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Size-dependent macrophage-targeting of mannose-modified rosiglitazone liposomes to alleviate inflammatory bowel disease

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Chinese Chemical Letters 2024年第1期35卷 385-391页

作者： Erjin Wang Run Han Mingyue wu Yuan He Yaxin Cheng Jiahong Lu Ying Zheng State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences(ICMS)University of MacaoMacao 999078China Department of Pharmacy Xuzhou Medical UniversityXuzhou 221004China Faculty of Health Sciences University of MacaoMacao 999078China Guangdong-Hong Kong-Macao Joint Lab on Chinese Medicine and Immune Disease Research University of MacaoMacao 999078China

Inflammatory bowel disease (IBD) is a refractory chronic intestinal inflammatory disease caused by a malfunction of immune system. As the key immune cells in the intestine, macrophages play an important role in maintaining intestinal homeostasis and tissue repair of the IBD. Pharmacological modulation of macrophage function exhibits the promising therapeutic effect for IBD. In this study, mannose-modified liposomes (MAN-LPs) are prepared for macrophage targeting to improve therapeutic efficiency. Rosiglitazone (ROSI) as an agonist of peroxisome proliferators-activated receptor γ (PPAR-γ) is used as the model drug to fabricate different sized liposomes. The impacts of mannose modification and particle size for macrophage targeting are investigated in cells, zebrafish, and mouse models and the therapeutic effects of the MAN-LPs are evaluated on dextran sulfate sodium (DSS)-induced IBD mouse. Compared to unmodified liposome, MAN-LPs display higher uptake by RAW 264.7 cells and better co-localization with macrophage in zebrafish model. Furthermore, MAN-LPs could effectively accumulate in the inflammatory intestinal sites in IBD mouse model. Most importantly, the targeting ability of MAN-LPs is obviously enhanced with the increasing of particle size, whereas the largest MAN-LPs particles achieve the best anti-inflammatory effect in cells, and a higher therapeutic efficiency in IBD mouse model. Therefore, mannose-modified liposome is a promising strategy for macrophage-targeting in IBD treatment. Particle size of MAN-LPs will affect macrophage targeting ability, as well as the therapeutic effect in-vivo.

关键词： Macrophage targeting Liposome Mannose Particle size Inflammatory bowel disease

Atomically self-healing of structural defects in monolayer WSe2

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Chinese Physics B 2024年第9期33卷 53-59页

作者：李康舒李俊贤韩小藏周武赵晓续 School of Materials Science and Engineering Peking University School of Physical Sciences University of Chinese Academy of Sciences AI for Science Institute

Minimizing disorder and defects is crucial for realizing the full potential of two-dimensional transition metal dichalcogenides(TMDs) materials and improving device performance to desired properties. However, the methods in defect control currently face challenges with overly large operational areas and a lack of precision in targeting specific defects. Therefore,we propose a new method for the precise and universal defect healing of TMD materials, integrating real-time imaging with scanning transmission electron microscopy(STEM). This method employs electron beam irradiation to stimulate the diffusion migration of surface-adsorbed adatoms on TMD materials grown by low-temperature molecular beam epitaxy(MBE),and heal defects within the diffusion range. This approach covers defect repairs ranging from zero-dimensional vacancy defects to two-dimensional grain orientation alignment, demonstrating its universality in terms of the types of samples and defects. These findings offer insights into the use of atomic-level focused electron beams at appropriate voltages in STEM for defect healing, providing valuable experience for achieving atomic-level precise fabrication of TMD materials.

关键词： atom manipulation design fabrication nanoscale materials and structures: fabrication and characterization new materials: theory scanning transmission electron microscopy (STEM)

卵巢-附件影像报告和数据系统联合卵巢癌风险预测模型指数对卵巢良、恶性肿瘤的诊断价值

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中国医学影像学杂志 2024年第7期32卷 714-718页

作者：吴丽仙武立萍雍圆圆宁夏医科大学总医院心脑血管病医院妇科宁夏银川750000 宁夏医科大学总医院妇科宁夏银川750000

目的探讨卵巢-附件影像报告和数据系统(O-RADS)联合卵巢癌风险预测模型(ROMA)指数对卵巢肿瘤良恶性的诊断效能。资料与方法回顾性分析2021年1—12月宁夏医科大学总医院495例卵巢肿瘤的超声图像,根据O-RADS超声风险分层标准对附件区包块... 详细信息

