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Synthesis and Kinetics of Hydrogenated Rosin Dodecyl Ester as an Environmentally Friendly Plasticizer

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Journal of Renewable Materials 2020年第3期8卷 289-300页

作者： Qiaoguang Li Sheng Gong jie Yan Hongchao Hu Xugang Shu Hanqing Tong zhiye Cai School of Chemistry and Chemical Engineering Zhongkai University of Agriculture and EngineeringGuangzhou510225China Zhongkai University of Agriculture and Engineering College of Chemistry and Chemical EngineeringGuangdong University of TechnologyGuangdong Province Key Laboratory of Waterfowl Healthy BreedingGuangzhou510225China College of Chemical Engineering Guangdong University of Petrochemical TechnologyMaoming525000China

The plasticizer is an important polymer material ***-toxic and environmentally friendly plasticizers are developed recently in order to decrease fossil fuel reserves,serious environmental pollution and the toxicity of phthalate *** this study,a new,efficient and environmentally friendly plasticizer of hydrogenated rosin dodecyl ester was prepared by an esterification reaction of hydrogenated rosin and *** influences of different reaction conditions(including different catalysts,the catalyst concentration,the ratio of the reactants,reaction temperature,and reaction time)on the esterification yield are examined and *** rosin dodecyl ester with 71.8%yield was synthesized under the optimized reaction conditions(1:0.8 molar ratio of rosin to dodecanol,1 mol%tetrabutyl titanate concentration,and 210℃for 6 h).The esterification reaction is a second-order reaction,and kinetic calculations showed that the activation energy is 39.77 KJ·mol^(−1).The structure of the hydrogenated rosin dodecyl ester was confirmed by FT-IR spectroscopy and^(13)C NMR ***,the thermal stability of target product(hydrogenated rosin dodecyl ester)was also tested by thermal gravimetric analysis(TGA),which showed a good thermal stability.

关键词： Environmentally friendly plasticizer hydrogenated rosin dodecyl ester synthesis kinetics study

Biomechanical evaluation of different hydroxyapatite coatings on titanium for keratoprosthesis

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Frontiers of Materials Science 2015年第3期9卷 303-310页

作者： Ying DONG zhiye QIU Xiaoyu LIU Liqiang WANG jingxin YANG Yifei HUANG Fuzhai CUI Department of Ophthalmology The First Affiliated Hospital Chinese PLA General Hospital Beijing 100048 China Department of Ophthalmology Chinese PLA General Hospital Beijing 100853 China School of Materials Science and Engineering Tsinghua University Beijing 100084 China Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education School of Biological Science and Medical Engineering Beihang University Beijing 100191 China

Stable tissue integration is important to keratoprosthesis （KPro）. The aim of this study was to evaluate the tissue bonding ability of hydroxyapatite （HAp）-coated titanium KPro. The samples were divided into three groups： test groups （IBAD group and AD group） and Ti control. The coated samples had a HAp layer created by ion beam assisted deposition （IBAD） or aerosol deposition （AD）. The surface characteristics were analyzed with SEM, AFM, and XRD. The samples were surgically inserted into the muscles of rabbits. Eight weeks after healing, the attachment to the tissue was tested with a universal test device. The three samples exhibited distinctive surface morphology. The force to remove the HAp implants from the muscles was significantly greater than that of Ti group （P〈0.01）, with the AD samples requiring the greatest force （P〈0.01）. After removal, SEM showed that the tissue was firmly attached to the surface of AD samples. Photomicrographs of the peri-implant muscles showed a layer of aligned fibrous tissue without severe inflammation. The AD samples had more fibroblasts. Results indicate that because of enhanced mechanical adhesion of soft tissue to the implants, HAp-coated Ti by AD is a suitable KPro skirt material.

