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Safety of endoscopic ultrasound-guided ethanol ablation for pancreatic cystic lesions: A single-center experience of 214 patients

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Hepatobiliary & Pancreatic Diseases International 2019年第6期18卷 562-568页

作者： jin Ho Choi Sang Hyub Lee Young hoon Choi Min Su You Bang-Sup Shin Woo Hyun Paik ji Kon Ryu Yong-Tae Kim Department of Internal Medicine Liver Research Institute Seoul National University College of Medicine

Background:Endoscopic ultrasound-guided ethanol ablation(EUS-EA)for pancreatic cystic lesions(PCLs)has been used in recent years as a feasible treatment modality for low malignant probability PCLs or patients considered high-risk for *** present study aimed to confirm the safety of EUS-EA and to find predictive factors for adverse event(AE).Methods:A retrospective review was performed from the prospectively maintained database of patients who underwent EUS-EA for PCLs from June 2006 to April 2018 at Seoul National University *** primary outcomes of the study were the rates of AEs and severe AEs by *** secondary outcome was the predictive factors of AEs including acute pancreatitis and abdominal ***:A total of 214 patients were evaluated and the diagnoses of PCLs according to cystic fluid analysis and clinical features were as follows:serous cystic neoplasm(32.2%),mucinous cystic neoplasm(26.6%),branch duct type intraductal papillary mucinous neoplasm(BD-IPMN)(29.4%),and pseudocyst(11.7%).Three patients(1.4%)experienced severe ***,AEs occurred in 71(33.2%)***-IPMN(OR:2.87;95%CI:1.05–7.84;P=0.040),multilocular cysts(OR:3.59;95%CI:1.09–11.85;P=0.036),suspected ethanol leakage during procedure(OR:10.68;95%CI:1.98–57.53;P=0.006),and sticky cystic fluid(OR:3.83;95%CI:1.20–12.24;P=0.024)were predictive factors for post-procedural acute *** of uncinate process(OR:2.99;95%CI:1.22–7.35;P=0.017)and PCLs with exophytic portion(OR:3.70;95%CI:1.96–7.01;P<0.001)were predictive factors for post-procedural abdominal ***:EUS-EA is a safe procedure with a very low rate of severe *** seems possible to predict the AEs according to the features of the procedure and PCLs.

关键词： Pancreatic cyst EUS-guided ethanol ablation Adverse events

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Two plant NLR proteins confer strain-specific resistance conditioned by an effector from Pseudomonas syringae ***

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Journal of Genetics and Genomics 2022年第8期49卷 823-832页

作者： Xiaojuan Zheng Zhaoyang Zhou Zhen Gong Meijuan Hu Ye jin ahn Xiaojuan Zhang Yan Zhao Guoshu Gong jian Zhang jianru Zuo Guan-Zhu Han Sohn Kee hoon jian-Min Zhou State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyThe Innovative Academy of Seed DesignChinese Academy of SciencesBeijing 100101China CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijing 100049China College of Horticulture China Agricultural UniversityBeijing 100193China College of Life Sciences Jiangsu Key Laboratory for Microbes and Functional GenomicsNanjing Normal UniversityNanjingJiangsu 210023China Department of Life Sciences Pohang University of Science and TechnologyPohang 37673Republic of Korea School of Interdisciplinary Bioscience and Bioengineering Pohang University of Science and TechnologyPohang 37673Republic of Korea Plant Protection Department and Major Crop Disease Laboratory College of AgronomySichuan Agricultural UniversityChengduSichuan 611130China Hainan Yazhou Bay Seed Laboratory SanyaHainan 572025China

