for Exploring User Satisfaction with Mobile Payments

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Computers, Materials & Continua 2022年第11期73卷 3815-3826页

作者： jang hyun Kim jisung jang Yonghwan Kim Dongyan Nan Department of Human-Artificial Intelligence Interaction Sungkyunkwan UniversitySeoul03063Korea Department of Interaction Science Sungkyunkwan UniversitySeoul03063Korea Department of Applied Artificial Intelligence Sungkyunkwan UniversitySeoul03063Korea NAVER Green Factory Seongnam13561Korea

This study explored user satisfaction with mobile payments by applying a novel structural topic ***,we collected 17,927 online reviews of a specific mobile payment(i.e.,PayPal).Then,we employed a structural topic model to investigate the relationship between the attributes extracted from online reviews and user satisfaction with mobile ***,we discovered that“lack of reliability”and“poor customer service”tend to appear in negative ***,the terms“convenience,”“user-friendly interface,”“simple process,”and“secure system”tend to appear in positive *** the basis of information system success theory,we categorized the topics“convenience,”“user-friendly interface,”and“simple process,”as system *** addition,“poor customer service”was categorized as service ***,based on the previous studies of trust and security,“lack of reliability”and“secure system”were categorized as trust and security,*** outcomes indicate that users are satisfied when they perceive that system quality and security of specific mobile payments are *** the contrary,users are dissatisfied when they feel that service quality and reliability of specific mobile payments is ***,our research implies that a novel structural topic model is an effective method to explore mobile payment user experience.

关键词： Mobile payment user satisfaction online review structural topic model

Confluence of ZnO and PTFE Binder for Enhancing Performance of Thin-Film Lithium-Ion Batteries

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Energy & Environmental Materials 2024年第5期7卷 48-56页

作者： Subhashree Behera Swathi Ippili Venkatraju Jella Na-Yeong Kim Seong Cheol jang ji-Won Jung Soon-Gil Yoon hyun-Suk Kim Department of Materials Science and Engineering Chungnam National UniversityDaejeon 34134South Korea School of Materials Science and Engineering University of UlsanUlsan 44776South Korea Department of Energy and Materials Engineering Dongguk UniversitySeoul 04620South Korea

Developing anode materials with high specific capacity and cycling stability is vital for improving thin-film lithium-ion ***-film zinc oxide(ZnO)holds promise due to its high specific capacity,but it suffers from volume changes and structural stress during cycling,leading to poor battery *** this research,we ingeniously combined polytetrafluoroethylene(PTFE)with ZnO using a radio frequency(RF)magnetron co-sputtering method,ensuring a strong bond in the thin-film composite *** effectively reduced stress on the active material and mitigated volume change effects during Li^(+)ion intercalation and *** composite thin films are thoroughly characterized using advanced techniques such as X-ray diffraction,scanning electron microscopy,and X-ray photoelectron spectroscopy for investigating correlations between material properties and electrochemical ***,the ZnO/PTFE thin-film electrode demonstrated an impressive specific capacity of 1305 mAh g^(-1)(=7116 mAh cm^(-3))at a 0.5C rate and a remarkable capacity retention of 82%from the 1st to the 100th cycle,surpassing the bare ZnO thin film(50%).This study provides valuable insights into using binders to stabilize active materials in thin-film batteries,enhancing battery performance.

关键词： li-ion batteries metal oxides anodes polytetrafluoroethylene(PTFE) thin films

Decellularized sciatic nerve matrix as a biodegradable conduit for peripheral nerve regeneration

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Neural Regeneration Research 2018年第10期13卷 1796-1803页

作者： Jongbae Choi Jun Ho Kim ji Wook jang hyun Jung Kim Sung Hoon Choi Sung Won Kwon R&D Center Genewel Co.Ltd. Department of Surgery CHA Bundang Medical CenterCHA University

The use of autologous nerve grafts remains the gold standard for treating nerve defects, but current nerve repair techniques are limited by donor tissue availability and morbidity associated with tissue loss. Recently, the use of conduits in nerve injury repair, made possible by tissue engineering, has shown therapeutic potential. We manufactured a biodegradable, collagen-based nerve conduit containing decellularized sciatic nerve matrix and compared this with a silicone conduit for peripheral nerve regeneration using a rat model. The collagen-based conduit contains nerve growth factor, brain-derived neurotrophic factor, and laminin, as demonstrated by enzyme-linked immunosorbent assay. Scanning electron microscopy images showed that the collagen-based conduit had an outer wall to prevent scar tissue infiltration and a porous inner structure to allow axonal growth. Rats that were implanted with the collagen-based conduit to bridge a sciatic nerve defect experienced significantly improved motor and sensory nerve functions and greatly enhanced nerve regeneration compared with rats in the sham control group and the silicone conduit group. Our results suggest that the biodegradable collagen-based nerve conduit is more effective for peripheral nerve regeneration than the silicone conduit.

关键词： nerve regeneration biodegradable decellularized collagen nerve conduit growth factor peripheral nerve injury regeneration silicone conduit rat model