关键词： hydroxyapatite (HAp) titanium keratoprosthesis (KPro) biomechanics tissue attachment

T2 relaxation time measurements in the brains of scalded rats

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Science China(Life Sciences) 2017年第1期60卷 5-10页

作者： Tao jiang Liqi Xie Xin Lou Dawei Li zhiye Chen Huafeng Xiao Lin Ma Department of Radiology PLA General Hospital Department of Radiology PLA 401 Hospital Department of Burn and Plastic Surgery PLA 304 Hospital Department of Radiology PLA 302 Hospital

This study aimed to evaluate the T2 relaxation time of the brain in severely scalded rats using a magnetic resonance （MR） T2 mapping sequence, and to investigate the correlation between T2 relaxation time and plasma glucose level. Twenty-eight Wistar rats were randomly divided into the scalded group （n = 21）and control group （n = 7）. Magnetic resonance scans were performed with T1WI, T2WI, and T2-mapping sequences in the scalded group; the scans were performed 1 day prior to scalding and 1, 3, 5, and 7 days post-scalding; in addition, identical MR scans were performed in the control group at the same time points. T2-maps were generated and T2 relaxation times were acquired from the following brain regions： the hippocampus, thalamus, caudate-putamen, and cerebrum. Pathological changes of the hippocampus were observed. The plasma glucose level of each rat was measured before each MR scan, and a correlation analysis was performed between T2 relaxation time and plasma glucose level. We found that conventional T 1WI and T2WI did not reveal any abnormal signals or morphological changes in the hippocampus, thalamus, caudate-putamen,： or cerebrum post-scalding. Both the T2 relaxation times of the selected brain regions and plasma glucose levels increased 1, 3, and 5 days post-scalding, and returned to normal levels 7 days post-scalding. The most marked increase of T2 relaxation time was found in the hippocampus; similar changes were also revealed in the thalamus, caudate-putamen, and cerebrum. No correlation was found between T2 relaxation time and plasma glucose level in scalded rats. Pathological observation of the hippocampus showed edema 1, 3, and 5 days post-scalding, with recovery to normal findings at 7 days post-scalding. Thus, we concluded that T2 mapping is a sensitive method for detecting and monitoring scald injury in the rat brain. As the hippocampus is the main region for modulating a stress reaction, it showed significantly increased water content along with

关键词： burns magnetic resonance imaging T2 relaxation time hippocampus

Improving the Antibacterial Property of Chitosan Hydrogel Wound Dressing with Licorice Polysaccharide

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Journal of Renewable Materials 2020年第10期8卷 1343-1355页

作者： Haiwei Ren Li Wang Hui Bao Yunya Xia Dada Xu Weijie Zhang zhiye Wang School of Life Science and Engineering Lanzhou University of TechnologyLanzhou730050China Institute of Biology Gansu Academy of SciencesLanzhou73000China

A series of hydrogels with different ratios of chitosan and licorice polysaccharide(LP)were prepared by crosslinking to different concentrations of genipin(gp).They were characterized by FTIR(Fourier transform infrared spectroscopy),SEM(Scanning electron microscope),swelling ratio,rheological measurements,degradation with time,cytotoxicity,and antibacterial *** show that the hydrogels have porous *** an increase in LP content,the swelling rate grows in the early stage of immersion in buffer and drops *** swelling ratio ranged from 986%to 1677%,and stiffness varied from 777 Pa to 1792 *** addition of LP reduced the mechanical strength and delayed gelation and degradation of the ***,the most important discovery was that gp increases the viability of NIH 3T3 cells from 94%to 137%,and LP raises the bacteriostatic efficacy from 51%to 78%.Hydrogels synthesized from 1%genipin,3%chitosan,and 4%licorice polysaccharide showed the best antibacterial and fibroblast proliferation promoting *** exhibited moderate swelling and degradation rates over time,while being more suitable to affect healing of chronic wound *** results provide a new strategy to improve the antibacterial effectiveness and cyto-compatibility of chitosan hydrogels with water soluble active LPs from Glycyrrhiza that derive from traditional Chinese medicine.