Pseudomonas syringae ***(Psa)causes bacterial canker,a devastating disease threatening the Actinidia fruit *** a search for non-host resistance genes against Psa,we find that the nucleotidebinding leucine-rich repeat receptor(NLR)protein ZAR1 from both Arabidopsis and Nicotiana benthamiana(Nb)recognizes Hop Z5 and triggers cell *** recognition requires ZED1 in Arabidopsis and jiM2 in Nb plants,which are members of the ZRK pseudokinases and known components of the ZAR1 ***,Arabidopsis ZAR1 and RPM1,another NLR known to recognize Hop Z5,confer disease resistance to Hop Z5 in a strain-specific ***,ZAR1,but not RPM1,is solely required for resistance to *** ES4326(Psm)carrying hop Z5,whereas RPM1 is primarily required for resistance to *** DC3000(Pst)carrying hop ***,the ZAR1-mediated resistance to Psm hop Z5 in Arabidopsis is insensitive to SOBER1,which encodes a deacetylase known to suppress the RPM1-mediated resistance to Pst hop *** addition,hop Z5 enhances *** virulence in the absence of ZAR1 or RPM1 and that SOBER1 abolishes such virulence *** the study suggests that ZAR1 may be used for improving Psa resistance in Actinidia and uncovers previously unknown complexity of effectortriggered immunity and effector-triggered virulence.

关键词： NLR ZAR1 Pseudomonas syringae pv.actinidiae Immunity Disease resistance

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Engineering Geometric Electrodes for Electric Field-Enhanced High-Performance Flexible In-Plane Micro-Supercapacitors

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Energy & Environmental Materials 2023年第4期6卷 114-120页

作者： jihong Kim Sung Min Wi Jong-Guk ahn Sangjun Son Hee Young Lim Yeonsu Park Hye ji Eun Jong Bae Park Hyunseob Lim Sangyeon Pak A-Rang Jang Young-Woo Lee Department of Energy Engineering Soonchunhyang UniversityAsan 31538Korea Department of Chemistry Gwangju Institute of Science and TechnologyGwangju 61005Korea Jeonju Centre Korea Basic Science InstituteJeonju 54907Korea Prof.S.Pak School of Electronic and Electrical Engineering Hongik UniversitySeoul 04066Korea Division of Electrical Electronic and Control EngineeringKongju National UniversityCheonan 31080Korea

In plane micro-supercapacitors that are miniaturized energy storage components have attracted significant attention due to their high power densities for various ubiquitous and sustainable device systems as well as their facile integration on various flexible/wearable *** implement the micro-supercapacitors in various practical applications that can accompany solid state or gel electrolyte and flexible substrates,ions must be readily transported to electrodes for achieving high power ***,we show large enhancement in electrochemical properties of flexible,inplane micro-supercapacitor using sharp-edged interdigitated electrode design,which was simply fabricated through direct laser scribing *** sharp-edged electrodes allowed strong electric field to be induced at the corners of the electrode fingers which led to the greater accumulation of ions near the surface of electrode,significantly enhancing the energy storage performance of *** electric field-enhanced in-plane micro-supercapacitor showed the volumetric energy density of 1.52 Wh L^(−1)and the excellent cyclability with capacitive retention of 95.4%after 20000 *** further showed various practicability of our sharp-edged design in micro-supercapacitors by showing circuit applicability,mechanical stability,and air *** results present an important pathway for designing electrodes in various energy storage devices.

关键词： electric field enhancement flexible energy storage device microsupercapacitors sharp electrodes

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A combination of immunoadjuvant nanocomplexes and dendritic cell vaccines in the presence of immune checkpoint blockade for effective cancer immunotherapy

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Cellular & Molecular Immunology 2021年第6期18卷 1599-1601页

作者： Manh-Cuong Vo Seo-Yeon ahn Tan-Huy Chu Saji Uthaman Shammer Pillarisetti Tung Nguyen Thanh Uong Thangaraj Jaya Lakshmi Mihee Kim Ga-Young Song Sung-hoon Jung Deok-Hwan Yang Jae-Sook ahn Hyeoung-Joon Kim In-Kyu Park Je-Jung Lee Institute of Research and Development Duy Tan UniversityDanangVietnam Research Center for Cancer Immunotherapy Chonnam National University Hwasun HospitalHwasunJeollanamdoRepublic of Korea Department of Hematology-Oncology Chonnam National University Hwasun HospitalChonnam National University Medical SchoolGwangjuRepublic of Korea Department of Polymer Science and Engineering Chungnam National UniversityDaejeonRepublic of Korea Department of Biomedical Science Chonnam National University Medical SchoolGwangjuRepublic of Korea Department of Radiation Oncology Chonnam National University Hwasun HospitalChonnam National University Medical SchoolGwangjuSouth Korea View author publications