目的探讨卵巢-附件影像报告和数据系统(O-RADS)联合卵巢癌风险预测模型(ROMA)指数对卵巢肿瘤良恶性的诊断效能。资料与方法回顾性分析2021年1—12月宁夏医科大学总医院495例卵巢肿瘤的超声图像,根据O-RADS超声风险分层标准对附件区包块进行分类。以手术病理结果为“金标准”,绘制受试者工作特征曲线,计算O-RADS对附件肿块的诊断效能,对O-RADS4类,联合ROMA指数计算诊断符合率。结果O-RADS2~5类卵巢肿瘤的恶性率分别为0、2.7%、43.6%、86.8%;O-RADS超声风险分层诊断卵巢肿瘤的曲线下面积为0.929,对附件区良、恶性肿瘤的最佳截断值为>3类,诊断卵巢肿瘤的敏感度为90.8%、特异度为89.4%、阳性预测值为67.9%,阴性预测值为97.5%,诊断符合率为89.7%;O-RADS 2~5类诊断卵巢肿瘤的符合率分别为100%、97.3%、43.6%、86.8%,O-RADS 4类是卵巢肿瘤良恶性鉴别的难点,将O-RADS 4类联合ROMA指数后诊断符合率由43.6%升至72.7%。结论O-RADS超声风险分层对卵巢肿瘤有较好的诊断价值。但O-RADS 4类是诊断难点,O-RADS 4类联合ROMA指数能显著提高卵巢肿瘤的诊断符合率。

关键词：卵巢肿瘤超声检查卵巢-附件影像报告和数据系统卵巢癌风险预测模型

A NOTE ON THE GENERAL STABILIZATION OF DISCRETE FEEDBACK CONTROL FOR NON-AUTONOMOUS HYBRID NEUTRAL STOCHASTIC SYSTEMS WITH A DELAY

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Acta Mathematica Scientia 2024年第3期44卷 1145-1164页

作者：冯立超张春艳曹进德武志辉 College of Science North China University of Science and TechnologyTangshan063210China School of Mathematics Southeast UniversityNanjing210096China Department of Mathematics Harbin University of Science and TechnologyHarbin150080China

Discrete feedback control was designed to stabilize an unstable hybrid neutral stochastic differential delay system(HNSDDS) under a highly nonlinear constraint in the H_∞ and exponential ***,the existing work just adapted to autonomous cases,and the obtained results were mainly on exponential *** comparison with autonomous cases,non-autonomous systems are of great interest and represent an important ***,discrete feedback control has here been adjusted with a time factor to stabilize an unstable non-autonomous HNSDDS,in which new Lyapunov-Krasovskii functionals and some novel technologies are *** should be noted,in particular,that the stabilization can be achieved not only in the routine H_∞ and exponential forms,but also the polynomial form and even a general form.

关键词： hybrid neutral stochastic differential delay system discrete feedback control general stabilization polynomial stabilization

Experimental observation of the significant difference between surface and bulk Kondo processes in Kondo lattice YbCu_(2)Si_(2)

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Science China(Physics,Mechanics & Astronomy) 2024年第4期67卷 154-160页

作者： Yin-Zou Zhao Jiao-Jiao Song Qi-Yi wu Hao Liu Chen Zhang Bo Chen Hong-Yi Zhang Zhen-Hua Chen Yao-Bo Huang Xue-Qing Ye Ya-Hua Yuan Yu-Xia Duan Jun He Jian-Qiao Meng School of Physics Central South UniversityChangsha 410083China Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201204China

Synchrotron-based angle-resolved photoemission spectroscopy was employed to investigate the temperature evolution of the Yb 4 f spectral for surface and bulk in the Kondo lattice YbCu_(2)Si_(2).Our study quantitatively distinguishes between the surface and bulk hybridization processes,revealing that the onset temperatures for both surface and bulk hybridization processes are significantly higher than the Kondo ***,we found that the effective surface Kondo temperature is much lower than that of the *** findings offer valuable insights into the understanding of heavy fermion physics.

关键词： Kondo lattice angle-resolved photoemission spectroscopy electronic structure hybridization surface state

An air-stable single-crystal layered oxide cathode based on multifunctional structural modulation for high-energy-density sodium-ion batteries

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Science China Chemistry 2024年

作者： Yi-Feng Liu Hai-Yan Hu Jia-Yang Li Hongrui Wang Yi Zhao Jingqiang Wang Yuan-Bo wu Yan-Jiang Li Guang-Yu Zhang Qing-Qun Sun Yan-Fang Zhu Rui-Ren Tang Xiong-Wei wu Jia-Zhao Wang Shi-Xue Dou Shu-Lei Chou Yao Xiao Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education) Nankai University School of Chemistry and Materials Science Hunan Agricultural University Institute of Energy Materials Science University of Shanghai for Science and Technology Wenzhou Key Laboratory of Sodium-Ion Batteries Wenzhou University Technology Innovation Institute for Carbon Neutralization Institute for Carbon Neutralization College of Chemistry and Materials Engineering Wenzhou University College of Chemistry and Chemical Engineering Central South University

P2-type layered oxide, Na2/3Ni1/3Mn2/3O2, has drawn particular interest as a promising cathode material for sodium-ion batteries(SIBs) due to its fast sodium-ion transport channels with low migration potential. However, some catastrophic flaws, such as air instability, complicated multiphase evolution, and irreversible anionic redox, limit its electrochemical performance and hinder its application. Here, an air-stable single-crystal P2-type Na2/3Ni1/3Mn1/3Ti1/3O2is proposed based on the multifunctional structural modulation of Ti substitution that could alleviate the issues for practical SIBs. As a result, the cathode with high energy density shows excellent air stability and highly reversible phase transitions(P2–OP4), and delivers faster kinetics and stable anion redox chemistry. Meanwhile, a thorough investigation of the relationship between structure, function, and properties is demonstrated,emphasizing formation processes, electrochemical behavior, structural evolution, and air stability. Overall, this study provides the direction of multifunctional structural modulation for the development of high-performance sodium-based layered cathode materials for practical applications.