关键词： Chitosan licorice polysaccharide hydrogel antibacterial property wound dressing

Comparison of Flame-retardancy Property and Mechanism between a Phosphate Ester and a Phosphoramine Flame-retardants

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Journal of Wuhan University of Technology(Materials Science) 2021年第1期36卷 148-156页

作者： QIN Shiqian YANG Zhiyi ZHANG Shuai ZHANG zhiye WANG Xinlong YANG Xiushan LUO Tao YANG Lin School of Chemical Engineering Sichuan UniversityChengdu 610065China

A halogen-free flame-retardant (hydroquinone bis (N,N’-diarylphosphoramidate),4N-HDP) containing phosphorus-nitrogen was *** structure was characterized by infrared spectroscopy (IR),nuclear magnetic resonance (^(1)H-NMR and^(31)P-NMR).Thermogravimetric analysis (TG),limiting oxygen index (LOI),UL-94 vertical burning test (UL-94),thermogravimetric-infrared instrument (TG-IR) and scanning electron microscopy (SEM) were used to compare the flame-retarding performance and mechanism of hydroquinone bis (diphenyl phosphate) (HDP) and ***,IR and TG-IR were used for comparative analysis,indicating that both HDP and 4N-HDP are flame-retardants,and the gas phase and condensed phase act *** the pyrolysis process,it is divided into two steps:the first step is the breakage of large molecules to small molecules;the second step is the gasification and carbonization of small molecules,and eventually produces phosphate ester and non-flammable *** the comparison of various results,it could be found that 4N-HDP has better flame-retarding performance compared to HDP in the composite with polycarbonate (PC).

关键词： flame-retardant phosphoramine thermogravimetric analysis polycarbonates TG-IR

Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-jie Quan Hao Liang Yong-Hong Tang Li jiang Xiong-Ying ji Feng-Ying Zhang Ping Zhang Bo Ouyang Department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China Department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism

急性心肌梗死相关线粒体基因的生物信息学鉴定与验证

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中国组织工程研究 2025年第31期29卷 6697-6707页

作者：田宇诗付强李冀黑龙江中医药大学基础医学院黑龙江省哈尔滨市150040 黑龙江中医药大学黑龙江省哈尔滨市150040

背景:线粒体在急性心肌梗死损伤和修复中具有重要意义,因此基于线粒体基因探索急性心肌梗死发病进展具有重要的临床意义。目的:探究线粒体基因是否可以作为评估急性心肌梗死进展的可靠生物标志物。方法:从高通量基因表达数据库下载急性... 详细信息

背景:线粒体在急性心肌梗死损伤和修复中具有重要意义,因此基于线粒体基因探索急性心肌梗死发病进展具有重要的临床意义。目的:探究线粒体基因是否可以作为评估急性心肌梗死进展的可靠生物标志物。方法:从高通量基因表达数据库下载急性心肌梗死数据集GSE66360,GSE12288,在线粒体蛋白质数据库获取人类线粒体基因集;对急性心肌梗死数据集GSE66360进行差异基因分析及加权基因共表达网络分析,两者取交集后获得基因进行蛋白质-蛋白质相互作用分析、基因本体论和京都基因与基因组百科全书分析;将交集基因与人类线粒体基因取交集以获得差异线粒体基因,对差异线粒体基因进行基因集富集分析和免疫浸润分析,并在外部数据集GSE12288中进行受试者工作特征曲线分析,验证线粒体差异基因的表达特征。结果与结论:①获得急性心肌梗死差异基因548个,差异基因分析及加权基因共表达网络分析显示Blue模块包含基因最多(4992个),二者交集基因共有116个,其中肿瘤坏死因子、白细胞介素1B、白细胞介素6、Toll样受体4和白细胞介素10为核心基因;②基因本体论分析显示生物过程主要涉及炎症反应、肿瘤坏死因子产生的正调控及细胞表面受体信号通路,细胞组成主要涉及三级颗粒膜、质膜外层和质膜等,分子功能主要涉及免疫球蛋白G结合、跨膜信号受体活性及趋化因子活性等,京都基因与基因组百科全书分析显示,这些基因主要涉及肿瘤坏死因子、白细胞介素17及核转录因子κB通路;③共获得8个差异线粒体基因,经过最小绝对收缩和选择算子和比例风险回归模型分析后筛选出4个特征基因,包括佛波醇-12-肉豆酸酯-13-乙酰基诱导蛋白1、BCL2-相关蛋白A1、溶质载体家族25成员37和脱氧核糖核酸聚合酶β,并分别对应了肿瘤蛋白53、氧化磷酸化、硫代谢及甘油磷脂代谢通路;④受试者工作特征曲线分析显示4个特征基因均具有诊断意义,并与静息树突状细胞、幼稚B细胞呈显著负相关性;⑤提示佛波醇-12-肉豆酸酯-13-乙酰基诱导蛋白1、BCL2-相关蛋白A1、溶质载体家族25成员37和脱氧核糖核酸聚合酶β表达特征可作为预测急性心肌梗死中线粒体功能的潜在生物标志物,可进一步提高急性心肌梗死预测的准确性。