Nanovaccines are used as delivery platforms for antigens and adjuvants, which activate antigen-presenting cells (APCs) and enhance anticancer immune responses.1,2 Researchers have recently developed a self-assembled nanocomplex using a polysorbitol-co-PEI (PSPEI) polymer complexed with poly(I:C) (PIC). By binding to different surface proteins, this nanocomplex enhances the intracellular delivery of cargos and induces potent anticancer immune responses against melanoma cells.3 We have previously demonstrated that PD-1/PD-L1 blockade enhanced the efficacy of DC-based cancer immunotherapy.4,5 Moreover, the combination of nanomedicines and PD-L1 blockade has been reported to enhance CD8+ T cell activation and inhibit immunosuppressive cells within the tumor microenvironment.6 In the present study, we investigated the therapeutic efficacy of a combinatorial treatment comprising the immunoadjuvant nanocomplex PSPEI-PIC, a DC vaccine, and PD-L1 blockade in a murine colon cancer model.

关键词： adjuvant vaccines immunotherapy

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Cholecystoduodenal fistula presenting with upper gastrointestinal bleeding: A case report

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World Journal of Clinical Cases 2021年第2期9卷 410-415页

作者： jin Myung Park Chang Don Kang ji Hyun Kim Sang hoon Lee Seung-Joo Nam Sung Chul Park Sung JoonLee Seungkoo Lee Department of Internal Medicine Kangwon National University School of MedicineChuncheon 24289Kangwon DoSouth Korea Department of Gastroenterology Kangwon National University HospitalChuncheon 24289Kangwon DoSouth Korea Anatomy and Pathology Kangwon National University School of MedicineChuncheon 200947Kangwon DoSouth Korea Department of Pathology Kangwon National University HospitalChuncheon 24289Kangwon DoSouth Korea

BACKGROUND Cholecystoduodenal fistula is a rare complication of *** are usually non-specific and often indistinguishable from those of etiologic diseases,but it rarely presents as severe gastrointestinal *** associated with cholecystoduodenal fistula usually requires surgery because significant bleeding from the cystic artery is unlikely to be resolved by conservative management or endoscopic *** SUMMARY We report a case of cholecystoduodenal fistula that presented with hematemesis which was diagnosed by endoscopy and computed *** hemostasis could not be achieved,but surgical treatment was ***,we have presented a literature *** Cholecystoduodenal fistula should be considered as differential diagnosis when a patient with history of gallstone disease presents with gastrointestinal bleeding.

关键词： Biliary fistula Hematemesis Cholecystitis Gallstones Cholecystectomy Case report

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Biliary drainage for obstructive jaundice caused by unresectable hepatocellular carcinoma: the endoscopic versus percutaneous approach

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Hepatobiliary & Pancreatic Diseases International 2012年第6期11卷 636-642页

作者： Jongkyoung Choi ji Kon Ryu Sang Hyub Lee Dong-Won ahn jin-Hyeok Hwang Yong-Tae Kim Yong Bum Yoon Joon Koo Han Department of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul Korea Department of Internal Medicine National Medical Center Seoul Korea Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Gyeonggi-do Korea Department of Internal Medicine Seoul National University Boramae Medical Center Seoul Korea Department of Radiology Seoul National University College of Medicine Seoul Korea