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Maximizing hydrogen evolution via Co-Ni dual atoms and nanoclusters on hierarchically ordered porous carbon framework

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Science China Materials 2024年第10期67卷 3197-3205页

作者： Qian Li Pan Zhang Huaiguang Li Yuan Wang Dongsheng Tang Qun Li Jiabin wu Synergetic Innovation Center for Quantum Effects and Application Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of EducationCollege of Physics and Information ScienceHunan Normal UniversityChangsha 410081China National Key Laboratory of Advanced Micro and Nano Manufacture Technology School of Integrated CircuitsPeking UniversityBeijing 100871China The Chinese University of Hong Kong ShenzhenShenzhen 518172China CAS Key Laboratory of Nanosystem and Hierarchical Fabrication&CAS Center for Excellence in Nanoscience National Center for Nanoscience and TechnologyBeijing 100190China Department of Chemistry Tsinghua UniversityBeijing 100084China Insititute of Microelectronics State Key Laboratory of Analog and Mixed-Signal VLSIUniversity of MacaoMacao 519000China

Efficient hydrogen production through water splitting relies on the development of high-performance catalysts for the hydrogen evolution reaction(HER).In this study,we synthesized the CoNi SAs@NPs-NC catalyst using multi-metal single-crystal ordered macroporous metal-organic frameworks(MOFs)as *** catalyst features a hierarchical porous structure with ordered macropores and micropores,which not only provides a high specific surface area but also promotes efficient mass ***,the incorporation of bimetallic components,coupled with synergistic interactions between single atoms(SAs)and nanoparticles(NPs),significantly enhances its catalytic *** CoNi SAs@NPs-NC nanocatalysts demonstrated exceptional activity in the HER,recording overpotentials of 90 mV in 1 M KOH and 61 mV in 0.5 M H_(2)SO_(4),both at a current density of 10 mA cm^(−2).In addition,density functional theory(DFT)analysis was employed to investigate the synergistic interactions among CoNi NPs,SAs,and nitrogen *** finding highlights the promising potential of the CoNi SAs@NPs-NC catalyst for efficient hydrogen evolution,making it a valuable candidate for advancing the field of water splitting.

关键词： three dimensional ordered macroporous Co-Ni dual atoms Co-Ni nanoclusters HER synergistic effect

Rediscovery of numerical Lüscher's formula from the neural network

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Chinese Physics C 2024年第7期48卷 38-44页

作者：陆宇王一佳陈莹吴佳俊 School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

We present that by predicting the spectrum in discrete space from the phase shift in continuous space,the neural network can remarkably reproduce the numerical Lüscher's formula to a high *** model-independent property of the Lüscher's formula is naturally realized by the generalizability of the neural *** exhibits the great potential of the neural network to extract model-independent relation between model-dependent quantities,and this data-driven approach could greatly facilitate the discovery of the physical principles underneath the intricate data.

关键词： Luescher's formula neural network finite volume effects LQCD

Investigation and Mitigation of Carbon Deposition over Copper Catalyst during Electrochemical CO_(2)Reduction

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Precision Chemistry 2024年第4期2卷 151-160页

作者： Jing-Wen DuanMu Zhi-Zheng wu Fei-Yue Gao Peng-Peng Yang Zhuang-Zhuang Niu Yu-Cai Zhang Li-Ping Chi Min-Rui Gao Division of Nanomaterials and Chemistry Hefei National Laboratory for Physical Sciences at the MicroscaleUniversity of Science and Technology of ChinaHefei 230026China

Copper(Cu)is considered to be the most effective catalyst for electrochemical conversion of carbon dioxide(CO_(2))into value-added hydrocarbons,but its stability still faces considerable ***,we report the poisoning effect of carbon deposition during CO_(2)reduction on the active sites of Cu electrodea critical deactivation factor that is often *** find that,*C,an intermediate toward methane formation,could desorb on the electrode surface to form carbon *** reveal a strong correlation between the formation of methane and the carbon deposition,and the reaction conditions favoring methane production result in more carbon *** deposited carbon blocks the active sites and consequently causes rapid deterioration of the catalytic *** further demonstrate that the carbon deposition can be mitigated by increasing the roughness of the electrode and increasing the pH of the *** work offers a new guidance for designing more stable catalysts for CO_(2)reduction.

关键词： carbon deposition roughness in situ spectrum CO_(2)electroreduction copper catalyst