关键词：线粒体急性心肌梗死生物信息学机器学习免疫浸润分析氧化应激炎症凋亡

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Histopathological and imageological studies on clinical outcomes of mineralized collagen reconstruction rod for femoral head necrosis with one case report

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Regenerative Biomaterials 2017年第4期4卷 243-249页

作者： Baogang Xie Hao Wang jianhua Hao Ping Wang Na Zhang jingjing Wu zhiye Qiu Fuzhai Cui Department of Orthopaedics 254th Hospital of PLANo.60 Huangwei RoadHebei DistrictTianjin 300142China School of Materials Science and Engineering Tsinghua UniversityHaidian District Beijing 100084China

In this article,the biodegradation process and bone formation of a mineralized collagen reconstruction rod embedding in necrosis of human femoral head were investigated by imageological and histological *** radiography(CR)computerized tomography(CT),common pathological section and hard tissue section analysis were used to evaluated the dynamics of imageological and histopathological changes of femoral head,interface between the host bone and implant and the bone reconstruction *** results showed that the density of rods increased closed to that of host bones after 1 year implanting,and the interface between them turns to *** tissue grinding sections analysis showed osteocytes appearing in sparse bone trabecular and bone pit region,as well as a few vessels in the degraded dye powder matrix were noticed,indicating the new bone forming between the implants and host *** decalcified sections analysis showed scattered osteoclasts,multinucleated giant cells and fibrosis components existing in the degraded rod and the host bone *** debris was endocytosed by giant cells,and vascular network formed around the boundaries of the implanted *** good osteointegration has been expressed by the interface between the implanted rod and the host bone becoming *** results indicated that the implanted rod degradation process and new bones regeneration simultaneously occurred around the boundaries of embedding *** bone and host bone were hinged and co-existed.

关键词： femoral head necrosis mineralized collagen reconstruction rod for femoral head necrosis

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浙江省高职院校现代学徒制政策执行效果评价

职业技术 2025年第1期24卷 39-46页

作者：季青媛浙江艺术职业学院杭州310053

浙江加快改造提升传统产业,大力培育战略性新兴产业与未来产业,打造新技术、新产业、新业态、新模式“四新”经济。为解决企业转型升级所引致的人才结构性供需矛盾问题,职业院校积极深化产教融合,推进现代学徒制,全面提升技术技能人才... 详细信息

浙江加快改造提升传统产业,大力培育战略性新兴产业与未来产业,打造新技术、新产业、新业态、新模式“四新”经济。为解决企业转型升级所引致的人才结构性供需矛盾问题,职业院校积极深化产教融合,推进现代学徒制,全面提升技术技能人才培养能力和水平。基于史密斯政策执行理论的四个维度,分析浙江省现代学徒制政策执行的影响因素,发现政策执行存在现代学徒制政策协同作用有待提升,企业主体地位有待充分显现,学生学徒双重身份保障不力,政策执行环境有待优化等问题。基于此,提出应加强政策顶层设计,强化执行机构能力,把控学徒培养质量,提升目标群体政策认同度,营造良好政策执行生态。

关键词：现代学徒制政策执行效果评价