BACKGROUND: For palliative treatment of the obstructive jaundice associated with unresectable hepatocellular carcinoma (HCC), percutaneous transhepatic biliary drainage (PTBD) or endoscopic retrograde biliary drainage (ERBD) has been performed. PTBD is preferred as an initial procedure. Little is known about the better option for patients with obstructive jaundice caused by unresectable HCC. METHODS: Sixty patients who had received ERBD or PTBD for the palliative treatment of obstructive jaundice caused by unresectable HCC between January 2006 and May 2010 were included in this retrospective study. Successful drainage, drainage patency, and the overall survival of patients were evaluated. RESULTS: Univariate analysis revealed that the overall frequency of successful drainage was higher in the ERBD group (22/29, 75.9%) than in the PTBD group (15/31, 48.4%) (P=0.029); but multivariate analysis showed marginal significance (P=0.057). The duration of drainage patency was longer in the ERBD group than in the PTBD group (82 vs 37 days, respectively, P=0.020). Regardless of what procedure was performed, the median survival time of patients who had a successful drainage was much longer than that of the patients who did not have a successful drainage (143 vs 38 days, respectively, P<0.001).CONCLUSION: Besides PTBD, ERBD may be used as the initial treatment option to improve obstructive jaundice in patients with unresectable HCC if there is a longer duration of drainage patency after a successful drainage.

关键词： hepatocellular carcinoma obstructive jaundice endoscopic retrograde biliary drainage percutaneous transhepatic biliary drainage

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Berberine inhibits inflammatory activation of rat brain microglia

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Neural Regeneration Research 2010年第18期5卷 1384-1390页

作者： Kyong Nyon Nam Jae-Hong Kim hoon-ji Jung Jung-Mi Park Sang-Kwan Moon Young-Suk Kim Sun Yeou Kim Eunjoo H. Lee Department of Medical Science Graduate School of East-West Medical ScienceKyung Hee University Department of Cardiovascular & Neurologic Diseases (Stroke Center) Hospital of Oriental MedicineKyung Hee University

Chronic activation of microglial cells endangers neuronal survival through the release of various proinflammatory and neurotoxic factors. Berberine, the effective ingredient of Coptidis Rhizoma and Cortex Phellodendti, has a wide range of pharmacological functions, including anti-inflammatory, anti-atherosclerotic and anti-cancer effects. The neuroprotective potential of berberine has previously been demonstrated. The present study aimed to examine whether berberine could repress microglial activation and can be considered a potential therapeutic candidate to target neurodegenerative diseases. Primary microglial cells and BV2 microglial cells were cultured and stimulated with bacterial lipopolysaccharide （LPS）. Berberine chloride was treated prior to LPS or simultaneously with LPS stimulation. Results revealed that berberine was effective at inhibiting nitric oxide release from primary microglial cells when cells were exposed to the compound prior to LPS or simultaneously with LPS. It also reduced the LPS-stimulated production of tumor necrosis factor-α, interleukin-1β, prostaglandin E2, and intracellular reactive oxygen species and nuclear factor-kappa activation. Additionally, berberine reduced nitric oxide release from microglia stimulated with interferon-γ and amyloid β. These results suggest that berberine provides neuroprotection by reducing the production of various neurotoxic molecules from activated microglia.

关键词： brain inflammation berberine interleukin-1β microglia nuclear factor-kappa nitric oxide prostaglandin tumor necrosis factor-a

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Mismatched effects of receptor interacting protein kinase-3 on hepatic steatosis and inflammation in nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2018年第48期24卷 5477-5490页

作者： Waqar Khalid Saeed Dae Won Jun Kiseok Jang Sang Bong ahn Ju Hee Oh Yeon ji Chae Jai Sun Lee Hyeon Tae Kang Department of Gastroenterology Hanyang University College of Medicine Seoul 04763 South Korea Department of Pathology Hanyang University College of Medicine Seoul 04763 South Korea Department of Internal Medicine Eulji University Daejeon 34824 South Korea Department of Translational Medicine Hanyang University College of Medicine Seoul 04763 South Korea

AIM To validate the effects of receptor interacting protein kinase-3(RIP3) deletion in non-alcoholic fatty liver disease(NAFLD) and to clarify the mechanism of *** Wild-type(WT) and RIP3 knockout(KO) mice werefed normal chow and high fat(HF) diets for 12 wk. The body weight was assessed once weekly. After 12 wk, the liver and serum samples were extracted. The liver tissue expression levels of RIP3, microsomal triglyceride transfer protein, protein disulfide isomerase, apolipoprotein-B, X-box binding protein-1, sterol regulatory element-binding protein-1c, fatty acid synthase, cluster of differentiation-36, diglyceride acyltransferase, peroxisome proliferator-activated receptor alpha, tumor necrosis factor-alpha(TNF-α), and interleukin-6 were assessed. Oleic acid treated primary hepatocytes from WT and RIP3 KO mice were stained with Nile red. The expression of inflammatory cytokines, including chemokine(C-X-C motif) ligand(CXCL) 1, CXCL2, and TNF-α, in monocytes was *** RIP3 KO HF diet fed mice showed a significant gain in body weight, and liver weight, liver to body weight ratio, and liver triglycerides were increased in HF diet fed RIP3 KO mice compared to HF diet fed WT mice. RIP3 KO primary hepatocytes also had increased intracellular fat droplets compared to WT primary hepatocytes after oleic acid treatment. RIP3 overexpression decreased hepatic fat content. Quantitative real-time polymerase chain reaction analysis showed that the expression of very-low-density lipoproteins secretion markers(microsomal triglyceride transfer protein, protein disulfide isomerase, and apolipoprotein-B) was significantly suppressed in RIP3 KO mice. The overall NAFLD Activity Score was the same between WT and RIP3 KO mice; however, RIP3 KO mice had increased fatty change and decreased lobular inflammation compared to WT mice. Inflammatory signals(CXCL1/2, TNF-α, and interleukin-6) increased after lipopolysaccharide and pancaspase inhibitor(necroptotic conditi

关键词： Necroptosis Receptor interacting protein kinase-3 Mixed lineage kinase domain-like protein Non-alcoholic fatty liver disease Steatosis

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Acute idiopathic pancreatitis in pregnancy:A case study

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World Journal of Gastroenterology 2014年第43期20卷 16364-16367页

作者： ji Yeon Kim Sung hoon Jung Hyung Wook Choi Dong jin Song Cheol Yoon Jeong Dong Hyun Lee Il Soon Whang Department of Internal Medicine Cheil General Hospital and Women’s Healthcare CenterKwandong University College of MedicineSeoul KS013South Korea

Acute pancreatitis during pregnancy is a rare event,and can be associated with high maternal mortality and fetal *** disease is thought to be the most common causative factor of acute pancreatitis,but,in many cases,the cause remains *** report a case of a 36-year-old woman at 35 wk of gestation,who presented with severe pain confined to the upper abdomen and radiating to the *** patient was diagnosed with acute idiopathic pancreatitis,which was managed conservatively;she recovered within several days and then delivered a healthy *** it is important to consider acute pancreatitis when a pregnant woman presents with upper abdominal pain,nausea and vomiting in order to improve fetal and maternal outcomes for patients with acute pancreatitis.

关键词： Acute pancreatitis Pregnancy Pancreatitis in pregnancy Idiopathic Idiopathic acute pancreatitis

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Effect of botulinum toxin type A on the cervical sympathetic trunk in chronic relapsing inflammatory optic neuropathy

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Chinese Medical Journal 2021年第22期134卷 2771-2772页

作者： ji Yeong Kim Yong Ho Lee Young hoon Kim Department of Anesthesiology and Pain Medicine Seoul St.Mary’s HospitalCollege of MedicineThe Catholic University of KoreaSeoulRepublic of Korea

To the Editor:Optic neuritis(ON)usually ends with one episode,but recurs in 3%to 5%of *** recurrent patients,those that emerge negative from multiple sclerosis or neuromyelitis optica(NMO)workup are diagnosed with chronic relapsing inflammatory optic neuropathy(CRION).This disease group,first named by Kidd et al,[1]refers to a clinical situation in which inflammatory optic nerve inflammation on both sides occurs repeatedly and worsens when steroids or immu-nosuppressants are *** diagnosis is important in this group because the risk of blindness is significant,and as such,treatment is focused on preserving ***,because a significant number of CRION patients suffer from ocular pain,alleviation of pain should not be overlooked.

关键词： neuropathy diagnosis inflammation

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